The content of the dissertation has been devided into four parts. Part-I illustrates overview on enynes and dienynes through C-C bond formation reactions. Further it also described importance and synthesis of diene aldehyde, alkyne aldehyde, enyne, dienyne derivatives and iodine mediated reactions in organic synthesis. Part-II is about an approach for the synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives starting from β-halo styrene and phenyl acetylene derivatives in the presence of PdCl2 and CuI catalysts. Functional groups such as aldehyde, cyano and ester groups are well tolerated and afford the desired functionlized dienynes. Further, these 1,3-buta-diene-3-yne derivatives are utilized for the synthesis of novel trisubstituted pyridine derivatives. In Part-III, an efficient method for the synthesis of polysubstituted cyclopentene and cyclopenta[b]carbazole derivatives through the iodine promoted electrocyclization of substituted indoles and 4-Arylidene-3,6-diarylylhex-2-en-5-ynal derivatives is reported. Polysubstituted cyclopentene derivatives were furnished through 4π electrocyclization reactions with indole, 7-methylindole and 5-bromoindole as coupling partners. Whereas, cyclopenta[b]carbazole derivatives were produced via 6π electrocyclization in the case of methoxy (-OMe) substituted indoles. The methods reported are diastereo- and regioselectively proceeding under straightforward and mild conditions. Part-IV describes synthesis of fused bridgehead carbocycles from dimerization of unsymmetrical 1,3-butadiene-3-ynal derivatives via iodine mediated iso-Nazarov reaction. Bridgehead carbocyclic derivatives are produced as major products in the reaction, which involves the generation of new C-C bonds and new stereo centers. On the other hand,. The methods reported herein are diastereo- and regioselective and proceed under mild conditions.

Part-1
1. Corey, E. J.; Cheng, X. M. The Logic of Chemical Synthesis, John Wiley & Sons, Newyork, 1989.
2. Brahmachari, G. RSC Adv., 2016, 6, 64676.
3. Nair, V.; Vellalath, S.; Pattoorpadi Babu, B. Chem. Soc. Rev., 2008, 37, 2691.
4. (a) Parsons, P. J.; Penkett, C. S.; Shell, A. J. Chem. Rev., 1996, 96, 195 (b) Mehta, G.; Srikrishna, A. Chem. Rev., 1997, 97, 671 (c) Dounay, A. B.; Overman, L. E. Chem. Rev., 2003, 103, 2945 (d) Kang E. J.; Lee, E. Chem. Rev., 2005, 105, 4348 (e) Saragi, T. P. I.; Spehr, T.; Siebert, A.; Fuhrmann-Lieker, T.; Salbeck, J. Chem. Rev., 2007, 107, 1011 (f) Martins, M. A. P.; Frizzo, C. P.; Moreira, D. N.; Zanatta, N.; Bonacorso, H. G. Chem. Rev., 2008, 108, 2015 (g) Martins, M. A. P.; Frizzo, C. P.; Moreira, D. N.; Buriol, L.; Machado, P. Chem. Rev., 2009, 109, 4140 (h) Toure, B. B.; Hall, D. G. Chem. Rev., 2009, 109, 4439 (i) Brahmachari, G. Handbook of Pharmaceutical Natural Products, Wiley-VCH, Weinheim, 2010, vol. 1 and 2 (j) Brahmachari, G. Bioactive Natural Products: Opportunities and Challenges in Medicinal Chemistry, ed. World Scientific Publishing Co., Singapore, 2011 (k) Brahmachari, G. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds, ed. CRC Press/Taylor Francis Group, LLC, USA, 2013 (l) Ylijoki, K. E. O.; Stryker, J. M. Chem. Rev., 2013, 113, 2244 (m) Chen, J.-R.; Hu, X.-Q.; Lu L.-Q.; Xiao, W.-J. Chem. Rev., 2015, 115, 5301 (n) Brahmachari, G. Bioactive Natural Products: Chemistry and Biology, ed. Wiley-VCH, Weinheim, 2015 (o) Armaly, A. M.; DePorre, Y. C.; Groso, E. J.; Riehl P. S.; Schindler, C. S. Chem. Rev., 2015, 115, 9232.
5. (a) Kuwajima, I.; Nakamura, E. in Comprehensive Organic Synthesis, ed. Trost, B. M.; Fleming, I. Pergamon, New York, 1991, vol. 2, p. 441 (b) Lee, V. J. in Comprehensive Organic Synthesis, ed. Trost, B. M.; Fleming, I. Pergamon, New York, 1991, vol. 4, p. 117.
6. Werstiuk, N. H, Tetrahedron, 1983, 39, 205.
7. Hoppe, D.; Hense, T. Angew. Chem., Int. Ed. Engl., 1997, 36, 2282.
8. Hoppe, D.; Marr, F.; Bruggemann, M. Top. Organomet. Chem., 2003, 5, 61.
9. (a) Miyaura, N.; Suzuki, A. Chem. Rev., 1995, 95, 2457 (b) Franzén, R. Can. J. Chem., 2000, 78, 957. (c) Franzén, R.; Xu, Y. Can. J. Chem., 2005, 83, 266 (c) Yin, L.; Liebscher, J. Chem. Rev., 2006, 107, 133 (d) Barluenga, J.; Tomás-Gamasa, M.; Aznar, F.; Valdés, C. Nat. Chem., 2009, 1, 494 (e) Clapés, P.; Fessner, W.-D.; Sprenger G. A.; Samland, A. K. Curr. Opin. Chem. Biol., 2010, 14, 154 (f) Gillingham, D. G.; Stallforth, P.; Adibekian, A.; Seeberger, P. H.; Hilvert, D. Nat. Chem., 2010, 2, 102 (g) Soloducho, J.; Cabaj, J.; Idzik, K.; Nowakowska-Oleksy, A.; Swist A.; Lapkowski, M. Curr. Org.Chem., 2010, 14, 1234 (h) Resch, V.; Schrittwieser, J. H.; Siirola E.; Kroutil, W. Curr. Opin. Biotechnol., 2011, 22, 793 (i) Perez, M.; Fananas-Mastral, M.; Bos, P. H.; Rudolph, A.; Harutyunyan, S. R.; Feringa, B. L. Nat. Chem., 2011, 3, 377 (j) Bhunia, A.; Yetra, R. S.; Biju, A. T. Chem. Soc. Rev., 2012, 41, 3140 (k) Brahmachari, G. Chem. Soc. Rev., 2016, 16, 98.
10. Sonogashira, K. J. Organomet. Chem., 2002, 653, 46.
11. King, A. O.; Yasuda, N. Top. Organomet. Chem., 2004, 6, 205.
12. King, A. O., Yasuda, N. Top. Organomet. Chem., 2005, 9, 646.
13. Chinchilla, R.; Najera, C. Chem. Rev. 2007, 107, 874.
14. Pal, M.; Subramanian, V.; Parasuraman, K.; Yeleswarapu, K. R. Tetrahedron 2003, 59, 9563.
15. (a) McGarvey, B. D.; Attygalle, A. B.; Starratt, A. N.; Xiang, B.; Schroeder, F. C.; Brandle, J. E.; Meinwald, J. Nat. Prod. 2003, 66, 1395.
16. Robinson, C. Y.; Waterhous, D. V.; Muccio, D. D.; Brouillette, W. J. Bioorg. Med. Chem. Lett. 1995, 5, 953.
17. Asfaw, N.; Storesund, H. J.; Skattebol, L.; Aasen A, J. Phytochemistry 1999, 52, 1491.
18. Hiraoka, H.; Mori, N.; Nishida, R.; Kuwahara, Y. Biosci. Biotechnol. Biochem. 2001, 65, 2749.
19. Matsumoto, H.; Asato, A. E.; Denny, M.; Baretz, B.; Yen, Y.-P.; Tong, D.; Liu, R. S. H. Biochemistry 1980, 19, 4589.
20. Knowles, W. S. Angew. Chem. Int. Ed. 2002, 41, 1998.
21. Noyori, R. Angew. Chem. Int. Ed. 2002, 41, 2008.
22. Sharpless, K. B. Angew. Chem., Int. Ed. 2002, 41, 2024.
23. Chauvin, Y. Angew. Chem., Int. Ed. 2006, 45, 3740.
24. (a) Schrock, R. R. Angew. Chem. Int. Ed. 2006, 45, 374. (b) Grubbs, R. H. Angew. Chem. Int. Ed. 2006, 45, 3760.
25. Schnelle, S. W. Curr. Top. Med. Chem., 2002, 2, 1087.
26. Velcicky, J.; Lanver, A.; Lex, J.; Prokop, A.; Wiederm T.; Schmalz, H.-G. Chem. Eur. J., 2004, 10, 5087.
27. Hatton, W.; Arosio, D.; Re, M.; Giudici, D.; Bernardi A.; Seneci, P. C. R. Chim., 2010, 13, 1284.
28. Mieczkowski A.; Agrofoglio, L. A. Modified Nucleosides: in Biochemistry, Biotechnology and Medicine, ed. Herdewijn, P. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008, 393.
29. Marques, A.-S.; Coeffard, V.; Chataigner, I.; Vincent, G. Moreau, X. Org. Lett., 2016, 18, 5296.
30. Poulsen, P. H.; Feu, K. S.; x Paz, K. S.; Jensen, F.; Jørgensen, K. A. Angew. Chem., Int. Ed., 2015, 54, 8203.
31. Tanaka, K.; Hagiwara, Y.; Hirano, M. Eur. J. Org. Chem., 2006, 3582.
32. Albrecht, Ł.; Dickmeiss, G.; Acosta, F. C.; Rodrı´guez-Escrich, C.; Davis R. L.; Jørgensen, K. A. J. Am. Chem. Soc., 2012, 134, 2543.
33. Dou, Q. Y.; Tu, Y. Q.; Zhang, Y.; Tian, J. M.; Zhang F. M.; Wang, S. H. Adv. Synth. Catal., 2016, 358, 874.
34. Li, P.-F.; Wang, H.-L.; Qu, J. J. Org. Chem., 2014, 79, 3955.
35. (a) Sugi, M.; Nagase, R.; Misaki, T.; Nakatsuji, H.; Tanabe, Y. Eur. J.Org. Chem., 2016, 4834; (b) Hu, Y.; Floss, H. G. J. Am. Chem. Soc., 2004, 126, 3837.
36. An, P.; Xu, N.-S.; Zhang, H.-L.; Cao, X.-P.; Shiand, Z.-F.; Wen, W. Chem. Asian J., 2015, 10, 1959.
37. Meisner, J. S.; Sedbrook, D. F.; Krikorian, M.; Chen, J.; Sattler, A.; Carnes, M. E.; Murray, C. B.; Steigerwald, M.; Nuckolls, C. Chem. Sci., 2012, 3, 1007.
38. Hearne, Z.; Li, C.-J. Chem. Commun., 2017, 53, 6136.
39. Vidhani, D. V.; Krafft, M. E.; Alabugin, I. V. Org. Lett., 2013, 15, 17.
40. Patel, B. A.; Kim, J.-I.; Bender, D. D.; Kao, L.-C.; Heck, R. F. J. Org. Chem., 1981, 46, 6.
41. (a) Tanaka, K.; Hagiwara, Y.; Hirano, M. Angew. Chem., Int. Ed. 2006, 45, 2734 (b) Hartung, J. Pure Appl. Chem. 2005, 77, 1559 (c) Tanaka, K.; Hagiwara, Y.; Noguchi, K. Angew. Chem. Int. Ed. 2005, 44, 7260.
42. (a) Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2003, 125, 30 (b) Tanaka, K.; Fu, G. C. Angew. Chem., Int. Ed. 2002, 41, 1607 (c) Csa´ky¨, A. G.; Contreras, C.; Mba, M.; Plumet, J. Synlett 2002, 1451.
43. (a) Hayashi, T.; Yamamoto, A.; Hagihara, T. J. Org. Chem. 1986, 51, 723 (b) Tanaka, K.; Fu, G. C. J. Am. Chem. Soc. 2003, 125, 8078 (c) Tanaka, K.; Fu, G. C. J. Am. Chem. Soc. 2002, 124, 10296 (d) de Parrodi, C. A.; Walsh, P. J. Angew. Chem., Int. Ed. 2009, 48, 4679
44. (a) Stork, G.; Niu, D.; Fujimoto, A.; Koft, E. R.; Balkovec, J. M.; Tata, J. R.; Dake, G. R. J. Am. Chem. Soc. 2001, 123, 3239 (b) Yan, J.; Herndon, J. W. J. Org. Chem. 1998, 63, 2325 (c) Honzawa, S.; Yamamoto, Y.; Yamashita, A.; Sugiura, T.; Kurihara, M.; Arai, M. A.; Kato, S.; Kittaka, A. Bioorg. Med. Chem. 2008, 16, 3002 (d) Dubon, P.; Schelwies, M.; Helmchen. G. Chem. Eur. J. 2008, 14, 6722 (e) Weaving, R.; Roulland, E.; Monneret, C.; Florent, J. Tetrahedron Lett. 2003, 44, 2579 (f) Tanaka, K.; Fu, G. C. J. Am. Chem. Soc. 2001, 123, 11492 (g) Collum, D. B.; McDonald, J. H.; Still, W. C., III. J. Am. Chem. Soc. 1980, 102, 2118 (h) Dai, P.; Trullinger, T. K.; Liu, X.; Dussault, P. H. J. Org. Chem. 2006, 71, 2283 (i) Nayek, A.; Banerjee, S.; Sinha, S.; Ghosh, S. Tetrahedron Lett. 2004, 45, 6457 (j) Chollet, A.; Diguarher, T. L.; Murray, L.; Bertrand, M.; Tucker, G. C.; Sabatini, M.; Pierre´, A.; Atassi, G.; Bonnet, J.; Casara, P. Bioorg. Med. Chem. 2001, 11, 295. (k) Crimmins, M. T.; She, J. J. Am. Chem. Soc. 2004, 126, 12790 (l) Tomooka, K.; Kikuchi, M.; Igawa, K.; Suzuki, M.; Keong, P.; Nakai, T. Angew. Chem., Int. Ed. 2000, 39, 4502 (m) Nicolaou, K. C.; Murphy, F.; Barluenga, S.; Oshima, T.; Wei, H.; Xu, J.; Gray, D. L. F.; Baudoin, O. J. Am. Chem. Soc. 2000, 122, 3830 (n) Nicolaou, K. C.; Li, Y.; Weyershausen, B.; Wei, H. Chem. Commun. 2000, 307 (o) Nakatani, K.; Okamoto, A.; Matsuno, T.; Saito, I. J. Am. Chem. Soc. 1998, 120, 11219 (p) Nicolaou, K. C.; Fylaktakidou, K. C.; Monenschein, H.; Li, Y.; Weyershausen, B.; Mitchell, H. J.; Wei, H.; Guntupalli, P.; Hepworth, D.; Sugita, K. J. Am. Chem. Soc. 2003, 125, 15433 (q) Smith, A. B.; Ott, G. R. J. Am. Chem. Soc. 1998, 120, 3935 (r) Nakatani, K.; Okamoto, A.; Saito, I. Angew. Chem., Int. Ed. 1997, 36, 2794 (s) Nicolaou, K. C.; Li, Y.; Fylaktakidou, K. C.; Mitchell, H. J.; Wei, H.; Weyershausen, B. Angew. Chem., Int. Ed. 2001, 40, 3849 (t) Myers, A. G.; Glatthar, R.; Hammond, M.; Harrington, P. M.; Kuo, E. Y.; Liang, J.; Schaus, S. E.; Wu, Y.; Xiang, J. J. Am. Chem. Soc. 2002, 124, 5380 (u) Stevens, R. V.; Beualieu, N.; Chan, W. H.; Daniewski, A. R.; Takeda, T.; Waldner, A.; Williard, P. G.; Zutter, U. J. Am. Chem. Soc. 1986, 108, 1039 (v) Mukai, C.; Kataoka, O.; Hanaoka, M. J. Org. Chem. 1995, 60, 5910 (w) Marshall, J. A.; Sehon, C. A. J. Org. Chem. 1997, 62, 4313 (x) Smith, A. B.; Wan, Z. J. Org. Chem. 2000, 65, 3738 (y) Chakraborty, T. K.; Thippeswamy, D.; Suresh, V. R.; Jayaprakash, S. Chem. Lett. 1997, 563 (z) Drouet, K. E.; Theodorakis, E. A. Chem. Eur. J. 2000, 6, 1987 (aa) Marshall, J. A.; Devender, E. A. V. J. Org. Chem. 2001, 66, 8037 (ab) Gopalarathnam, A.; Nelson, S. G. Org. Lett. 2006, 8, 7. (ac) Motozaki, T.; Sawamura, K.; Suzuki, A.; Yoshida, K.; Ueki, T.; Ohara, A.; Munakata, R.; Takao, K.; Tadanoi, K. Org. Lett. 2005, 7, 2261 (ad) Shao, J.; Panek, J. S. Org. Lett. 2004, 6, 3083. (ae) Miyakoshi, N.; Mukai, C. Org. Lett. 2003, 5, 2335 (af) Shimizu, K.; Takimoto, M.; Mori, M. Org. Lett. 2003, 5, 2323 (ag) Reddy, Y. K.; Falck, J. R. Org. Lett. 2002, 4, 969 (ah) Miyakoshi, N.; Aburano, D.; Mukai, C. J. Org. Chem. 2005, 70, 6045 (ai) Organ, G. M.; Wang, J. J. Org. Chem. 2002, 67, 7847.
45. Fawcett, C. H.; Spencer, D. M.; Wain, R. L.; Fallis, A. G.; Jones, S. E. R. H.; LeQuan, M.; Page, C. B.; Thaller, V.; Shubrook, D. C.; Whitham, P. M. J. Chem. Soc. C, 1968, 2466.
46. Guo, D.; Chen, T.; Ye, D.; Xu, J.; Jiang, H.; Chen, K.; Wang, H.; Liu, H. Org. Lett. 2011, 13, 2884.
47. Komatsu, K.; Urano, Y.; Kojima, H.; Nagano, T. J. Am. Chem. Soc. 2007, 129, 13447.
48. Murugavel, G.; Punniyamurthy, T. Org. Lett., 2013, 15, 15.
49. Chatani, N.; Morimoto, T.; Fukumoto, Y.; Murai, S. J. Am. Chem. Soc. 1998, 120, 5335.
50. Xie, Y.; Wang, J. Chem. Commun. 2018, 54, 4597.
51. Fontana, A.; d’Ippolito, G.; D’Souza, L.; Mollo, E.; Parameswaram P. S.; Cimino, G. J. Nat. Prod., 2001, 64, 131.
52. Rudi, A.; Schleyer, M.; Kashman, Y. J. Nat.Prod., 2000, 63, 1434.
53. Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science, 1992, 256, 1172.
54. Nicolaou, K. C.; Dai, W. M. Angew. Chem., Int. Ed. Engl., 1991, 30, 1387.
55. Goldberg, I. H. Acc. Chem. Res., 1991, 24, 191.
56. Schaus, S. E.; Cavalieriand, D.; Myers, A. G. Proc. Natl. Acad. Sci. U. S. A., 2001, 98, 11075.
57. Kim, H.; Lee, H.; Lee, D.; Kim, S.; Kim, D. J. Am. Chem. Soc., 2007, 129, 2269.
58. Saito, S.; Yamamoto, Y. Chem. Rev., 2000, 100, 2901.
59. Wessig, P.; Mu¨ller, G. Chem. Rev., 2008, 108, 2051.
60. Campbell, K.; Kuehl, C. J.; Ferguson, M. J.; Stang, P. J.; Tykwinski, R. R. J. Am. Chem. Soc., 2002, 124, 7266.
61. Pell, C. J.; Ozerov, C. J. ACS Catal., 2014, 4, 3470.
62. Xu, H.-D.; Zhang, R.-W.; Li, X.; Huang, S.; Tang, W.; Hu, W.-H. Org. Lett., 2013, 15, 840.
63. Garcia-Garrido, S. E. in Modern Alkyne Chemistry, ed. Trost, B. M.; Li, C. -J. Wiley, Weinheim, 2015, 301.
64. Fontana, A.; d’Ippolito, G.; D’Souza, L.; Mollo, E.; Parameswaram, P. S.; Cimino, G.; J. Nat. Prod. 2001, 64, 131.
65. Kobayashi, S.; Hori, M.; Xing, P. S.; Hirama, W.; Hirama, M. J. Org. Chem. 2006, 2, 636.
66. Kim, H.; Lee, H.; Lee, D.; Kim, S.; Kim, D. J. Am. Chem. Soc. 2007, 129, 2269.
67. Katagiri, T.; Tsurugi, H.; Satoh, T.; Miura, M. Chem. Commun., 2008, 3405.
68. Saito, S.; Yamamoto, Y. Chem. Rev. 2000, 100, 2901.
69. Wang, L.; Maddess, M. L.; Lautens, M. J. Org. Chem. 2007, 72, 1822.
70. Pell, C. J.; Ozerov, O. V. ACS Catal., 2014, 4, 3470.
71. Xu, H.-D.; Zhang, R.-W.; Li, X.; Huang, S.; Tang, W.; Hu, W.-H. Org. Lett., 2013, 15, 840.
72. Garcia-Garrido, S. E. in Modern Alkyne Chemistry, ed. Trost, B. M.; Li, C.-J. Wiley, Weinheim, 2015, 301.
73. Trost, B. M.; Masters, J. T. Chem. Soc. Rev., 2016, 45, 2212.
74. Wakatsuki, Y.; Yamazaki, H.; Kumegawa, N.; Satoh, T.; Satoh, J. Y. J. Am. Chem. Soc., 1991, 113, 9604.
75. Wakatsuki, Y.; Koga, N.; Yamazaki, H.; Morokuma, K. J. Am. Chem. Soc., 1994, 116, 8105 .
76. Trost, B. M.; Sorum, M. T.; Chan, C.; Ru¨hter, C. J. Am. Chem. Soc., 1997, 119, 698.
77. Lee, C.-C.; Lin, Y.-C.; Liu, Y.-H.; Wang, Y. Organometallics, 2005, 24, 136.
78. Yi, C. S.; Liu, N. Organometallics, 1996, 15, 3968.
79. Bianchini, C.; Frediani, P.; Masi, D.; Peruzzini, M.; Zanobini, F. Organometallics, 1994, 13, 4616.
80. Kovalev, I. P.; Yevdakov, K. V.; Strelenko, Y. A.; Vinogradov, M. G.; Nikishin, G. I. J. Organomet. Chem., 1990, 386, 139.
81. Asao, N.; Aikawa, H.; Yamamoto, Y. J. Am. Chem. Soc. 2004, 126, 7458.
82. Knight, D. W.; Nott, A. P. J. Chem. Soc., Perkin Trans. 1, 1982, 0, 623.
83. Liang, R.; Jiang, H.; Zhu, S. Chem. Commun., 2015, 51, 5530.
84. Shimizu, K.; Takimoto, M.; Sato, M.; Mori, M. J. Org. met. Chem. 2006, 691, 5466.
85. Aldegunde, M. J.; Garcia-Fandino, R.; Castedo, L.; Granja, J. R. Chem. Eur. J. 2007, 13, 513.
86. Olivo, H. F.; Vela´zquez, F.; Trevisan, H. Org. Lett., 2000, 2, 4055.
87. Pérez-Estrada, S.; Sayar, N.; Granja, J. R. Org. Chem. Front., 2016, 3, 1331.
88. Hitt, D. M.; O’Connor, J. M. Chem. Rev. 2011, 111, 7904.
89. Matsuyama, N.; Tsurugi, H. Satoh, T.; Miura, M. Adv. Synth. Catal. 2008, 350, 2274.
90. Trost, B. M.; Sorum, M. T.; Chan, C.; Harms, A. E.; Ruhter, G. J. Am. Chem. Soc. 1997, 119, 698.
91. Straub, T.; Haskel, A.; Eisen, M. S. J. Am. Chem. Soc. 1995, 117, 6364.
92. Wu, Y. T.; Lin, W.; Liu, C.; Wu, C. Adv. Synth. Catal. 2008, 350, 1841.
93. Rubio-Perez, L.; Azpiroz, R.; Di Giuseppe, A.; Polo, V.; Castarlenas, R.; Perez-Torrente, J. J.; Oro, L. A. Chem. Eur. J. 2013, 19, 15304.
94. Zhdankin, V. V. Hypervalent Iodine Chemistry: Preparation, Structure, and Synthetic Applications of Polyvalent Iodine Compounds, Wiley, Chichester, UK, 2013.
95. Tremblay, J. -F. Chem. Eng. News 2011, 49, 22.
96. Banerjee, A. K.; Vera, W.; Mora, H.; Laya, M. S.; Bedoya, L.; Cabrera, E. V. J. Sci. Ind. Res. India, 2006, 65, 299.
97. Togo, H.; Iida, S. Synlett 2006, 2159.
98. Das, S.; Borah, R.; Devi, R. R.; Thakur, A. J. Synlett 2008, 2741.
99. Jereb, M.; Vrazic, D.; Zupan, M. Tetrahedron 2011, 67, 1355.
100. Parvatkar, P. T.; Parameswaran, P. S.; Tilve, S. G. Chem. Eur. J. 2012, 18, 5460.
101. (a) Ren, Y.-M.; Cai, C.; Yang, R.-C. RSC Adv. 2013, 3, 7182 (b) Finkbeiner, P.; Nachtsheim, B. J. Synthesis 2013, 45, 979.
102. Hibbert, H. J. Am. Chem. Soc.1915, 37, 1748.
103. Metrangolo, P.; Resnati, G., Halogen Bonding I, Springer, 2015.
104. Metrangolo, P.; Resnati, G. Halogen Bonding II, Springer, 2015.
105. Cavallo, G.; Metrangolo, P.; Milani, R.; Pilati, T.; Priimagi, A.; Resnati, G.; Terraneo, G. 2016, 116, 2478.
106. Bulfield, D.; Huber, S. M. Chem. Eur. J. 2016, 22, 14434.
107. Walter, S. M.; Kniep, F.; Herdtweck, E.; Huber, S. M. Angew. Chem., Int. Ed. 2011, 50, 7187.
108. Kniep, F.; Jungbauer, S. H.; Zhang, Q.; Walter, S. M.; Schindler, S.; Schnapperelle, I.; Herdtweck, E.; Huber, S. M. Angew. Chem., Int. Ed. 2013, 52, 7028.
109. Jungbauer, S. H.; Walter, S. M.; Schindler, S.; Rout, L.; Kniep, F.; Huber, S. M. Chem. Commun. 2014, 50, 6281.
110. Takeda, Y.; Hisakuni, D.; Lin, C.-H.; Minakata, S. Org. Lett. 2015, 17, 318.
111. Tian, J.-S.; K.W.J. Ng, J.-R. Wong, T.-P. Loh, Angew. Chem., Int. Ed. 2012, 51, 9105.
112. Yang, D.; Sun, P.; Wei, W.; Meng, L.; He, L.; Fang, B.; Jiang, W.; Wang, H. Org. Chem. Front., 2016, 3, 1457.
113. Dhineshkumar, J.; Lamani, M.; Alagiri, K.; Prabhu, K. R. Org. Lett. 2013, 15, 1092.

Part-2
1 Trost, B. M.; Masters, J. T. Chem. Soc. Rev., 2016, 45, 2212
2 Gholami, M.; Tykwinski, R. R. Chem. Rev. 2006, 106, 4997
3 Faulkner, D. J. Nat. Prod. Rep. 2001, 18, 1.
4 Pell C. J.; Ozerov, O. V. ACS Catal., 2014, 4, 3470
5 Xu, H.-D.; Zhang, R.-W.; Li, X.; Huang, S.; Tang, W.; Hu, W.-H. Org. Lett., 2013, 15, 840
6 Garcia-Garrido, S. E. in Modern Alkyne Chemistry, ed. B.M. Trost and C. -J. Li, Wiley, Weinheim, 2015, 301
7 Haskel, A.; Wang, J. Q.; Straub, T.; Neyroud, T. G.; Eisen, M. S. J. Am. Chem. Soc. 1999, 121, 3025 (8) Ritleng, V.; Sirlin, C.; Pfeffer, M. Chem. Rev. 2002, 102, 1731
8 Katayama, H.; Ozawa, F. Coord. Chem. Rev. 2004, 248, 1703
9 Nishiura, M.; Hou, Z. J. Mol. Catal. A 2004, 213, 101
10 Bustelo, E.; Dixneuf, P. H. in Handbook of C-H Transformations, Vol. 1 (Ed: G. Dyker), Wiley-VCH, Weinheim, 2005, Chap. II.
11 (a) Wakatsuki, Y.; Yamazaki, H.; Kumegawa, N.; Satoh, T.; Satoh, J. Y. J. Am. Chem. Soc., 1991, 113, 9604; (b) Wakatsuki, Y.; Koga, N.; Yamazaki H.; Morokuma, K. J. Am. Chem. Soc., 1994, 116, 8105; (c) Trost, B. M.; Sorum, M. T.; Chan C.; Ru¨hter, G. J. Am. Chem. Soc., 1997, 119, 698; (d) Lee, C.-C.; Lin, Y.-C.; Liu Y.-H.; Wang, Y. Organometallics, 2005, 24, 136; (e) Yi, C. S.; Liu, N. Organometallics, 1996, 15, 3968; (f) Bianchini, C.; Frediani, P.; Masi, D.; Peruzzini, M.; Zanobini, F. Organometallics, 1994, 13, 4616; (g) Kovalev, I.P.; Yevdakov, K.V.; Strelenko, Y. A.; Vinogradov M. G. ; Nikishin, G. I. J. Organomet. Chem., 1990, 386, 139.
12 Wakatsuki, H. Y.; Yamazaki, Y.; Kumegawa, N.; Satoh T.; Satoh, J. Y. J. Am. Chem. Soc.,
1991, 113, 9604.
13 Wakatsuki, Y.; Koga, N.; Yamazaki, H.; Morokuma, K. J. Am. Chem. Soc., 1994, 116, 8105.
14 Trost, B. M.; Sorum, M. T.; Chan C.; Ruhter, G. J. Am. Chem. Soc., 1997, 119, 698.
15 Lee, C.-C.; Lin, Y.-C.; Liu, Y.-H.; Wang, Y. Organometallics, 2005, 24, 136.
16 Yi, C. S.; Liu, N. Organometallics, 1996, 15, 3968.
17 Bianchini, C.; Frediani, P. Masi, D.; Peruzzini, M.; Zanobini, F. Organometallics, 1994, 13, 4616.
18 Kovalev, I. P.; Yevdakov, K. V.; Strelenko, Y. A.; Vinogradov, M. G.; Nikishin, G. I. J. Organomet Chem., 1990, 386, 139.
19 Liu, Z.; Schmidt, I.; Thamyongkit, P.; Loewe, R. S.; Syomin, D.; Diers, J. R.; Zhao, Q.; Misra, V.; Lindsey, J. S.; Bocian, D. F. Chem. Mater. 2005, 17, 3728.
20 Gholami, M.; Tykwinski, R. R. Chem. Rev. 2006, 106, 4997.
21 Dörfler, M.; Tschammer, N.; Hamperl, K.; Hübner, H.; Gmeiner, P. J. Med. Chem. 2008, 51, 6829.
22 Jones, T. H.; Adams, R. M. M.; Spande, T. F.; Garrafo, H. M.; Kaneko, T.; Schultz, T. R. J.
Nat. Prod. 2012, 75, 1930.
23 Matsuyama, N.; Tsurugi, H.; Satoh, T.; Miura, M. Adv. Synth. Catal. 2008, 350, 2274.
24 Ogata, K.; Murayama, H.; Sugasawa, J.; Suzuki, N.; Fukuzawa, S.-i. J. Am. Chem.
Soc. 2009, 131, 3176
25 Ogata, K.; Sugasawa, J.; Atsuumi, Y.; Fukuzawa, S. I. Org. Lett. 2010, 12, 14.
26 Ogata, K.; Atsuumi, Y.; Fukuzawa, S.-i. Org. Lett. 2011, 13, 122.
27 Trost, B. M.; Sorum, M. T.; Chan, C.; Harms, A. E.; Ruhter, G. J. Am. Chem. Soc. 1997, 119, 698.
28 Krause, J.; Cestaric, G.; Haack. K.-J.; Seevogel, K.; Storm, W.; Porschke, K.-R. J. Am. Chem. Soc. 1999, 121, 980.
29 Haskel, A.; Straub, T.; Dash, A. K.; Eisen, M. S. J. Am. Chem. Soc. 1999, 121, 3014.
30 Straub, T.; Haske, A.; Eisen, M. S. J. Am. Chem. Soc. 1995, 117, 6364.
31 Dash, A. K.; Gourevich, I.; Wang, J. Q.; Wang, J.; Kapon, M.; Eisen, M. S. Organometallics 2001, 20, 5084.
32 Wu, Y. -T.; Lin, W.-C.; Liu, C.-J.; Wu, C.-Y. Adv. Synth. Catal. 2008, 350, 1841.
33 Rubio-Pérez, L.; Azpíroz, R.; Giuseppe, A. D.; Polo, V.; Castarlenas, R.; Pérez-Torrente, J. J.; Oro, L. A. Chem. Eur. J. 2013, 19, 15304.
34 Azpíroz, R.; Rubio-Pérez, L.; Castarlenas, R.; Pérez-Torrente, J. J.; Oro, L. A. Chem Cat Chem 2014, 6, 2587.
35 Uruvakili, A.; Gangadhararao, G.; Kumara Swamy, K. C. Org. Biomol. Chem., 2015, 13, 10060.
36 Huang, C.-Y.; Kavala, V.; Kuo, C.-W.; Konala, A.; Yang, T.-H.; Yao, C.-F. J. Org. Chem., 2017, 82, 1961.
37 Ichake, S. S.; Konala, A.; Kavala, V.; Kuo, C.-W.; Yao, C.-F. Org. let., 2017, 19, 54.
38 Yang, T.-H.; Kuo, C.-W.; Kavala, V.; Konala, A.; Huang C.-Y.; Yao, C.-F. Chem. Commun., 2017, 53, 1676.
39 Konala, A.; Kuo, C.-W.; Lin, L.; Chiang, T.-T.; Huang, C.-Y.; Yang, T.-H.; Kavala V.; Yao, C.-F. Chem. Commun., 2016, 52, 7870.
40 Kavala, V.; Wang, C.-C.; Wang, Y.-H.; Kuo, C.-W.; Janreddy, D.; Huang, W.-C.; Kuo, T.-S.; He, C. H.; Chen, M.-L.; Yao, C.-F. Adv. Synth. Catal. 2014, 356, 2609.
41 See ESI† for further details. 4a (CCDC no. 1557911), 6a (CCDC no. 1556913). 6’a (CCDC no. 1556912), 8 (CCDC no. 1556914), 10a (CCDC no. 1557912); Yang, W.; Ruan, Z.; Wang, Y.; Kirk, K. V.; Ma, Z.; Arey, B. J.; Cooper, C. B.; Seethala, R.; Feyen, J. H. M.; Dickson Jr, J. K. J. Med.Chem., 2009, 52, 1204.
42 Basnet, A.; Thapa, P.; Karki, R.; Na, Y.; Jahng, Y.; Jeong, B.-S.; Jeong, T. C.; Lee, C.-S.; Lee, E.-S. Bioorg. Med. Chem., 2007, 15, 435.
43 Huang, H.; Cai, J.; Tang, L.; Wang, Z.; Li, F.; Deng, G.-J. J. Org. Chem., 2016, 81, 1499.
44 Gomha S. M.; Dawood, K. K.; J. Heterocycl. Chem., 2017, 54, 1943.

Part-3
1. Bian, M.; Li, L.; Ding, H. Synthesis 2017, 49, 4383.
2. Li, L.; Aibibula, P.; Jia, Q.; Jia, Y. Org. Lett. 2017, 19, 2642.
3. Reddy, B. V. S.; Someswarao, B.; Prudhviraju, N.; Reddy, B. J. M.; Sridhar, B.; Kumar, S. K. Org. Biomol. Chem. 2015, 13, 6737-6741.
4. Xi, Z.; Zhang, W.-X. Synlett 2008, 2557.
5. Zou, Y.; Daane, K. M.; Bentley W. J.; Millar, J. G. J. Agr. Food Chem. 2010, 58, 4977.
6. Meinwald J.; Jones, T. H. J. Am. Chem. Soc. 1978, 100, 1883.
7. Chandra, G.; Moon, Y. W.; Lee, Y.; Jang, J. Y.; Song, J.; Nayak, A.; Oh, K.; Varughese. A.; Mulamoottil, P.; Sahu, K.; Kim, G.; Chang, T-S.; Noh, M.; Lee, S. K.; Choi, S.; Jeong, L. S. J. Med. Chem. 2015, 58, 5108.
8. Baker, J. R.; Thominet, O.; Britton, H.; Caddick, S. Org. Lett. 2007, 9, 45-48.
9. Hervey, P. S.; Perry, L. M. Drugs 2000, 60, 447.
10. Wei, Y.; Shi, M. Org. Chem. Front. 2017, 4, 1876-1890.
11. Wang, Z.; Xu, X.; Kwon, O. Chem. Soc. Rev. 2014, 43, 2927.
12. Ivanova, O. A.; Chagarovskiy, A. O.; Shumsky, A. N.; Krasnobrov, V. D.; Levina, I. I.; Trushkov, I. V. J. Org. Chem. 2018, 83, 543.
13. Liu, Q.-S.; Wang, D.-Y.; Yang, Z.-J.; Luan, Y.-X.; Yang, J.-F.; Li, J.-F.; Pu, Y.-G.; Ye. M. J. Am. Chem. Soc. 2017, 139, 18150.
14. Sasaki, M.; Kondo, Y.; Nishio, T. Org. Lett. 2016, 18, 3858-3861.
15. Hong, B.-C.; Dange, N. S.; Hsu, C.-S.; Liao, J.-H. Org. Lett. 2010, 12, 4812.
16. Halimehjani, A. Z.; Namboothiri, I. N. N.; Hooshmand, S. E. RSCAdv. 2014, 4, 31261.
17. Nair, V.; Vellalath, S.; Poonoth, M.; Suresh, E. J. Am. Chem.Soc. 2006, 128, 8736−8737.
18. Chiang, P. C.; Kaeobamrung, J.; Bode, J. W. J. Am. Chem. Soc. 2007, 129, 3520.
19. Chiang, P.-C.; Rommel, M.; Bode, J. W. J. Am. Chem. Soc. 2009, 131, 8714−8718.
20. Zhao, G.-L.; Ullah, F.; Deiana, L.; Lin, S.; Zhang, Q.; Sun, J.; Ibrahem, I.; Dziedzic, P.; Cordova, A. Chem. - Eur. J. 2010, 16, 1585.
21. Vinogradov, M. G.; Turova, O. V.; Zlotin, S. G. Org. Biomol. Chem. 2017, 15, 8245.
22. Wenz, D. R.; Read de Alaniz, J. Eur. J. Org. Chem. 2015, 23−37.
23. Riveira, M. J.; Marsili, L. A.; Mischne, M. P. 2017, 15, 9255.
24. Zhong, M.-J.; Wang, X.-C.; Zhu, H.-T.; Hu, J.; Liu, L.; Liu, X. Y.; Liang, Y. -M. J. Org. Chem. 2012, 77, 10955.
25. Marques, A.-S.; Coeffard, V.; Chataigner, I.; Vincent, G.; Moreau, X. Org. Lett. 2016, 18, 5296.
26. Lin, C.-C.; Teng, T.-M.; Odedra, A.; Liu, R.-S. J. Am. Chem. Soc. 2007, 129, 3798.
27. Lin, C.-C.; Teng, T.-M.; Tsai, C.-C.; Liao, H.-Y.; Liu, R.-S. J. Am. Chem. Soc. 2008, 130, 16417.
28. William, R.; Leng, W. L.; Wang, S.; Liu, X.-W. Chem. Sci. 2016, 7, 1100.
29. William, R.; Wang, S.; Ding, F.; Arviana, E. N.; Liu, X.-W. Angew. Chem., Int. Ed. 2014, 53, 10742.
30. Bandi, V.; Kavala, V.; Hsu, C.-H.; Konala, A.; Villuri, B. K.; Kotipalli, T.; Kuo, C.-W.; Yao, C.-F. RSC Adv. 2017, 7, 46704.
31. Vivekanand, T.; Satpathi, B.; Bankar, S. K.; Ramasastry, S. S. V. RSC Adv. 2018, 8, 18576.
32. Satpathi, B.; Mondal, A.; Ramasastry, S. S. V. Chem.-Asian J. 2018, 13, 1642.
33. Bankar, S. K.; Singh, B.; Tung, P.; Ramasastry, S. S. V. Angew. Chem., Int. Ed. 2018, 57, 1678
34. Ye, J.-H.; Zhu, L.; Yan, S.-S.; Miao, M.; Zhang, X.-C.; Zhou, W.-J.; Li, J.; Lan, Y.; Yu, D.-G. ACS Catal. 2017, 7, 8324.
35. Gawande, S. D.; Kavala, V.; Zanwar, M. R.; Kuo, C. W.; Huang, H.-N.; He, C.-H.; Kuo, T.-S.; Yao, C.-F. Adv. Synth. Catal. 2013, 355, 3022.
36. Dalpozzo, R. Chem. Soc. Rev. 2015, 44, 742.
37. Dhineshkumar, J.; Lamani, M.; Alagiri, K.; Prabhu, K. R. A. Org.Lett. 2013, 15, 1092.
38. Vonder Heiden, D.; Bozkus, S.; Klussmann, M.; Breugst, M. J. Org.Chem. 2017, 82, 4037.
39. Breugst, M.; Detmar, E.; Vonder Heiden, D. ACS Catal. 2016, 6, 3203.

Part-4
1. Riveira, M. J.; Quiroga, G. N.; Mata, E. J.; Gandon, V.; Mischne, M. P. J. Org. Chem. 2015, 80, 6515.
2. Vinogradov, M. G.; Turova, O. V.; Zlotin, S. G. Org. Biomol. Chem., 2017, 15, 8245.
3. Riveira, M. J.; Marsili, L. A.; Mischne M. P. Org. Biomol. Chem., 2017, 1, 9255.
4. Bee, C.; Leclerc, E.; Tius, M. A. Org. Lett. 2003, 5, 4927.
5. Lin, C.-C.; Teng, T.-M.; Tsai, C.-C.; Liao, H.-Y.; Liu, R.-S. J. Am. Chem. Soc. 2008, 130, 16417.
6. Sudhakar, G.; Mahesh, S. K.; Vemulapalli, S. P. B.; Nanubolu, J. Org. Lett. 2017, 19, 4500.
7. Riveira M. J. ; Mischne, M. P. J. Org. Chem. 2014, 79, 8244.
8. Faza, O. N.; Lopez, C. S.; Alvarez, R. A.; de Lera, A. R. Chem. Eur. J. 2009, 15, 1944.
9. Denmark, S. E.; Hite, G. A. Helv. Chim. Acta, 1988, 71, 195.
10. Miller, A. K.; Banghart, M. R.; Beaudry, C. M.; Suh, J. M.; Trauner, D. Tetrahedron, 2003, 59, 8919.
11. Riveira, M. J.; Mischne, M. P. Synth. Commun., 2013, 43, 208. Mandal, S.; Parida, K. N.; Samanta, S.; Moorthy, J. N. J. Org. Chem., 2011, 76, 7406.
12. Buback, J.; Kullmann, M.; Langhojer, F.; Nuernberger, P.; Schmidt, R.; Würthner, F.; Brixner, T. J. Am. Chem. Soc., 2010, 132, 16510.
13. Huang, C.-N.; Kuo, P.-Y.; Lin, C.-H.; Yang, D.-Y. Tetrahedron, 2007, 63, 10025.
14. Krasnaya, Z. A. Chem. Heterocycl. Compd., 1999, 35, 1255.
15. Marcus, A. P.; Lee, A. S.; Davis, R. L.; Tantillo, D. J.; Sarpong, R. Angew. Chem., Int. Ed., 2008, 47, 6379.
16. Tietze, L. F. Domino Reactions: Concepts for EfficientOrganicSynthesis, Wiley-VCH, Weinheim, Germany, 2014.
17. Pellissier, H. Chem. Rev., 2013, 11, 442.
18. Padwa A.; Bur, S. K. Tetrahedron, 2007, 63, 5341.
19. Tietze L. F.; Brasche, G.; Gericke, K. M. Domino Reactions in Organic Synthesis, Wiley-VCH, Weinheim, Germany, 2006.
20. Nicolaou, K. C.; Edmonds, D. J.; Bulger, P. G. Angew. Chem., Int. Ed., 2006, 45, 713.
21. Tietze, L. F. Chem. Rev., 1996, 96, 115.
22. Waldmann, H. Organic Synthesis HighlightsII, ed. H. Waldmann, VCH, Weinheim, Germany, 1995.
23. Lin, C.-C.; Teng, T.-M.; Odedra A.; Liu, R.-S. J. Am.Chem. Soc., 2007, 129, 3798.
24. Lin, C.-C.; Teng, T.-M.; Tsai, C.-C.; Liao, H.-Y.; Liu, R.-S. J. Am. Chem. Soc., 2008, 130, 16417.
25. Brooks, J. L.; Caruana P. A.; Frontier, A. J. J. Am. Chem.Soc., 2011, 133, 12454.
26. Brooks, J. L.; Frontier, A. J. J. Am. Chem. Soc., 2012, 134, 16551.
27. Brooks, J. L.; Huang, Y.-W. Frontier, A. J. Org. Synth., 2014, 91, 93.
28. Marques, A.-S.; Coeffard, V.; Chataigner, I.; Vincent, G.; Moreau, X. Org. Lett., 2016, 18, 5296.
29. Rieder, C. J.; Winberg K. J.; West, F. G. J. Am. Chem.Soc., 2009, 131, 7504.
30. Piancatelli, G.; Scettri, A.; Barbadoro, S. Tetrahedron Lett., 1976, 17, 3555
31. Planas, L. J.; Viret, P.; Royer, J. J. Org. Chem., 2004, 69, 3087.
32. Li, W.-D. Z.; Duo W.-G.; Zhuang, C.-H. Org. Lett., 2011, 13, 3538.