研究生: |
Cagayan, Gerald Reymari Acoba Cagayan, Gerald Reymari Acoba |
---|---|
論文名稱: |
以奈米光柵耦合表面電漿子共振增強拉曼散射於生醫感測之應用 Nanograting-coupled Surface Plasmon Resonance (SPR)-enhanced Raman Scattering for biosensing applications |
指導教授: |
邱南福
Chiu, Nan-Fu |
口試委員: |
邱南福
Chiu, Nan-Fu 張家禎 Chang, Chia-Chen 陳震宇 Chen, Chen-Yu |
口試日期: | 2024/03/29 |
學位類別: |
碩士 Master |
系所名稱: |
光電工程研究所 Graduate Institute of Electro-Optical Engineering |
論文出版年: | 2024 |
畢業學年度: | 112 |
語文別: | 英文 |
論文頁數: | 73 |
中文關鍵詞: | 表面電漿子共振增 、拉曼散射 、奈米光柵耦合 、生醫感測之 |
英文關鍵詞: | surface plasmon resonance, Raman scattering, grating-coupling, Raman enhancement, biosensing |
DOI URL: | http://doi.org/10.6345/NTNU202400462 |
論文種類: | 學術論文 |
相關次數: | 點閱:155 下載:0 |
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Enormous interest in biosensors has drawn considerable attention among researchers, given its wide applications in clinical treatment, biomedical technology, healthcare, pharmaceuticals, and food science. Specifically, the surface plasmon resonance (SPR) technique has served as a robust biosensor, and its versatile principle makes SPR a widely utilized sensing method extensively employed to study biomolecular interactions, material properties, and chemical processes. In this study, we designed a grating-coupler SPR system integrated into a preconfigured Raman spectrometer system to measure the Raman enhancement on Rhodamine 6G adsorbed on two different structures: linear and circular nanograting. Experiments show that SPR-Raman enhancement is achieved for linear and circular structures by approximately 2.14 × 103 and 2.46 × 103, respectively, when the sample is simultaneously excited by the Raman probe at normal incidence and the SPR system at resonance angle. The propagating SPPs allow the sample to be in an excited state, providing an enhanced evanescent field, which is then coupled with the localized SPPs upon Raman excitation and measurement. These results suggest that SPR can be used to enhance the Raman signal of an analyte and improve detection.
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