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研究生: 詹士賢
CHAN, Shih-Hsien
論文名稱: 有機不對稱催化合成異噁唑啶之衍生物
Enantioselective synthesis of the isoxazolidine derivatives
指導教授: 陳焜銘
Chen, Kwun-Min
學位類別: 碩士
Master
系所名稱: 化學系
Department of Chemistry
論文出版年: 2020
畢業學年度: 108
語文別: 中文
論文頁數: 101
中文關鍵詞: 有機不對稱催化異噁唑啶掌性磷酸催化劑布忍斯特酸相對離子對
英文關鍵詞: Organic asymmetric catalysis, isoxazolidine, chiral phosphoric acid catalyst, Brønsted acid, counterion pair
DOI URL: http://doi.org/10.6345/NTNU202001141
論文種類: 學術論文
相關次數: 點閱:131下載:0
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  • 第一章 緒論 1 1-1 前言 1 1-2 有機不對稱合成方式 3 1-2-1 對掌輔助劑(chiral auxiliary) 3 1-2-2 對掌試劑(chiral reagent) 4 1-2-3 對掌催化劑(chiral catalyst) 6 1-3 有機催化分類 7 1-3-1 共價催化-烯胺與亞銨離子 8 1-3-2 非共價催化-氫鍵催化 11 1-3-3 自由基催化-SOMO催化 15 1-3-4 相對離子催化—磷酸催化 17 1-4利用掌性磷酸催化合成異噁唑啶衍生物研究動機 21 第二章 實驗結果與討論 23 2-1 篩選親核劑(nucleophile) 23 2-2 優化反應條件以及取代基效應 25 2-3 掌性反應條件及取代基效應探討 30 2-4 反應條件機制之探討 35 2-5 結論 36 第三章 實驗流程與數據 37 3-1 分析儀器及基本實驗 37 3-2實驗步驟 39 3-2-1 吡咯類四級碳之異噁唑啶衍生物之基本反應操作步驟 39 3-3光譜數據 40 參考資料 53 附錄一 1H及13C-NMR光譜圖 58 附錄二 X-ray 單晶繞射結 構解析與數據 85

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    49 鄭祐松,,2019年,博士論文,不對稱有機催化之手性藥物合成

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