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研究生: 劉育豪
LIU, Yu-Hao
論文名稱: 建立國人n-6及n-3脂肪酸膳食評估運算方法
To develope the dietary calculation method on n-6 and n-3 fatty acids in Taiwan
指導教授: 盧立卿
Lyu, Li-Ching
學位類別: 碩士
Master
系所名稱: 人類發展與家庭學系
Department of Human Development and Family Studies
論文出版年: 2013
畢業學年度: 101
語文別: 中文
論文頁數: 161
中文關鍵詞: n-6脂肪酸n-3脂肪酸24小時飲食回憶飲食頻率問卷每日飲食指南
英文關鍵詞: n-6 fatty acids, n-3 fatty acids, 24-hour dietary recalls, food frequency questionnaires, food guide
論文種類: 學術論文
相關次數: 點閱:238下載:21
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  • 目前國內少有針對膳食n-6及n-3脂肪酸進行探討,而國際間在分析膳食n-6及n-3脂肪酸時,其加總項目並無一定論;在n-6/n-3攝取比值方面,則因臨床數據不充足,建議值的訂定仍需要有更多研究進行探討。本研究目的在建立本土的n-6及n-3脂肪酸食品營養成份資料庫,以及藉由24小時飲食回憶及飲食頻率問卷,了解國人n-6及n-3脂肪酸攝取狀況及飲食型態,同時檢測兩方法之相對效度,並進一步模擬出符合n-6及n-3脂肪酸建議量之飲食型態。
    本研究受試者主要來自民國98年11月至民國99年3月,於臺北市立婦幼醫院招募之孕婦,並於民國101年4月至12月(其新生兒滿2歲時),在詢問婦女後續受訪意願下,同時並進行配偶的招募,共針對36位幼兒父母(父母親各18位)進行研究分析。利用24小時飲食回憶及飲食頻率問卷,收集幼兒父母的整日飲食內容,並運用本研究室研發之運算系統NUFOOD.2進行分析。本研究同時建立n-6及n-3多元不飽和脂肪酸資料庫,以精進n-6及n-3脂肪酸攝取量之估算,資料收集為將運算系統NUFOOD.2內建之733種食物原料,增設8種多元不飽和脂肪酸,並完成數據補遺,其脂肪酸分別為C18:2 n-6、C18:3 n-3、C18:3 n-6、C18:4 n-3、C20:4 n-6、C20:5 n-3、C22:5 n-3、C22:6 n-3。為模擬「達到n-6及n-3脂肪酸建議攝取量之飲食型態」,本研究另利用受試者之24小時飲食回憶資料,進行飲食型態之調整。統計分析以SPSS 20.0進行處理。
    結果發現,在24小時飲食回憶評估方面,成人每日平均熱量攝取為1983 kcal,蛋白質77 g、脂質70 g、醣類260 g,各占總熱量攝取的15.7%、30.9%、53.4%;在n-6及n-3脂肪酸的部分,n-6脂肪酸21614 mg、n-3脂肪酸2544 mg、n-6/n-3比值為8.9。而在飲食頻率問卷評估方面,成人每日平均熱量攝取為2848 kcal,蛋白質109 g、脂質123 g、醣類327 g,各占總熱量攝取的15.1%、38.2%、46.7%;在n-6及n-3脂肪酸的部分,n-6脂肪酸35359 mg、n-3脂肪酸4446 mg、n-6/n-3比值則為8.1。分析本研究受試者n-6及n-3脂肪酸主要食物來源,則發現最主要來自於植物油類、牛肉類、蛋類、豬肉類及魚類。在食物攝取份量及頻率上,植物油類每日平均攝取34.8 g(約6茶匙);牛肉類每日平均攝取16 g(約1/4個掌心大),平均每月攝取1.8次;蛋類每日平均攝取46.7 g(約1個),平均每週攝取3.1次;豬肉類每日平均攝取77.0 g(約1個掌心大),平均每週攝取2.4次;魚類每日平均攝取18.2 g(約1/4個掌心大),平均每週攝取1.9次。針對24小時飲食回憶及飲食頻率問卷,進行兩方法之相對效度分析,結果發現,若以皮爾森積差相關分析,則EPA及DHA呈顯著正相關(p < .01),相關係數分別為.53及.48;若以斯皮爾曼等級相關分析,則是DHA及n-6/n-3攝取比值呈顯著正相關(p < .05),相關係數分別為.45及.37。其次將飲食頻率問卷資料以24小時飲食回憶熱量校正(calibrated FFQ),則發現兩方法之相對效度,除了C18:3 n-6及C18:4 n-3統計上未達顯著以外,其餘脂肪酸皆呈現顯著正相關 (p < .05),相關係數介於.37到.73之間。在飲食型態的部分,若將受試者六大類食物調整成新版每日飲食指南建議份量,並在豆魚肉蛋類替換入12公克(約1/4掌心大)的鯖魚,或是95公克(約一個手掌大)的鱈魚,在油脂類則是替換入1茶匙的芥花油,則必需脂肪酸C18:2 n-6及C18:3 n-3可達到臺灣建議之總熱量4-8%及0.6-1.2%,EPA及DHA總量則可達到日本官方建議之1000 mg,n-6/n-3攝取比值則降至5.1-5.3。
    由結果顯示,飲食頻率問卷所評估之脂肪酸攝取量,相較於24小時飲食回憶,會有部分高估的情況(p < .05)。在受試者的飲食型態發現,必需脂肪酸C18:2 n-6及C18:3 n-3的主要食物來源以植物油居多;而EPA及DHA主要食物來源以魚類居多,此結果與世界衛生組織(2008)的主要食物來源報告內容一致。經過24小時飲食回憶之熱量校正後,更能呈現出飲食頻率問卷的良好相對效度;說明在以飲食頻率問卷進行膳食評估調查時,宜再收集受試者之24小時飲食回憶資料,以協助後續相對效度分析之校正。在模擬「達到n-6及n-3脂肪酸建議攝取量之飲食型態」的部分,將受試者之飲食型態調整成新版每日飲食指南的型式後,僅須再提高富含EPA及DHA魚類的攝取份量,以及增加富含C18:3 n-3植物油的使用份量,即可達到n-6及n-3脂肪酸建議量;而模擬後之n-6/n-3攝取比值約為5,此結果或許可以作為國內實踐n-6及n-3脂肪酸建議攝取量之n-6/n-3建議攝取比值。
    基於適當的n-6及n-3脂肪酸攝取量,能降低心血管疾病的死亡率及發炎相關疾病的嚴重性,針對國人n-3脂肪酸未達建議值的現象,建議提倡民眾提高富含EPA及DHA魚類的攝取份量,並增加富含C18:3 n-3植物油的使用份量,以維護國人的健康。

    Currently, research on dietary n-6 and n-3 fatty acid in Taiwan is scare, and related international studies have not reached a consensus on the analysis of these two types of fatty acids. Furthermore, because clinical data regarding the dietary n-6/n-3 fatty acid ratio are insufficient, the establishment of recommended values requires further research and discussion. The objective of this study was to establish a domestic database on the nutritional composition of foods containing n-6 and n-3 fatty acids and to obtain the dietary patterns and n-6 and n-3 fatty acid intake in the Taiwanese population. Questionnaires that evaluated participant 24-hour dietary recalls and food frequency questionnaires were conducted. In addition, we assessed the relative validity of the two questionnaires and simulated dietary patterns that fulfilled the recommended intakes of n-6 and n-3 fatty acids.
    The participants of the study were pregnant women recruited at the Heping Fuyou branch of Taipei City Hospital, from November 2009 to March 2010. Between April and December 2012 (when the newborns of the participants reached the age of 2 y), the spouses of the participants were also recruited after assessing the participants’ willingness to conduct follow-up interviews. We employed the NUFOOD.2 computational system (researched and developed in our laboratory) to analyze the daily dietary intake of 36 parents (18 fathers and mothers, respectively) that was collected by using 24-hour dietary recalls and food frequency questionnaires (FFQ). In addition, we established a database of n-6 and n-3 polyunsaturated fatty acids to enhance the estimation precision of n-6 and n-3 fatty acid intake. Data were collected to establish 733 types of food ingredients in the NUFOOD.2 system; 8 types of polyunsaturated fatty acids were added (ie, C18:2 n-6, C18:3 n-3, C18:3 n-6, C18:4 n-3, C20:4 n-6, C20:5 n-3, C22:5 n-3, and C22:6 n-3); and missing data were provided. To simulate dietary patterns promoting the recommended intake of n-6 and n-3 fatty acids, we used the 24-hour dietary recall data of the participants to adjust their dietary patterns. Statistical analyses were conducted using SPSS 20.0 software.
    The results of the 24-hour dietary recalls evaluation indicated that the participants’ average daily calorie intake was 1983 kcal; the average intake of protein, fat, and carbohydrates was 77 g, 70 g, and 260 g, respectively, and accounted for 15.7%, 30.9%, and 53.4% of the total calorie intake, respectively; the average intake of n-6 and n-3 fatty acids was 21614 mg and 2544 mg, respectively (the n-6/n-3 ratio was 8.9). The results of the FFQ indicated that participant average daily calorie intake was 2848 kcal; the average intake of protein, fat, and carbohydrates was 109 g, 123 g, and 327 g, respectively, and accounted for 15.1%, 38.2%, and 46.7% of the total calorie intake, respectively; the average intake of n-6 and n-3 fatty acids was 35359 mg and 4446 mg, respectively (the n-6/n-3 ratio was 8.1). Analysis showed that participants’ primary food sources for n-6 and n-3 fatty acids were vegetable oil, beef, eggs, pork, and fish. The average daily intake and frequency of related food sources were as follows: 34.8 g (approximately 6 t.) of vegetable oil; 16 g (approximately 1/4 of a human palm) of beef, 1.8 times per month on average; 46.7 g (approximately 1 serving) of eggs (average of 3.1/wk); 77 g (approximately a human palm) of pork (average of 2.4/wk); and 18.2 g (approximately 1/4 of a human palm) of fish (average of 1.9/wk). Regarding the relative validity of the 24-hour dietary recalls and FFQ, the Pearson product-moment correlation analysis indicated that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) exhibited a positive correlation (p < .01), with respective correlation coefficients of .53 and .48. The Spearman’s rank correlation coefficient analysis showed a positive correlation (p < .05) between DHA and the dietary n-6/n-3 fatty acid ratio, with correlation coefficients of .45 and .37, respectively. The FFQ data were calibrated using the 24-hour dietary recall data; the calorie-adjusted results indicated that the relative validity of the 2 questionnaires exhibited a positive correlation for all fatty acids (p < .05), with correlation coefficients ranging between .37 and .73, whereas C18:3 n-6 and C18:4 n-3 did not achieve statistical significance. For dietary patterns, the recommended intake of C18:2 n-6 and C18:3 n-3 essential fatty acids (respectively accounting for 4-8% and 0.6-1.2% of total calories) for the Taiwanese population can be achieved by adjusting the 6 major food groups of the participants’ diet to the recommended intake based on a new food guide, that is, substituting 12 g (approximately 1/4 of a human palm) of Mackerel or 95 g (approximately a human palm) of codfish into the soybean/fish/meat/eggs group and substituting 1 t. of canola oil into the fats and oil group. In addition, the suggested combined intake (1000 mg) of EPA and DHA based on the official Japanese recommendations can be attained through this adjustment, and the dietary n-6/n-3 fatty acid ratio is reduced to 5.1-5.3.
    The results showed that the fatty acid intake evaluated through the FFQ was partially overestimated compared to the 24-hour dietary recalls (p < .05). Participant dietary patterns indicated that the primary food source of C18:2 n-6 and C18:3 n-3 essential fatty acids was vegetable oil, and the food source for EPA and DHA was fish, which is consistent with the World Health Organization 2008 report on primary food sources. The excellent relative validity of the FFQ was further demonstrated following the 24-hour dietary recall calibration. The concurrent collection of 24-hour dietary recalls data and FFQ during dietary assessment surveys facilitates the calibration of relative validity in subsequent analyses. Regarding the simulation of dietary patterns that promote recommended n-6 and n-3 fatty acid intake, the results show that an increased intake of fish (high in EPA and DHA) and vegetable oil (high in C18:3 n-3) is required after participant dietary patterns were adjusted based on the new food guide model, which provides the recommended intake of n-6 and n-3 fatty acids. After the simulation, the dietary n-6/n-3 fatty acid ratio was found to be approximately 5. This result can possibly be adopted as a recommended n-6/n-3 intake ratio in the domestic implementation of n-6 and n-3 fatty acid suggested intake amounts.
    Since an appropriate n-6 and n-3 fatty acid intake can reduce cardiovascular mortality and severity of inflammation-related diseases, for people n-3 fatty acid intake below the recommended value of the phenomenon, it is recommended to promote public rich in EPA and DHA increased intake of fish, and increase rich in C18:3 n-3 servings of vegetable oils used to protect people's health.

    第一章 緒論 1 第一節 研究動機 1 第二節 研究目的與問題 3 第三節 名詞解釋 4 第二章 文獻探討 5 第一節 n-6/n-3脂肪酸攝取比值的重要性 5 一、n-6及n-3脂肪酸之營養生化功能 5 二、n-6及n-3脂肪酸攝取量與比值的重要性 6 第二節 n-6及n-3脂肪酸之食品營養成份資料庫建立 7 一、建立食品營養成份資料庫 7 二、選用n-6及n-3脂肪酸種類 8 三、資料庫的更新與維護 10 第三節 n-6及n-3脂肪酸建議攝取及食物種類 14 一、n-6及n-3脂肪酸建議攝取量 14 二、n-6/n-3脂肪酸建議攝取比值 15 三、n-6及n-3脂肪酸食物來源 16 第四節n-6及n-3脂肪酸之膳食評估法 17 一、膳食評估法 17 二、n-6及n-3脂肪酸膳食評估法之相對效度研究 18 第三章 研究方法 20 第一節 研究架構 20 第二節 研究設計與實施程序 21 一、研究設計 21 二、實施程序流程圖 22 第三節 研究對象 23 第四節 研究工具 24 一、基本資料問卷 24 二、飲食相關問卷 24 三、追蹤過程登記表 25 四、師大食品營養素資料庫 第二版 25 第五節 資料收集與訪員訓練 27 一、訪員訓練 27 二、資料收集 27 第六節 資料處理 31 一、基本資料問卷 31 二、飲食相關問卷 31 三、營養素完成率 32 四、模擬n-6及n-3脂肪酸建議攝取量之飲食型態 33 第六節 統計分析 34 第四章 研究結果 35 第一節 幼兒父母基本資料分析 35 第二節 營養素攝取狀況 39 一、營養素 41 二、營養素密度 48 第三節 飲食型態與各營養素主要食物來源 52 一、飲食型態 52 二、各營養素主要食物來源 60 第四節 24小時飲食回憶與飲食頻率問卷之相對效度 76 一、營養素相對效度 76 二、營養素密度相對效度 76 三、經由24小時飲食回憶熱量校正之營養素相對效度 76 第五節 飲食n-6及n-3脂肪酸分析 84 一、飲食n-6及n-3脂肪酸分佈性 84 二、模擬n-6及n-3脂肪酸建議攝取量之飲食型態 88 第五章 討論 99 第一節 n-6及n-3脂肪酸攝取狀況 99 一、n-6及n-3脂肪酸攝取量分析 99 二、n-6/n-3攝取比值分析 100 第二節 n-6及n-3脂肪酸之食物攝取狀況 103 一、n-6及n-3脂肪酸之食物攝取份量及頻率分析 103 二、n-6及n-3脂肪酸之主要食物來源分析 103 第三節 24小時飲食回憶與飲食頻率問卷之相對效度 107 一、營養素相對效度分析 107 二、校正熱量後之營養素相對效度分析 109 第四節 模擬n-6及n-3脂肪酸建議攝取量之飲食型態 111 一、比對n-6及n-3脂肪酸攝取現況與建議攝取量 111 二、模擬n-6及n-3脂肪酸建議攝取量之飲食型態 111 第六章 結論 119 一、營養素攝取狀況 119 二、飲食型態與各營養素主要食物來源 119 三、24小時飲食回憶與飲食頻率問卷之相對效度 120 四、飲食n-6及n-3脂肪酸分析 120 第七章 研究限制與建議 122 一、招募受試者 122 二、建立n-6及n-3脂肪酸資料庫 123 三、收集飲食問卷資料 124 四、衛教方面建議 125 參考文獻 127 一、中文部分 127 二、英文部分 129 附錄 133 附錄一 父親研究調查同意書 134 附錄二 母親研究調查同意書 135 附錄三 幼兒研究調查同意書 136 附錄四 父親基本資料問卷 137 附錄五 母親基本資料問卷 138 附錄六 父親24小時飲食回憶問卷 139 附錄七 母親24小時飲食回憶問卷 140 附錄八 父親飲食頻率問卷 141 附錄九 母親飲食頻率問卷 145 附錄十 量化工具使用原則 149 附錄十一 訪員注意事項 150 附錄十二 飲食頻率問卷架構說明 151 附錄十三 父親基本資料問卷編碼 156 附錄十四 母親基本資料問卷編碼 158 附錄十五 各類食物之常用營養教育份數及其單位克數表 160 附錄十六 本資料庫(NUFOOD.2) 中可檢測出C18:4 n-3之食物種類 161

    一、中文部分
    日本厚生勞動省(2010a)。日本人の食事摂取基準。取自http://www.mhlw.go.jp/shingi/2009/05/dl/s0529-4g.pdf
    日本文部科學省(2010b)。五訂增補-日本食品標準成分表-脂肪酸成分表編。取自http://www.mext.go.jp/component/b_menu/shingi/toushin/__icsFiles/afieldfile/2011/07/28/1299320_1.pdf
    行政院衛生署(民86)。食品營養成分資料庫-食品成分表使用說明。取自http://consumer.fda.gov.tw/FoodAnalysis/index.htm
    任倩儀(民90)。家庭親子間飲食與身體活動量之研究(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    行政院衛生署(民99)。1993 - 1996 臺灣國民營養健康狀況變遷調查結果。取自http://consumer.fda.gov.tw/files/Research/1993%20-%201996/01.pdf
    行政院衛生署(民100a)。每日飲食指南。取自http://consumer.fda.gov.tw/Pages/Detail.aspx?nodeID=72&pid=392
    行政院衛生署(民100b)。食品營養成分資料庫-食品營養成分表使用說明。取自http://consumer.fda.gov.tw/Food/TFND.aspx?nodeID=178
    行政院衛生署(民100c)。食品營養成分資料庫簡介。取自http://consumer.fda.gov.tw/Food/TFND.aspx?nodeID=178
    行政院衛生署(民101)。國人膳食營養素參考攝取量及其說明(第七版)。臺北市 : 行政院衛生署食品藥物管理局。
    郭月霞、曾美智、劉金華、黃士懿(民99)。重度憂鬱症患者飲食攝取之初探。臺灣營養學會雜誌,35(1),34-45。
    陳姮霏(民92)。懷孕婦女飲食狀況對新生兒體型影響之前瞻性研究(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    許祐寧(民93)。婦女懷孕三期飲食狀況、膳食評估法與影響新生兒體型之前瞻性研究分析(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    陳葵蓉(民99)。懷孕婦女三期營養攝取及飲食喜好之相關研究(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    黃思華(民88)。大台北地區夫妻飲食及相關因子之探討(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    黃鉅凱(民96)。以飲食頻率問卷評估婦女飲食型態、昇糖指數及昇糖負荷對懷孕結果之研究(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    韩庆、李丽立、黄春红、朱志红、王波(2010)。洞庭湖鲶鱼体表黏液和肌肉营养组成对比分析。食品科学,31(3),97-101。
    褚得敏(民91)。降低飲食脂質攝取對年輕人血脂質與血漿脂肪酸組成的影響(未出版之碩士論文)。臺北醫學大學,臺北市。
    葉乃華(民92)。飲食頻率問卷之建立及其效度研究(未出版之碩士論文)。國立臺灣大學,臺北市。
    趙蓓敏、鄧樹玫(民85)。臺灣常見食用魚類之脂質、脂肪酸組成及膽固醇含量調查。中華民國營養學會雜誌,21(2),147-159。
    翟建富(民97)。現代文明疾病: 現代文明疾病的因應。科學發展,422,12-17。
    廖欣瑩(民100)。以飲食頻率問卷評估婦女孕前至產後飲食型態對其體重變化與懷孕結果之影響(未出版之碩士論文)。國立臺灣師範大學,臺北市。
    蔡滎陽(民81)。臺灣地區豬用飼料與豬屠體衛生安全監控之現況分析(未出版之碩士論文)。國立中興大學,臺中市。
    謝明哲(民99)。實用營養學。臺北市:華杏。
    顏宏達、薛丁瑋、林志勳(民87)。臺灣養豬飼料中電解質平衡之調查。中國畜牧學會會誌,27(4),451-458。
    羅巧珍(民92)。懷孕到產後飲食營養與體重變化之前瞻性研究(未出版之碩士論文)。國立臺灣師範大學,臺北市。

    二、英文部分
    American Heart Association. (2012). Fish 101-AHA recommendation. Retrieved from http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/Fish-101_UCM_305986_Article.jsp#aha_recommendation
    American Heart Association Council on Epidemiology and Prevention. (2013). American heart association guide for improving cardiovascular health at the community level, 2013 update: a scientific statement for public health practitioners, healthcare providers, and health policy makers. Circulation, 127(16), 1730-1753.
    Block, G., Wakimoto, P., Jensen, C., Mandel, S., & Green, R. R. (2006). Validation of a food frequency questionnaire for Hispanics. Prev Chronic Dis, 3(3), A77.
    Blasbalg, T. L., Hibbeln, J. R., Ramsden, C. E., Majchrzak, S. F., & Rawlings, R. R. (2011). Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. American Journal of Clinical Nutrition, 93(5), 950-962.
    Candela, C. G., Lopez, L. M. B., & Kohen, V. L. (2011). Importance of a balanced omega 6/omega 3 ratio for the maintenance of health. Nutritional recommendations. Nutrition Hospitalaria, 26(2), 323-329.
    European Food Safety Authority. (2010). Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. Retrieved from http://www.efsa.europa.eu/en/efsajournal/doc/1461.pdf
    Food and Agriculture Organization of the United Nations and the World Health Organization (1994). Fats and oils in human nutrition report of a joint expert consultation. FAO Food Nutr Pap, 57, i-xix, 1-147.
    Food and Agriculture Organization of the United Nations and the World Health Organization (2008). Fats and fatty acids in human nutrition report of an expert consultation. FAO Food Nutr Pap, 91, i-xvii, 1-166.
    Friesen, R. W., & Innis, S. M. (2009). Dietary arachidonic acid to EPA and DHA balance is increased among Canadian pregnant women with low fish intake. Journal of Nutrition, 139(12), 2344-2350.
    Food Standards Agency (FSA). (2010). McCance & Widdowson’s composition of foods integrated dataset (CoFIDS). Retrieved from http://www.food.gov.uk/multimedia/pdfs/cofuserdoc.pdf
    Goto, C., Tokudome, Y., Imaeda, N., Takekuma, K., Kuriki, K., Igarashi, F.,… Shinkan Tokudome, S. (2006). Validation study of fatty acid consumption assessed with a short food frequency questionnaire against plasma concentration in middle-aged Japanese people. Scandinavian Journal of Food and Nutrition, 50(2), 77-82.
    Haessler, E., Hutson, A., & Langkamp-Henken, B. (1999). Convergent and discriminant validity of a food frequency questionnaire for remote recall of diet during pregnancy. J Am Diet Assoc, 99(9), A32
    Hauner, H., Much, D., Vollhardt, C., Brunner, S., Schmid, D., Sedlmeier, E. M.,...Amann-Gassner, U. (2012). Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. American Journal of Clinical Nutrition, 95(2), 383-394.
    Iribarren, C., Markovitz, J. H., Jacobs, D. R., Schreiner, P. J., Daviglus, M., & Hibbeln, J. R. (2004). Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults - the CARDIA study. European Journal of Clinical Nutrition, 58(1), 24-31.
    International Society for the Study of Fatty Acids and Lipids. (2004). Recommendations for dietary intake of polyunsaturated fatty acids in healthy adults. Retrieved from http://www.issfal.org/news-links/resources/publications/PUFAIntakeReccomdFinalReport.pdf
    Lucas, M., Asselin, G., Merette, C., Poulin, M. J., & Dodin, S. (2009). Validation of an FFQ for evaluation of EPA and DHA intake. Public Health Nutrition, 12(10), 1783-1790.
    Margetts, B. M., & Nelson, M. (1997). Design concepts in nutritional epidemiology, second edition. Oxford, England: Oxford University Press.
    McNaughton, S. A., Hughes, M. C., & Marks, G. C. (2007). Validation of a FFQ to estimate the intake of PUFA using plasma phospholipid fatty acids and weighed foods records. British Journal of Nutrition, 97(3), 561-568.
    Parra, M. S., Schnaas, L., Meydani, M., Perroni, E., Martı´nez, S., & Romieu, I. (2002). Erythocyte cell membrane phospholipid levels compared against reported dietary intakes of polyunsaturated fatty acids in pregnant Mexican women. Public Health Nutrition, 5(6A), 931-937.
    Plourde, M., & Cunnane, S. (2007). Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab, 32(4), 619–634.
    Simopoulos, A. P., Leaf, A., & Salem, N. Jr. (1999). Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann Nutr Metab, 43(2), 127-130.
    Simopoulos, A. P., & Cleland, L. G. (Eds.). (2003). Omega-6/omega-3 essential fatty acid ratio: the scientific evidence [Special issue]. World Review of Nutrition and Dietetics, 92.
    Simopoulos, A. P. (2006). Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomedicine & Pharmacotherapy, 60(9), 502-507.
    Simopoulos, A. P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine, 233(6), 674-688.
    Simopoulos, A. P. (2011). Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Molecular Neurobiology, 44(2), 203-215.
    Sartorelli, D. S., Nishimura, R. Y., Castro, G. S. F., Barbieri, P., & Jordao, A. A. (2012). Validation of a FFQ for estimating omega-3, omega-6 and trans fatty acid intake during pregnancy using mature breast milk and food recalls. European Journal of Clinical Nutrition, 66(11), 1259-1264.
    Thompson, F. E., & Byers, T. (1994). Dietary assessment resource manual. Journal of Nutrition, 124(11), S2245-S2317.
    United States Department of Agriculture. (2010a). Composition of foods raw, processed, prepared USDA national nutrient database for standard reference, Release 25. Retrieved from http://www.ars.usda.gov/SP2UserFiles/Place/12354500/Data/SR25/sr25_doc.pdf
    United States Department of Agriculture. (2010b). Dietary reference intakes: recommended intakes for individuals. Retrieved from http://www.iom.edu/Activities/Nutrition/SummaryDRIs/~/media/Files/Activity%20Files/Nutrition/DRIs/5_Summary%20Table%20Tables%201-4.pdf
    Willett, W. (1998). Nutritional epidemiology, second edition. New York, United States: Oxford University Press.
    Wolmarans, P. (2009). Background paper on global trends in food production, intake and composition. Annals of Nutrition and Metabolism, 55(1-3), 244-272.

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