研究生: |
黃香萍 Hsing-Ping Huang |
---|---|
論文名稱: |
以動物模式探討運動對人類乳癌作用之影響 Effect of exercise on tumor progression - in vitro and in vivo breast cancer model |
指導教授: |
王鶴森
Wang, Ho-Seng 張嘉銘 Chang, Jia-Ming |
學位類別: |
博士 Doctor |
系所名稱: |
體育學系 Department of Physical Education |
論文出版年: | 2014 |
畢業學年度: | 102 |
語文別: | 中文 |
論文頁數: | 111 |
中文關鍵詞: | 癌症 、血管新生 、細胞激素 、乳酸 |
英文關鍵詞: | cancer, angiogenesis growth factor, cytokines, lactate |
論文種類: | 學術論文 |
相關次數: | 點閱:311 下載:0 |
分享至: |
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
雖然流行病學及臨床病學研究皆指出運動可減少罹患某些特定癌症的風險,但運動對癌細胞分子層次的影響及能量代謝的過程仍不清楚。本研究目的首先以細胞模式探討不同濃度之乳酸對人類乳癌細胞MDA-MB-231的影響。不同乳酸濃度加入乳癌細胞中培養,觀察細胞內MCT1、MCT4、CD147及HIF-1α之變化,結果顯示乳酸會造成MCT1、MCT4及HIF-1α蛋白表現下降之趨勢。由此推論乳酸可改變乳癌細胞MCT1、MCT4及HIF-1α之蛋白表現。接下來,以動物模式探討運動對於人類乳癌腫瘤之作用。給予荷腫瘤動物進行中及高強度之跑步機運動,速度設定分別為16 m/min及20 m/min,每次30分鐘,連續28天。結果顯示運動會有抑制腫瘤生長之趨勢,分析來自人類腫瘤分泌之血清血管相關的生長因子17項指標及血清中來自老鼠來源的細胞激素32項指標中,分別有2項和血管新生作用相關之指標及9項血清細胞激素指標之反應和運動強度之作用具相關性,包括抑制腫瘤分泌G-CSF及follistatin之濃度,以及減少血清IL-7、IL-9、IL-12 (p40)、IL-12 (p70)、IL-13、GM-CSF及M-CSF指標之濃度。同時分析腫瘤內MCT1、MCT4、CD147及HIF-1α之蛋白表現,MCT1、MCT4及HIF-1α蛋白表現有下降之趨勢。本研究結論為運動介入可抑制人類腫瘤血管新生相關之生長因子分泌,改變腫瘤之生長養分供給,以及引起小鼠血清細胞激素表達的改變,調節免疫作用及發炎作用,進而造成抑制腫瘤生長之趨勢。另外,由細胞模式可以看出,乳酸造成腫瘤MCT1、MCT4及HIF-1α蛋白表現有下降之趨勢,且在動物實驗中亦發現有相同的結果,顯示乳酸可能會影響腫瘤能量代謝的過程。未來,對於乳癌患者來說,中及高強度運動可能可做為輔助治療癌症的策略之一。
Recent epidemiologic studies have provided the first observation that regular exercise with moderate intensity is beneficial to cancer patients, but the molecular mechanisms underlying this relationship remain unclear. Therefore, the aim of this study was firstly to investigate the effect of lactate on breast cancer, which is affected by monocarboxylic acid transporter enzymes and hypoxia enzyme such as MCT1, MCT4, CD147 and HIF-1α protein. As a result, it shows a decreasing trend of the protein amount of MCT1, MCT4 and HIF-1α. Secondly, the aim of this study was to investigate the effect of exercise on breast cancer growth in vivo. Mice bearing breast tumor were given middle and high intensity treadmill exercise for 28 days with 30 minutes per day, the speed was set 16 m/min and 20 m/min. Animal study revealed that the development of the tumor on the breast tumor-bearing mice was inhibited during exercise program. Further research shows that human angiogenesis growth factor such as G-CSF, follistatin and mouse cytokine such as IL-7、IL-9、IL-12 (p40)、IL-12 (p70)、IL-13、GM-CSF and M-CSF, were highly correlated with exercise program. The level of MCT1, MCT4 and HIF-1α were also decreased accordingly with the result of lactate-treated breast cancer cells. In conclusion, exercise could inhibit the level of angiogenesis growth factor, change the nutrient supply of tumor growth, thus cause the change of cytokine profiles in inflammatory cytokines and angiogenesis associated cytokines, and further regulate immunological response and inflammation status, thereby inhibit the growth of the tumor. This result implied that the inhibition of tumor growth was mediated by the effect of lactate, which is in accordance with the decrease of MCT1, MCT4 and HIF-1α in vitro and in vivo. For breast cancer patient, it is suggested that middle or high intensity exercise programs could be beneficial for cancer management and act as an adjuvant therapy during cancer treatment.
張幸、余斌、蔡保塔(2006)。不同運動強度對大鼠骨骼肌中低氧誘導因子-1α mRNA表達的影響。中華創傷骨科雜誌,8(5),453- 457。
黃國欽,邱亦涵,何采容(2009)。在長期訓練下不同運動項目在急性期蛋白、肝功能及細胞激素之變化。運動教練科學,13,81-91。
鄒志兵、毛淑章、鄭瀾(2012)。低氧訓練大鼠骨骼肌組織低氧誘導因子1對血管新生的影響。中華組織工程研究,16(20),3654- 3658。
衛生福利部國民健康署(2014,2月)。中華民國100年癌症登記報告。取自http://www.hpa.gov.tw/BHPNet/Web/Stat/StatisticsShow.aspx?No=201404160001
Adamopoulos, S., Parissis, J., Karatzas, D., Kroupis, C., Georgiadis, M., Karavolias, G., . . . Kremastinos, D. T. (2002). Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. Journal of the American College of Cardiology, 39(4), 653-663.
Adolfsson, J., Ljungqvist, A., Tornling, G., & Unge, G. (1981). Capillary increase in the skeletal muscle of trained young and adult rats. Journal of Physiology, 310, 529-532.
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006). Inflammation and cancer: How hot is the link? Biochemical Pharmacology, 72(11), 1605-1621. doi: 10.1016/j.bcp.2006.06.029
Ahmed, R. L., Thomas, W., Yee, D., & Schmitz, K. H. (2006). Randomized controlled trial of weight training and lymphedema in breast cancer survivors. Journal of Clinical Oncology, 24(18), 2765-2772. doi: 10.1200/JCO.2005.03.6749
Almeida, P. W., Gomes-Filho, A., Ferreira, A. J., Rodrigues, C. E., Dias-Peixoto, M. F., Russo, R. C., . . . Pussieldi, G. A. (2009). Swim training suppresses tumor growth in mice. Journal of Applied Physiology (1985), 107(1), 261-265. doi: 10.1152/japplphysiol.00249.2009
Annibaldi, A., & Widmann, C. (2010). Glucose metabolism in cancer cells. Current Opinion in Clinical Nutrition & Metabolic Care, 13(4), 466-470. doi: 10.1097/MCO.0b013e32833a5577
Anversa, P., Levicky, V., Beghi, C., McDonald, S. L., & Kikkawa, Y. (1983). Morphometry of exercise-induced right ventricular hypertrophy in the rat. Circulation Research, 52(1), 57-64.
Aoi, W., Iwashita, S., Fujie, M., & Suzuki, M. (2004). Sustained swimming increases erythrocyte MCT1 during erythropoiesis and ability to regulate pH homeostasis in rat. International Journal of Sports Medicine, 25(5), 339-344. doi: 10.1055/s-2004-815846
Babaei-Jadidi, R., Li, N., Saadeddin, A., Spencer-Dene, B., Jandke, A., Muhammad, B., . . . Nateri, A. S. (2011). FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. Journal of Experimental Medicine, 208(2), 295-312. doi: 10.1084/jem.20100830
Baker, J. M., De Lisio, M., & Parise, G. (2011). Endurance exercise training promotes medullary hematopoiesis. The Journal of Federation of American Societies for Experimental Biology, 25(12), 4348-4357. doi: 10.1096/fj.11-189043
Baker, S. K., Tarnopolsky, M. A., & Bonen, A. (2001). Expression of MCT1 and MCT4 in a patient with mitochondrial myopathy. Muscle and Nerve, 24(3), 394-398.
Baracos, V. E. (1989). Exercise inhibits progressive growth of the Morris hepatoma 7777 in male and female rats. Canadian Journal of Physiology and Pharmacology, 67(8), 864-870.
Becker, H. M., Broer, S., & Deitmer, J. W. (2004). Facilitated lactate transport by MCT1 when coexpressed with the sodium bicarbonate cotransporter (NBC) in Xenopus oocytes. Biophysical Journal, 86(1 Pt 1), 235-247. doi: 10.1016/S0006-3495(04)74099-0
Bellance, N., Benard, G., Furt, F., Begueret, H., Smolkova, K., Passerieux, E., . . . Rossignol, R. (2009). Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory capacity. International Journal of Biochemistry and Cell Biology, 41(12), 2566-2577. doi: 10.1016/j.biocel.2009.08.012
Benoy, I. H., Salgado, R., Van Dam, P., Geboers, K., Van Marck, E., Scharpe, S., . . . Dirix, L. Y. (2004). Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clinical Cancer Research, 10(21), 7157-7162. doi: 10.1158/1078-0432.CCR-04-0812
Bergers, G., & Benjamin, L. E. (2003). Tumorigenesis and the angiogenic switch. Nature Reviews Cancer, 3(6), 401-410. doi: 10.1038/nrc1093
Bhattacharya, I., & Boje, K. M. (2006). Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: A pharmacokinetic simulation-based evaluation. Journal of Pharmacokinetics and Pharmacodynamics, 33(5), 657-681. doi: 10.1007/s10928-006-9029-x
Bikfalvi, A. (2004). Platelet factor 4: An inhibitor of angiogenesis. Seminars in Thrombosis and Hemostasis, 30(3), 379-385. doi: 10.1055/s-2004-831051
Bonen, A., Miskovic, D., Tonouchi, M., Lemieux, K., Wilson, M. C., Marette, A., &Halestrap, A. P. (2000). Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles. American Journal of Physiology – Endocrinology and Metabolism, 278(6), E1067-1077.
Bonen, A., Tonouchi, M., Miskovic, D., Heddle, C., Heikkila, J. J., & Halestrap, A. P. (2000). Isoform-specific regulation of the lactate transporters MCT1 and MCT4 by contractile activity. American Journal of Physiology – Endocrinology and Metabolism, 279(5), E1131-1138.
Borish, L. C., & Steinke, J. W. (2003). 2. Cytokines and chemokines. Journal of Allergy and Clinical Immunology, 111(2 Suppl), S460-475.
Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D. (1996). Angiogenic growth factor mRNA responses in muscle to a single bout of exercise. Journal of Applied Physiology (1985), 81(1), 355-361.
Brezden, C. B., Phillips, K. A., Abdolell, M., Bunston, T., & Tannock, I. F. (2000). Cognitive function in breast cancer patients receiving adjuvant chemotherapy. Journal of Clinical Oncology, 18(14), 2695-2701.
Campbell, K. L., & McTiernan, A. (2007). Exercise and biomarkers for cancer prevention studies. Journal of Nutrition, 137(1 Suppl), 161S-169S.
Capello, M., Ferri-Borgogno, S., Cappello, P., & Novelli, F. (2011). Alpha-Enolase: A promising therapeutic and diagnostic tumor target. Federation of European Biochemical Societies, 278(7), 1064-1074. doi: 10.1111/j.1742-4658.2011.08025.x
Cerretelli, P., & Gelfi, C. (2011). Energy metabolism in hypoxia: Reinterpreting some features of muscle physiology on molecular grounds. European Journal of Applied Physiology and Occupational Physiology, 111(3), 421-432. doi: 10.1007/s00421-010-1399-5
Chandrasekar, B., Melby, P. C., Sarau, H. M., Raveendran, M., Perla, R. P., Marelli-Berg, F. M., . . . Singh, I. S. (2003). Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. The Journal of Biological Chemistry,278(7), 4675-4686. doi: 10.1074/jbc.M207006200
Chang, Y. S., di Tomaso, E., McDonald, D. M., Jones, R., Jain, R. K., & Munn, L. L. (2000). Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14608-14613. doi: 10.1073/pnas.97.26.14608
Chavey, C., Bibeau, F., Gourgou-Bourgade, S., Burlinchon, S., Boissiere, F., Laune, D., . . . Lazennec, G. (2007). Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Research, 9(1), R15. doi: 10.1186/bcr1648
Chen, M. F., Chen, H. I., & Jen, C. J. (2010). Exercise training upregulates macrophage MKP-1 and affects immune responses in mice. Medicine & Science in Sports & Exercise, 42(12), 2173-2179. doi: 10.1249/MSS.0b013e3181e2158d
Chen, X., Lin, J., Kanekura, T., Su, J., Lin, W., Xie, H., . . . Chang, J. (2006). A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Research, 66(23), 11323-11330. doi: 10.1158/0008-5472.CAN-06-1536
Cohen, L. A., Choi, K., Backlund, J. Y., Harris, R., & Wang, C. X. (1991). Modulation of N-nitrosomethylurea induced mammary tumorigenesis by dietary fat and voluntary exercise. In Vivo, 5(4), 333-344.
Colbert, L. H., Mai, V., Perkins, S. N., Berrigan, D., Lavigne, J. A., Wimbrow, H. H., . . . Hursting, S. D. (2003). Exercise and intestinal polyp development in APCMin mice. Medicine & Science in Sports & Exercise, 35(10), 1662-1669. doi: 10.1249/01.MSS.0000089349.54813.41
Colbert, L. H., Mai, V., Tooze, J. A., Perkins, S. N., Berrigan, D., & Hursting, S. D. (2006). Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice. Carcinogenesis, 27(10), 2103-2107. doi: 10.1093/carcin/bgl056
Coles, L., Litt, J., Hatta, H., & Bonen, A. (2004). Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle. Journal of Physiology, 561(Pt 1), 253-261. doi: 10.1113/jphysiol.2004.073478
Courneya, K. S., Mackey, J. R., & McKenzie, D. C. (2002). Exercise for breast cancer survivors: Research evidence and clinical guidelines. Physician and Sportsmedicine, 30(8), 33-42. doi: 10.3810/psm.2002.08.402
Coussens, L. M., & Werb, Z. (2002). Inflammation and cancer. Nature, 420(6917), 860-867. doi: 10.1038/nature01322
Cuezva, J. M., Krajewska, M., de Heredia, M. L., Krajewski, S., Santamaria, G., Kim, H., . . . Reed, J. C. (2002). The bioenergetic signature of cancer: A marker of tumor progression. Cancer Research, 62(22), 6674-6681.
Cummings, S. R., Tice, J. A., Bauer, S., Browner, W. S., Cuzick, J., Ziv, E., . . . Kerlikowske, K. (2009). Prevention of breast cancer in postmenopausal women: Approaches to estimating and reducing risk. Journal of the National Cancer Institute, 101(6), 384-398. doi: 10.1093/jnci/djp018
Daido, S., Kanzawa, T., Yamamoto, A., Takeuchi, H., Kondo, Y., & Kondo, S. (2004). Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Research, 64(12), 4286-4293. doi: 10.1158/0008-5472.CAN-03-3084
Deckers, M. M., van Bezooijen, R. L., van der Horst, G., Hoogendam, J., van Der Bent, C., Papapoulos, S. E., & Lowik, C. W. (2002). Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology, 143(4), 1545-1553. doi: 10.1210/endo.143.4.8719
Demark-Wahnefried, W., Peterson, B. L., Winer, E. P., Marks, L., Aziz, N., Marcom, P. K., . . . Rimer, B. K. (2001). Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. Journal of Clinical Oncology, 19(9), 2381-2389.
Deshmane, S. L., KremLev, S., Amini, S., & Sawaya, B. E. (2009). Monocyte chemoattractant protein-1 (MCP-1): An overview. Journal of Interferon and Cytokine Research, 29(6), 313-326. doi: 10.1089/jir.2008.0027
Dorner, B. G., Scheffold, A., Rolph, M. S., Huser, M. B., Kaufmann, S. H., Radbruch, A., . . . Kroczek, R. A. (2002). MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. Proceedings of the National Academy of Sciences of the United States of America, 99(9), 6181-6186. doi: 10.1073/pnas.092141999
Dranoff, G. (2004). Cytokines in cancer pathogenesis and cancer therapy. Nature Reviews Cancer, 4(1), 11-22. doi: 10.1038/nrc1252
Dreher, D., & Junod, A. F. (1996). Role of oxygen free radicals in cancer development. European Journal of Cancer, 32A(1), 30-38.
Dufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002). IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. Journal of Immunology, 168(7), 3195-3204.
Fairey, A. S., Courneya, K. S., Field, C. J., & Mackey, J. R. (2002). Physical exercise and immune system function in cancer survivors: A comprehensive review and future directions. Cancer, 94(2), 539-551. doi: 10.1002/cncr.10244
Fang, J., Quinones, Q. J., Holman, T. L., Morowitz, M. J., Wang, Q., Zhao, H., . . . Wahl, M. L. (2006). The H+-linked monocarboxylate transporter (MCT1/SLC16A1): A potential therapeutic target for high-risk neuroblastoma. Molecular Pharmacology, 70(6), 2108-2115. doi: 10.1124/mol.106.026245
Fei, P., Wang, W., Kim, S. H., Wang, S., Burns, T. F., Sax, J. K., . . . El-Deiry, W. S. (2004). Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell, 6(6), 597-609. doi: 10.1016/j.ccr.2004.10.012
Fishbein, W. N. (1986). Lactate transporter defect: A new disease of muscle. Science, 234(4781), 1254-1256.
Folkman, J. (1971). Tumor angiogenesis: Therapeutic implications. New England Journal of Medicine, 285(21), 1182-1186. doi: 10.1056/NEJM197111182852108
Folkman, J. (1990). What is the evidence that tumors are angiogenesis dependent? Journal of the National Cancer Institute, 82(1), 4-6.
Friedenreich, C. M. (2011). Physical activity and breast cancer: review of the epidemiologic evidence and biologic mechanisms. Recent Results in Cancer Research, 188, 125-139. doi: 10.1007/978-3-642-10858-7_11
Friedenreich, C. M., & Orenstein, M. R. (2002). Physical activity and cancer prevention: Etiologic evidence and biological mechanisms. Journal of Nutrition, 132(11 Suppl), 3456S-3464S.
Funasaka, T., Yanagawa, T., Hogan, V., & Raz, A. (2005). Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. Journal of Federation of American Societies for Experimental Biology, 19(11), 1422-1430. doi: 10.1096/fj.05-3699com
Gago-Dominguez, M., Jiang, X., & Esteban Castelao, J. (2007). Lipid peroxidation and the protective effect of physical exercise on breast cancer. Medical Hypotheses, 68(5), 1138-1143. doi: 10.1016/j.mehy.2006.09.026
Gale, N. W., & Yancopoulos, G. D. (1999). Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes and Development, 13(9), 1055-1066.
Gallagher, S. M., Castorino, J. J., Wang, D., & Philp, N. J. (2007). Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Research, 67(9), 4182-4189. doi: 10.1158/0008-5472.CAN-06-3184
Gao, X., Hu, H., Zhu, J., & Xu, Z. (2007). Identification and characterization of follistatin as a novel angiogenin-binding protein. Federation of European Biochemical Societies Letters, 581(28), 5505-5510. doi: 10.1016/j.febslet.2007.10.059
Garcia, J. J., Bote, E., Hinchado, M. D., & Ortega, E. (2011). A single session of intense exercise improves the inflammatory response in healthy sedentary women. Journal of Physiology and Biochemistry, 67(1), 87-94. doi: 10.1007/s13105-010-0052-4
Gately, S., Twardowski, P., Stack, M. S., Cundiff, D. L., Grella, D., Castellino, F. J., . . . Soff, G. A. (1997). The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proceedings of The National Academy of Sciences of the United States of America, 94(20), 10868-10872.
Gleeson, M. (2007). Immune function in sport and exercise. Journal of Applied Physiology (1985), 103(2), 693-699. doi: 10.1152/japplphysiol.00008.2007
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011). The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nature Reviews Immunology, 11(9), 607-615. doi: 10.1038/nri3041
Goldhammer, E., Tanchilevitch, A., Maor, I., Beniamini, Y., Rosenschein, U., & Sagiv, M. (2005). Exercise training modulates cytokines activity in coronary heart disease patients. International Journal of Cardiology, 100(1), 93-99. doi: 10.1016/j.ijcard.2004.08.073
Gomez, A. M., Martinez, C., Fiuza-Luces, C., Herrero, F., Perez, M., Madero, L., . . . Ramirez, M. (2011). Exercise training and cytokines in breast cancer survivors. International Journal of Sports Medicine, 32(6), 461-467. doi: 10.1055/s-0031-1271697
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379(6560), 88-91. doi: 10.1038/379088a0
Griguer, C. E., Oliva, C. R., & Gillespie, G. Y. (2005). Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. Journal of Neuro-Oncology, 74(2), 123-133. doi: 10.1007/s11060-004-6404-6
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010). Immunity, inflammation, and cancer. Cell, 140(6), 883-899. doi: 10.1016/j.cell.2010.01.025
Hafstad, A. D., Lund, J., Hadler-Olsen, E., Hoper, A. C., Larsen, T. S., & Aasum, E. (2013). High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity. Diabetes, 62(7), 2287-2294. doi: 10.2337/db12-1580
Halestrap, A. P., & Meredith, D. (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Archiv. European Journal of Physiology, 447(5), 619-628. doi: 10.1007/s00424-003-1067-2
Harriss, D. J., Atkinson, G., Batterham, A., George, K., Cable, N. T., Reilly, T., . . . Renehan, A. G. (2009). Lifestyle factors and colorectal cancer risk (2): A systematic review and meta-analysis of associations with leisure-time physical activity. Colorectal Disease, 11(7), 689-701. doi: 10.1111/j.1463-1318.2009.01767.x
Harriss, D. J., Atkinson, G., George, K., Cable, N. T., Reilly, T., Haboubi, N., . . . Renehan, A. G. (2009). Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index. Colorectal Disease, 11(6), 547-563. doi: 10.1111/j.1463-1318.2009.01766.x
Hashimoto, T., Hussien, R., Oommen, S., Gohil, K., & Brooks, G. A. (2007). Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis. The Journal of Federation of American Societies for Experimental Biology, 21(10), 2602-2612. doi: 10.1096/fj.07-8174com
Hashizume, H., Baluk, P., Morikawa, S., McLean, J. W., Thurston, G., Roberge, S., . . . McDonald, D. M. (2000). Openings between defective endothelial cells explain tumor vessel leakiness. American Journal of Pathology, 156(4), 1363-1380. doi: 10.1016/S0002-9440(10)65006-7
Hendrix, M. J., Seftor, E. A., Meltzer, P. S., Gardner, L. M., Hess, A. R., Kirschmann, D. A., . . . Seftor, R. E. (2001). Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry. Proceedings of the National Academy of Sciences of the United States of America, 98(14), 8018-8023. doi: 10.1073/pnas.131209798
Hermansen, L., Maehlum, S., Pruett, E. D. R., Vaage, O., Waldum, H., & Wessel-Aas, T. (1975). Lactate removal at rest and during exercise. Metabolic Adaptation to Prolonged Physical Exercise. doi: 10.1007/978-3-0348-5523-5_11.
Herrero, F., San Juan, A. F., Fleck, S. J., Balmer, J., Perez, M., Canete, S., . . . Lucia, A. (2006). Combined aerobic and resistance training in breast cancer survivors: A randomized, controlled pilot trial. International Journal of Sports Medicine, 27(7), 573-580. doi: 10.1055/s-2005-865848
Hoffman-Goetz, L., MacNeil, B., Arumugam, Y., & Randall Simpson, J. (1992). Differential effects of exercise and housing condition on murine natural killer cell activity and tumor growth. International Journal of Sports Medicine, 13(2), 167-171. doi: 10.1055/s-2007-1021250
Hoffman, S. A., Paschkis, K. E., Debias, D. A., Cantarow, A., & Williams, T. L. (1962). The influence of exercise on the growth of transplanted rat tumors. Cancer Research, 22, 597-599.
Holmes, M. D., & Willett, W. C. (1995). Can breast cancer be prevented by dietary and lifestyle changes? Annals of Medicine, 27(4), 429-430.
Hoshino, D., Matsumae, H., Kato, M., & Hatta, H. (2010). Higher lactate transporter protein and citrate synthase activity following short-term high-intensity repetition training in mice. International Journal of Sport and Health Science, 8, 43-49.
Hoshino, D., Koshikawa, N., Suzuki, T., Quaranta, V., Weaver, A. M., Seiki, M., & Ichikawa, K. (2012). Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies. PLoS Computational Biology, 8(4), e1002479. doi: 10.1371/journal.pcbi.1002479
Hoshino, E., Karino, H., & Yamada, T. (1981). Lactate metabolism by human dental plaque and veillonella under aerobic and anaerobic conditions. Archives of Oral Biology, 26(1), 17-22.
Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., . . . Mizushima, T. (2011). Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. Journal of Neuroscience, 31(14), 5225-5234. doi: 10.1523/JNEUROSCI.5478-10.2011
Howard-Anderson, J., Ganz, P. A., Bower, J. E., & Stanton, A. L. (2012). Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: A systematic review. Journal of the National Cancer Institute, 104(5), 386-405. doi: 10.1093/jnci/djr541
Hsieh, C. C., Sprod, L. K., Hydock, D. S., Carter, S. D., Hayward, R., & Schneider, C. M. (2008). Effects of a supervised exercise intervention on recovery from treatment regimens in breast cancer survivors. Oncology Nursing Forum, 35(6), 909-915. doi: 10.1188/08.ONF.909-915
Hussien, R., & Brooks, G. A. (2011). Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiological Genomics, 43(5), 255-264. doi: 10.1152/physiolgenomics.00177.2010
Hutnick, N. A., Williams, N. I., Kraemer, W. J., Orsega-Smith, E., Dixon, R. H., Bleznak, A. D., & Mastro, A. M. (2005). Exercise and lymphocyte activation following chemotherapy for breast cancer. Medicine & Science in Sports & Exercise, 37(11), 1827-1835.
Hwang, J. T., Kwon, D. Y., & Yoon, S. H. (2009). AMP-activated protein kinase: A potential target for the diseases prevention by natural occurring polyphenols. Nature Biotechnology, 26(1-2), 17-22. doi: 10.1016/j.nbt.2009.03.005
Hwang, T. L., Liang, Y., Chien, K. Y., & Yu, J. S. (2006). Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics, 6(7), 2259-2272. doi: 10.1002/pmic.200500345
Iacono, K. T., Brown, A. L., Greene, M. I., & Saouaf, S. J. (2007). CD147 immunoglobulin superfamily receptor function and role in pathology. Experimental and Molecular Pathology, 83(3), 283-295. doi: 10.1016/j.yexmp.2007.08.014
Ikeda, K., Yamaguchi, T., Fukunaga, S., Hoshino, M., & Matsuzaki, K. (2011). Mechanism of amyloid beta-protein aggregation mediated by GM1 ganglioside clusters. Biochemistry, 50(29), 6433-6440. doi: 10.1021/bi200771m
Irwin, M. L., CrumLey, D., McTiernan, A., Bernstein, L., Baumgartner, R., Gilliland, F. D., . . . Ballard-Barbash, R. (2003). Physical activity levels before and after a diagnosis of breast carcinoma: The Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer, 97(7), 1746-1757. doi: 10.1002/cncr.11227
Ishibashi, Y., Matsumoto, T., Niwa, M., Suzuki, Y., Omura, N., Hanyu, N., . . . Urashima, M. (2004). CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma. Cancer, 101(9), 1994-2000. doi: 10.1002/cncr.20593
Izumi, H., Takahashi, M., Uramoto, H., Nakayama, Y., Oyama, T., Wang, K. Y., . . . Kohno, K. (2011). Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Science, 102(5), 1007-1013. doi: 10.1111/j.1349-7006.2011.01908.x
Jager, A., Sleijfer, S., & van der Rijt, C. C. (2008). The pathogenesis of cancer related fatigue: Could increased activity of pro-inflammatory cytokines be the common denominator? European Journal of Cancer, 44(2), 175-181. doi: 10.1016/j.ejca.2007.11.023
Jain, R. K. (2003). Molecular regulation of vessel maturation. Nature Medicine, 9(6), 685-693. doi: 10.1038/nm0603-685
Jain, V. K., & Turner, N. C. (2012). Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer. Breast Cancer Research, 14(3), 208. doi: 10.1186/bcr3139
James, O. A. (2007). Approach to the patient with lymphadenopathy and splenomegaly. In: Lee G, Daniel AA, eds. Cecil Medicine. 23rd ed. Philadelphia: Saunders, 1264-7.
Jensen, L., Pilegaard, H., Neufer, P. D., & Hellsten, Y. (2004). Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 287(2), R397-402. doi: 10.1152/ajpregu.00071.2004
Jiang, X. P., Yang, D. C., Elliott, R. L., & Head, J. F. (2000). Reduction in serum IL-6 after vacination of breast cancer patients with tumour-associated antigens is related to estrogen receptor status. Cytokine, 12(5), 458-465. doi: 10.1006/cyto.1999.0591
Jones, L. W., Eves, N. D., Courneya, K. S., Chiu, B. K., Baracos, V. E., Hanson, J., . . . Mackey, J. R. (2005). Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts. Clinical Cancer Research, 11(18), 6695-6698. doi: 10.1158/1078-0432.CCR-05-0844
Jones, L. W., Viglianti, B. L., Tashjian, J. A., Kothadia, S. M., Keir, S. T., Freedland, S. J., . . . Dewhirst, M. W. (2010). Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. Journal of Applied Physiology, (1985), 108(2), 343-348. doi: 10.1152/japplphysiol.00424.2009
Juel, C., & Halestrap, A. P. (1999). Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. Journal of Physiology, 517 (Pt 3), 633-642.
Juel, C., Klarskov, C., Nielsen, J. J., Krustrup, P., Mohr, M., & Bangsbo, J. (2004). Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle. American Journal Physiology- Endocrinology Metabolism, 286(2), E245-251. doi: 10.1152/ajpendo.00303.2003
Kanzawa, T., Zhang, L., Xiao, L., Germano, I. M., Kondo, Y., & Kondo, S. (2005). Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene, 24(6), 980-991. doi: 10.1038/sj.onc.1208095
Kemi, O. J., Haram, P. M., Loennechen, J. P., Osnes, J. B., Skomedal, T., Wisloff, U., & Ellingsen, O. (2005). Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovascular Research, 67(1), 161-172. doi: 10.1016/j.cardiores.2005.03.010
Kennedy, K. M., & Dewhirst, M. W. (2010). Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation. Future Oncology, 6(1), 127-148. doi: 10.2217/fon.09.145
Kijima, T., Takeuchi, K., Tetsumoto, S., Shimada, K., Takahashi, R., Hirata, H., . . . Kawase, I. (2011). Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer. Cancer Science, 102(8), 1602-1604. doi: 10.1111/j.1349-7006.2011.01970.x
Kim, J. W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3(3), 177-185. doi: 10.1016/j.cmet.2006.02.002
Kirk, P., Wilson, M. C., Heddle, C., Brown, M. H., Barclay, A. N., & Halestrap, A. P. (2000). CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO Journal, 19(15), 3896-3904. doi: 10.1093/emboj/19.15.3896
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., . . . Strieter, R. M. (1992). Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science, 258(5089), 1798-1801.
Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011). Otto Warburg's contributions to current concepts of cancer metabolism. Nature Review Cancer, 11(5), 325-337. doi: 10.1038/nrc3038
Kozian, D. H., Ziche, M., & Augustin, H. G. (1997). The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis. Laboratory Investigation, 76(2), 267-276.
Krneta, J., Kroll, J., Alves, F., Prahst, C., Sananbenesi, F., Dullin, C., . . . Augustin, H. G. (2006). Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors. Cancer Research, 66(11), 5686-5695. doi: 10.1158/0008-5472.CAN-05-3821
Lappe, J. M., & Tinley, S. T. (1998). Prevention of osteoporosis in women treated for hereditary breast and ovarian carcinoma: A need that is overlooked. Cancer, 83(5), 830-834.
Lee, S., & Margolin, K. (2011). Cytokines in cancer immunotherapy. Cancers (Basel), 3(4), 3856-3893. doi: 10.3390/cancers3043856
Li, C. Y., Shan, S., Cao, Y., & Dewhirst, M. W. (2000). Role of incipient angiogenesis in cancer metastasis. Cancer and Metastasis Reviews, 19(1-2), 7-11.
Li, N. J., Liu, Z., Zhang, Y., Yue, C. X., Wei, W., Li, L. L., . . . Bi, F. (2011). The effect of small GTPase Cdc42 on the multidrug resistance of oxaliplatin-resistant colon cancer cell lines. Sichuan Da Xue Xue Bao Yi Xue Ban, 42(4), 466-470.
.
Li, Y., Xu, J., Chen, L., Zhong, W. D., Zhang, Z., Mi, L., . . . Chen, Z. N. (2009). HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology, 54(6), 677-687. doi: 10.1111/j.1365-2559.2009.03280.x
Ligibel, J. (2011). Obesity and breast cancer. Oncology (Williston Park), 25(11), 994-1000.
Lin, W. W., & Karin, M. (2007). A cytokine-mediated link between innate immunity, inflammation, and cancer. Journal of Clinical Investigation, 117(5), 1175-1183. doi: 10.1172/JCI31537
Lira, F. S., Rosa, J. C., Zanchi, N. E., Yamashita, A. S., Lopes, R. D., Lopes, A. C., . . . Seelaender, M. (2009). Regulation of inflammation in the adipose tissue in cancer cachexia: Effect of exercise. Cell Biochemistry and Function, 27(2), 71-75. doi: 10.1002/cbf.1540
Lloyd, P. G., Prior, B. M., Yang, H. T., & Terjung, R. L. (2003). Angiogenic growth factor expression in rat skeletal muscle in response to exercise training. American Journal of Physiology. Heart and Circulatory Physiology, 284(5), H1668-1678. doi: 10.1152/ajpheart.00743.2002
Lopez-Rios, F., Sanchez-Arago, M., Garcia-Garcia, E., Ortega, A. D., Berrendero, J. R., Pozo-Rodriguez, F., . . . Cuezva, J. M. (2007). Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas. Cancer Research, 67(19), 9013-9017. doi: 10.1158/0008-5472.CAN-07-1678
Lu, H., Ouyang, W., & Huang, C. (2006). Inflammation, a key event in cancer development. Molecular Cancer Research, 4(4), 221-233. doi: 10.1158/1541-7786.MCR-05-0261
Lu, Q., Ceddia, M. A., Price, E. A., Ye, S. M., & Woods, J. A. (1999). Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice. American Journal of Physiology, 276(2 Pt 2), R482-489.
Ma, L., Li, N., He, X., & Zhang, Q. (2011). MiR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line. Beijing Da Xue Xue Bao, 43(1), 129-133.
MacNeil, B., & Hoffman-Goetz, L. (1993a). Effect of exercise on natural cytotoxicity and pulmonary tumor metastases in mice. Medicine & Science in Sports & Exercise, 25(8), 922-928.
MacNeil, B., & Hoffman-Goetz, L. (1993b). Exercise training and tumour metastasis in mice: Influence of time of exercise onset. Anticancer Research, 13(6A), 2085-2088.
Mathupala, S. P., Heese, C., & Pedersen, P. L. (1997). Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. Journal of Biological Chemistry, 272(36), 22776-22780.
Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2009). Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Seminars in Cancer Biology, 19(1), 17-24. doi: 10.1016/j.semcancer.2008.11.006
Medina, R. A., & Owen, G. I. (2002). Glucose transporters: Expression, regulation and cancer. Biological Research, 35(1), 9-26.
Mehl, K. A., Davis, J. M., Clements, J. M., Berger, F. G., Pena, M. M., & Carson, J. A. (2005). Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. Journal of Applied Physiology (1985), 98(6), 2219-2225. doi: 10.1152/japplphysiol.00975.2004
Meredith, D., & Christian, H. C. (2008). The SLC16 monocaboxylate transporter family. Xenobiotica, 38(7-8), 1072-1106. doi: 10.1080/00498250802010868
Milne, H. M., Wallman, K. E., Gordon, S., & Courneya, K. S. (2008). Effects of a combined aerobic and resistance exercise program in breast cancer survivors: A randomized controlled trial. Breast Cancer Research and Treatment, 108(2), 279-288. doi: 10.1007/s10549-007-9602-z
Mock, V., Frangakis, C., Davidson, N. E., Ropka, M. E., Pickett, M., Poniatowski, B., . . . McCorkle, R. (2005). Exercise manages fatigue during breast cancer treatment: A randomized controlled trial. Psycho-Oncology, 14(6), 464-477. doi: 10.1002/pon.863
Moldoveanu, A. I., Shephard, R. J., & Shek, P. N. (2000). Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. Journal of Applied Physiology (1985), 89(4), 1499-1504.
Morris, M. E., & FelmLee, M. A. (2008). Overview of the proton-coupled MCT (SLC16A) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. American Association of Pharmaceutical Scientists, 10(2), 311-321. doi: 10.1208/s12248-008-9035-6
Murphy, E. A., Davis, J. M., Barrilleaux, T. L., McClellan, J. L., Steiner, J. L., Carmichael, M. D., . . . Green, J. E. (2011). Benefits of exercise training on breast cancer progression and inflammation in C3(1)SV40Tag mice. Cytokine, 55(2), 274-279. doi: 10.1016/j.cyto.2011.04.007
Murphy, E. A., Davis, J. M., Brown, A. S., Carmichael, M. D., Mayer, E. P., & Ghaffar, A. (2004). Effects of moderate exercise and oat beta-glucan on lung tumor metastases and macrophage antitumor cytotoxicity. Journal of Applied Physiology (1985), 97(3), 955-959. doi: 10.1152/japplphysiol.00252.2004
Nagano, M., Hoshino, D., Koshiba, S., Shuo, T., Koshikawa, N., Tomizawa, T., . . . Seiki, M. (2011). ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. Journal of Biological Chemistry, 286(36), 31598-31609. doi: 10.1074/jbc.M110.199430
Natori, T., Sata, M., Washida, M., Hirata, Y., Nagai, R., & Makuuchi, M. (2002). G-CSF stimulates angiogenesis and promotes tumor growth: Potential contribution of bone marrow-derived endothelial progenitor cells. Biochemical and Biophysical Research Communications, 297(4), 1058-1061.
Nemet, D., Oh, Y., Kim, H. S., Hill, M., & Cooper, D. M. (2002). Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics, 110(4), 681-689.
Nieman, D. C., Brendle, D., Henson, D. A., Suttles, J., Cook, V. D., Warren, B. J., . . . Nehlsen-Cannarella, S. L. (1995). Immune function in athletes versus nonathletes. International Journal of Sports Medicine, 16(5), 329-333. doi: 10.1055/s-2007-973014
Nishida, N., Yano, H., Nishida, T., Kamura, T., & Kojiro, M. (2006). Angiogenesis in cancer. Vascular Health and Risk Management, 2(3), 213-219.
Ogawa, M. (1993). Differentiation and proliferation of hematopoietic stem cells. Blood, 81(11), 2844-2853.
Ohira, T., Schmitz, K. H., Ahmed, R. L., & Yee, D. (2006). Effects of weight training on quality of life in recent breast cancer survivors: The Weight Training for Breast Cancer Survivors (WTBS) study. Cancer, 106(9), 2076-2083. doi: 10.1002/cncr.21829
Olfert, I. M., Breen, E. C., Mathieu-Costello, O., & Wagner, P. D. (2001). Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia. Journal of Applied Physiology (1985), 91(3), 1176-1184.
Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., . . . Dang, C. V. (2000). Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. Journal of Biological Chemistry, 275(29), 21797-21800. doi: 10.1074/jbc.C000023200
Pain, S. J., Vowler, S., & Purushotham, A. D. (2005). Axillary vein abnormalities contribute to development of lymphoedema after surgery for breast cancer. British Journal of Surgery, 92(3), 311-315. doi: 10.1002/bjs.4835
Parr, C., Watkins, G., Boulton, M., Cai, J., & Jiang, W. G. (2005). Placenta growth factor is over-expressed and has prognostic value in human breast cancer. European Journal of Cancer, 41(18), 2819-2827. doi: 10.1016/j.ejca.2005.07.022
Pedersen, B. K., Rohde, T., & Zacho, M. (1996). Immunity in athletes. Journal of Sports Medicine and Physical Fitness, 36(4), 236-245.
Pedersen, S. F., Kramhoft, B., Jorgensen, N. K., & Hoffmann, E. K. (1996a). Shrinkage-induced activation of the Na+/H+ exchanger in Ehrlich ascites tumor cells: Mechanisms involved in the activation and a role for the exchanger in cell volume regulation. Journal of Membrane Biology, 149(2), 141-159.
Petersen, A. M., & Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology (1985), 98(4), 1154-1162. doi: 10.1152/japplphysiol.00164.2004
Pike, S. E., Yao, L., Jones, K. D., Cherney, B., Appella, E., Sakaguchi, K., . . . Tosato, G. (1998). Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. Journal of Experimental Medicine, 188(12), 2349-2356.
Pinheiro, C., Albergaria, A., Paredes, J., Sousa, B., Dufloth, R., Vieira, D., . . . Baltazar, F. (2010). Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma. Histopathology, 56(7), 860-867. doi: 10.1111/j.1365-2559.2010.03560.x
Pinheiro, C., Longatto-Filho, A., Scapulatempo, C., Ferreira, L., Martins, S., Pellerin, L., . . . Baltazar, F. (2008). Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Archiv, 452(2), 139-146. doi: 10.1007/s00428-007-0558-5
Price, D. J., Miralem, T., Jiang, S., Steinberg, R., & Avraham, H. (2001). Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth and Differentiation, 12(3), 129-135.
Pritchard, S. C., Nicolson, M. C., Lloret, C., McKay, J. A., Ross, V. G., Kerr, K. M., . . . McLeod, H. L. (2001). Expression of matrix metalloproteinases 1, 2, 9 and their tissue inhibitors in stage II non-small cell lung cancer: Implications for MMP inhibition therapy. Oncology Reports, 8(2), 421-424.
Radak, Z., Gaal, D., Taylor, A. W., Kaneko, T., Tahara, S., Nakamoto, H., & Goto, S. (2002). Attenuation of the development of murine solid leukemia tumor by physical exercise. Antioxid Redox Signal, 4(1), 213-219. doi: 10.1089/152308602753625979
Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., & Thompson, C. B. (2003). Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and Cellular Biology, 23(20), 7315-7328.
Risau, W. (1997). Mechanisms of angiogenesis. Nature, 386(6626), 671-674. doi: 10.1038/386671a0
Rivilis, I., Milkiewicz, M., Boyd, P., Goldstein, J., Brown, M. D., Egginton, S., . . . Haas, T. L. (2002). Differential involvement of MMP-2 and VEGF during muscle stretch- versus shear stress-induced angiogenesis. American Journal of Physiology. Heart and Circulatory Physiology, 283(4), H1430-1438. doi: 10.1152/ajpheart.00082.2002
Robinson, N. E. (1985). Respiratory adaptations to exercise. Veterinary Clinics of North America. Equine Practice, 1(3), 497-512.
Sakai, C., Hoshino, Y., Sato, Y., & Sato, E. (2011). Evaluation of maturation competence of metaphase II oocytes in mice based on the distance between pericentriolar materials of meiotic spindle: Distance of PCM during oocyte maturation. Journal of Assisted Reproduction and Genetics, 28(2), 157-166. doi: 10.1007/s10815-010-9496-2
Sakazaki, Y., Hoshino, T., Takei, S., Sawada, M., Oda, H., Takenaka, S., . . . Aizawa, H. (2011). Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD. PLoS One, 6(9), e24177. doi: 10.1371/journal.pone.0024177
Salgado, R., Junius, S., Benoy, I., Van Dam, P., Vermeulen, P., Van Marck, E., . . . Dirix, L. Y. (2003). Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. International Journal of Cancer, 103(5), 642-646. doi: 10.1002/ijc.10833
Scappaticci, F. A. (2002). Mechanisms and future directions for angiogenesis-based cancer therapies. Journal of Clinical Oncology, 20(18), 3906-3927.
Schmitz, K. H., Ahmed, R. L., Hannan, P. J., & Yee, D. (2005). Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiology, Biomarkers and Prevention, 14(7), 1672-1680. doi: 10.1158/1055-9965.EPI-04-0736
Schneiderhan, W., Scheler, M., Holzmann, K. H., Marx, M., Gschwend, J. E., Bucholz, M., . . . Oswald, F. (2009). CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in vivo and in vitro models. Gut, 58(10), 1391-1398. doi: 10.1136/gut.2009.181412
Segal, R., Evans, W., Johnson, D., Smith, J., Colletta, S., Gayton, J., . . . Reid, R. (2001). Structured exercise improves physical functioning in women with stages I and II breast cancer: Results of a randomized controlled trial. Journal of Clinical Oncology, 19(3), 657-665.
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008). Cytokines and their relationship to the symptoms and outcome of cancer. Nature Reviews Cancer, 8(11), 887-899. doi: 10.1038/nrc2507
Shen, D., Dalton, T. P., Nebert, D. W., & Shertzer, H. G. (2005). Glutathione redox state regulates mitochondrial reactive oxygen production. Journal of Biological Chemistry, 280(27), 25305-25312. doi: 10.1074/jbc.M500095200
Shephard, R. J., Rhind, S., & Shek, P. N. (1995). The impact of exercise on the immune system: NK cells, interleukins 1 and 2, and related responses. Exercise and Sport Sciences Reviews, 23, 215-241.
Smith, T. A. (1999). Facilitative glucose transporter expression in human cancer tissue. British Journal of Biomedical Science, 56(4), 285-292.
Sonveaux, P., Vegran, F., Schroeder, T., Wergin, M. C., Verrax, J., Rabbani, Z. N., . . . Dewhirst, M. W. (2008). Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. Journal of Clinical Investigation, 118(12), 3930-3942. doi: 10.1172/JCI36843
Sood, A. K., Seftor, E. A., Fletcher, M. S., Gardner, L. M., Heidger, P. M., Buller, R. E., . . . Hendrix, M. J. (2001). Molecular determinants of ovarian cancer plasticity. American Journal of Pathology, 158(4), 1279-1288. doi: 10.1016/S0002-9440(10)64079-5
Spence, R. R., Heesch, K. C., & Brown, W. J. (2010). Exercise and cancer rehabilitation: A systematic review. Cancer Treatment Reviews, 36(2), 185-194. doi: 10.1016/j.ctrv.2009.11.003
Sun, J., & HemLer, M. E. (2001). Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Research, 61(5), 2276-2281.
Suzuki, K., Nakaji, S., Yamada, M., Totsuka, M., Sato, K., & Sugawara, K. (2002). Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exercise Immunology Review, 8, 6-48.
Suzuki, K., Yamada, M., Kurakake, S., Okamura, N., Yamaya, K., Liu, Q., . . . Sugawara, K. (2000). Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans. European Journal of Applied Physiology and Occupational Physiology, 81(4), 281-287. doi: 10.1007/s004210050044
Takakura, N., Watanabe, T., Suenobu, S., Yamada, Y., Noda, T., Ito, Y., . . . Suda, T. (2000). A role for hematopoietic stem cells in promoting angiogenesis. Cell, 102(2), 199-209.
Thomas, C., Perrey, S., Lambert, K., Hugon, G., Mornet, D., & Mercier, J. (2005). Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fatigue indexes in humans. Journal of Applied Physiology (1985), 98(3), 804-809. doi: 10.1152/japplphysiol.01057.2004
Thompson, H. J. (1994). Effect of exercise intensity and duration on the induction of mammary carcinogenesis. Cancer Research, 54(7 Suppl), 1960s-1963s.
Thune, I., Brenn, T., Lund, E., & Gaard, M. (1997). Physical activity and the risk of breast cancer. New England Journal of Medicine, 336(18), 1269-1275. doi: 10.1056/NEJM199705013361801
Tong, X., Zhao, F., & Thompson, C. B. (2009). The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Current Opinion in Genetics and Development, 19(1), 32-37. doi: 10.1016/j.gde.2009.01.002
Trabold, O., Wagner, S., Wicke, C., Scheuenstuhl, H., Hussain, M. Z., Rosen, N., . . . Hunt, T. K. (2003). Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair and Regeneration, 11(6), 504-509.
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T., . . . Tanaka, T. (2007). Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Oncology Reports, 17(4), 731-735.
Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006). The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. Journal of Biological Chemistry, 281(14), 9030-9037. doi: 10.1074/jbc.M511397200
Verloop, J., Rookus, M. A., van der Kooy, K., & van Leeuwen, F. E. (2000). Physical activity and breast cancer risk in women aged 20-54 years. Journal of the National Cancer Institute, 92(2), 128-135.
Wahl, M. L., Owen, J. A., Burd, R., Herlands, R. A., Nogami, S. S., Rodeck, U., . . . Owen, C. S. (2002). Regulation of intracellular pH in human melanoma: Potential therapeutic implications. Molecular Cancer Therapeutics, 1(8), 617-628.
Walenta, S., & Mueller-Klieser, W. F. (2004). Lactate: Mirror and motor of tumor malignancy. Seminars in Radiation Oncology, 14(3), 267-274. doi: 10.1016/j.semradonc.2004.04.004
Wan, Y. Y., Tian, G. Y., Guo, H. S., Kang, Y. M., Yao, Z. H., Li, X. L., . . . Lin, D. J. (2013). Endostatin, an angiogenesis inhibitor, ameliorates bleomycin-induced pulmonary fibrosis in rats. Respiratory Research, 14(1), 56. doi: 10.1186/1465-9921-14-56
Wang, J. G., Li, N. N., Li, H. N., Cui, L., & Wang, P. (2011). Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. Neuropeptides, 45(2), 151-156. doi: 10.1016/j.npep.2011.01.002
Wang, Q., & Morris, M. E. (2007). The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 35(8), 1393-1399. doi: 10.1124/dmd.107.014852
Wang, Z., Chen, Z., Gao, Y., Li, N., Li, B., Tan, F., . . . He, J. (2011). DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer. Cancer Biology Therapy, 11(5), 490-496. doi: 10.4161/cbt.11.5.14550
Warburg, O. (1956a). On respiratory impairment in cancer cells. Science, 124(3215), 269-270.
Warburg, O. (1956b). On the origin of cancer cells. Science, 123(3191), 309-314.
Warburg, O., Wind, F., & Negelein, E. (1927). The metabolism of tumors in the body. Journal of General Physiology, 8(6), 519-530.
Westerlind, K. C. (2003). Physical activity and cancer prevention--mechanisms. Medicine & Science in Sports & Exercise, 35(11), 1834-1840. doi: 10.1249/01.MSS.0000093619.37805.B7
Woods, J. A., Davis, J. M., Smith, J. A., & Nieman, D. C. (1999). Exercise and cellular innate immune function. Medicine and Science in Sports and Exercise, 31(1), 57-66.
World Heath Organization. (2014, February). Retrieved from http://www.who.int/cancer/en/
Xie, H., Valera, V. A., Merino, M. J., Amato, A. M., Signoretti, S., Linehan, W. M., . . . Seth, P. (2009). LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Molecular Cancer Therapeutics, 8(3), 626-635. doi: 10.1158/1535-7163.MCT-08-1049
Xu, D., & HemLer, M. E. (2005). Metabolic activation-related CD147-CD98 complex. Molecular Cellular Proteomics, 4(8), 1061-1071. doi: 10.1074/mcp.M400207-MCP200
Yang, F. C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., . . . Clapp, D. W. (2008). Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell, 135(3), 437-448. doi: 10.1016/j.cell.2008.08.041
Yamada, M., Suzuki, K., Kudo, S., Totsuka, M., Nakaji, S., & Sugawara, K. (2002). Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation. Journal of Applied Physiology (1985), 92(5), 1789-1794. doi: 10.1152/japplphysiol.00629.2001
Zancan, P., Sola-Penna, M., Furtado, C. M., & Da Silva, D. (2010). Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells. Molecular Genetics and Metabolism, 100(4), 372-378. doi: 10.1016/j.ymgme.2010.04.006
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., . . . Semenza, G. L. (2008). Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. Journal of Biological Chemistry, 283(16), 10892-10903. doi: 10.1074/jbc.M800102200
Zhu, Z., Jiang, W., Zacher, J. H., Neil, E. S., McGinley, J. N., & Thompson, H. J. (2012). Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Cancer Prev Res (Phila), 5(3), 414-422. doi: 10.1158/1940-6207.CAPR-11-0454
Zou, W., Yang, H., Hou, X., Zhang, W., Chen, B., & Xin, X. (2007). Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells. Cancer Letters, 248(2), 211-218. doi: 10.1016/j.canlet.2006.07.005