研究生: |
巴達禮 Pateliya Mujjamil Habib |
---|---|
論文名稱: |
GREENER APPROACHES TOWARDS THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE N, O, S-HETEROCYCLES AND ANTIBACTERIAL AGENTS GREENER APPROACHES TOWARDS THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE N, O, S-HETEROCYCLES AND ANTIBACTERIAL AGENTS |
指導教授: | 姚清發 |
學位類別: |
博士 Doctor |
系所名稱: |
化學系 Department of Chemistry |
論文出版年: | 2010 |
畢業學年度: | 99 |
語文別: | 英文 |
論文頁數: | ? |
中文關鍵詞: | 在水中合成 、無催化劑 、抗菌劑 |
論文種類: | 學術論文 |
相關次數: | 點閱:132 下載:4 |
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本論文主要的目標是發展新的綠色化學的合成方式及抗菌劑的和成。
此論文分成三個章節。第一章節分為兩部分,A部分是介紹不需使用催化劑,即可使吲哚加成至β-硝基苯乙烯。B部分則是介紹不需使用溶劑,即可使吡咯與吲哚加成至β-硝基苯乙烯。
第二章節為利用在水中且無催化劑之條件下,促進吲哚與2-aryl-3-2H-chromenes進行烷基化反應。
第三章節亦分為兩部分,A部分介紹有關[3+2]-環加成反應。B部分是介紹3-phenyl-5-((4-phenyl-2-(phenylimino)thiazol-3(2H)-yl)methyl)oxazo- lidin-2-one的合成。
The dissertation is divided into three chapters. The first chapter is divided into two sections, Section A deals with the catalyst-free aqueous mediated conjugative addition of indoles to β-nitrostyrenes and Section B describes the conjugative addition of pyrrole and indole to β-nitroalkenes under solvent free condition (SFC). Second chapter provides a detailed study of “On-Water” promoted C-alkylation of indoles with 2-aryl-3-2H-chromenes under catalyst-free conditions’’ and mechanistic insights. Third chapter is divided into three sections A, B and C; Section A and B which describe the [3+2]-cycloaddition synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d] [1,2,3]triazole and triazole-oxazolidinones derivatives respectively. Section C deals with the synthesis of a new class oxazolidinone C-5-(aryl-imino)thiazo and pharmacologically active Linezolid analogues.
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