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研究生: 高昌弘
Gao, Chang-Hong
論文名稱: 三價鐵超氧化物對四氫呋喃之催化探討
Catalytic study of Iron(III)-Superoxo complex towards tetrahydrofuran
指導教授: 李位仁
Lee, Way-Zen
學位類別: 碩士
Master
系所名稱: 化學系
Department of Chemistry
論文出版年: 2019
畢業學年度: 107
語文別: 中文
論文頁數: 33
中文關鍵詞: 鐵超氧化物鐵過氧化物鐵過氧氫化物
英文關鍵詞: iron superoxo, iron peroxo, iron hydroperoxo
DOI URL: http://doi.org/10.6345/NTNU201900403
論文種類: 學術論文
相關次數: 點閱:145下載:0
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  • 生物體中細胞色素P450的催化循環過程中,推測會有鐵超氧化物、鐵過氧化物和鐵過氧氫化物之中間體生成,其中鐵超氧化物為重要的中間體。本研究利用三氮二氧五牙基H2(BDPP)與二價鐵金屬離子反應形成前驅物FeII(BDPP) (1)。在-70 oC下,將氧氣通入前驅物1會形成FeIII(BDPP)(O2˙) (2);若持續通入氧氣五個小時,則會生成(FeIII(BDPP))2(μ - O2) (3)。 將其樣品偵測氣相色譜法-質譜聯用(Gas chromatography–mass spectrometry),則會得到產物2-羥基四氫呋喃(2-hydroxy-tetrahydro-furan)與γ-丁內酯(γ-butyrolactone)。和提前加入的內標準品十二烷(Dodecane)相比較,則可得出產率。

    living organism, the catalytic process of cytochrome P450 is presumed to produce iron superoxo , iron peroxo and iron hydroperoxo intermediates. Among them iron superoxo is an the first critical intermediate. In this study, N3O2 petadentate ligand, H2(BDPP), was reacted with FeCl2 to form FeII(BDPP) (1) precursor. At -70 oC, FeII(BDPP) (1) was reacted with dioxygen to produce FeIII(BDPP)(OO˙) (2). If dioxygen was continuously supplied for five hours, (FeIII(BDPP))2(μ - O2) (3) was formed.
    From sample detection of gas chromatography-mass spectrometry, the product 2-hydroxytetrahydrofuran and γ-butyrolactone are obtained. The yield is obtained in comparison with the internal standard dodecane , which was added in advance.

    目錄 I 圖索引 III 中文摘要 V Abstract VI 第一章 緒論 1 1-1 大自然中含鐵金屬的蛋白及酵素 2 1-2 鐵金屬錯合物與氧氣之反應 10 1-3 研究方向 14 第二章 實驗部分 15 2-1 實驗藥品 15 2-2 實驗儀器及條件 16 2-3 鐵錯合物的製備 19 第三章 結果與討論 20 3-1 鐵超氧化物的性質與反應性 20 3-2 FeIII(BDPP)(OO˙)(2)與四氫呋喃升溫至不同溫度催化之探討 22 3-3 不同反應溫度下形成(FeIII(BDPP))2(μ - O2) (3)與四氫呋喃進行 催化 26 3-4 呋喃與不同當量四氫呋喃混合在低溫形成超氧化物之反應 29 第四章 結論與展望 30 參考文獻 32 附錄 A-1

    1. Shu-Shan Gao, Nathchar Naowarojna, Ronghai Cheng, Xueting Liuand Pinghua Liu, Nat. Prod. Rep., 2018, 35, 792–837
    2. Robert M. Cicchillo, Houjin Zhang, Joshua A. V. Blodgett, John T. Whitteck, Gongyong Li, Satish K. Nair, Wilfred A. van der Donk & William W. Metcalf, Nature ,2009, 459, 871–874
    3. Pamela A. Williams, Jose Cosme, Dijana Matak Vinkovic, Alison Ward, Hayley C. Angove, Philip J. Day, Clemens Vonrhein, Ian J. Tickle, Harren Jhoti Science, 2004, 305, 683–686
    4. Sussan Ghassabian, Tristan Rawling, Fanfan Zhou, Munikumar R. Doddareddy, Bruce N. Tattam, David E. Hibbs, Robert J. Edwards, Pei H. Cui, Michael Murray Biochemical Pharmacology, 2012, 84, 215–223
    5. James Belcher, Kirsty J. McLean, Sarah Matthews, Laura S. Woodward, Karl Fisher, Stephen E. J. Rigby, David R. Nelson, Donna Potts, Michael T. Baynham, David A. Parker, David Leys, and Andrew W. Munro J Biol Chem. 2014, 289, 6535–6550
    6. Peter L. Roach , Ian J. Clifton, Charles M. H. Hensgens , Norio Shibata , Christopher J. Schofield , Janos Hajdu & Jack E. Baldwin* Nature 1997, 387, 827–830
    7. Esta Tamanaha, Bo Zhang, Yisong Guo, Wei-chen Chang, Eric W. Barr, Gang Xing, Jennifer St. Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Jr., and Carsten Krebs J. Am. Chem. Soc. 2016, 138, 8862−8874
    8. Wonwoo Nam , Acc. Chem. Res., 2015, 48 (8), pp 2415–2423
    9. Yong-Min Lee, Seungwoo Hong, Yuma Morimoto, Woonsup Shin, 33 Shunichi Fukuzumi, and Wonwoo Nam, J. Am. Chem. Soc. 2010, 132, 10668–10670
    10. Chien-Wei Chiang, Scott T. Kleespies, Heather D. Stout, Katlyn K. Meier, Po-Yi Li, Emile L. Bominaar, Lawrence Que, Jr.,Eckard Münck, and Way-Zen Lee J. Am. Chem. Soc. 2014, 136, 10846−10849
    11. Maike N. Blakely, Maksym A. Dedushko, Penny Chaau Yan Poon, Gloria Villar-Acevedo, and Julie A. Kovacs J. Am. Chem. Soc. 2019, 141, 1867−1870

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