研究生: |
王翠芬 |
---|---|
論文名稱: |
素食停經婦女體內Isoflavones與DHA狀態之探討 |
指導教授: |
吳文惠
Wu, Wen-Huey 呂紹俊 Lu, Shao-Chun |
學位類別: |
碩士 Master |
系所名稱: |
人類發展與家庭學系 Department of Human Development and Family Studies |
論文出版年: | 2002 |
畢業學年度: | 90 |
語文別: | 中文 |
中文關鍵詞: | 素食者 、停經婦女 、異黃酮 、DHA 、心臟血管疾病 、2OHE1 、16αOHE1 |
論文種類: | 學術論文 |
相關次數: | 點閱:262 下載:14 |
分享至: |
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為探討素食者體內異黃酮與DHA狀態及對健康之影響,在台北地區招募身體健康、無高血脂且無使用荷爾蒙之葷食停經婦女26位,與素食停經婦女39位,進行實驗一:比較葷食與素食停經婦女血漿異黃酮狀態(daidzein 與 genistein)及尿液雌激素代謝物(2-hydroxyestrone,2OHE1 ; 16α-hydroxyestrone,16αOHE1) 排出,及兩者之相關性,結果顯示素食者血漿中daidzein 與 genistein皆明顯比葷食者高,反應了素食者黃豆製品攝取量確實高於葷食者。素食者尿液中2OHE1/creatinine以及2OHE1/16αOHE1 比值皆明顯較葷食者高,而血漿中daidzein含量與尿液中2OHE1/16αOHE1 比值有顯著正相關(R=0.53, p=0.004),與16αOHE1/creatinine有負相關,但未達統計上的顯著意義(R=-0.318,p=0.108),因此推論素食停經婦女雌激素代謝途徑傾向較低致癌性,且可能是受到飲食中高異黃酮攝取的影響。
實驗二以素食停經婦女為對象,評估補充DHA後,對其心臟血管疾病危險因子之影響,首先依據素食停經婦女血中三酸甘油酯與膽固醇含量分為正常血脂者(<200 mg/dl)與血脂偏高者(≧200 mg/dl),所有素食者每日服用6 ml安慰劑(corn oil),經過2週適應期(run-in)後,,正常血脂者一半補充corn oil (6 ml/d)為placebo (normal)組(n=12),另一半補充來自藻類的DHA oil (6 ml/d,2.1 g DHA)為DHA (normal)組(n=12),血脂偏高者皆補充DHA oil (6 ml/d,2.1 g DHA)為DHA (hyperlipidemic)組(n=9)。於六週實驗期前後收集共兩次血液與尿液樣本。結果顯示補充DHA 後,DHA (normal)組LDL氧化1小時、2小時與3小時之TBARS產生量增加,且血漿中α-tocopherol含量明顯下降,而DHA (hyperlipidemic)組尿液中nitric oxide濃度高於補充前。DHA補充後normal組與hyperlipidemic組LDL中DHA含量明顯增加,placebo組則不變。血漿中總抗氧化狀態、lipoprotein(a)、以及尿液中F2α-isoprostane 含量不受DHA補充影響。整體來看,素食停經婦女補充DHA會使體外LDL氧化增加但對體內氧化壓力無明顯改變,對於血脂質則無明顯好處,唯可增加血脂偏高的素食停經婦女nitric oxide生成,因此,本研究僅發現補充DHA對於素食停經婦女的心臟血管疾病危險因子的微小影響。
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162.張瀝分。魚油對有或無投荷爾蒙補充治療之停經婦女血脂與脂蛋白之影響。1999師大家政教育所碩士論文。