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研究生: 宋元景
Sung, Yuan-Ching
論文名稱: 磁性熱消融技術之電子醫材開發
Development of electronic medical materials for magnetic thermal ablation technology
指導教授: 謝振傑
Chieh, Jen-Jie
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2019
畢業學年度: 107
語文別: 中文
論文頁數: 123
中文關鍵詞: 高週波機械磁性流體液態金屬
英文關鍵詞: High-frequency induction heater, Magnetic fluid, Liquid metal
DOI URL: http://doi.org/10.6345/NTNU201900983
論文種類: 學術論文
相關次數: 點閱:111下載:0
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  • 甲狀腺惡性腫瘤(癌)是內分泌科門診中最常見的癌症,同時於過去十年資料顯示其發生率有逐漸上升的趨勢。甲狀腺疾病好發於20到40歲的年輕女性,常見症狀為吞嚥困難、呼吸困難、聲音沙啞、沒感冒卻持續咳嗽不止等症狀,經專科醫師診治的有甲狀腺結節、甲狀腺機能亢進、甲狀腺癌。
    本研究藉由鎵基複合粒子,用感應加熱的方式來使鎵基複合粒子升溫以熱療形態達到治療甲狀腺癌的目的,而鎵基複合粒子帶來的磁控性能在治療上有局部治療和指引標的的功能。
    高週波感應加熱機坊間皆為使用交流380V,或是220V,同時額外接著水冷系統,因此使用起來非常不便。本研究藉由更改高週波感應加熱機的內部設計,使其使用110V,且只需要少量的冷卻水,達到可隨時隨地使用的便利性。

    Thyroid malignancy is the most common cancer in the endocrinology clinic, and the incidence of the disease has shown a gradual increase in the past decade. Thyroid disease occurs in young women between the ages of 20 and 40. Common symptoms include dysphagia, difficulty breathing, hoarseness, and no cough but persistent coughing. Symptoms of thyroid nodules, hyperthyroidism, and thyroid cancer are diagnosed by specialists.
    In this study, gallium-based magnetic particles were used to induce the heating of gallium-based magnetic particles in the form of hyperthermia to achieve the purpose of treating thyroid cancer. The magnetic control performance brought by the gallium-based magnetic particles has the function of local treatment and guidance in treatment.
    The high-frequency induction heater uses AC 380V or 220V, and additionally follows the water cooling system, so it is very inconvenient to use. This study changed the internal design of the high-frequency induction heater to 110V, and only needed a small amount of cooling water to achieve the convenience of anytime, anywhere.

    摘要 i Abstract ii 目錄 iii 圖目錄 v 表目錄 viii 第一章 緒論 1 1.1 甲狀腺癌 1 1.2 金屬物質產熱 2 1.2.1 液態金屬鎵的產熱 2 1.2.2 磁性物質的產熱 3 1.3 金屬物質產熱的應用 3 1.4 研究目的與動機 4 第二章 實驗原理 5 2.1 LC共振 5 2.2 電磁感應加熱原理 6 2.2.1 感應加熱模擬原理 7 2.3 必歐-沙伐定律 (Biot-Savart Law) 8 2.4 布朗和奈爾鬆弛理論 (Brownian and Neél relaxation time) 10 2.5 渦電流 (Eddy Current) 12 第三章 模擬設計與實驗方法 13 3.1 COMSOL Multiphysics模擬 13 3.1.1圓形線圈電磁感應加熱的幾何建模 13 3.1.2 鎵基複合粒子在不同線圈的幾何建模 16 3.2 鎵基複合粒子產熱特性之實驗 19 3.2.1產熱特性實驗建置 20 3.2.2 熱療效果實驗建置 21 3.3 鎵基複合粒子在不同線圈實驗配置 26 3.3.1 三匝圓形線圈 26 3.3.2 一組方形線圈 27 3.3.3 兩組方形線圈 27 3.3.4 三組方形線圈 28 3.4 鎵基複合粒子在不同熱消融之電子醫材實驗配置 29 第四章 結果與討論 32 4.1 COMSOL Multiphysics模擬結果 32 4.1.1鎵基複合粒子電磁感應加熱的模擬結果 32 4.1.2 鎵基複合粒子在不同線圈的幾何結果 38 4.2 鎵基複合粒子物理特性探討 51 4.2.1 產熱特性探討 51 4.3 鎵基複合粒子不同線圈之熱療效果探討 76 4.3.1 三匝圓形線圈之熱療效果 76 4.3.2 一組方形線圈之熱療效果 87 4.3.3 兩組方形線圈之熱療效果 96 4.3.4 三組方形線圈之熱療效果 105 4.4 鎵基複合粒子在自製熱消融之電子醫材實驗結果 117 第五章 結論與未來研究方向 121 5.1結論 121 5.2未來研究方向 121 參考文獻 123

    [1] 衛生福利部雙和醫院, "甲狀腺癌年輕化 別輕忽身體小徵兆", 2018
    [2] Y. Gao and J. Liu, "Gallium-based thermal interface material with high compliance and wettability," Applied Physics A, vol. 107, pp. 701-708, 2012.
    [3] S. Vijay, T. Shi-Yang, O. M. A. P., P. Phred, E. Nicky, K.-z. Kourosh, et al., "Liquid Metal Marbles," Advanced Functional Materials, vol. 23, pp. 144-152, 2013.
    [4] K. E. Spells, "The determination of the viscosity of liquid gallium over an extended nrange of temperature," Proceedings of the Physical Society, vol. 48, p. 299, 1936.
    [5] C. R. Chitambar, "Medical applications and toxicities of gallium compounds," Int J Environ Res Public Health, vol. 7, pp. 2337-61, 2010.
    [6] L. Wang and J. Liu, "Printing low-melting-point alloy ink to directly make a solidified circuit or functional device with a heating pen," Physical and Engineering Sciences, vol. 470, p. 20140609, 2014.
    [7] Junjie Yan, Yue Lu, Guojun Chen, Min Yang and Zhen Gu, " Advances in liquid metals for biomedical applications," The Royal Society of Chemistry, vol. 47, pp. 2518-2533, 2018.
    [8] 臺北市立聯合醫院, "甲狀腺疾病外科手術治療", 2018
    [9] 中山醫學大學附設醫院, "【醫影部】甲狀腺結節微創治療 甲狀腺結節射頻消融治療及護理", 2018.
    [10] F. Semiconductor, "Induction Heating System Topology Review," 2000.
    [11] W. ROetzel and B. Spang, "C3 Typical Values of Overall Heat Transfer COefficients," in VDI Heat Atlas, ed Berlin, Heidelberg: Springer Berlin Heidelberg, 2010, pp. 75-78.
    [12] K. Takegami, Y. Kaneko, T. Watanabe, T. Maruyama, Y. Matsumoto, and H. Nagawa, "Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound," Ultrasound in Medicine & Biology, vol.
    [13] T. A. Steinke, "Thrombus removal," ed: Google Patents, 2013.

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