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研究生: 黃婉茹
Huang Wan-ju
論文名稱: 利用無水氯化鐵以及溴化丙烯基催化硫化物或吲哚進行1,4-加成至αβ共軛不飽和烯類
The iron(Ⅲ)chloride or allyl bromide 1,4-addition of mercaptans or indole to αβ-unsaturated enes
指導教授: 姚清發
Yao, Ching-Fa
學位類別: 碩士
Master
系所名稱: 化學系
Department of Chemistry
論文出版年: 2007
畢業學年度: 95
語文別: 中文
論文頁數: 131
中文關鍵詞: 無水氯化鐵硫化物吲哚溴化丙烯基
英文關鍵詞: iron(Ⅲ)chloride, allyl bromide, mercaptans, indole
論文種類: 學術論文
相關次數: 點閱:136下載:0
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  • 在無溶劑和空氣中,我們用無水鐵 (Ⅲ)來快速催化αβ共軛不飽和酮和硫化物,進行1,4加成。我們發現,當αβ共軛不飽和酮本身反應性越好,或著是立體障礙越小 (如MVK 1a和thiophenol 2a),則在室溫下所需要的時間就會越短;反之 (如trans-4-phenyl-3-butene-2-one 1b),則反應時間拉長,也都獲得高產率的keto-sulfide。相較於其他路易斯酸,無水氯化鐵 (Ⅲ)較容易取得,也更具有活性。

    在50℃下,利用溴化烯丙基 7 (allyl bromide)催化indole與αβ共軛不飽和酮進行1,4加成反應,可得到高產率的keto-indole。如果反應系統是在室溫日照光下的條件,也可獲得高產率的1,4加成產物。
    使用有機催化試劑7,相較於已知使用過渡態金屬路易斯酸,反應後之系統更容易純化,產率更高。

    目錄 頁碼 第一部份 0 中文摘要 1 英文摘要 2 前言 3 目標 11 結果與討論 12 結果 22 實驗部分 儀器設備 23 藥品試劑 24 實驗步驟 25 參考資料 26 光譜資料 29 光譜圖 36 頁碼 第二部份 84 中文摘要 85 英文摘要 86 前言 87 目標 95 結果與討論 96 結論 114 實驗部分 儀器設備 115 藥品試劑 116 實驗步驟 117 參考資料 119 光譜資料 122 光譜圖 131

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