上呼吸道包含鼻腔、咽部以及喉部，這段呼吸道的暢通主要由顏面、舌下、上喉和喉返神經的呼吸相關活性所控制。肺迷走傳入神經為肺部主要接受週邊刺激的傳入神經纖維，包含了肺C纖維、肺牽張慢速適應受器與快速適應受器。本論文的目的是探討大鼠肺迷走傳入神經興奮後對於上呼吸道運動神經的影響，為達此目的，本論文分成六個實驗，除第四個實驗外，其餘實驗所用的動物，都是麻痺並以人工呼吸機維持呼吸。第一實驗是研究大鼠舌下神經對於肺C纖維受到頸靜脈注射辣椒素後的反應，結果顯示肺C纖維興奮後會抑制舌下神經節律性的吸氣前與吸氣活性，並誘發短暫的連續性放電活性。舌下神經主要可以分為內支與外支舌下神經，這兩個分支分別支配舌頭的伸肌與縮肌，而肺C纖維興奮後所引起的反射作用，對於內支與外支舌下神經的影響是否相同並不清楚，因此，第二個實驗是同時紀錄內支與外支舌下神經，探討其對肺C纖維興奮後的反應，結果顯示肺C纖維興奮後會同時抑制內支與外支舌下神經的節律性活性，但只會誘發內支舌下神經產生明顯的連續性放電。為了進一步探究舌下神經對於肺C纖維興奮後的反應機制，論文的第三個實驗是利用單根神經分離技術，觀察舌下運動神經元的反應，結果顯示大鼠的舌下神經元包含了呼氣-吸氣神經元、吸氣神經元與靜止神經元，肺C纖維興奮後會抑制舌下神經的節律性活性主要是由於降低了呼氣-吸氣與吸氣神經元的放電率和放電起始時間，而舌下神經的連續性放電活性則可能是由於靜止神經元被辣椒素誘發放電所引起。論文的第四個實驗是要研究舌下神經所支配的舌肌所產生的力量，在肺C纖維興奮所引起的反射是否降低，為量測舌肌收縮所引發的力量，動物在自動呼吸情況下，短暫堵住呼吸道以誘發舌肌力量，發現堵塞呼吸道所誘發的舌肌前伸與後縮力量會增強，這種增強作用會被肺C纖維興奮所抑制，這些結果顯示肺C纖維受刺激後所引起的反射作用，會促使舌下神經活動與舌肌誘發力量降低，可能會不利於上呼吸道的暢通。
活化其他種類的肺迷走傳入神經對於上呼吸道運動神經可能會引起不同的效應，本論文的第五個實驗是研究上呼吸道運動神經(顏面、舌下、上喉與喉返神經)對於肺牽張慢速適應受器與快速適應受器活性改變所引起的反射性反應，方法是增加呼氣末正壓來改變上述兩類接受器的活性，將人工呼吸機的呼氣口接一小管，將管口插入水平面下以增加動物的呼氣末正壓，發現中等程度呼氣末正壓所引起的反射作用，會抑制上呼吸道運動神經與膈神經的吸氣節律，但卻不影響這些運動神經的吸氣前活動，這種現象為稱分開反應，換言之，上呼吸道運動神經在膈神經靜止不活動時仍保有節律性的放電，進一步記錄各運動神經的單根神經元活動，發現分開反應主要是由於中等程度呼氣末正壓會促進呼氣-吸氣神經元在呼氣時的活動，但卻抑制其在吸氣時的活動，可能是由於中等程度呼氣末正壓所引起這種不同的反射作用，才引起了分開反應，迴歸分析的結果顯示低到中等程度呼氣末正壓改變所引起的反射作對於呼氣-吸氣神經元在吸氣前(也就是呼氣)時期的放電率成線性增強，卻不影響其在吸氣時的放電率，暗示上呼吸道運動神經元在呼氣與吸氣時期，可能接受不同的調控作用。本論文最後一個實驗是探討甘胺酸抑制作用是否會調控上呼吸道的吸氣前活動，以證實上述所謂上呼吸道運動神經元接受不同調控的推論，實驗是以甘胺酸受器拮抗劑(strychnine)阻斷甘胺酸的傳導作用，結果顯示阻斷甘胺酸受器的作用後，不但使舌下神經在正常呼吸週期的吸氣前活動消失，且會抑制持續肺脹大所引起的吸氣前活性增強，顯示甘胺酸傳導作用可能與上呼吸道運動神經的吸氣前活動有關。綜合本論文研究所得的結果，顯示幾個結論是：(1)肺C纖維興奮後引起的反射作用可能經由抑制舌下神經與舌肌活性來影響上呼吸道的暢通；(2)藉由改變呼氣末正壓來調節肺牽張慢速適應受器與快速適應受器的活性會導致上呼吸道運動神經與膈神經的呼吸節律分離，此結果可能是增加呼氣末壓力會促進上呼吸道吸氣前活性並抑制吸氣活性所導致，暗示上呼吸道運動神經與膈神經的呼吸節律可能受到不同的調控，且上呼吸道運動神經在吸氣前與吸氣時的活動可能也受到不同的調節；(3)甘胺酸的抑制作用可能參與調節上呼吸道運動神經的吸氣前活

The upper airway (UAW) is composed of the nasal cavity, pharynx and larynx. The patency of the UAW is primarily controlled by the respiratory-related activity of the UAW motor nerves, such as the facial, hypoglossal, superior laryngeal and recurrent laryngeal nerve. Pulmonary vagal afferents, including pulmonary vagal C-fiber (PCF) receptors, slowly adapting stretch receptors (SARs) and rapidly adapting receptors (RARs), are the main sensory afferents arising from the lungs and play an important role in regulating respiration. However, modulation of pulmonary vagal afferents on the UAW motor activity has not yet fully understood. Purpose of present dissertation was to investigate responses of the UAW motor nerves to pulmonary vagal afferent activation in the rat. At first, responses of the hypoglossal nerve to PCF receptor activation by intra-jugular capsaicin administration were examined in the anesthetized and artificially ventilated rats. The results showed that capsaicin-induced PCF receptor activation produced reflex inhibition on phasic (pre-inspiratory; Pre-I, and inspiratory; I) activity but excited tonic activity of the whole hypoglossal nerve. This raised a question whether decrease in the two branches, the medial hypoglossal branch (MHN) innervated the tongue protrudor muscles and lateral hypoglossal branch (LHN) supplied to the tongue retractor muscles was similar or dissimilar. To answer this question, the MHN and LHN were simultaneously recorded to examine their response to capsaicin treatment. The results showed that phasic activity of both hypoglossal branches was similarly reduced, while tonic activity was significantly evoked in the MHN versus LHN. To evaluate the motoneuronal activity underlying the hypoglossal discharge during PCF receptor activation, data from single fiber recording on these two hypoglossal branches revealed that decrease in phasic hypologlossal activity was mainly due to the decrease in discharge rate and a delay onset of the expiratory-inspiratory (EI) and inspiratory (I) hypoglossal motoneurons. However, tonic hypoglossal activity was resulted from the recruitment of silent hypoglossal motoneurons. Results from a further study showed that both protrusive and retractive tongue force development were reduced following intra-jugular capsaicin injection in spontaneously breathing rats. These results suggest that PCF receptor activation by capsaicin may have produced a disadvantage or even risk for the UAW patency. In contrast, activation of other pulmonary vagal afferents, such as SARs and RARs, may have produced distinct effects. Activation of SARs and RARs was achieved by changing positive end-expired pressure (PEEP). The results indicated that elevation of PEEP induced uncoupling of UAW phasic activity from the phrenic burst. This uncoupling was primarily due to a result of persistent firing of Pre-I of the UAW nerves and of the EI motoneurons during phrenic apnea caused by increasing PEEP. Data from the analysis by linear regression illustrated a differential influence of PEEP on EI motoneurons during Pre-I duration vs. I phase. Finally, blockade of glycinergic transmission by strychnine attenuated Pre-I activity of the hypoglossal nerve during control condition, and also during the advanced onset of the Pre-I activity caused by increase of PEEP and sustained lung inflation. In conclusion, the present results suggest that: (1) PCF receptor activation may produce a unfavorable modulation of the pharyngeal patency by the decrease in activity of the hypoglossal nerve and in tongue force development, (2) alteration of SARs and RARs activity by manipulating PEEP evokes an excitation on Pre-I but inhibition on I activity of the UAW motor nerves, and (3) glycinergic inhibition is probably critical for regulation of Pre-I activity of the UAW motor nerves.

Adrian ED. Afferent impulses in the vagus and their effect on respiration. J. Physiol. 79: 332-358, 1933.

Adachi S, Lowe AA, Tsuchiya M, Ryan CF and Fleetham JA. Genioglossus muscle activity and inspiratory timing in obstructive sleep apnea. Am. J. Orthod. Dentofacial Orthop. 104: 138-145, 1993.

American Academy of Sleep Medicine. Sleep related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep. 22: 667-689, 1999.

Agostoni E, Chinnock JE, Daly M de B and Murray JG. Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J. Physiol. 135: 182-205, 1957.

Amis TC, O’Neill N, Wheately JR, van der Touw T, di Somma E and Brancatisano A. Soft palate muscle responses to negative upper airway pressure. J. Appl. Physiol. 86: 523-530, 1999.

Amri M, Lamkadem M and Car A. Activity of extrinsic tongue muscles during swallowing in sheep. Brain Res. 503: 141-143, 1989.

Anand A and Paintal AS. Reflex effects following selective stimulation of J receptors in the cat. J. Physiol. 299: 553-572, 1980.

Aoki CRA, Liu H, Downey GP, Mitchell J and Horner RL. Cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats. Am. J. Respir. Crit. Care Med. 173: 555-565, 2006.

Ayappa I and Rapoport DM. The upper airway in sleep: physiology of the pharynx. Sleep Med. Rev. 7: 9-33, 2003.

Badier M, Jammes Y, Romero-Colomer P and Lemerre C. Tonic activity in inspiratory muscles and phrenic motoneurons by stimulation of vagal afferents. J. Appl. Physiol. 66: 1613-1619, 1989.

Baekey DM, Morris KF, Gestreau C, Li Z, Lindsey BG and Shannon R. Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the cat. J. Physiol. 534: 565-581, 2001.

Bailey EF and Fregosi RF. Pressure-volume behavior of the rat upper airway: effects of tongue muscle activation. J. Physiol. 548: 563-568, 2003.

Bailey EF and Fregosi RF. Coordination of intrinsic and extrinsic tongue muscles during spontaneous breathing in the rat. J. Appl. Physiol. 96: 440-449, 2004.

Bailey EF and Fregosi RF. Modulation of upper airway muscle activities by bronchopulmonary afferents. J. Appl. Physiol. 101: 609-617, 2006.

Bailey EF, Huang YH and Fregosi RF. The anatomic consequences of intrinsic tongue muscle activation. J. Appl. Physiol. 101: 1377-1385, 2006

Bailey EF, Janssen PL and Fregosi RF. PO2-dependent changes in intrinsic and extrinsic tongue muscle activities in the rat. Am. J. Respir. Crit. Care Med. 171: 1403-1407, 2005.

Bailey EF, Jones CL, Reeder JC, Fuller DD and Fregosi RF. Effect of pulmonary stretch receptor feedback and CO2 on upper airway and respiratory pump muscle activity in the rat. J. Physiol. 532: 525-534, 2001.

Barnes PJ. Neurogenic inflammation in the airways. Respir. Physiol. 125: 145-154, 2001.

Bartlett D Jr. Upper airway motor systems. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 8, p. 223–245.

Bartlett D Jr. Respiratory functions of the larynx. Physiol. Rev. 69: 33-57, 1989.

Bartlett D Jr Knuth SL and Gdovin MJ. Influence of laryngeal CO2 on respiratory activities of motor nerves to accessory muscles. Respir. Physiol. 90: 289-297, 1992.

Bartlett D Jr, Jeffery PK, Sant’Ambrogio G and Wise JCM. Location of stretch receptors in the trachea and bronchi of the dog. J. Physiol. 258: 409-420, 1976.

Bartlett D Jr and St John WM. Comparison of phrenic motoneuron responses to hypercapnia and isocapnic hypoxia. J. Appl. Physiol. 46: 1096-1102, 1979.

Bartlett D Jr. and St. John WM. Influence of lung volume on phrenic, hypoglossal and mylohyoid nerve activities. Respir. Physiol. 73: 97-109, 1988.

Bellemare F, Pecchiari M, Bandini M, Sawan M and D’Angelo E. Reversibility of airflow obstruction by hypoglossus nerve stimulation in anesthetized rabbits. Am. J. Respir. Crit. Care Med. 172: 606-612, 2005.

Belvisi MG. Sensory and airway inflammation: role of Aδ and C-fibers. Pulm. Pharmacol. Ther. 16: 1-7, 2003.

Bergren DR and Peterson DF. Identification of vagal sensory receptors in the rat lung: are there subtypes of slowly adapting receptors? J. Physiol. 464: 681-698, 1993.

Bergeron C, Kimoff J and Hamid O. Obstructive sleep apnea syndrome and inflammation. J. Allergy Clin. Immunol. 116: 1393-1936, 2005.

Berkowitz RG, Sun QJ and Pilowsky PM. Congenital bilateral vocal cord paralysis and the role of glycine. Ann. Otol. Rhinol. Laryngol. 114: 494-498, 2005.

Bianchi AL, Denavit-Saubié and Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75: 1-45, 1995.

Bixler EO, Vgontzas AN, Ten Have T, Tyson K and Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am. J. Respir. Care Med. 157(1): 144-148, 1998.

Bonham AC, Coles SK and McCrimmon DR. Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats. J. Physiol. 464: 725-745, 1993.

Bonham AC and Joad JP. Neurones in commissural nucleus tractus solitarii required for full expression of the pulmonary C fibre reflex in rat. J. Physiol. 441: 95-112, 1991.

Bonham AC and McCrimmon DR. Neurones in a discrete region of the nucleus tractus solitarius are required for the Breuer-Hering reflex in rat. J Physiol 427: 261-280, 1990.

Bou-Flores C and Berger AJ. Gap junction and inhibitory synapses modulate inspiratory motoneuron synchronization. J. Neurophysiol. 85: 1543-1551, 2001.

Brennick MJ, Pickup S, Dougherty L, Cater JR and Kuna ST. Pharyngeal airway wall mechanics using tagged magnetic resonance imaging during medial hypoglossal nerve stimulation in rats. J. Physiol. 561: 597-610, 2004.

Brennick MJ, Trouard TP, Gmitro AF and Fregosi RF. MRI study of pharyngeal airway changes during stimulation of the hypoglossal nerve branches in rats. J. Appl. Physiol. 90: 1373-1384, 2001.

Brouillette RT and Thach BT. Control of genioglossus muscle inspiratory activity. J. Appl. Physiol. 49: 801-808, 1980.

Bruce EN, Mitra J and Cherniack NS. Central and peripheral chemoreceptor inputs to phrenic and hypoglossal motoneurons. J, Appl. Physiol. 53: 1504-1511, 1982.

Bruintjes TD, van Olphen AF, Hillen B and Huizing EH. A functional anatomic study of the relationship of the nasal cartilages and muscles to nasal valve area. Laryngoscope. 108: 1025-1032, 1998.

Burki NK, Alam M and Lee LY. The pulmonary effects intravenous adenosine in asthmatic subjects. Respir. Res. 7: 139, 2006.

Büsselberg D, Bischoff AM, Paton JF and Richter DW. Reorganisation of respiratory network activity after loss of glycinergic inhibition. Pflugers Arch. 441: 444-449, 2001.

Büsselberg D, Bischoff AM, and Richter DW. A combined blockade of glycine and calcium-dependent potassium channels abolishes the respiratory rhythm. Neuroscience 122: 831-841, 2003.

Callanan D, Dixon M and Widdicombe JG. The acute effects of SO2 on pulmonary mechanics, breathing patterns and pulmonary vagal afferent receptors in the rabbit. J. Physiol. 247: 23-24, 1975.

Carley DW, Pavlovic S, Malis M, Knezevic N, Saponjic J, Li C and Radulovacki M. C-fiber activation exacerbates sleep-disordered breathing in rats. Sleep Breath 8: 147-154, 2004.

Carlson DM, Onal E, Carley DW, Lopata M and Basner RC. Palatal muscle electromyogram activity in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 152: 1022-1027, 1995.

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD and Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389: 816-824, 1997.

Chamberlin NL, Bocchiaro CM, Greene RW and Feldman JL. Nicotine excitation of rat hypoglossal motoneurons. Neuroscience. 115: 861-870, 2002.

Chan CS, Woolcock AJ, Sullivan CE. Nocturnal asthma: role of snoring and obstructive sleep apnea. Am. Rev. Respir. Dis. 137: 1502-1504, 1988.

Chan E, Steenland HW, Liu H and Horner RL. Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states. Am. J. Respir. Crit. Care Med. 174: 1264-1273, 2006.

Chang Y, Hoover DB and Hancock JC. Endogenous tachykinins cause bradycardia by stimulating cholinergic neurons in the isolated guinea pig heart. Am. J. Physiol. 278: R1483-1489, 2000.

Chen HF and Kou YR. Vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism in dogs. J. Appl. Physiol. 88: 1247-1253, 2000.

Chen HF, Lee BP and Kou YR. Two subgroups of lung vagal C-fibers with different vulnerabilities to blockades by perivagal capsaicin and vagal cooling in dogs. Chin. J. Physiol. 42: 219-225, 1999.

Chen HF, Lee BP and Kou YR. Different roles of subgroup of lung vagal C-fiber afferents in the tachypneic response to pulmonary air embolism in dogs. Chin. J. Physiol. 43: 185-190, 2000.

Cheng YP, Wang YH, Cheng LP and He RR. Electrophysiologic effects of capsaicin on pacemaker cells in sinoatrial nodes of rabbits. Acta. Pharmacol. Sin. 24: 826-830, 2003.

Clozel JP, Roberts AM, Hoffman JI, Coleridge HM and Coleridge JC. Vagal chemoreflex coronary vasodilation evoked by stimuilating pulmonary C-fibers in dogs. Circ. Res. 57: 450-460, 1985.

Coast JR, Romeo RM and Cassidy SS. Diaphragmatic vasodilation elicited by pulmonary C-fiber stimulation. Respir. Physiol. 75: 279-288, 1989.

Coleridge HM. and Coleridge JCG. Reflexes evoked from tracheobronchial tree and lungs. In: Cherniak, N.S. and J.G. Widdicombe, “Handbook of Physiology, Section3: The Respiratory ssystem. In: Control of breathing, part 1, vol.II: Americal Physiological Society, Washington, DC., pp. 395-429, 1986.

Coleridge HM and Coleridge JCG. Impulse activity in afferent vagal C-fibers with endings in the intrapulmonary airways of dogs. Respir. Physiol. 29: 125-142, 1977.

Coleridge HM, Coleridge JC, Green JF and Parsons GH. Pulmonary C-fiber stimulation by capsaicin evokes reflex cholinergic bronchial vasodilation in sheep. J. Appl. Physiol. 72: 770-778, 1992.

Cortright DN and Szallasi A. Biochemical pharmacology of the vanilloid receptor TRPV1. Eur. J. Biochem. 271: 1814-1819, 2004.

Chuaychoo B, Lee MG, Kollarik M and Undem BJ. Effect of 5-hydroxytryptamine on vagal C-fiber subtypes in guinea pig lungs. Pulm. Pharmacol. Ther. 18: 269-276, 2005.

Crayton SC, Mitchell JH and Payne FC 3rd. Reflex cardiovascular response during injection of capsaicin into skeletal muscle. Am. J. Physiol. 240: H315-319, 1981.

Daly MD and Kirkman E. Cardiovascular responses to stimulation of pulmonary C fibres in the cat: their modulation by changes in respiration. J. Physiol. 402: 43-63, 1988.

Davies A, Dixon M, Callanan D, Huszczuk A, Widdicombe JG and Wise JCM. Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide. Respir. Physiol. 34: 83-101, 1978.

Davies A and Roumy M. The effect of transient stimulation of lung irritant receptors on the pattern of breathing in rabbits. J. Physiol. 124: 389-401, 1982.

Deegan PC and McNicholas. Pathophysiology of obstructive sleep apnea. Eur. Respir. J. 8: 1161-1178, 1995.

Deep V, Singh M and Ravi K. Role of vagal afferents in the reflex effects of capsaicin and lobeline in monkeys. Respir. Physiol. 125: 155-168, 2001.

Delpierre S, Balzamo E and Jammes Y. Resistive loading reduces ventilatory response to strychnine in anesthetized rabbits. Neurosci. Lett. 255: 29-32, 1998.

Diaz V, Dorion D, Renolleau S, Létourneau P, Kianicka I and Praud JP. Effects of capsaicin pretreatment on expiratory laryngeal closure during pulmonary edema in lambs. J. Appl. Physiol. 86: 1570-1577, 1999.

DiCarlo SE, Collins HL and Chen CY. Vagal afferents reflexly inhibit exercise in conscious rats. Med. Sci. Sports Exerc. 26: 459-62, 1994.

Dobbins EG and Feldman JL. Differential innervation of protrudor and retractor muscles of the tongue in rat. J. Comp. Neurol. 357: 376-394, 1995.

Donato R and Nistri A. Relative contribution by GABA or glycine to Cl- mediated synaptic transmission on rat hypoglossal motoneurons in vitro. J. Neurophysiol. 84: 2715-2724, 2000.

Dutschmann M and Herbert H. The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat. Eur. J. Neurosci. 24: 1071-1084, 2006.

Dutschmann M and Paton JF. Inhibitory synaptic mechanisms regulating upper airway patency. Respir. Physiol. Neurobiol. 131: 57-63, 2002a.

Dutschmann M and Paton JF. Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat. J. Physiol. 543: 643-653, 2002b.

Dutschmann M and Paton JFR. Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am. J. Physiol. 282: R999-1005, 2002c.

Dutschmann M, Wilson RJA, Paton JFR. Respiratory activity in neonatal rats. Auton. Neurosci. 84: 19-29, 2000.

Eikermann M, Vogt FM, Herbstreit F, Vahid-Dastgerdi M, Zenge MO, Ochterbeck C, de Greiff A and Peters J. The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade. Am. J. Crit. Care Med. 175: 9-15, 2007.

Eisele DW, Smith PL, Alam DS and Schwartz AR. Direct hypoglossal nerve stimulation in obstructive sleep apnea. Arch. Otolaryngol. Head Neck Surg. 123: 57-61, 1997.

Engleman HM and Douglas NJ. Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnonea syndrome. Thorax. 59: 618-622, 2004.

Ezure K and Tanaka I. Pump neurons of the nucleus of the solitary tract project widely to the medulla. Neurosci. Lett. 215: 123-126, 1996.

Ezure K and Tanaka I. Distribution and medullary projection on respiratory neurons in the dorsolateral pons of the rat. Neuroscience. 141: 1011-1023, 2006.

Ezure K, Tanaka I and Kondo M. Glycine is used as transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat. J. Neurosci. 23: 8941-8948, 2003.

Ezure K, Tanaka I and Miyasaki M. Electrophysiological and pharmacological analysis of synaptic inputs to pulmonary rapidly adapting receptor relay neurons in the rat. Exp. Brain Res. 128: 471-480, 1999.

Ezure K, Tanaka I and Saito Y. Activity of brainstem respiratory neurones just before the expiration-inspiration transition in the rat. J. Physiol. 577: 629-640, 2003.

Ezure K, Tanaka I, Saito Y and Otake K. Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat. J. Comp. Neurol. 446: 81-94, 2002.

Feldman JL and Del Negro CA. Looking for inspiration: new perspectives on respiratory rhythm. Nat. Rev. Neurosci. 7: 232-242, 2006.

Feldman JL and Gautier H. Interaction of pulmonary afferents and pneumotaxic center in control of respiratory pattern in cats. J. Neurophysiol. 39:31-44, 1976.

Feldman JL, Neverova NV and Saywell SA. Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir. Physiol. Neurobiol. 147: 131-143, 2005.

Fenik V, Davies RO, Pack AI and Kubin L. Differential suppression of upper airway motor activity during carbachol-induced REM sleep-like atonia. Am. J. Physiol. 275: R1013-1024, 1998.

Ford TW and McWilliam PN. The effects of electrical stimulation of myelinated and non-myelinated vagal fibres on heart rate in the rabbit. J. Physiol. 380: 341-347, 1986.

Franklin KA, Gislason T, Omenaas E, Jogi R, Jensen EJ, Lindberg E, Gunnbjornsdottir M, Nystrom L, Laerum BN, Bjornsson E, Toren K and Janson C. The influence of active and passive smoking on habitual snoring. Am. J. Respir. Crit. Care Med. 170: 799-803, 2004.

Fregosi RF and Fuller DD. Respiratory-related control of extrinsic tongue muscle activity. Respir. Physiol. 110: 295-306, 1997.

Fukuda Y and Honda Y. Role of vagal afferents on discharge patterns and CO2-responsiveness of efferent superior laryngeal, hypoglossal, and phrenic respiratory activities in anesthetized rats. Jpn. J. Physiol. 32: 689-698, 1982.

Fukuda Y and Honda Y. Effects of hypocapnia on respiratory timing and inspiratory activities of the superior laryngeal, hypoglossal, and phrenic nerves in the vagotomized rat. Jpn. J. Physiol. 33: 733-742, 1983.

Fukuda Y and Honda Y. Modification by chemical stimuli of temporal difference in the onset of inspiratory activity between vagal (supeior laryngeal) or hypoglossal and phrenic nerves of the rat. Jpn. J. Physiol. 38: 309-319, 1988.

Fuller DD. Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles. J. Appl. Physiol. 98: 1761-1767, 2005.

Fuller DD, Mateika JH and Fregosi RF. Co-activation of tongue protrudor and retractor muscles during chemoreceptor stimulation in the rat. J. Physiol. 507: 265-276, 1998.

Fuller DD, Williams JS, Janssen PL and Fregosi RF. Effect of co-activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat. J. Physiol. 519: 601-613, 1999.

Funk GD, Smith JC and Feldman JL. Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. J. Neurophysiol. 72: 2538-2541, 1994.

Gandevia SC, Taylor JL and Butler JE. Stopping exercise: role of pulmonary C fibers and inhibition of motoneurons. News Physiol. Sci. 15: 241-245, 2000.

Gdovin MJ, Knuth SL and Bartlett D Jr. Respiratory motor nerve activities during spontaneous bladder contractions. J. Appl. Physiol. 77: 1349-1354, 1994.

George CFP. Sleep. 5: Driving and automobile crashes in patients with obstructive sleep apnoea/hypopnoea syndrome. Thorax. 59: 804-807, 2004.

Gestreau C, Dutschmann M, Obled S and Bianchi AL. Activation of XII motoneurons and premotor neurons during various oropharyngeal behaviors. Respir. Physiol. Neurobiol. 147: 159-176, 2005.

Gilliam EE and Goldberg SJ. Contractile properties of the tongue muscles: effects of hypoglossal nerve and extracellular motoneuron stimulation in rat. J. Neurophysiol. 74: 547-555, 1995.

Gislason T, Johannsson JH, Haraldsson A, Olafsdottir BR, Jonsdottir H, Kong A, Frigge ML, Jonsdottir GM, Hakonarson H, Gulcher J and Stefansson K. Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome. Am. J. Respir. Crit. Care Med. 166: 833-838, 2002.

Goding GS, Eisele DW, Testerman R, Smith PL, Roertgen K and Schwartz AR. Relief of upper airway obstruction with hypoglossal nerve stimulation in the canine. Laryngoscope. 108: 162-169, 1998.

Granger DN, Vowinkel T and Petnehazy T. Modulation of the inflammatory responses in cardiovascular disease. Hypertension. 43: 924-931, 2004.

Green JH, Schertel ER, Coleridge HM and Coleridge JCG. Effect of pulmonary arterial PCO2 on slowly adapting pulmonary stretch receptors. J. Appl. Physiol. 60: 2048-2055, 1986.

Green JF, Schmidt ND, Schultz HD, Roberts AM, Coleridge HM and Coleridge JCG. Pulmonary C-fibers evoked both apnea and tachypnea of pulmonary chemoreflex. J. Appl. Physiol. 57: 562-567, 1984.

Groneberg DA, Quarcoo D, Frossard N and Fisher A. Neurogenic mechanisms in bronchial inflammatory diseases. Allergy 59: 1139-1152, 2004.

Gu Q and Lee LY. Hypersensitivity of pulmonary C fibre afferents induced by cationic proteins in the rat. J. Physiol. 537: 887-897, 2001.

Gu Q and Lee LY. Alveolar hypercapnia augments pulmonary C-fiber responses to chemical stimulants: role of hydrogen ion. J. Appl. Physiol. 93: 181-188, 2002.

Gu Q and Lee LY. Sensitization of pulmonary chemosensitive neurons by bombesin-like peptides in rats. Am. J. Physiol. 289: L1104-1112, 2005.

Gu Q and Lee LY. Characterization of acid signaling in rat vagal pulmonary sensory neurons. Am. J. Physiol. 291: L58-L65, 2006.

Gu Q, Ruan T, Hong JL, Burki N and Lee LY. Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats. J. Appl. Physiol. 95: 1315-1324, 2003.

Guo Y, Goldberg SJ and McClung JR. Compartmental organization of styloglossus and hyoglossus motoneurons in the hypoglossal nucleus of the rat. Brain Res. 728: 277-280, 1996.

Haight JS and Cole P. The site and function of the nasal valve. Laryngoscope. 93: 49-55, 1983.

Haji A, Okazaki M and Takeda R. GABAA receptor-mediated inspiratory termination evoked by vagal stimulation in decerebrate cats. Neuropharmacology 38: 1261-1272, 1999.

Haji A, Takeda R and Okazaki M. Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacol. Ther. 86: 277-304, 2000

Harper RM and Sauerland EK. The role of the tongue in sleep apnea. In “Sleep Apnea
Syndromes” vol. 11, Guilleminault, C. and W.C. Dement Eds., Kroc Foundation Series, Alan, R. Liss, Inc. N.Y., page 219-234, 1978.

Harris MB and St. John WM. Tonic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation. Am. J. Physiol.: R215-221, 2003.

Harris MB and St. John WM. Phasic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation. Am. J. Physiol.: R450-455, 2005.

Hatipoğlu U and Rubinstein I. Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis. Respiration. 70: 665-671, 2003.

Haxhiu MA, van Lunteren E, Deal EC and Cherniack NS. Effect of stimulation of pulmonary C-fiber receptors on canine respiratory muscles. J. Appl. Physiol. 65: 1087-1092, 1988.

Hedrick MS, Ryan ML and Bisgard GE. Recurrent laryngeal nerve activation by α2 adrenergic agonists in goats. Respir. Physiol. 101: 129-137, 1995.

Hetzel M, Kochs M, Marx N, Woehrle H, Mobarak I, Hombach V and Hetzel J. Pulmonary hemodynamics in obstructive sleep apnea: frequency and causes of pulmonary hypertension. Lung. 181: 157-166, 2003.

Ho CY and Lee LY. Ozone enhances excitabilities of pulmonary C fibers to chemical and mechanical stimuli in anesthetized rats. J. Appl. Physiol. 85: 1509-1515, 1998.

Ho CY, Gu Q, Hong JL and Lee LY. Prostaglandin E2 enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat. Am. J. Respir. Crit. Care Med. 165: 528-533, 2000.

Ho CY, Gu Q, Lin YS and Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir. Physiol. 127: 113-124, 2001.

Hong JL, Ho CY, Kwong K and Lee LY. Activation of pulmonary C fibers by adenosine in anaesthetized rats: role of adenosine A1 receptors. J. Physiol. 508: 109-118, 1998.

Horner RL, Innes JA, Morrell MJ, Shea SA and Guz A. The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans. J. Physiol. 476: 141-151, 1994.

Horner RL, Liu X, Gill H, Nolan P, Liu H and Sood S. Effects of sleep-wake state on the genioglossus vs. diaphragm muscle response to CO2 in rats. J. Appl. Physiol. 92: 878-887, 2002.

Huang J, Sahin M and Durand DM. Dilation of the oropharynx via selective stimulation of the hypoglossal nerve. J. Neural. Eng. 2: 73-80, 2005.

Huang Q and St. John WM. Respiratory neural activities after caudal-to-rostral ablation of medullary regions. J. Appl. Physiol. 64: 1405-1411, 1988.

Huang Q, Zhou D, St. John WM and Bartlett D. Jr. Influence of lung volume on activities of branches of the recurrent laryngeal nerve. J. Appl. Physiol. 67: 1179-1184, 1989.

Hudgel DW and Harasick T. Fluctuation in timing of upper airway and chest wall inspiratory muscle activity in obstructive sleep apnea. J. Appl. Physiol. 69: 443-450, 1990.

Hwang JC, Bartlett D Jr and St. John WM. Characterization of respiratory-moulated activities of hypoglossal motoneurons. J. Appl. Physiol. 55: 793-798, 1983a.

Hwang JC, Chien CT and St. John WM. Characterization of respiratory-related activity of the facial nerve. Respire. Physiol. 73: 175-187, 1988.

Hwang JC and St. John WM. Alterations of hypoglossal motoneuronal activities during pulmonary inflations. Exp. Neurol. 97): 615-625, 1987.

Hwang JC and St John WM. Respiratory-modulated activities of motor units of the facial nerve. Respir. Physiol. 73: 189-200, 1988.

Hwang JC and St. John WM. Facilitation and inhibition of phrenic motoneuronal activities by lung inflation. J. Appl. Physiol. 74: 2485-2492, 1993.

Hwang JC, St. John WM and Bartlett D Jr. Respiratory-related hypoglossal nerve activity: influence of anesthetics. J. Appl. Physiol. 55: 785-792, 1983b.

Hwang JC, St John WM and Bartlett D Jr. Receptors responding to changes in upper airway pressure. Respir. Physiol. 55: 355-366, 1984.

Hwang JC and Young SB. Influences of airflow in the upper airway upon phasic hypoglossal and phrenic activities: afferent pathways. Chin. J. Physiol. 32: 1-12, 1989.

Iizuka M. GABAA and glycine receptors in regulation of intercostals and abdominal expiratory activity in vitro in neonatal rat. J. Physiol. 551: 617-633, 2003.

Jacquin TD, Sadoc G, Borday V and Champagnat J. Pontine and medullary control of the respiratory activity in the trigeminal and facial nerves of the newborn mouse: an in vitro study. Eur. J. Neurosci. 11: 231-222, 1999.

Janczewski WA and Feldman JL. Distinct rhythm generators for inspiration and expiration in the juventile rat. J. Physiol. 570: 407-420, 2006.

Janczewski WA, Onimaru H, Homma I and Feldman JL. Opioid-resistant respiratory pathway from preinpiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J. Physiol. 545: 1017-1026, 2002.

Janssen PL, Williams JS and Fregosi RF. Consequences of periodic augmented breaths on tongue muscle activities in hypoxia rats. J. Appl. Physiol. 88: 1915-1923, 2000.

Jeggo RD, Kellett DO, Wang Y, Ramage AG and Jordan D. The role of central 5-HT3 receptors in vagal reflex inputs to neurons in the nucleus tractus solitarius of anaesthetized rats. J. Physiol. 566: 939-953, 2005.

Jelev A, Sood S, Liu H, Nolan P and Horner RL. Microdialysis of 5-HT into hypoglossal motor nucleus differentially modulate genioglossus activity across natural sleep-wake states in rats. J. Physiol. 532: 467-481, 2001.

John J, Bailey EF and Fregosi RF. Respiratory-related discharge of genioglossus muscle motor units. Am. J. Respir. Crit. Care Med. 172: 1331-1337, 2005.

Johnson SM, Wilkerson JER, Wenninger MR, Henderson DR and Mitchell GS. Role of synaptic inhibition in turtle respiratory rhythm generation. J. Physiol. 544: 253-265, 2002.

Jones JFX, Wang J and Jordan D. Activity of C fibre cardiac vagal efferents in anesthetized cats and rats. J. Physiol. 507: 869-880, 1998.

Joos GF, Germonpré PR and Pauwels RA. Role of tachykinins in asthma. Allergy. 55: 321-337, 2000.

Jordan D. Central nervous pathways and control of the airways. Respir. Physiol. 125: 67-81, 2001.

Kappagoda CT and Ravi K. The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume. Exp. Physiol. 91: 647-654, 2006.

Kashyap R, Hock LM and Bowman TJ. Higher prevalence of smoking diagnosed as having obstructive sleep apnea. Sleep Breath 5: 167-172, 2001.

Katz ES and White DP. Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 170: 553-560, 2004.

Kaufman MP, Ordway GA and Waldrop TG. Effect of PEEP on discharge of pulmonary C-fibers in dogs. J. Appl. Physiol. 59: 1085-1089, 1985.

Kawai Y and Senba E. Electrophysiological and morphological characteristics of nucleus tractus solitarii neurons projecting to the ventrolateral medulla. Brain Res. 877: 374-378, 2000.

Keller CJ and Loeser A. Der zentripetale Lungenvagus. Z. Biol. 89: 373-395, 1929.

Keller E, Kohl J and Koller EA. Location of pulmonary stretch receptors in the guinea-pig. Respir. Physiol. 76: 149-157, 1989.

Kimura N, Perry SF and Remmers JE. Strychnine eliminates reciprocation and augmentation of respiratory bursts of the in vitro frog brainstem. Neurosci. Lett. 225: 9-12, 1997.

Knowlton GC and Larrabee MG. A unitary analysis of pulmonary volume receptors. Am. J. Physiol. 147: 100-114, 1946.

Kohl J, Freund U and Koller EA. Reflex apnea induced by high-frequency oscillatory ventilation in rabbits. Respir. Physiol. 84: 209-222, 1991.

Kollarik M, Dinh QT, Fischer A and Undem BJ. Capsaicin-sensitive and –insensitive vagal bronchopulmonary C-fibres in the mouse. J. Physiol. 551: 869-879, 2003.

Kollarik M and Undem BJ. Mechanisms of acid-induced activation of airway afferent nerve fibers in guinea-pig. J. Physiol. 543: 591-600, 2002.

Kollarik M and Undem BJ. Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice. J. Physiol. 555: 115-123, 2004.

Krauhs JM. Morphology of presumptive slowly adapting receptors in dog trachea. Anat. Rec. 210: 73-85, 1984.

Kuna ST. Interaction of hypercapnia and phasic volume feedback on motor control of the upper airway. J. Appl. Physiol. 63: 1744-1749, 1987.

Kubin L, Alheid GF, Zuperku EJ and McCrimmon DR. Central pathways of pulmonary and lower airway vagal afferents. J. Appl. Physiol. 101: 618-627, 2006.

Kuna ST and Remmers JE. Premotor input to hypoglossal motoneurons from Kölliker-Fuse neurons in decerebrate cats. Respir. Physiol. 117: 85-95, 1999.

Kwong K and Lee LY. PGE2 sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli. J. Appl. Physiol. 93: 1419-1428, 2002.

Lai CJ and Kou YR. Stimulation of pulmonary rapidly adapting receptors by inhaled wood smoke in rats J. Physiol. 508(2): 597-607, 1998.

Lai CJ and Kou YR. Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats J. Appl. Physiol. 84: 30-36, 1998.

Lai CJ, Ho CY and Kou YR. Activation of lung vagal sensory receptors by circulatory endotoxin in rats. Life Sci. 70: 2125-2138, 2002.

Lai CJ, Ruan T and Kou YR. The involvement of hydroxyl radical and cyclooxygenase metabolites in the activation of lung vagal sensory receptors by circulatory endotoxin in rats. J. Appl. Physiol. 98: 620-628, 2005.

Lee BP, Chen HF, Hsu FC, Kuo TBJ and Yang MH. Effects of pulmonary air embolism on discharge of slowly adapting pulmonary stretch receptors. J. Appl. Physiol. 76: 97-103, 1994.

Lee LY, Burki NK, Gerhardstein DC, Gu Q, Kou YR and Xu J. Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors. Pulm. Pharmacol. Ther. 20: 355-364, 2007.

Lee LY and Gu Q. Mechanisms of bronchopulmonary C-fiber hypersensitivity induced by cationic proteins. Pulm. Pharmacol. Ther. 16: 15-22, 2003.

Lee LY, Gu Q and Gleich GJ. Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung. J. Appl. Physiol. 91: 1318-1326, 2001.

Lee LY, Lin YS, Gu Q, Chung E and Ho CY. Functional morphology and physiological properties of bronchopulmonary C-fiber afferents. Anat. Rec. 270A: 17-24, 2003.

Lee LY and Lundberg JM. Capsazepine abolishes pulmonary chemoreflexes induced by capsaicin in anesthetized rats. J. Appl. Physiol. 76: 1848-1855, 1994.

Lee LY, Morton RF and Kou YR. Acute effects of cigarette smoke on breathing in rats: vagal and nonvagal mechanisms. J. Appl. Physiol. 68: 955-961, 1990.

Lee LY and Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir. Physiol. 125: 47-65, 2001.

Lee MG, MacGlashan Jr. DW and Undem BJ. Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fiber activation. J. Physiol. 566: 205-212, 2005.

Lee MG, Weinreich D and Undem BJ. Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. Br. J. Pharmacol. 146: 596-603, 2005.

Leiter JC and St John WM. Phrenic, vagal and hypoglossal activities in rat: pre-inspiratory, inspiratory, expiratory components. Respir. Physiol. Neurobiol. 142: 115-126, 2004.

Li H, Meng X and Yang H. The relationship between content of substance P, VIP in pharyngeal tissue and narrow pharyngeal cavity of patients with OSAS. Lin Chuang Er Bi Yan. Hou Ke Za Zhi 15: 539-541, 2001.

Li YM, Shen L, Peever JH and Duffin J. Connections between respiratory neurons in the neonatal rat transverse medullary slice studied with cross-correlation. J. Physiol. 549.1: 327-332, 2003.

Lin CY and Hwang JC. Responses of respiratory-modulated facial nerve activity to activation of the ventrolateral subarea of the nucleus of the tractus solitarius. Chin. J. Physiol. 37: 185-191, 1994.

Lin RL, Gu Q, Lin YS and Lee LY. Stimulatory effect of CO2 on vagal bronchopulmonary C-fiber afferents during airway inflammation. J. Appl. Pysiol. 99: 1704-1711, 2005.

Lin YS, Gu Q and Lee LY. Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats. Am. J. Respir. Crit. Care Med. 167: 1096-1101, 2003.

Lin YS and Lee LY. Stimulation of pulmonary vagal C-fibers by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. J. Physiol. 539: 947-955, 2002.

Longhurst JC, Kaufman MP, Ordway GA and Musch TI. Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs. Am. J. Physiol. 247: R552-559, 1984.

Longhurst JC, Mitchell JH and Moore MB. The spinal cord ventral root: an afferent pathway of the hind-limb pressor reflex in cats. J. Physiol. 301: 467-476, 1980.

Lowe AA. The neural regulation of tongue movement. Prog. Neurobiol. 15: 295-344, 1981.

Liu X, Sood S, Liu H and Horner RL. Opposing muscarinic and nicotinic modulation of hypoglossal motor output to genioglossus muscle in rats in vivo. J. Physiol. 565: 965-980, 2005.

Lu IJ, Ku LC, Lin JT, Lee KZ and Hwang JC. Pulmonary C-fiber activation enhances respiratory-related activities of the recurrent laryngeal nerve in rats. Chin. J. Physiol. 45: 143-154, 2002.

Lu IJ, Lee KZ, Lin JT and Hwang JC. Capsaicin administration inhibits the abducent branch but excites the thyroarytenoid branch of the recurrent laryngeal nerves in the rat. J. Appl. Physiol. 98: 1646-1652, 2005.

Lu IJ, Lee KZ and Hwang JC. Capsaicin-induced activation of pulmonary vagal C-fibers produces reflex laryngeal closure in the rat. J. Appl. Physiol. 101: 1104-1112, 2006.

Ludlow CL. Central nervous system control of the laryngeal muscles in humans. Respir. Physiol. 147: 205-222, 2005.

Ma A, Bravo M and Kappagoda CT. Responses of bronchial C-fiber afferents of the rabbit to changes in lung compliance. Respir. Physiol. Neurobiol. 138: 155-163, 2003.

Ma AA, Ravi K, Bravo EM and Kappagoda CT. Effects of gadolinium chloride on slowly adapting and rapidly adapting receptors of the rabbit lung. Respir. Physiol. Neurobiol. 141: 125-135, 2004.

Malhotra A and White DP. Obstructive sleep apnoea. Lancet. 360: 237-245, 2002.

Mann EA, Burnett T, Cornell S, Ludlow CL. The effect of neuromuscular stimulation of the genioglossus on the hypopharyngeal airway. Laryngoscope. 112: 351-356, 2002.

Markstahler U, Kremer E, Kimmina S, Becker K and Richter DW. Effects of functional knock-out of a1 glycine-receptors on breathing movements in oscillator mice. Respir. Physiol. Neurobiol. 130: 33-42, 2002.

Martin RJ, van Lunteren E and Haxhiu MA. Upper airway muscle and diaphragm responses to hypoxia in the piglet. J. Appl. Physiol. 68: 672-677, 1990.

Mateika JH, Millrood DL, Kim J, Rodriguez HP and Samara GJ. Response of human tongue protrudor and retractors to hypoxia and hypercapnia. Am. J. Repir. Crit. Care Med. 160: 1979-1982, 1999.

Mathew OP. Upper airway negative-pressure effects on respiratory activity of upper airway muscles. J. Appl. Physiol. 56: 500-505, 1984.

Matsumoto S. Effects of ammonia and histamine on lung irritant receptors in the rabbit. Respir. Physiol. 77: 301-308, 1989.

Matsumoto S. Effects of vagal stimulation on slowly adapting pulmonary stretch receptors and lung mechanics in anesthetized rabbits. Lung. 174: 333-344, 1996.

Matsumoto S, Ikeda M and Nishikawa T. Effects of sodium and potassium channel blockers on hyperinflation-induced slowly adapting pulmonary stretch receptor stimulation in the rat. 67: 2167-2175, 2000.

Matsumoto S, Ikeda M, Nishikawa T, Tanimoto T, Yoshida S and Saiki C. Inhibitory mechanism of slowly adapting pulmonary stretch receptors after release from hyperinflation in anesthetized rabbits. Life. Sci. 67: 1423-1433, 2000.

Matsumoto S, Ikeda M, Nishikawa T, Yoshida S, Tanimoto T, Ito M, Saiki C and Takeda M. Excitatory mechanism of deflationary slowly adapting pulmonary stretch receptors in the rat lung. J. Pharmacol. Exp. Ther. 300: 597-604, 2002.

Matsumoto S, Kanno T, Yamasaki M, Nagayama T and Shimizu T. Pulmonary C-fibers elicit both apneusis and tachypnea in the rabbit. Respir. Physiol.87: 165-181, 1992.

Matsumoto S, Nagayama T, Yamasaki M, Kanno T and Shimizu T. Colinergic and H1-receptor influences of histamine on slowly adapting pulmonary stretch receptor activity in the rabbit. J. Auto. Nerv. Syst. 40:107-120, 1992.

Matsumoto S and Shimizu T. Flecainide blocks the stimulatory effect of veratridine on slowly adapting pulmonary stretch receptors in anesthetized rabbits without changing lung mechanics. Acta. Physiol. Scand. 155: 297-302, 1995.

Matsumoto S, Takeda M, Saiki C, Takahashi T and Ojima K. Effects of tachykinins on rapidly adapting pulmonary receptors and total lung resistance in anesthetized, artificially ventilated rabbits. J. Pharmacol. Exp. Ther. 283: 1026-1031, 1997.

Matsumoto S, Takahashi T, Tanimoto T, Saiki C, Takeda M and Ojima K. Excitatory mechanism of veratridine on slowly adapting pulmonary stretch receptors in anesthetized rabbits. Life. Sci. 63: 1431-1437, 1998.

Matsumoto S, Takahashi T, Tanimoto T, Saiki C and Takeda M. Effects of potassium channel blockers on CO2-induced slowly adapting pulmonary stretch receptor inhibition. J. Pharmacol. Exp. Ther. 290: 974-979, 2000.

Matsumoto S, Tanimoto T, Yoshida S, Ikeda M, Saiki C, Shimazu Y, Aoba T, Nasu M and Suzuki K. Effects of acetazolamide and 4-aminopyridine on CO2-induced slowly adapting pulmonary stretch receptor inhibiion in rats. Chem. Senses. 29: 351-361, 2004.

Matsumoto S, Tanimoto T, Yoshida S, Ikeda M, Takeda M, Saiki C, Shimazu Y, Aoba T, Nasu M and Suzuki K. Effects of acetazolamide and 7-aminopyrdine on CO2-induced slowly adapting pulmonary stretch receptor inhibition in rats. Chem. Senses. 29: 351-361, 2004.

Matsuoka T and Mortola JP. Effects of hypoxia and hypercapnia on the Hering-Breuer reflex of the conscious newborn rat. J. Appl. Physiol. 78: 5-11, 1995.

McClung JR and Goldberg SJ. Organization of motoneurons in the dorsal hypoglossal nucleus that innervate the retrusor muscles of the tongue in the rat. Anat. Rec. 254: 222-230, 1999.

McClung JR and Goldberg SJ. Functional anatomy of the hypoglossal innervated muscles of the rat tongue: a model for elongation and protrusion of the mammalian tongue. Anat. Rec. 260:378-386, 2000a.

McClung JR and Goldberg SJ. Organization of the hypoglossal motoneurons that innervate the horizontal and oblique components of the genioglossus muscle in the rat. Brain Res. 950: 321-324, 2000b.

Mellen NM, Janczewski WA, Bocchiaro CM and Feldman JL. Opioid-induced quantal slowling reveals dual networks for respiratory rhythm generation. Neuron. 37: 821-826, 2003.

Meessen NE, van der Grinten CP, Folgering HT and Luijendijk SC. Tonic activity in inspiratory muscles during continuous negative airway pressure. Respir. Physiol. 92: 151-166, 1993.

Meessen NE, van der Grinten CP, Luijendijk SC and Folgering HT. Continuous negative airway pressure increases tonic activity in diaphragm and intercostals muscles in humans. J. Appl. Physiol. 77: 1256-1262, 1994.

Mezzanotte WS, Tangel DJ and White DP. Influence of sleep onset upper-airway muscle activity in apnea patients versus normal controls. Am. J. Respir. Crit. Care Med. 153: 1880-1887, 1996.

Miller AJ. Oral and pharyngeal reflexes in the mammalian nervous system: their diverse range in complexity and the pivotal role of the tongue. Crit. Rev. Oral. Biol. Med. 13: 409-425, 2002.

Mitchell GS, Cross BA and Hiramoto T and Scheid P. Effects of intrapulmonary CO2 and airway pressure on phrenic activity and pulmonary stretch receptor discharge in dogs. Respir. Physiol. 40: 29-48, 1980.

Mitra J, Prabhakar NR, Haxhiu MA and Cherniack NS. The effects of hypercapnia and cooling the ventral medullary surface on capsaicin induced respiratory reflexes. Respir. Physiol. 60: 377-385, 1985.

Morrison JL, Sood S, Liu X, Liu H, Park E, Nolan P and Horner RL. Glycine at hypoglossal motor nucleus: genioglossus activity, CO2 responses, and the additive effects of GABA. J. Appl. Physiol. 93: 1786-1796, 2002.

Morrison JL, Sood S, Liu H, Park E, Nolan P and Horner RL. GABAA receptor antagonism at the hypoglossal motor nucleus genioglossus muscle activity in NREM but not REM sleep. J. Physiol. 548: 569-583, 2003a.

Morrison JL, Sood S, Liu H, Park E, Liu X, Nolan P and Horner RL. Role of inhibitory amino acids in control of hypoglossal motor outflow to genioglossus muscle in naturally sleeping rats. J. Physiol. 552: 975-991, 2003b.

Mortimore IL and Douglas NJ. Palatal muscle EMG response to negative pressure in awake sleep apneic and control subjects. Am. J. Respir. Crit. Care Med. 156: 867-873, 1997.

Mortola JP, Sant’Ambrogio G and Clement MG. Localization of irritant receptors in the airways of the dog. Respir. Physiol. 24: 107-114, 1975.

Mu L and Sanders I. Neuromuscular organization of the canine tongue. Anat. Rec. 256: 412-424, 1999.

Mu L and Sanders I. Neuromuscular specialization of the pharyngel dilator muscles: II. Compartmentalization of the canine genioglossus muscle. Anat. Rec. 260: 308-325, 2000.

Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA and Guyenet PG. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat. Neurosci. 7: 1360-1369, 2004.

Mutoh T, Joad JP and Bonham AC. Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guina-pigs. J. Physiol. 523: 223-233, 2000.

Mutoh Y, Tsubone H, Nishimura R and Sasaki N. Effects of halothane, enflurane, isoflurane, and sevoflurane on slowly adapting pulmonary stretch receptor activity in anesthetized dogs. Lung. 176: 181-190, 1998.

Mutoh T, Tsubone H, Nishimura R and Sasaki N. Effects of volatile anesthetics on vagal C-fiber activities and their reflexes in anesthetized dogs. Respir. Physiol. 112: 253-264, 1998.

Muzzin S, Baconnier P and Benchetrit G. Entrainment of respiratory rhythm by periodic lung inflation: effect of airflow rate and duration. Am. J. Physiol. 263: R292-300, 1992.

Muzzin S, Trippenbach T, Baconnier P and Benchetrit G. Entrainment of the respiratory rhythm by periodic lung inflation during vagal cooling. Respir. Physiol. 75: 157-172, 1989.

Neff RA, Mihalevich M and Mendelowitz D. Stimulation of NTS activities NMDA and non-NMDA receptors in rat cardiac vagal neurons in the nucleus ambiguous. Brain Res. 792: 277-282, 1998.

Nemmar A, Delaunois A, Beckers JF, Sulon J, Bloden S and Gustin P. Modulatory effect of imetit, a histamine H3 receptor agonist, on C-fibers, cholinergic fibers and mast cells in rabbit lung in vitro. Eur. J. Pharmacol. 371: 23-30, 1999.

Oh EJ and Weinreich D. Bradykinin decrease K+ and increase Cl- conductances in vagal afferent neurons of the guinea pig. J. Physiol. 558: 513-526, 2004.

O'Halloran KD, Curran AK and Bradford A. Effect of upper airway cooling and CO2 on diaphragm and geniohyoid muscle acitivitu in the rat. Eur. Respir. J. 9: 2323-2327, 1996.

O’Halloran KD, Herman JK and Bisgard GE. Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats. J. Appl. Physiol. 87: 590-597, 1999.

Ohga E, Tomita T, Wada H, Yamamoto H, Nagase T and Ouchi Y. Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J. Appl. Physiol. 94: 179-184, 2003.

Oku Y, Dick TE and Cherniack NS. Phase-dependent dynamic responses of respiratory motor activities following perturbation of the cycle in the cat. J. Physiol. 461: 321-337, 1993.

Oliven A, O'Hearn DJ, Boudewyns A, Odeh M, De Backer W, van de Heyning P, Smith PL, Eisele DW, Allan L, Schneider H, Testerman R and Schwartz AR. Upper airway response to electrical stimulation of the genioglossu in obstructive sleep apnea. J. Appl. Physiol. 95: 2023-2029, 2003.

Onimaru H and Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J. neurosci. 23: 1478-1486, 2003.

Onimaru H, Kumagawa Y and Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J. Neurophysiol. 96: 55-61, 2006.

Ono K, Shiba K, Nakazawa K and Shimoyama I. Synaptic origin of the respiratory-modulated activity of laryngeal motoneurons. Neuroscience. 140: 1079-1088, 2006.

Ono T, Ishiwata Y, Inaba N, Kuroda T and Nakamura Y. Modulation of the inspiratory-related activity of hypoglossal premotor neurons during ingestion and rejection in the decerebrate cat. J. Neurophysiol. 80: 48-58, 1998.

Otake K, Nakamura Y, Tanaka I and Ezure K. Morphology of pulmonary rapidly adapting receptor relay neurons in the rat. J. Comp. Neurol. 430: 458-470, 2001.

Pack AI and Delaney RG. Response of pulmonary rapidly adapting receptors during lung inflation. J. Appl. Physiol. 55: 955-963, 1983.

Paintal AS. Impulses in vagal afferent fibers from specific pulmonary deflation receptors. The response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine and nicotine, and their role in respiratory and cardiovascular reflexes. Q. J. Exp. Physiol. 40: 89-111, 1955.

Palecek F, Sant’Ambrogio G, Sant’Ambrogio FB and Mathew OP. Reflex responses to capsaicin: intravenous, aerosol and intratracheal administration. J. Appl. Physiol. 67: 1428-1437, 1989.

Pascual-Font A, Maranillo E, Merchan A, Vazquez T, Safiudo JR, Valderrama-Canales F. Central projections of the rat superior laryngeal nerve. Acta. Otorrinolaringol. Esp. 57: 295-299, 2006a.

Pascual-Font A, Maranillo E, Merchan A, Vazquez T, Safiudo JR, Valderrama-Canales F. Central projections of the rat recurrent laryngeal nerve. Acta Otorrinolaringol Esp. 57: 253-256, 2006b.

Paton JF. Rhythmic bursting of pre- and post-inspiratory neurones during central apnoea in mature mice. J. Physiol. 502: 623-639, 1997.

Paton JF, Li YW and Kasparov S. Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract. Neuroscience. 93: 143-154, 1999.

Patrick GB, Strohl KP, Rubin SB and Altose MD. Upper airway and diaphragm muscle responses to chemical stimulation and loading. J. Appl. Physiol. 53: 1133-1137, 1982.

Peever JH, Mateika JH and Duffin J. Respiratory control of hypoglossal motoneurones in the rat. Pflügers Arch. 442: 78-86, 2001.

Peever JH, Shen L and Duffin J. Respiratory pre-motor control of hypoglossal motoneurons in the rat. Neuroscience. 110: 711-722, 2002.

Pelleg A and Hurt CM. Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals. J. Physiol. 490: 265-275, 1996.

Peng B, Li SW, Kang H and Huang XZ. Cognitive and emotional impairment in obstructive sleep apnea syndrome. Chin. Med. Sci. J. 19: 262-265, 2004.

Peppard PE, Young T, Palta M and Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N. Engl. J. Med. 342: 1378-1384, 2000.

Petrillo GA, Glass L and Trippenbach T. Phase locking of the respiratory rhythm in cats to a mechanical ventilator. Can. J. Physiol. Pharmacol. 61: 599-607, 1983.

Pickar JG. The thromboxane A2 mimetic U-46619 inhibits somatomotor activity via a vagal reflex from the lung. Am. J. Physiol. 275: R706-712, 1998.

Pickar JG, Hill JM and Kaufman MP. Stimulation of vagal afferents inhibits locomotion in mesencephalic cats. J. Appl. Physiol. 74: 103-110, 1993.

Pierce RJ and Worsnop CJ. Upper airway function and dysfunction in respiration. Clin. Exp. Pharmacol. Physiol. 26: 1-10, 1999.

Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA and White DP. Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences. Respir. Physiol. 127: 23-28, 2001.

Pisarri TE, Coleridge JC and Coleridge HM. Capsaicin-induced bronchial vasodilation in dogs: central and peripheral neural mechanisms. J. Appl. Physiol. 74: 259-266, 1993.

Pisarri TE, Jonzon A, Coleridge JCG and Coleridge HM. Rapidly adapting receptors monitor lung compliance in spontaneously dogs. J. Appl. Physiol. 68: 1997-2005, 1990.

Pisarri TE, Yu J, Coleridge HM and Coleridge JC. Background activity in pulmonary vagal C-fibers and its effects on breathing. Respir. Physiol. 64: 29-43, 1986.

Qureshi A and Ballard RD. Obstructive sleep apnea. J. Allergy Clin. Immun. 112: 643-651, 2003.

Ravi K. Distribution and location of slowly adapting pulmonary stretch receptors in the airways of cats. J. Auton. Nerv. Syst. 15: 205-216, 1986.

Ravi K. Role of vagal and sympathetic afferents in reflex respiratory responses to capsaicin in dogs. Can. J. Physiol. Pharmacol. 66: 946-50, 1988.

Ravi K and Singh M. Role of vagal lung C-fibres in the cardiorespiratory effects of capsaicin in monkeys. Respir. Physiol. 106: 137-151, 1996.

Redline S, Tishler PV, Hans MG, Tosteson TD, Strohl KP and Spry K. Racial differences in sleep-disordered breathing in African-Americans and Caucasians. Am .J. Respir. Crit. Care Med. 155: 186-192, 1997.

Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I, Ferrette V and Krejci P. The familial aggregation of obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 151: 682-687, 1995.

Remmers JE, DeGroot WJ, Sauerland EK and Anch AM. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 44: 931-938, 1978.

Revelette WR, Jewell LA and Frazier DT. Effect of diaphragm small-fiber afferent stimulation on ventilation in dogs. J. Appl. Physiol. 65: 2097-106, 1988.

Richmonds CR and Hudgel DW. Hypoglossal and phrenic motoneuron responses to serotonergic active agents in rats. Respir. Physiol. 106: 153-160, 1996.

Riha RL, Brander P, Vennelle M and Douglas NJ. A cephalometric comparison of patients with the sleep apnea/hypopnea syndrome and their siblings. Sleep. 28: 315-320, 2005.

Roda F, Gestreau C and Bianchi AL. Discharge pattern of hypoglossal motoneurons during fictive breathing, coughing, and swallowing. J. Neurophysiol. 87: 1703-1711, 2002.

Roda F, Pio J, Bianchi AL and Gestreau C. Effects of anesthetics on hypoglossal nerve discharge and c-fos expression in brainstem hypoglossal premotor neurons. J. Comp. Neurol. 468: 571-586, 2004.

Ruan T, Ho CY and Kou YR. Afferent vagal pathways mediating respiratory reflexes evoked by ROS in the lungs of anesthetized rats. J. Appl. Physiol. 94: 1987-1998, 2003.

Ruan T, Lin YS, Lin KS and Kou YR. Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibers in rats. J. Physiol. 565: 563-578, 2005.

Ruan T, Gu Q, Kou YR and Lee LY. Hyperthermia increases sensitivity of pulmonary C-fiber afferents in rats. J. Physiol. 565: 295-308, 2005.

Ryan CM and Bradley TD. Pathogenesis of obstructive sleep apnea. J. Appl. Physiol. 99: 2440-2450, 2005.

Ryan D, McNicholas WT, O’Regan RG and Nolan P. Effect of upper airway negative pressure and lung inflation on larygneal motor unit activity in rabbit. J. Appl. Physiol. 92: 269-278, 2002.

Ryan S, McNicholas WT, O’Regan RG and Nolan P. Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat. J. Physiol. 537.1: 251-265, 2001.

Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation. 112: 2660-2667, 2005.

Saboisky JP, Butler JE, Fogel RB, Taylor JL, Trinder JA, White DP and Gandevia SC. Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. J. Neurophysiol. 95: 2213-2212, 2006.

Saito Y, Ezure K and Tanaka I. Difference between hypoglossal and phrenic activities during lung inflation and swallowing in the rat. J. Physiol. 544: 1983-193, 2002.

Sant’Ambrogio G. Information arising from the tracheobronchial tree of mammals. Physiol. Rev. 62: 531-569, 1982.

Sant’Ambrogio G and Widdicombe J. Reflexes from airway rapidly adapting receptors. Respir. Physiol. 125: 33-45, 2001.

Santos C, Braghiroli A, Mazzini L, Pratesi R, Oliveira LV and Mora G.. Sleep-related breathing disorders in amyotrophic lateral sclerosis. Monaldi. Arch. Chest Dis. 59: 160-165, 2003.

Satoh I, Shiba K, Kobayashi N, Nakajima Y and Konno A. Upper airway motor ourputs during sneezing and coughing in decerebrate cats. Neurosci. Res. 32: 131-135, 1998.

Sawczuk A and Mosier KM. Neural control of tongue movement with respect to respiration and swallowing. Crit. Rev. Oral. Biol. Med. 12: 18-37, 2001.

Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, Maislin G and Pack AI. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am. J. Respir. Crit. Care Med. 168: 522-530, 2003.

Schelegle ES, Alfaro MF, Putney L, Stovall M, Tyler N and Hyde DM. Effect of C-fiber-mediated, ozone-induced rapid shallow breathing on airway epithelial injury in rats. J. Appl. Physiol. 91: 1611-1618, 2001.

Schelegle ES and Green JF. An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors. Respir. Physiol. 125: 17-31, 2001.

Schelegle ES, Mansooe JK and Green JF. Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs. J. Appl. Physiol. 79: 600-606, 1995.

Schertel ER, Adams L, Schneider DA, Smith KS and Green JF. Rapid shallow breathing evoked by capsaicin from isolated pulmonary circulation. J. Appl. Physiol. 61: 1237-1240, 1986.

Schmid K, Foutz AS, and Denavit-Saubi M. Inhibitions mediated by glycine and GABA A receptors shape the discharge pattern of bulbar respiratory neurons. Brain. Res. 710: 150-160, 1996.

Seller H, Czachurski J and Zanzinger J. Activation of chemosensitive neurons in the ventrolateral medulla by capsaicin in cats. Neurosci. Lett. 226: 195-198, 1997.

Selvaratnam SR, Parkis MA and Funk GD. Developmental modulation of mouse hypoglossal nerve inspiratory output in vitro by noradrenergic receptor agonists. Brain Res. 805: 104-115, 1998.

Seyedi N, Maruyama R and Levi R. Bradykinin activates a cross-signaling pathway between sensory and adrenergic nerve endings in the heart: a novel mechanism of ischemic norepinephrine release? J. Pharmacol. Exp. Ther. 290: 656-663, 1999.

Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, O'Connor GT, Boland LL, Schwartz JE and Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am. J. Respir. Crit. Care Med. 163: 19-25, 2001.

Shea SA, Edwards JK and White DP. Effect of wake-sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans. J. Physiol. 520(3): 897-908, 1999.

Shi YX, Seto-Poon M and Wheatley JR. Alae nasi activation decreases nasal resistance during hyperoxic hypercapnia. J. Appl. Physiol. 85: 294-300, 1998.

Sica, AL, Cohen, MI, Donnelly DF and Zhang H. Hypoglossal motoneuron responses to pulmonary and superior laryngeal afferent inputs. Respir. Physiol. 56: 339-357, 1984.

Sica, AL, Cohen, MI, Donnelly DF and Zhang H. Responses of recurrent laryngeal motoneurons to changes in pulmonary afferent inputs. Respir. Physiol. 62: 153-168, 1985.

Simon PM, Habel AM, Daupenspeck JA and Leiter JC. Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans. J. Appl. Physiol. 89: 760-769, 2000.

Smith JC, Ellenberger HH, Ballanyi K, Richter DW and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.

Sood S, Liu X, Liu H, Nolan P and Horner RL. 5-HT at hypoglossal motor nucleus and respiratory control genioglossus muscle in anesthetized rats. Respir. Physiol. Neurobiol. 138: 205-221, 2003.

Sood S, Morrison JL, Liu H and Horner RL. Role of endogenous serotonin in modulating genioglossus muscle activity in awake and sleeping rats. Am. J. Respir. Crit. Care. Med. 172: 1338-1347, 2005.

Sood S, Raddatz E, Liu X, Liu H and Horner RL. Inhibition of serotonergic medullary raphe obscurus neurons suppresses genioglossus and diaphragm activities in anesthetized but not conscious rats. J. Appl. Physiol. 100: 1807-1821, 2006.

St. John WM. Neurogenesis of patterns of autonomic ventilatory activity. Prog. Neurobiol. 56: 97-117, 1998.

St. John, Bartlett D Jr, Knuth KV and Hwang JC. Brain stem genesis of automatic ventilatory patterns independent of spinal mechanisms. J. Appl. Physiol. 51: 204-210, 1981.

St. John WM and Paton JF. Neurogenesis of gasping does not require inhibitory transmission using GABAA or glycine receptors. Respir. Physiol. Neurobiol. 132: 265-277, 2002.

St John WM, Paton JF and Leiter JC. Uncoupling of rhythmic hypoglossal from phrenic activity in the rat. Exp. Physiol. 89: 727-37, 2004.

St. John WM and Zhou D. Differing control of neural activities during various portions of expiration in the cat. J. Physiol. 417: 189-204, 1989.

St. John WM and Zhou D. Discharge of vagal pulmonary receptors differentially alters neural activities during various stages of expiration in the cat. J. Physiol. 424: 1-12, 1990.

St. John WM and Zhou D. Reduction of neural activities to upper airway muscles after elevations in static lung volume. J. Appl. Physiol. 73: 707-07, 1992.

St. John WM, Zhou D and Fregosi RF. Expiratory neural activities in gasping. J. Appl. Physiol. 66: 223-231, 1989.

Staszewska-Wolley J, Luk DE and Nolan PN. Cardiovascular reflexes mediated by capsaicin sensitive cardiac afferent neurones in the dog. Cardiovasc. Res. 20: 897-906, 1986.

Stauffer JL, Buick MK, Bixler EO, Sharkey FE, Abt AB, Manders EK, Kales A, Cadieux RJ, Barry JD and Zwillich CW. Morphology of the uvula in obstructive sleep apnea. Am. Rev. Respir. Dis. 140: 724-728, 1989.

Steenland HW, Liu H, Sood S, Liu X and Horner RL. Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in vivo. Neuroscience. 138: 1407-1424, 2006.

Strohl KP. Respiratory activation of the facial nerve and alar muscles in anaesthetized dogs. J. Physiol. 363: 351-362, 1985.

Strohl KP, Hensley MJ, Hallett M, Saunders NA, and Ingram RH Jr. Activation of upper airway muscles before onset of inspiration in normal humans. J. Appl. Physiol. 49: 638-642, 1980.

Strohl KP, O’Cain CF and Slutsky AS. Alae nasi activation and nasal resistance in healthy subjects. J. Appl. Physiol. 52: 1432-1437, 1982.

Sun QJ, Berkowitz RG and Pilowsky PM. Response of laryngeal motoneurons to hyperventilation induced apnea in the rat. Respir. Physiol. Neurobiol. 146: 155-163, 2005.

Takemoto H. Morphological analyses of the human tongue musculature for three-dimensional modeling. J. Speech Lang. Hear Res. 44: 95-107, 2001.

Tanabe A, Fujii T and Onimaru H. Facilitation of respiratory rhythm by a mu-opioid agonist in newborn rat pons-medulla-spinal cord preparations. Neurosci. Lett. 375: 19-22, 2005.

Tangel DJ, Messanotte WS and White DP. Influence of sleep on tensor palatine EMG and upper airway resistance in normal men. J. Appl. Physiol. 70: 2574-2581, 1991.

Tangel DJ, Mezzanotte WS and White DP. Respiratory-related control of palatoglossus and levator palatine muscle activity. J. Appl. Physiol. 78: 680-688, 1995.

Taylor-Clark T and Undem BJ. Transduction mechanisms in airway sensory nerves. J. Appl. Physiol. 101: 950-959, 2006.

Tomomune N and Takata M. Excitatory and inhibitory postsynaptic potentials in cat hypoglossal motoneurons during swallowing. Exp. Brain Res. 71: 262-272, 1988.

Toppin VAL, Harris MB, Kober AM, Leiter JC and St. John WM. Persistent of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation. J. Appl. Physiol. doi:10.1152/japplphysiol.00071.2007.

Travers JB and Rinaman L. Identification of lingual motor control circuits using two strains of pseudorabies virus. Neuroscience. 115: 1139-1151, 2002.

Tsai CY, Wu CC, Lee KZ and Hwang JC. Muscarinic M2 receptor mediated bradycardia and hypotension induced by capsaicin administration in the rat. BioFormosa. 40: 25-35, 2005.

Tsubone H. Characteristics of vagal afferent activity in rats: three types of pulmonary receptors responding to collapse, inflation, and deflation of the lung. Exp. Neurol. 92: 541-552, 1986.

Tsuiki S, Ono T, Ishiwata Y and Kuroda T. Functional divergence of human genioglossus motor units with respiratory-related activity. Eur. Respir. J. 15: 906-910, 2000.

Umezaki T, Nakazawa K and Miller AD. Behaviors of hypoglossal hyoid motoneurons in laryngeal and vestibular reflexes and in deglutition and emesis. Am. J. Physiol. 274: R950-955, 1998.

Undem BJ, Carr MJ and Kollarik M. Physiology and plasticity cough fibers in the guinea pig. Pulm. Pharmaco. Ther. 15: 193-198, 2002.

Undem BJ, Chuaychoo B, Lee MG, Weinreich D, Myers AC and Kollarik M. Subtypes of vagal afferent C-fibres in guinea-pig lungs. J. Physiol. 556: 905-917, 2004.

van de Graaff WB, Gottfried SB, Mitra J, van Lunteren E, Cherniack NS and Strohl KP. Respiratory function of hyoid muscles and hyoid arch. J. Appl. Physiol. 57: 197-204, 1984.

van der Touw T, O’Neill N, Amis T, Wheatley J and Brancatisano A. Soft palate muscle activity in response to hypoxic hypercapnia. J. Appl. Physiol. 77: 2600-2605, 1994.

van Lunteren E, Haxhiu MA and Cherniack NS. Respiratory changes in nasal muscle length. J. Appl. Physiol. 59: 453-458, 1985.

van Lunteren E, Haxhiu MA, Mitra J and Cherniack NS. Effects of dopamine, isoproterenol, and lobeline on cranial and phrenic motoneurons. J. Appl. Physiol. 56: 737-745, 1984.

van Lunteren E, Strohl KP, Parker DM, Bruce EN, van de Graaff WB and Cherniack NS. Phasic volume-related feedback on upper airway muscle activity. J. Appl. Physiol. 56: 730-36, 1984

van Lunteren E, van de Graaff WB, Parker DM, Mitra J, Haxhiu MA, Strohl KP and Cherniack NS. Nasal and laryngeal reflex responses to negative upper airway pressure. J. Appl. Physiol. 56: 746-52, 1984.

Van Zutphen C, Janssen P, Hassan M, Cabrera R, Bailey EF and Fregosi RF. Regional velopharyngeal compliance in the rat: influence of tongue muscle contraction. NMR. Biomed. 2007. [Epub ahead of print]

Vasilakos K, Wilson RJ, Kimura N and Remmers JE. Ancient gill and lung oscillators may generate the respiratory rhythm of frogs and rats. J. Neuroniol. 62: 369-385, 2005.

Veeken R, Leonard M, Stetter A, Hilgers KF, Mann JF, Reeh PW, Geiger H and Luft FC. Pulmonary serotonin 5-HT3-sensitive afferent fibers modulate renal sympathetic nerve activity in rats. Am. J. Physiol. 272: H979-986, 1997.

Vesely KR, Hyde DM, Stovall MY, Harkema, JR, Green JF and Schelegle ES. Capsaicin-sensitive C-fibre-mediated protective responses in ozone inhalation in rats. J. Appl. Physiol. 86: 951-962, 1999.

Vgontzas AN, Bixler EO and Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med. Rev. 9: 211-224, 2005.

Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G and Chrousos GP. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist. J. Clin. Endocrinol. Metab. 89: 4409-4413, 2004.

Waldbaum S, Hadziefendic S, Erokwu B, Zaidi SIA and Haxhiu MA. CAN innervation of posterior cricoarytenoid muscles: a transneuronal labeling study. Respir. Physiol. 126: 113-125, 2001.

Waldrop, T.G. Respiratory responses to chemical activation of left ventricular receptors. Respir. Physiol. 63: 383-93, 1986.

Wang AL, Blackford TL and Lee LY. Vagal bronchopulmonary C-fibers and acute ventilatory responses to inhaled irritants. Respir. Physiol. 104: 231-239, 1996.

Wang J, Irnaten M, Venkatesan, Evans C, Baxi S and Mendelowitz D. Synaptic activation of hypoglossal respiratory motoneurons during inspiration in rats. Neurosci. Lett. 332: 195-199, 2002.

Wang R, Xu F, Zhang J and Zhang C. Carotid sinus nerve is involved in cardiorespiratory responses to intracarotid injection of capsaicin in the rat. J. Appl. Physiol. 100: 60-66, 2006.

Wang Y, Jones JFX, Jeggo RD, de Burgh Daly M, Jordan D and Ramage AG. Effect of pulmonary C-fibre afferent stimulation on cardiac vagal neurones in the nucleus ambiguous in anaesthetized cats. J. Physiol. 526: 157-165, 2001.

Watanabe T, Isono S, Tanaka A, Tanzawa H and Nishino T. Contribution of body habitus and craniofacial characteristics to segmental closing pressures of the passive pharynx in patients with sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 165: 260-265, 2002.

Weiner D, Mitra J, Slamone J and Cherniack NS. Effect of chemical stimuli on nerves supplying upper airway muscles. J. Appl. Physiol. 52: 530-536, 1982.

Wetter DW, Young TB, Bidwell TR, Badr MS and Palta M. Smoking as a risk factor for sleep-disordered breathing. Arch. Intern. Med. 154: 2219-2224, 1994.

Wheatley JR, Tangel DJ, Mezzanotte WS and White DP. Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway. J. Appl. Physiol. 75: 2117-2124, 1993.

Widdicombe J. Airway receptors. Respir. Physiol. 125: 3-15, 2001.

Widdicombe J. Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs). Anat. Rec. 270A: 2-10, 2003.

Wiegand DA, Latz B, Zwillich CW and Wiegand L. Upper airway resistance and geniohyoid muscle activity in normal men during wakefulness and sleep.
J Appl Physiol. 69:1252-1261, 1990a.

Wiegand DA, Latz B, Zwillich CW and Wiegand L. Geniohyoid muscle activity in normal men during wakefulness and sleep. J. Appl. Physiol. 69:1262-1269, 1990b

Wiegand L, Zwillich CW, Wiegand D and White DP. Changes in upper airway muscle activation and ventilation during phasic REM sleep in normal men. J. Appl. Physiol. 71: 488-497, 1991.

Wilson CG and Bonham AC. Effect of cardiopulmonary C fibre activation on the firing activity of ventral respiratory group neurones in the rat. J. Physiol. 504: 453-466, 1997.

Wilson CG, Zhang Z and Bonham AC. Non-NMDA receptors transmit cardiopulmonary C fibre input in nucleus tractus solitarii in rats. J. Physiol. 496: 773-785, 1996.

Withington DJ, Mifflin SW and Spyer KM. Intracellular analysis of respiratory-modulated hypoglossal motoneurons in the cat. Neuroscience. 25: 1041-1051, 1988.

Wu JS and Hwang JC. Respiratory-related facial nerve activity in responses to activation of the rostral ventrolateral medulla in the cat. Chin. J. Physiol. 40: 97-105, 19973.

Xu J, Yang W, Zhang G, Gu Q and Lee LY. Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons. Am. J. Physiol. Lung Cell Mol. Physiol. 292: L54-61, 2007.

Xue BJ and He RR. Changes in heart rate, blood pressure and renal sympathetic nerve activity induced by microinjection of capsaicin into area postrema in rats. Sheng. Li. Xue. Bao. 52: 435-439, 2000.

Yajima Y and Hayashi Y. Identification of motoneurons in the nucleus ambiguous by antidromic stimulation of the superior and the recurrent laryngeal nerves in rats. Brain Res. 288(1-2): 302-306, 1983.

Yasuda K, Robinson DM, Selvaratnam SR, Walsh CW, McMorland AJC and Funk GD. Modulation of hypoglossal motoneuron excitability by NK1 receptor activation in neonatal mice in vitro. J. Physiol. 534: 447-464, 2001.

Yasui Y, Kogo M, Iida S, Hamaguchi M, Koizumi H, Kohara H and Matsuya T. Respiratory activities in relation to external glossal muscles. J. Osaka. Univ. Dent. Sch. 33: 27-33, 1993.

Yoo PB and Durand DM. Effects of selective hypoglossal nerve stimulation on canine upper airway mechanics. J. Appl. Physiol. 99: 937-943, 2005.

Young T, Peppard PE and Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am. J. Respir. Crit. Care Med. 165: 1217-1239, 2002.

Young T, Peppard P, Palta M, Hla KM, Finn L, Morgan B and Skatrud J. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch. Intern. Med. 157: 1746-1752, 1997.

Yu J, Lin S, Zhang J, Otmishi P and Guardiola JJ. Airway nociceptors activated by pro-inflammatory cytokines. Respir. Physiol. Neurobiol. 156: 116-119, 2007.

Yu J. Airway mechanosensors. Respir. Physiol. Neurobiol. 148: 217-243, 2005.

Yu J, Pisarri TE, Coleridge JC and Coleridge HM. Response of slowly adapting pulmonary stretch receptors to reduced lung compliance. 71: 425-431, 1991.

Yu J and Zhang J. A single pulmonary mechano-sensory unit possesses multiple encoders in rabbits. Neurosci. Lett. 362: 171-175, 2004.

Yu X, Fujimoto K, Urushibata K, Matsuzawa Y and Kubo K. Cephalometric analysis in obese and nonobese patients with obstructive sleep apnea syndrome. Chest. 124: 212-218, 2003.

Zar JH. Biostatistical analysis. Prentice-Hall, Englewood Cliffs, NJ, 1984.

Zhou D, Huang Q, St. John WM and Bartlett D Jr. Respiratory activities of intralaryngeal branches of the recurrent laryngeal nerve. J. Appl. Physiol. 67: 1171-1178, 1989.