研究生: |
范雅雯 Ya-Wen Fan |
---|---|
論文名稱: |
探討薑黃素結合臨床抗癌藥物在人類膀胱癌細胞中之效果及機轉 The effect and molecular action of curcumin in FDA-approved clinical drug-treated human bladder cancer cells |
指導教授: |
蘇純立
Su, Chun-Li |
學位類別: |
碩士 Master |
系所名稱: |
人類發展與家庭學系 Department of Human Development and Family Studies |
論文出版年: | 2014 |
畢業學年度: | 102 |
語文別: | 中文 |
論文頁數: | 104 |
中文關鍵詞: | 人類膀胱癌細胞 、薑黃素 、極光激酶 、細胞凋亡 、細胞自噬 、FDA核准臨床用藥 |
英文關鍵詞: | Human bladder cancer cell, Curcumin, Aurora A, Apoptosis, Autophagy, FDA-approved anti-cancer drugs |
論文種類: | 學術論文 |
相關次數: | 點閱:230 下載:3 |
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膀胱癌是泌尿系統中最常見的腫瘤疾病,可能與環境中砷暴露量較高而導致Aurora A過度表現有關。膀胱癌中發現Aurora A及表皮生長因子(EGF)有過度活化的情形,跟細胞增生有關。FDA核准的臨床藥物以Gemcitabine搭配Cisplatin/Carboplatin是目前傾向使用的化療藥物。希望將臨床藥物搭配薑黃素,藉由抑制Aurora A基因及相關蛋白表現,延緩癌細胞生長。以MTT assay決定各臨床藥物作用在膀胱癌T24細胞的濃度為0.05~0.1 μM Gemcitabine加0.5 μM Cisplatin/ 5 μM Carboplatin。結合薑黃素15 μM計算出CI值皆呈現協同作用。以流式細胞儀分析細胞週期,臨床用藥結合薑黃素增加代表細胞凋亡比例sub-G1 phase,增加代表可能跟抑制Aurora A相關G2/M phase停滯的比例,而且同時會引起細胞自噬作用。以西方墨點法發現薑黃素合併使用臨床藥物,抑制phospho-Aurora A、p62、Beclin-1、phospho-PI3K、phospho-p70s6k、Atg12-Atg5等蛋白表現,增加LC3-II、phospho-mTOR、phospho-AKT、phospho-MEK、phospho-ERK等蛋白表現。綜合以上結果,薑黃素合併臨床用藥能增加膀胱癌T24細胞毒殺效果及增加sub-G1期凋亡比例,增加化療敏感性,且抑制T24細胞Aurora A的活性,經由活化MEK/ERK路徑而促進自噬作用。
Bladder cancer is the ninth most common cancer worldwide and the fourteenth most diagnosed malignancy in Taiwan (2013). Gemcitabine plus cisplatin (GC) treatment is prefered for nowadays treatment. For patients with impaired renal function, gemcitabine plus carboplatin (GCa) treatment is recommended. Overexpressions of Aurora A kinase and epidermal growth factor (EGF) were observed in bladder cancer cells. Our previously data demonstrate that curcumin significantly inhibited Aurora A gene expression, in part caused failure of various mitotic events and G2/M arrest of human bladder cancer cells. In this study, human bladder cancer T24 cells were treated with the existing chemotherapy (GC or GCa) in the presence and absence of curcumin. Addition of curcumin not only produced synergism using combination index analysis, but also raised the percentages of phases in sub-G1 (apoptosis rate) and G2/M using flow cytometry. Combinatio of cucurmin induced autophagy. Decreasing of phospho-Aurora A, p62, Beclin-1, phospho-PI3K, phospho-p70s6k, Atg12-Atg5 and increasing of LC3-II, phospho-mTOR, phospho-AKT, phospho-MEK, phospho-ERK were observed. Taken together, clinical drugs combined with curcumin not only inhibited activity of aurora a, but also promoted apoptosis and autophagy in T24 cells.
Adams, J. M., & Cory, S. (2007). The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 26(9), 1324-1337. doi: 10.1038/sj.onc.1210220
Althouse R, H. J., Tomatis L, Wilbourn J. (1979). Chemicals and industrial processes associated with cancer in humans. lARC monographs, IARC Monogr Eval Carcinog Risk Chem Hum 1–20(Suppl 1):1–71.
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: problems and promises. Mol Pharm, 4(6), 807-818. doi: 10.1021/mp700113r
Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan S. T., Misra K., Priyadarsini I. K., Rajasekharan K. N., Aggarwal, B. B. (2008). Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol, 76(11), 1590-1611. doi: 10.1016/j.bcp.2008.08.008
Andrews, P. D., Knatko, E., Moore, W. J., & Swedlow, J. R. (2003). Mitotic mechanics: the auroras come into view. Curr Opin Cell Biol, 15(6), 672-683.
Babchia, N., Calipel, A., Mouriaux, F., Faussat, A. M., & Mascarelli, F. (2010). The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK. Invest Ophthalmol Vis Sci, 51(1), 421-429. doi: 10.1167/iovs.09-3974
Baehrecke, E. H. (2005). Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol, 6(6), 505-510. doi: 10.1038/nrm1666
Basile, V., Ferrari, E., Lazzari, S., Belluti, S., Pignedoli, F., & Imbriano, C. (2009). Curcumin derivatives: molecular basis of their anti-cancer activity. Biochem Pharmacol, 78(10), 1305-1315. doi: 10.1016/j.bcp.2009.06.105
Bischoff, J. R., & Plowman, G. D. (1999). The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol, 9(11), 454-459.
Bjorkoy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Overvatn, A., Stenmark, H., Johansen, T., Johansen, T. (2005). p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol, 171(4), 603-614. doi: 10.1083/jcb.200507002
Boccardo, F., & Palmeri, L. (2006). Adjuvant chemotherapy of bladder cancer. Ann Oncol, 17 Suppl 5, v129-132. doi: 10.1093/annonc/mdj967
Botrugno, O. A., Robert, T., Vanoli, F., Foiani, M., & Minucci, S. (2012). Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy. Clin Cancer Res, 18(9), 2436-2442. doi: 10.1158/1078-0432.ccr-11-0767
Boya, P., Gonzalez-Polo, R. A., Casares, N., Perfettini, J. L., Dessen, P., Larochette, N., Metivier, D., Meley, D., Souquere, S., Yoshimori. T., Pierron, G., Condogno, P., Kroemer, G. (2005). Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol, 25(3), 1025-1040. doi: Doi 10.1128/Mcb.25.3.1025-1040.2005
Briassouli, P., Chan, F., Savage, K., Reis-Filho, J. S., & Linardopoulos, S. (2007). Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res, 67(4), 1689-1695. doi: 10.1158/0008-5472.can-06-2272
Chan, W. H., & Wu, H. J. (2006). Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Acta Pharmacol Sin, 27(9), 1192-1198. doi: 10.1111/j.1745-7254.2006.00374.x
Cheetham, G. M. T., Knegtel, R. M. A., Coll, J. T., Renwick, S. B., Swenson, L., Weber, P., Lippke, J. A., Austen, D. A. (2002). Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase. Journal of Biological Chemistry, 277(45), 42419-42422. doi: 10.1074/jbc.C200426200
Chen, N., & Karantza-Wadsworth, V. (2009). Role and regulation of autophagy in cancer. Biochim Biophys Acta, 1793(9), 1516-1523. doi: 10.1016/j.bbamcr.2008.12.013S0167-4889(08)00436-9 [pii]
Chen, S. S., Chang, P. C., Cheng, Y. W., Tang, F. M., & Lin, Y. S. (2002). Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. Embo j, 21(17), 4491-4499.
Chendil, D., Ranga, R. S., Meigooni, D., Sathishkumar, S., & Ahmed, M. M. (2004). Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene, 23(8), 1599-1607. doi: 10.1038/sj.onc.1207284
Chou, T. C., & Talalay, P. (1984). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul, 22, 27-55.
Ciuffreda, L., Di Sanza, C., Incani, U. C., & Milella, M. (2010). The mTOR pathway: a new target in cancer therapy. Curr Cancer Drug Targets, 10(5), 484-495.
Colquhoun, A. J., & Mellon, J. K. (2002). Epidermal growth factor receptor and bladder cancer. Postgraduate Medical Journal, 78(924), 584-589. doi: 10.1136/pmj.78.924.584
da Silva, G. N., de Castro Marcondes, J. P., de Camargo, E. A., da Silva Passos Junior, G. A., Sakamoto-Hojo, E. T., & Salvadori, D. M. (2010). Cell cycle arrest and apoptosis in TP53 subtypes of bladder carcinoma cell lines treated with cisplatin and gemcitabine. Exp Biol Med (Maywood), 235(7), 814-824. doi: 10.1258/ebm.2010.009322
DeGregorio, M., Lum, B., Holleran, W., Wilbur, B., & Sikic, B. (1986). Preliminary observations of intraperitoneal carboplatin pharmacokinetics during a phase I study of the Northern California Oncology Group. Cancer Chemotherapy and Pharmacology, 18(3), 235-238. doi: 10.1007/BF00273393
Ferlay J, S. I., Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. (2012). GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Retrieved Available from: http://globocan.iarc.fr, accessed on day/month/year.
Fu, J., Bian, M., Jiang, Q., & Zhang, C. (2007). Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res, 5(1), 1-10. doi: 10.1158/1541-7786.mcr-06-0208
Furukawa, T., Kanai, N., Shiwaku, H. O., Soga, N., Uehara, A., & Horii, A. (2006). AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. Oncogene, 25(35), 4831-4839. doi: 10.1038/sj.onc.1209494
Gandini, S., Botteri, E., Iodice, S., Boniol, M., Lowenfels, A. B., Maisonneuve, P., & Boyle, P. (2008). Tobacco smoking and cancer: a meta-analysis. Int J Cancer, 122(1), 155-164. doi: 10.1002/ijc.23033
Giam, M., Huang, D. C., & Bouillet, P. (2008). BH3-only proteins and their roles in programmed cell death. Oncogene, 27 Suppl 1, S128-136. doi: 10.1038/onc.2009.50onc200950 [pii]
Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2008). Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol, 75(4), 787-809. doi: 10.1016/j.bcp.2007.08.016
Gonzalez-Polo, R. A., Boya, P., Pauleau, A. L., Jalil, A., Larochette, N., Souquere, S., Eskelinen, E. L., Pierron, G., Saftig, P., Kroemer, G. (2005). The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci, 118(14), 3091-3102. doi: Doi 10.1242/Jcs.02447
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2013). Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J, 15(1), 195-218. doi: 10.1208/s12248-012-9432-8
Hall MC, C. S., Dalbagni G, Pruthi RS, Seigne JD, Skinner EC, Wolf JS Jr, Schellhammer PF. (2007). Guideline for the Management of Nonmuscle Invasive Bladder Cancer: (Stages Ta,T1, and Tis): 2007 Update. American Urological Association Education and Research, Inc.
Harada, H., Quearry, B., Ruiz-Vela, A., & Korsmeyer, S. J. (2004). Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A, 101(43), 15313-15317. doi: 10.1073/pnas.0406837101
Hengartner, M. O. (2000). The biochemistry of apoptosis. Nature, 407(6805), 770-776. doi: 10.1038/35037710
Huett, A., Goel, G., & Xavier, R. J. (2010). A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol, 26(4), 302-309. doi: 10.1097/MOG.0b013e32833ae2ed00001574-201007000-00003 [pii]
Hung, L. Y., Tseng, J. T., Lee, Y. C., Xia, W., Wang, Y. N., Wu, M. L., Chuang, Y. H., Lai, C. H., Chang, W. C. (2008). Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res, 36(13), 4337-4351. doi: 10.1093/nar/gkn417
Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008). Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG. Mol Biol Cell, 19(12), 5360-5372. doi: DOI 10.1091/mbc.E08-01-0080
Jagetia, G. C., & Aggarwal, B. B. (2007). "Spicing up" of the immune system by curcumin. J Clin Immunol, 27(1), 19-35. doi: 10.1007/s10875-006-9066-7
Janku, F., McConkey, D. J., Hong, D. S., & Kurzrock, R. (2011). Autophagy as a target for anticancer therapy. Nat Rev Clin Oncol, 8(9), 528-539. doi: 10.1038/nrclinonc.2011.71
Jin, Z. J. (1980). [Addition in drug combination (author's transl)]. Zhongguo Yao Li Xue Bao, 1(2), 70-76.
Kerr, J. F., Wyllie, A. H., & Currie, A. R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 26(4), 239-257.
Komatsu, M., Waguri, S., Koike, M., Sou, Y. S., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K. (2007). Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell, 131(6), 1149-1163. doi: 10.1016/j.cell.2007.10.035
Kondo, Y., Kanzawa, T., Sawaya, R., & Kondo, S. (2005). The role of autophagy in cancer development and response to therapy. Nat Rev Cancer, 5(9), 726-734. doi: 10.1038/nrc1692
Lai, C. H., Tseng, J. T., Lee, Y. C., Chen, Y. J., Lee, J. C., Lin, B. W., Huang, T. C., Liu, Y. W., Leu, T. H., Liu, Y. W., Chen, Y. P., Chang, W. C., Hung, L. Y. (2010). Translational up-regulation of Aurora-A in EGFR-overexpressed cancer. J Cell Mol Med, 14(6b), 1520-1531. doi: 10.1111/j.1582-4934.2009.00919.x
Larsen, K. B., Lamark, T., Overvatn, A., Harneshaug, I., Johansen, T., & Bjorkoy, G. (2010). A reporter cell system to monitor autophagy based on p62/SQSTM1. Autophagy, 6(6), 784-793. doi: 12510 [pii]
Lavrik, I., Golks, A., & Krammer, P. H. (2005). Death receptor signaling. J Cell Sci, 118(Pt 2), 265-267. doi: 10.1242/jcs.01610
Lee, Y. J., Soh, J. W., Jeoung, D. I., Cho, C. K., Jhon, G. J., Lee, S. J., & Lee, Y. S. (2003). PKC epsilon -mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells. Biochim Biophys Acta, 1593(2-3), 219-229. doi: S0167488902003920 [pii]
Li, J., Hou, N., Faried, A., Tsutsumi, S., Takeuchi, T., & Kuwano, H. (2009). Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann Surg Oncol, 16(3), 761-771. doi: 10.1245/s10434-008-0260-0
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999). Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature, 402(6762), 672-676. doi: 10.1038/45257
Lim, J., Kim, H. W., Youdim, M. B., Rhyu, I. J., Choe, K. M., & Oh, Y. J. (2011). Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux. Autophagy, 7(1), 51-60.
Limtrakul, P. (2007). Curcumin as chemosensitizer. Adv Exp Med Biol, 595, 269-300. doi: 10.1007/978-0-387-46401-5_12
Lin, S. S., Huang, H. P., Yang, J. S., Wu, J. Y., Hsia, T. C., Lin, C. C., Lin, C. W., Kuo, C. L., Gibson, Wood, W., Chung, J. G. (2008). DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett, 272(1), 77-90. doi: 10.1016/j.canlet.2008.06.031
Liu, H. S., Ke, C. S., Cheng, H. C., Huang, C. Y., & Su, C. L. (2011). Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Mol Pharmacol, 80(4), 638-646. doi: 10.1124/mol.111.072512
Liu, J., Mao, W., Ding, B., & Liang, C. S. (2008). ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol, 295(5), H1956-1965. doi: 10.1152/ajpheart.00407.2008
Liu, Q., & Ruderman, J. V. (2006). Aurora A, mitotic entry, and spindle bipolarity. Proc Natl Acad Sci U S A, 103(15), 5811-5816. doi: 10.1073/pnas.0601425103
Lockshin, R. A., & Zakeri, Z. (2004). Apoptosis, autophagy, and more. Int J Biochem Cell Biol, 36(12), 2405-2419. doi: 10.1016/j.biocel.2004.04.011
Mancias, J. D., & Kimmelman, A. C. (2011). Targeting autophagy addiction in cancer. Oncotarget, 2(12), 1302-1306.
Martinez-Lopez, N., Athonvarangkul, D., Mishall, P., Sahu, S., & Singh, R. (2013). Autophagy proteins regulate ERK phosphorylation. Nat Commun, 4, 2799. doi: 10.1038/ncomms3799
Mizushima, N., Ohsumi, Y., & Yoshimori, T. (2002). Autophagosome formation in mammalian cells. Cell Struct Funct, 27(6), 421-429.
Mizushima, N., Yoshimori, T., & Levine, B. (2010). Methods in mammalian autophagy research. Cell, 140(3), 313-326. doi: 10.1016/j.cell.2010.01.028S0092-8674(10)00063-2 [pii]
Moll, U. M., Wolff, S., Speidel, D., & Deppert, W. (2005). Transcription-independent pro-apoptotic functions of p53. Curr Opin Cell Biol, 17(6), 631-636. doi: S0955-0674(05)00146-8 [pii]10.1016/j.ceb.2005.09.007
Myeku, N., & Figueiredo-Pereira, M. E. (2011). Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem, 286(25), 22426-22440. doi: 10.1074/jbc.M110.149252
Park, C., Kim, G. Y., Kim, G. D., Choi, B. T., Park, Y. M., & Choi, Y. H. (2006). Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep, 15(5), 1225-1231.
Pattingre, S., Espert, L., Biard-Piechaczyk, M., & Codogno, P. (2008). Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie, 90(2), 313-323. doi: 10.1016/j.biochi.2007.08.014
Pyo, J. O., Jang, M. H., Kwon, Y. K., Lee, H. J., Jun, J. I., Woo, H. N., Cho, D. H., Choi, B., Lee, H., Kim, J. H., Mizushima, N., Oshumi, Y., Jung, Y. K. (2005). Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem, 280(21), 20722-20729. doi: M413934200 [pii]10.1074/jbc.M413934200
Qu, W., Xiao, J., Zhang, H., Chen, Q., Wang, Z., Shi, H., Gong, L., Chen, J., Liu, Y., Cao, R., Lv, J. (2013). B19, a novel monocarbonyl analogue of curcumin, induces human ovarian cancer cell apoptosis via activation of endoplasmic reticulum stress and the autophagy signaling pathway. Int J Biol Sci, 9(8), 766-777. doi: 10.7150/ijbs.5711
Rasul, A., & M, T. (2013). Natural Compounds and Their Role in Autophagic Cell Signaling Pathways. doi: 10.5772/55447
Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z. W., Jimenez-Sanchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C., Menzies, F. M., Moreau, K., Narayanan, U., Renna, M., Siddiqi, F. H., Underwood, B. R., Winslow, A. R., Rubinsztein, D. C. (2010). Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev, 90(4), 1383-1435. doi: 10.1152/physrev.00030.200990/4/1383 [pii]
Reed, J. C. (1997). Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin Hematol, 34(4 Suppl 5), 9-19.
Romero-Hernandez, M. A., Eguia-Aguilar, P., Perezpena-DiazConti, M., Rodriguez-Leviz, A., Sadowinski-Pine, S., Velasco-Rodriguez, L. A., Cáceres-Cortés, J. R., Arenas-Huertero, F. (2013). Toxic effects induced by curcumin in human astrocytoma cell lines. Toxicol Mech Methods, 23(9), 650-659. doi: 10.3109/15376516.2013.826768
Saelens, X., Festjens, N., Vande Walle, L., van Gurp, M., van Loo, G., & Vandenabeele, P. (2004). Toxic proteins released from mitochondria in cell death. Oncogene, 23(16), 2861-2874. doi: 10.1038/sj.onc.12075231207523 [pii]
Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J., Haapasalo, A., Soininen, H., & Hiltunen, M. (2013). Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol, 106-107, 33-54. doi: 10.1016/j.pneurobio.2013.06.002
Scharstuhl, A., Mutsaers, H. A., Pennings, S. W., Russel, F. G., & Wagener, F. A. (2009). Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis. PLoS One, 4(8), e6688. doi: 10.1371/journal.pone.0006688
Sella, A., & Kovel, S. (2012). Combination of gemcitabine and carboplatin in urothelial cancer patients unfit for cisplatin due to impaired renal or cardiac function. Int Braz J Urol, 38(1), 49-56.
Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004). Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol, 6(12), 1221-1228. doi: 10.1038/ncb1192
Shishodia, S., Chaturvedi, M. M., & Aggarwal, B. B. (2007). Role of curcumin in cancer therapy. Curr Probl Cancer, 31(4), 243-305. doi: 10.1016/j.currproblcancer.2007.04.001
Shubassi, G., Robert, T., Vanoli, F., Minucci, S., & Foiani, M. (2012). Acetylation: a novel link between double-strand break repair and autophagy. Cancer Res, 72(6), 1332-1335. doi: 10.1158/0008-5472.can-11-3172
Sikora, E., Bielak-Zmijewska, A., Magalska, A., Piwocka, K., Mosieniak, G., Kalinowska, M., Widlak, P., Cymerman, I. A., Bujnicki, J. M. (2006). Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells. Mol Cancer Ther, 5(4), 927-934. doi: 10.1158/1535-7163.mct-05-0360
Su, C. L., Wang, Y. T., Chang, M. H., Fang, K., & Chen, K. (2013). The Novel Heterocyclic Trioxirane [(1,3,5-Tris Oxiran-2-yl)Methyl)-1,3,5-Triazinane-2,4,6-Trione (TATT)] Exhibits a Better Anticancer Effect than Platinum-Based Chemotherapy by Induction of Apoptosis and Curcumin Further Enhances its Chemosensitivity. Cell Biochem Biophys. doi: 10.1007/s12013-013-9752-z
Tang, D., Wu, D., Hirao, A., Lahti, J. M., Liu, L., Mazza, B., Kidd, V. J., Mak, T. W., Ingram, A. J. (2002). ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem, 277(15), 12710-12717. doi: 10.1074/jbc.M111598200M111598200 [pii]
Tian, B., Wang, Z., Zhao, Y., Wang, D., Li, Y., Ma, L., Li, X., Li, J., Xiao, N., Tian, J., Rodriguez, R. (2008). Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model. Cancer Lett, 264(2), 299-308. doi: 10.1016/j.canlet.2008.01.041
Um, Y., Cho, S., Woo, H. B., Kim, Y. K., Kim, H., Ham, J., Kim, S. N., Ahn, C. M., Lee, S. (2008). Synthesis of curcumin mimics with multidrug resistance reversal activities. Bioorg Med Chem, 16(7), 3608-3615. doi: 10.1016/j.bmc.2008.02.012
van Moorsel, C. J., Kroep, J. R., Pinedo, H. M., Veerman, G., Voorn, D. A., Postmus, P. E., Vermorken, J. B., van Groeningen, C. J., van der Vijgh, W. J., Peters, G. J. (1999). Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors. Ann Oncol, 10(4), 441-448.
von der Maase, H., Hansen, S. W., Roberts, J. T., Dogliotti, L., Oliver, T., Moore, M. J., Bodrogi, I., Albers, P., Knuth, A., Lippert, C. M., Kerbrat, P., Sanchez, Rovira, P., Wersall, P., Cleall, S. P., Roychowdhury, D. F., Tomlin, I., Visseren-Grul, C. M., Conte, P. F. (2000). Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol, 18(17), 3068-3077.
Walczak, H., & Krammer, P. H. (2000). The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res, 256(1), 58-66. doi: 10.1006/excr.2000.4840S0014-4827(00)94840-7 [pii]
Wang, X., Zhou, Y. X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., & Deng, C. X. (2006). Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene, 25(54), 7148-7158. doi: 10.1038/sj.onc.1209707
Warner, S. L., Bearss, D. J., Han, H., & Von Hoff, D. D. (2003). Targeting Aurora-2 kinase in cancer. Mol Cancer Ther, 2(6), 589-595.
Wei, Y., Zou, Z., Becker, N., Anderson, M., Sumpter, R., Xiao, G., Kinch, L., Koduru, P., Christudass, C. S., Veltri, R. W., Grishin, N. V., Peyton, M., Minna, J., Bhagat, G., Levine, B. (2013). EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell, 154(6), 1269-1284. doi: 10.1016/j.cell.2013.08.015
Xiao, K., Jiang, J., Guan, C., Dong, C., Wang, G., Bai, L., Sun, J., Hu, C., Bai, C. (2013). Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells. J Pharmacol Sci, 123(2), 102-109.
Xie, Z., & Klionsky, D. J. (2007). Autophagosome formation: core machinery and adaptations. Nat Cell Biol, 9(10), 1102-1109. doi: 10.1038/ncb1007-1102
Youle, R. J., & Strasser, A. (2008). The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol, 9(1), 47-59. doi: nrm2308 [pii]10.1038/nrm2308
Yousefi, S., Perozzo, R., Schmid, I., Ziemiecki, A., Schaffner, T., Scapozza, L., Brunner, T., Simon, H. U. (2006). Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol, 8(10), 1124-1132. doi: ncb1482 [pii]10.1038/ncb1482
Zapata, J. M., Pawlowski, K., Haas, E., Ware, C. F., Godzik, A., & Reed, J. C. (2001). A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem, 276(26), 24242-24252. doi: 10.1074/jbc.M100354200
Zhang, X., Chen, L. X., Ouyang, L., Cheng, Y., & Liu, B. (2012). Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif, 45(5), 466-476. doi: 10.1111/j.1365-2184.2012.00833.x
Zhou, G. Z., Zhang, S. N., Zhang, L., Sun, G. C., & Chen, X. B. (2014). A synthetic curcumin derivative hydrazinobenzoylcurcumin induces autophagy in A549 lung cancer cells. Pharm Biol, 52(1), 111-116. doi: 10.3109/13880209.2013.816971
Zhu, W., Cowie, A., Wasfy, G. W., Penn, L. Z., Leber, B., & Andrews, D. W. (1996). Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. Embo j, 15(16), 4130-4141.
Zou, Z., Yuan, Z., Zhang, Q., Long, Z., Chen, J., Tang, Z., Zhu, Y., Chen, S., Xu, J., Yan, M., Wang, J., Liu, Q. (2012). Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy, 8(12), 1798-1810. doi: 10.4161/auto.22110
姚欣, 王华庆, & 马腾骧. (2004). 膀胱癌系统化疗临床研究新进展. Chin J Urol, 25(12), 860-863.
許悌, & 郭漢崇. (1990). 膀胱癌的治療趨勢. Tz'u-Chi Med J, 1990(2. NO.4), 323-333.