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研究生: 黃君秦
Chun-Chin Huang
論文名稱: 下坡跑與離心阻力運動對脂締素及脈波傳導速率之影響
Effect of downhill running and eccentric resistance exercise on pulse wave velocity and adiponectin
指導教授: 王鶴森
Wang, Ho-Seng
林信甫
Lin, Hsin-Fu
學位類別: 碩士
Master
系所名稱: 體育學系
Department of Physical Education
論文出版年: 2012
畢業學年度: 100
語文別: 中文
論文頁數: 47
中文關鍵詞: 心血管疾病動脈硬化肌肉損傷延遲性肌肉酸痛發炎反應
英文關鍵詞: cardiovascular disease, arterial stiffness, muscle damage, delayed onset muscle soreness, inflammatory response
論文種類: 學術論文
相關次數: 點閱:386下載:22
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  • 背景: 近年來心血管疾病的問題與日俱增,脈波傳導速率 (pulse wave velocity, PWV) 及脂締素 (adiponectin) 皆是臨床上用以預測心臟血管疾病的指標,同時脂締素於人體中具有抗發炎及減緩動脈粥狀硬化等作用,然而離心運動所誘發之發炎反應是否會改變脂締素濃度並且影響脈波傳導速率,以及脂締素與 PWV 的關係仍需進一步釐清。目的:探討單次下坡跑與離心阻力運動對脂締素及PWV的影響,以及了解脂締素與 PWV 之相關。方法:招募18名自願參與的健康男性為研究對象,並隨機分派至下坡跑組(EE組;n=9)與離心阻力運動組(RE組;n=9),正式實驗前EE組需在跑步機上進行攝氧峰值 (VO2peak) 測驗;RE組則在斜式腿部推舉機接受下肢最大肌肉力量 (1RM) 測驗。接著讓EE組在跑步機上以75% VO2peak的強度進行一次30分鐘的下坡跑 (-10°) ;RE組則在斜式腿部推舉機上以120% 1RM 強度進行離心阻力運動(每組反覆次數6次,共計10組)。兩組別在運動前、運動後90分鐘、24及48小時檢測 PWV 與血清脂締素、肌酸激酶 (Creatine kinese, CK) 及C反應蛋白 (C-reactive protein, CRP) 濃度。結果:下坡跑與離心阻力運動組之平均CK值於運動後各時間點均顯著高於運動前 (p<.05),同時,平均PWV也於運動後24 (5.47 ± 0.59 m/s) 及48 (5.44 ± 0.68 m/s) 小時顯著高於運動前 (5.18 ± 0.47 m/s) (p<.05),但脂締素及CRP 濃度皆無顯著改變 (p>.05);而 PWV 與脂締素濃度變化量在運動後90分鐘呈顯著負相關 (r= -.501) (p<.05)。兩組別在所有依變項上,於不同時間點均無顯著差異 (p>.05)。結論: 單次下坡跑與離心阻力運動皆會引發肌肉損傷及動脈硬化指標─脈波傳導速率的顯著提升,但不會造成脂締素濃度的改變;因此從事下坡跑與離心阻力運動將可能導致短暫性中心動脈的發炎,而其途徑或許與脂締素無直接關係。

    Background: with the increasing prevalence of cardiovascular disease in modern society, pulse wave velocity (PWV) and adiponectin are both predictive markers for cardiovascular diseases in clinical settings. Adiponectin has been found vessel- protective that could exert anti-inflammatory effects and ameliorate atherosclerosis. However, it is still unknown whether inflammatory responses induced by eccentric exercise would interact with adiponectin as well as PWV. Purpose: to determine the effects of muscle damage induced by acute downhill running and eccentric resistance exercise on adiponectin and PWV as well as the relationship between adiponectin and PWV. Methods: eighteen apparent healthy males were recruited to participate this study. Participants were randomly assigned into downhill running (EE, n=9) and eccentric resistance exercise (RE, n=9) groups. Maximal oxygen uptake (VO2peak= 50.5 ± 7.6 ml/kg/min) of EE and one prepetition maximum of inclined leg press (1RM= 222.4 ± 55.2 kg) were determined prior to experiment. EE group performed 30 minutes of the downhill running at -10° of slope that could elicit 75% of individual VO2peak whereas RE group performed 120% 1RM eccentric contractions for 6 reps × 10 sets. PWV, serum adiponectin, creatine kinese (CK), and C-reactive protein (CRP) were measured pre-exercise, 90 minutes, 24 and 48 hours post-exercise. Results: CK of EE and RE group were significantly higher than the pre-exercise (p<.05); PWV of two groups were also significantly higher on 24 (5.47 ± 0.59 m/s) and 48 hours post-exercise (5.44 ± 0.68 m/s) as compared to pre-exercise (5.18 ± 0.47 m/s) (p<.05) respectively. Compared with pre-exercise, adiponectin and CRP were no altered after performing eccentric exercise (p>.05). However, PWV was negative correlated with adiponectin on 24 hours post-exercise (r= -.501) (p<.05). There were no significant differences among groups in all dependent variables (p>.05). Conclusion: muscle damage induced by an acute bout of downhill running and eccentric resistance exercise both increased PWV, but did not altered adiponectin response. This transient aortic arterial inflammatory may not directly relate to adiponectin.

    中文摘要...................................................i 英文摘要...................................................ii 謝誌.....................................................iii 目次.....................................................iv 後篇部分..................................................vi 表次....................................................vii 圖次...................................................viii 第壹章 緒論 第一節 問題背景.............................................1 第二節 研究目的.............................................2 第三節 研究假設.............................................2 第四節 名詞操作性定義.......................................2 第五節 研究限制.............................................4 第六節 研究的重要性.........................................4 第貳章 文獻探討 第一節 PWV、脂締素其影響因子與動脈硬化之相關研究...............5 第二節 離心運動對 PWV 的影響.................................7 第三節 離心運動與脂締素的關係................................9 第四節 本章總結............................................10 第参章 研究方法與步驟 第一章 受試對象...........................................11 第二章 實驗時間...........................................11 第三章 實驗流程...........................................11 第四章 實驗工具與測驗方法..................................14 第五章 檢測分析...........................................17 第六章 資料處理...........................................20 第肆章 結果 第一節 受試者基本資料 .....................................21 第二節 脈波傳導速率 .......................................22 第三節 脂締素 ............................................23 第四節 脈波傳導速率與脂締素變化量之相關......................24 第五節 血液中 CK、CRP 濃度 ................................25 第六節 肌肉酸痛指數........................................27 第伍章 討論與建議 第一節 血液中 CK、CRP 濃度與肌肉酸痛指數.....................28 第二節 脈波傳導速率........................................29 第三節 脂締素 ............................................30 第四節 脈波傳導速率與脂締素變化量之相關性.....................31 第五節 結論與建議..........................................32 參考文獻 中文文獻...................................................33 英文文獻...................................................33 後篇部分 一 附錄 附錄一 受試者需知 ..........................................39 附錄二 受試者健康問卷調查表 .................................40 附錄三 受試者同意書 ........................................41 附錄四 最大肌肉力量記錄表 ...................................42 附錄五 攝氧峰值記錄表 .......................... ...........43 附錄六 各依變項之原始資料表..................................44 附錄七 不同組別與不同時間點之 PWV 變異數分析摘要...............45 附錄八 不同組別與不同時間點之脂締素變異數分析摘要表............ 45 附錄九 不同組別與不同時間點之 CK 變異數分析摘要表..............45 附錄十 不同組別與不同時間點之 CRP 變異數分析摘要表.............46 附錄十一 不同組別與不同時間點之肌肉酸痛指標變異數分析摘要表......46 表次 表 4-1 受試者基本資料.......................................21 表 4-2 離心運動後 PWV 與脂締素濃度變化量之相關................24 圖次 圖 1-1 脈波傳導速率量測方式..................................3 圖 1-2 單次離心運動與脂締素及脈波傳導速率關係之示意圖............4 圖 3-1 實驗流程圖..........................................13 圖 3-2 實驗處理操作流程圖 ..................................14 圖 3-3 離心阻力運動步驟說明.................................16 圖 3-4 本研究受試者接受離心阻力運動的情形 ....................16 圖 3-5 本研究下坡跑採用跑步機................................17 圖 3-6 本研究受試者接受下坡跑運動的情形.......................17 圖 3-7 本研究受試者接受專業護士採血的情形.....................18 圖 3-8 applanation tonometry 波形偵測器....................19 圖 4-1 下坡跑與離心阻力運動組在不同時間點之脈波傳導速率的變化....22 圖 4-2 下坡跑與離心阻力運動組在不同時間點之脂締素濃度的變化.....23 圖 4-3 下坡跑與離心阻力運動組在不同時間點之 CK 濃度的變化.......25 圖 4-4 下坡跑與離心阻力運動組在不同時間點之 CRP 濃度的變化......26 圖 4-5 下坡跑與離心阻力運動組在不同時間點之肌肉酸痛指數的變化....27

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