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研究生: 黃逸群
Huang, Yi-Chiun
論文名稱: 低磁場核磁共振系統及其肝癌檢測應用
High-Tc SQUID based Low-Field NMR system for liver tumor discrimination
指導教授: 楊鴻昌
Yang, Hong-Chang
廖書賢
Liao, Shu-Hsien
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2015
畢業學年度: 103
語文別: 中文
論文頁數: 36
中文關鍵詞: 低磁場核磁共振縱向鬆弛時間肝癌檢測
論文種類: 學術論文
相關次數: 點閱:105下載:0
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  • 過去本實驗室已經成功整合超導量子干涉元件(SQUID, superconducting quantum interference device)和預極化(prepolarization)技術在台大醫院架設低磁場核磁共振系統(Low-field NMR)並運用於腫瘤量測之應用。為了克服臨床檢驗中微量生物樣品量測上的困難,本研究將實驗系統的接收線圈最佳化,藉此提升系統的訊雜比(signal-to-noise ratio,SNR)以降低需要的檢體量。
      在接收線圈的設計上,配合微量的樣品,將接收線圈的體積縮小,並使用不同匝數的接收線圈進行樣品檢測,比較其訊號強度,找出最佳的線圈匝數。此外更比較了梯度計與磁量計樣式的接收線圈,發現在少量樣品的檢測中,磁量計樣式的接收線圈具有較佳的訊雜比。最佳化後的接收線圈在量測0.1毫升的去離子水時SNR可達到18,較原先的系統提高了80 %。在腫瘤檢測的應用中,進行了微量的老鼠腫瘤與正常肝組織之縱向鬆弛時間(T1)之量測,可區別的最少樣品量達0.05克,符合臨床檢測中微量取樣的要求,具有臨床檢驗應用的潛力。

    目錄 第一章 緒論 ………………………………………………………………………1 第二章 實驗原理 ………………………………………………………………3 2-1 核磁共振原理 ………………………………………………………3 2-2 縱向鬆弛與橫向鬆弛 ………………………………………………7 2-3自由水分子 (free water) 與結合水分子 (bound water) …………10 第三章 實驗架構與系統改進 …………………………………………………11 3-1 系統架構介紹 …………………………………………………11 3-2 接收線圈最佳化 ………………………………………………13 3-3 實驗分析方法 …………………………………………………16 3-4 縱向鬆弛時間(T1) 之量測 ………………………………………19 第四章 實驗結果與數據討論 ………………………………………………… 20 4-1 接收線圈匝數最佳化 ………………………………………… 20 4-2 梯度線圈與法拉第線圈SNR之比較 ……………………………22 4-3 不同重量老鼠肝腫瘤與正常肝組織之T1量測 …………………24 第五章 結論 ……………………………………………………………………34 參考文獻 …………………………………………………………………………35

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