研究生: |
顏長德 |
---|---|
論文名稱: |
低磁場核磁共振應用於奈米磁性粒子之免疫檢測 |
指導教授: |
楊鴻昌
Yang, Shieh-Yueh 洪姮娥 Horng, Herng-Er |
學位類別: |
碩士 Master |
系所名稱: |
光電工程研究所 Graduate Institute of Electro-Optical Engineering |
論文出版年: | 2010 |
畢業學年度: | 98 |
語文別: | 中文 |
論文頁數: | 49 |
中文關鍵詞: | 核磁共振 、免疫檢測 |
英文關鍵詞: | NMR, Immunoassay |
論文種類: | 學術論文 |
相關次數: | 點閱:132 下載:0 |
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本研究我們嘗試用核磁共振原理將均勻分布在水中披覆著生物探針(bioprobe)的奈米磁性粒子與待測生物分子(biotarget),藉由結合後所形成的磁性叢集(magnetic cluster)會使水中氫原子核的橫向鬆弛時間(transverse relaxation time)改變,我們測量磁性叢集之磁共振頻譜訊號推出其線寬、T2與T2*等物理量變化,發展出一種嶄新生物標地物的分析方式。
此外我們利用不同濃度的奈米磁性粒子製作不同的T1樣品,藉此模擬不同組織在我們系統下進行T1權重造影(T1-weighted image)的結果,用以評估將來要對生物組織做核磁共振造影的可行性與改進方向。
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