研究生: |
黃逸群 Huang, Yi-Chiun |
---|---|
論文名稱: |
低磁場核磁共振系統及其肝癌檢測應用 High-Tc SQUID based Low-Field NMR system for liver tumor discrimination |
指導教授: |
楊鴻昌
Yang, Hong-Chang 廖書賢 Liao, Shu-Hsien |
學位類別: |
碩士 Master |
系所名稱: |
光電工程研究所 Graduate Institute of Electro-Optical Engineering |
論文出版年: | 2015 |
畢業學年度: | 103 |
語文別: | 中文 |
論文頁數: | 36 |
中文關鍵詞: | 低磁場核磁共振 、縱向鬆弛時間 、肝癌檢測 |
論文種類: | 學術論文 |
相關次數: | 點閱:90 下載:0 |
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過去本實驗室已經成功整合超導量子干涉元件(SQUID, superconducting quantum interference device)和預極化(prepolarization)技術在台大醫院架設低磁場核磁共振系統(Low-field NMR)並運用於腫瘤量測之應用。為了克服臨床檢驗中微量生物樣品量測上的困難,本研究將實驗系統的接收線圈最佳化,藉此提升系統的訊雜比(signal-to-noise ratio,SNR)以降低需要的檢體量。
在接收線圈的設計上,配合微量的樣品,將接收線圈的體積縮小,並使用不同匝數的接收線圈進行樣品檢測,比較其訊號強度,找出最佳的線圈匝數。此外更比較了梯度計與磁量計樣式的接收線圈,發現在少量樣品的檢測中,磁量計樣式的接收線圈具有較佳的訊雜比。最佳化後的接收線圈在量測0.1毫升的去離子水時SNR可達到18,較原先的系統提高了80 %。在腫瘤檢測的應用中,進行了微量的老鼠腫瘤與正常肝組織之縱向鬆弛時間(T1)之量測,可區別的最少樣品量達0.05克,符合臨床檢測中微量取樣的要求,具有臨床檢驗應用的潛力。
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