研究生: |
歐佳珍 |
---|---|
論文名稱: |
金奈米棒包覆二氧化矽與溫感型水膠與其在藥物傳輸上的應用 |
指導教授: | 陳家俊 |
學位類別: |
碩士 Master |
系所名稱: |
化學系 Department of Chemistry |
論文出版年: | 2006 |
畢業學年度: | 94 |
語文別: | 中文 |
中文關鍵詞: | 金柰米棒 、藥物傳輸 、二氧化矽 、水膠 |
論文種類: | 學術論文 |
相關次數: | 點閱:175 下載:0 |
分享至: |
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
摘要
近年來,許多將無機奈米結構與生物系統相連接的材料已經陸續應用於生物醫學的領域。在本篇論文中,利用金奈米棒為模板,在金奈米棒外面包覆二氧化矽或者是聚合物。
在金奈米棒包覆二氧化矽的部份,我們成功合成出均勻二氧化矽包覆在金奈米棒的材料,並藉由完全溶解內部的金奈米棒來合成出具有中空性質的二氧化矽奈米膠囊,或是部份溶解內部金奈米棒,製備出內外為不同材料的中空二氧化矽奈米膠囊。
在金奈米棒包覆聚合物部份,我們合成出金奈米棒外面包覆一層溫感型水膠P(NIPAAm-co-AAc)。溫感型水膠在溫度高於其相轉移溫度時,會有去澎潤現象,而釋出內部的水分。利用這個性質,我們將藥物包覆於這個材料中,內部的金奈米棒可以吸收特定波長的雷射使溫度升高,當溫度高於水膠的相轉移溫度,即可達到藥物釋放的目的。
在此,我們選用兩種以上不同吸收波長的金奈米棒來合成這個材料,便可以利用不同波長的雷射來釋放不同的藥物。
Abstract
Inorganic nanomaterials that interface with biological systems have recently attracted widespread interests in biomedical application. In this paper, we employ gold nanorods to be template to synthesize silica-coat or polymer-coating gold nanorods.
The part of silica-coating gold nanorods is successful to synthesize uniform silica-coating gold nanorods. Furthermore, we can synthesis not only silica nanocapsule by dissolving gold nanorod completely, but hollow silica-coating gold nanorods.
The part of polymer-coating gold nanorods, we can successfully synthesize thermo-responsive hydrogel-coated gold nanorods, poly(N-isopropylacrylamide-coAcrylic acid ) (p(NIPAAm-co-AAc)). Thermo-responsive hydrogel are observed that they are deswelling , then release water in hysrogel when heated above its lower critical solution temperature (LCST). Utilizing this property, we encapsulated drug in this material. The temperature of this material is raised when gold nanorods in core absorb laser of specific wavelength. It can be control drug release when temperature above LCST of hydrogel. At present,we use different gold nanorods that have different specific wavelength, it can successfully control release of different drug by absorbing laser of different wavelength.
(1)(a) Bruches,M. ; Moromme,M.; Gin,P. ; Weiss,S ;
Alivisatos,A.P. Science 1998,281,2013.
(b) Chan,W.C ; Nie,S. Science 1998,281,2016.
(c) Lin,C.C ; Yeh,Y,C.; Yang,C.Y. ; Chen,C.L. ; Chen,G.F. ;
Chen,C.C.; Wu,Y.C. J. Am. Chem. Soc. 2002,124,3508.
(2)(a) Cui,Y.; Wei,Q.Q.; Park,H.K.;Lieber,C.M. Science
2001,293,1289.
(b) Taton,T.A.; Lu,G.; Mirkin,C.A. J. Am. Chem. Soc.
2001,123,5164.
(c)Shim,M.; Kam,N.W.S.; Chen,R.J.; Li,Y.M.; Dai,H.J. Nano
Lett. 2002,2,285.
(3)(a) Jain,K.K. Science 2001,294,621.
(b) Schulze,A,; Downward,J. Nature Cell Biol. 2001,3,E190.
(4) Kamat, P. V.; Shanghavi,B. J. Phys. Chem. B. 1997
,101,7675.
(5) Chandrasekharan, N.; Kamat, P. V.; Hu, J.; Jones, G.
J. Phys. Chem. B . 2000,104,11103.
(6) Stolberg,L; Lipkowski,J. IRISH DEJOURNAL OF
ELECTROANALYTICAL CHEMISTRY 1991,300,563.
(7) Emory S.R.; Nie ,Smanalytical Chem. 1997,69 ,2631.
(8) Jana N. R.; Gearheart L. and Catherine J. Murphy, Chem.
Commun. 2001,617.
(9) Sun, Y.; Gates, B.; Mayers, B.; Xia, Y. Nano Lett. 2002;
2,165
(10) Rongchao Jin; YunWei Cao Chad A. Mirkin, K.L.Kelly,
George C.Schatz, J. G. Zheng. Science 2001, 294 ,
1901.
(11) Maillard, M.; Huang, P.; Brus, L. Nano Lett. 2003,3,1611
(12) Silvander, M.; Hansson, P.; Edwards, K. Langmui 2000,
16,369
(13) Braun,E; Eichen,Y; Silvan,U; Ben-Yoseph,G Nature
1998, 391 ,775.
(14) Michael H. H. ; Amer, C.; Peidong, Y Chem. Commun. 2000,
1063.
(15) Zhou, Y.; Yu, S. H.; Cui, X. P.; Wang, C. Y.; Chen, Z. Y.
Chem. Mater. 1999; 11, 545.
(16) Jeremy S,;David M. W; Sam B; Gareth B; Andrew P. E. Y; Karl
S. C;Malcolm L. H. G; David M. W; John L. H; Hee G. W.
Chem.Commun. 1999 ,699.
(17) S. Bhattacharrya, S.K. Saha and D. Chakravorty, Appl.
Phys. Letters 2000,76,3896.
(18) Cepak, V. M.; Martin, C. R. J. Phys. Chem. B.
1998,102,9985.
(19) Murphy,C.J.; Jana, N.R. Adv.Matter. 2002,14,80
(20)(a) Cottam, M. G.; Tilley D.R. Introduction to Surface and
Superlattice Excitation Cambridge: Cambridge
University Press,1989.
(b) Kittel,C Introduction to Solid state physics New
York:Wiley,c1996
(c) 陳俊顯 自然科學簡訊 2001,13,55
(21) (a) Link, S.; Burda, C.; Mohamed,M.B.; Nikoobakht, B.;
El-Sayed, M. A. J. Phys. Chem. A. 1999,103,1165.
(b) Link, S.; Burda, C.; Nikoobakht, B.; El-Sayed, M. A.J.
Phys. Chem. B. 2000,104,6152.
(c ) Chang,S.S.; Shih,C.W,;Cnen,C.D. Langmuir 1999,15,7
(22) Grabar, K.C.; Allison, K.J.; Baker, B.E.; Bright, R.M.;
Brown, K.R.;Freeman, R.G.; Fox, A.P.; Keating, C.D.;
Musick, M.D.; Natan, M.J. Langmuir 1996,12,2353.
(23) Yamanaka, S.A.; Kawola, J.S.; Loy, D.A.; Martino, A.
Chem. Mater. 1997,9,423.
(24) Elliot, D.J.; Furlong, D.N.; Grieser, F.; Mulvaney, P.;
Giersig, M. Colloids and Surfaces 1997,141,129,
(25) Freeman, R.G.; Grabar, K.C.; Allison, K.J.; Bright, R.M.;
Davis, J.A.;Guthrie, A.P.; Hommer, M.B.; Jackson, M.A.;
Smith, P.C.; Walter,D.G.; Natan, M.J. Science 1995,267,
1629.
(26) Liz-Marzan, L.M.; Giersig, M.; Mulvaney, P. Langmuir
1996,12,4329.
(27) Ung, T.; Liz-Marzan, L.M.; Mulvaney, P. Langmuir 1998,
14,3740.
(28) Decher,G. Science 1997,77,232
(29) Encai H.; Tianquan,L. Chem. Mater. 2000,2,392.
(30) Birrenbach G. J.Pharm.Sci. 1976,65,1763
(31) Couvreur P. FEBS-Lett. 1977.84,323.
(32) Kreuter J.Med.Microbiol.Immunol.Berl. 1978,165,111.
(33) Couvreur P. J.Pharm.Sci. 1979,68,1521.
(34) Wichterle,O.; Lim,D. Nature 1960,185,117
(35) Korsmeyer, R. W. Polymers for controlled drug delivery, CRC Press, 1991, Cpapter 2,
(36) N. A. Peppas. (Ed.), Hydrogels in medicine and pharmacy, Vol. 1 CRC Press, 1988.
(37) Hoffman A.S.; Afrassiabi, A. A.; Dong, L. C. J. Contr. Rel. 1986,4,213 .
(38) Bae Y.H.; Okano,T.; Kim,S.W. Makromol. Chem.
Rapid Commun. 1988,9,185
(39) Heskins, M; Guillet,J.E.; James,E. J. Macromol. Sci. Chem. 1968,A2,1441
(40) Kubota,K.; Ando,I; Fujishige,S.; Polym. J. 1990,22,15
(41) Otake,K.; Inomata,H.; Konno,M.; Saito,S. Macromol.
1990,23,283.
(42) Kubota,K,; Fujishige,S.; Ando,I.; J.Phys.Chem.1990,94,5154.
(43) Marchetti,M.; Pranger,S.; Cussler,E.L.; Macromol.1990,23,1760.
(44) Snowden J. Chowdhry Z. Vincent and E. Morris, J.
Chem. Farady Trans., 1996,92, 5013.
(45) Chen H. Langer R., Adv. Drug Deliv. Rev.1998,34,339.
(46) Allemann E. , Leroux J. L. and Gurny, R., Adv. Drug Deliv. Rev.1998,34,171.
(47) Ward K. L. and Tracy M. A. In「Encyclopedia of
Controlled Drug Delivery」 1999, ; Wiley, New York.
(48) Park,T.G.; Hoffman,A.S. J. of polym. Sci. , Park A, Polym. Chem. 1992.30,505.
(49) Haruma,K.; Kiji,F.; Yoshiro,M. Colloid Polym. Sci. 1992,270,53.
(50) Park,T.G.; Hoffman,A.S. Biotechnol. Prog. 1994,10,82.
(51) Huang,H.; Remsen,E.E.; Kowalewski,T.; Wooley,K.L. J. Am. Chem. Soc. 1999,121,3805.
(52) Thurmond,K.B.; Kowalewski,T.; Wooley,K.L. J. Am Chem. Soc.1997,119,6656.
(53) Huang,H.; Remsen,E.E.; Wooley,K.L. Chem. Commun.
1998,1415.
(54) Thurmond K.B.; Kowalewski,T. Wooley,K.L. J. Am. Chem. Soc. 1996,118,7239.
(55) Huang,H.; Remsen,E.E.; Wooley,K.L.; Gertzmann,R. J. Am. Chem. Soc. 1997,119,11653.
(56) Wooley,K.L Chem. Eur. J. 1997,3,1397.
(57) Saunders R.; Vincent,J. Chem. Farady Trans. 1996,92,3385.
(58) Gan,D.; Lyon,L.A. J. Am. Chem. Soc. 2001,123,7511.
(59) Wang,J.; Gan,D.; Lyon,L.A.; El-Sayed,M.A. J. Am Chem. Soc. 2001,123,11284.