調查發現台灣成人為B型肝炎帶原的比例頗高，而國內運動選手為B型肝炎帶原的比例也不少。運動選手常在重要比賽前，會有短期的密集運動訓練，是否因此而使B型肝炎帶原之選手的免疫功能產生負面的影響，目前尚無相關的研究。本研究之目的在探討連續五天密集運動訓練對健康B型肝炎帶原之選手T淋巴細胞的影響。本研究以16位志願之運動選手為研究對象，其中8位為健康B型肝炎帶原之選手(B肝組)，8位為健康之選手(控制組)，平均年齡為20.7±1.6歲；身高為177.1±5.1公分；體重為71±7.9公斤；最大攝氧量為52.7±5.4 ml/kg/min。兩組受試者皆在跑步機上，從事運動強度為75%VO2max，時間為30分鐘，連續五天的跑步運動，並於第一天運動前與第五天的運動前、運動後立刻、1.5、3及24小時，抽血分析受試者體內T淋巴細胞及其亞群(CD3+、CD4+CD8-、CD4-CD8+)的數目，以及T淋巴細胞增生的功能，並以混合設計二因子共變數分析處理。結果發現，B肝組和控制組在任何時間點上，血液中白血球、T淋巴細胞及其亞群數目，以及T淋巴細胞增生功能上皆沒有顯著差異。不過所有受試者，其白血球、T淋巴細胞及其亞群的數目在第五天運動後皆明顯增加(p<.05)，但在運動後的1.5小時，T淋巴細胞、CD4+CD8-細胞及CD4-CD8+細胞的數目卻都降至第一天運動前水準之下(p<.05)。而CD4/CD8比值也在第五天運動後顯著降低(p<.05)。T淋巴細胞增生功能則在第五天運動後的1.5小時降到最低值(p<.05)。經由本實驗結果可得到以下的結論：健康B型肝炎帶原者在連續五天密集的運動訓練後，其體內的免疫反應並沒有異於常人，不過所有受試者在連續五天運動後1-3小時的恢復期，其體內的免疫功能皆會受到顯著的抑制。

The purpose of this study was to investigate the effects of five-day consecutive training on T-lymphocyte in healthy hepatitis B carriers. Sixteen athletes (age=20.7±1.6 yrs, ht=177.1±5.1 cm, wt=71±7.9 kg, VO2max=52.7±5.4 ml/kg/min) from different sport teams were recruited as the subjects. Eight of the subjects who were healthy hepatitis B carriers served as the experimental group (B group), and the other eight normal healthy subjects was the Control group. All subjects were asked to run on treadmill at 75%VO2max, 30 minutes per day for five consecutive days. The blood samples were collected on day one at pre-exercise, day five at pre-exercise, post-exercise, 1.5 hr, 3 hr and 24 hr post-exercise. The T-lymphocyte number, its subpopulations (CD3+,CD4+CD8-,CD4-CD8+), and T-lymphocyte proliferation were measured and analyzed by two-way ANCOVA mixed design. The results indicated that there was no significant difference between B group and Control group on T-lymphocyte number, its subpopulations, and T-lymphocyte proliferation at any time. But the numbers of leukocyte, lymphocyte, T cell, CD4+CD8- cells and CD4-CD8+cells in all subjects were significantly increased immediately after exercise on day five. Then, those parameters were dramatically decreased at 1.5 hr post-exercise, which were significantly lower than pre-exercise on day one. In addition, the CD4/CD8 ratio was significantly decreased immediately after exercise on day five. T-lymphocyte proliferation was significantly suppressed at 1.5 hr post-exercise on day five. In summary, the immunological response to five-day consecutive training in healthy hepatitis B carriers was not different from that of normal healthy people. However, all subjects were undergone immunological suppression around 1-3 hr of recovery period after the consecutive training.

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