研究生: |
陳昭樺 CHEN, Chao-Hua |
---|---|
論文名稱: |
微波輔助研究碘介導的溴肉桂醛、苯甲醯氰和醋酸銨的三組分反應 Iodine Mediated Three Components Reaction of Bromocinnamaldehyde, Benzoyl Cyanide and Ammonium Acetate in Microwave |
指導教授: |
姚清發
Yao, Ching-Fa |
口試委員: |
姚清發
Yao, Ching-Fa 林文偉 Lin, Wen-wei 柳如宗 Liu, Ju-Tsung |
口試日期: | 2023/07/21 |
學位類別: |
碩士 Master |
系所名稱: |
化學系 Department of Chemistry |
論文出版年: | 2023 |
畢業學年度: | 111 |
語文別: | 中文 |
論文頁數: | 142 |
中文關鍵詞: | 微波輔助反應 、碘 、(Z)-6-(2-bromo-2-phenylvinyl)-4-hydroxy-2,4-diphenyl-3-azabicyclo [3.1.0] hex-2-ene-1,5-dicarbonitrile |
英文關鍵詞: | microwave-assisted reaction, iodine, (Z)-6-(2-bromo-2-phenylvinyl)-4-hydroxy-2,4-diphenyl-3-azabicyclo [3.1.0] hex-2-ene-1 ,5-dicarbonitrile |
研究方法: | 實驗設計法 |
DOI URL: | http://doi.org/10.6345/NTNU202301274 |
論文種類: | 學術論文 |
相關次數: | 點閱:88 下載:0 |
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論文的前半部為前言,主要是透過查詢過去的文獻,介紹3-azabicyclo[3.1.0]hexane 的衍生物作為藥物的研究價值,以及其他團隊的合成方法,並說明研究動機及目標。
後半部為介紹利用微波反應器在碘的作用下使 (Z)-3-bromo-3-phenylacrylaldehyde、3-oxo-3-phenylpropanenitrile與 Ammonium acetate 形成產物 (Z)-6-(2-bromo-2-phenylvinyl)-4-hydroxy-2,4-diphenyl-3-azabicyclo [3.1.0] hex-2-ene-1,5-dicarbonitrile。以及對 (Z)-3-bromo-3-phenylacrylaldehyde、3-oxo-3-phenylpropanenitrile進行官能基的取代,檢測官能基對反應條件的影響。
The first half of the thesis is the preface, which mainly introduces the research value of 3-azabicyclo[3.1.0]hexane derivatives as drugs and the synthesis methods of other teams through searching past literature, and explains the research motivation and goals.
The second half is to introduce the use of microwave reactors to form (Z)-6-(2-bromo-2 -phenylvinyl)-4-hydroxy-2,4-diphenyl-3-azabicyclo [3.1.0] hex-2-ene-1,5-dicarbonitrile, and for (Z)-3-bromo-3-phenylacrylaldehyde, 3- oxo-3-phenylpropanenitrile was used to replace the functional group, and the tolerance of the reaction conditions to the functional group was tested.
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