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研究生: 邱麗倫
論文名稱: 低磁場下的Fe304-Anti CRP之磁鬆弛研究
The Research of Magnetic Relaxation in Fe304-Anti CRP at Low Magnetic Field
指導教授: 楊鴻昌
Yang, Hong-Chang
洪姮娥
Horng, Herng-Er
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2012
畢業學年度: 100
語文別: 中文
論文頁數: 43
中文關鍵詞: 低磁場
論文種類: 學術論文
相關次數: 點閱:123下載:0
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  • 我們將預先極化技術以及超導量子干涉元件(Superconducting quantum interference device, SQUID)應用於低磁場核磁共振系統上。重新設計預先極化磁場線圈,使得預極化磁場提高到780高斯,10 ml水量的線寬為0.9 Hz,訊雜比為95。在磁性奈米粒子之磁鬆弛量測方面,固定Fe3O4-Anti CRP濃度下,縱向鬆弛時間T1與橫向鬆弛時間T2隨著溫度上升而變長,固定溫度下,縱向鬆弛時間T1與橫向鬆弛時間T2隨著Fe3O4-Anti CRP濃度增加而變短,最後與未標靶之磁流體做比較,Fe3O4-Anti CRP的1/T1與1/T2皆大於純磁流體的1/T1與1/T2。

    第一章 緒論 1 第二章 實驗原理 2 2-1 低磁場之核磁共振介紹 2 2-2 核磁共振原理 3 2-2-1 核磁共振 3 2-1-2 縱向鬆弛與橫向鬆弛 5 2-3 NMR於磁性標記免疫檢測之應用 11 2-4 C-反應蛋白(C-reactive Protein, CRP)簡介 13 第三章 實驗架構 14 3-1 系統架構介紹 14 3-2 預先極化線圈 (Pre-polarization coil) 16 3-3 冷卻水系統 19 第四章 實驗結果與數據討論 20 4-1不同濃度Fe3O4-Anti CRP之T1量測 20 4-1-1 568高斯下之T1量測 20 4-1-2 1高斯下之T1量測 24 4-2不同濃度Fe3O4-Anti CRP之T2量測 27 4-3不同濃度Fe3O4-Anti CRP之線寬變化 33 4-3-1利用柯西-勞倫茲分布特性計算線寬 33 4-3-2 線寬變化之量測 35 4-4 Fe3O4-Anti CRP與純磁流體之T1與T2比較 38 第五章 結論 40 參考文獻 41

    [1]H.C. Yang, S.Y. Yang, G.L. Fang, W.H. Huang, C.H. Liu, S.H. Liao, H.E. Horng, C.Y. Hong, J. Appl. Phys. 99, 124701 (2006)
    [2]K. Enpuku, T. Minotani, T. Gima, Y. Kuroki, Y. Itoh, M. Yamashita, Y. Katakura, S. Kuhara, Jpn. J. Appl. Phys. 38, L1102 (1999)
    [3]C.Y. Hong, C.C. Wu, Y.C. Chiu, S.Y. Yang, H.E. Horng, H.C. Yang, Appl. Phys. Lett. 88, 212512 (2006)
    [4]S. Appelt, A. Ben-Amar Baranga, C.J. Erickson, M.V. Romalis, A.R.Young, W. Happer,” Theory of spin-exchange optical pumping of 3He and 129Xe “, Phys. Rev. A 58, 1412 (1998).
    [5]M. Goldman, H. Jo’hannesson, O. Axelsson, M. Karlsson, “Hyperpolarization of 13C through order transfer from parahydrogen: A new contrast agent for MRI “, Magn.Reson. Imaging 23, 153 (2005)
    [6]G. Navon, Y.-Q. Song, T. Ro˜o˜m, S. Appelt, R.E. Taylor, A. Pines,” Enhancement of Solution NMR and MRI with Laser-Polarized Xenon”, Science 271, 1848 (1996).
    [7]S. Appelt, F.W. Ha‥sing, S. Baer-Lang, N.J. Shah, B. Blümich, “Enhancement of Solution NMR and MRI with Laser-Polarized Xenon”, Chem. Phys. Lett. 348, 263 (2001)
    [8]Shu-Hsien Liao and Herng-Er Horng, Hong-Chang Yang, and Shieh-Yueh Yang, “Longitudinal relaxation time detection using a high-Tc superconductive quantum interference device magnetmeter”,J. Appl. Phys. 102, 033914 (2007).
    [9]M.A. Espy, A.N. Matlachov, P.L. Volegov, J.C. Mosher, and R.H.Kraus Jr., ” SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields”, IEEE Trans.Appl. Supercon. 15, 635 (2005).
    [10]A.H. Trabesinger, R. McDermott, S.K. Lee, M. Mu1ck, J. Clarke, and A. Pines, “ SQUID-Detected Liquid State NMR in Microtesla Fields“, J. Phys. Chem. A 108, 957-963 (2004).
    [11]R. McDermott, S.K. Lee, B. ten Haken, A.H. Trabesinger, A. Pines, and J. Clarke, “Microtesla MRI with a superconducting quantum interference Device”, Proc. Natl. Acad. Sci. USA 101, 7857 (2004).
    [12]M. Mössle, S. Busch, M. Hatridge, W. Myers, A. Pines, and J. Clarke, “SQUID-detected microtesla MRI: a new modality for tumor detection”, paper presented at 2006 Applied Superconductivity conference, Aug. 27-Sept.1, 2006, Seattle, Washington, USA.
    [13]H. C. Seton, D.M. Busell, J.S.M. Hutchison, I. Nicholson, D.J. Lurie, Phys. Med. Biol. 73, 2133 (1992).
    [14]H. C. Seton, J.S.M. Hutchison, D. M. Busell, Meas. Sci. Technol. 8, 198 (1997).
    [15]H. C. Seton, J.S.M. Hutchison, D. M. Busell, IEEE Trans. Appl. Supercon. 7, 3213 (1997).
    [16]Hong-Chang Yang,Shu-Hsien Liao, Herng-Er Horng,Shing-Ling Kuo,Hsin-Hsien Chen, and S. Y. Yang, Appl. Phys. Lett. 88, 252505 (2006)
    [17]S. Kumar, R. Mathews, S. G.. Haupt, D.K. Lathrop, M. Takigawa, J. R. Rozen, S. L. Brown, R. H. Koch, Appl. Phys. Lett. 70, 1037 (1997).
    [18]S. Kumar, W. F. Avrin, B. R. Whitecotton, IEEE Trans. Magn. 32, 5261 (1996).
    [19]K. Schlenga, R. F. McDemott, J. Clarke, R. E. de Souza, A. Wong-Foy, A. Pines, Appl. Phys. Lett. 75, 3695 (1999).
    [20]N. Q. Fan, M. B. Heaney, J. Clarke, D. Newitt, L. L. Wald, E. L. Hahn, A. Bielecki, A. Pines, IEEE Trans. Magn 25, 1193 (1989).
    [21]M. A. Espy, A. N. Matlachov, P. L. Volegov, J. C. Mosher, and R. H. Kraus, Jr. IEEE Trans. Appl. Supercon. 15, 635 (2005).
    [22]M. Burghoff, S. Hartwig, L. Trahms, and J. Bernarding, Appl. Phys. Lett. 87, 054103 (2005)
    [23]M A Bernstein, K F King and X J Zhou. Handbook of MRI Pulse Sequences. Elsevier Academic Press, 960 (2004)
    [24]R. Kötitz, W. Weitschies, L. Trahms, W. Brewer and W. Semmler, J. of Magn. and Magn. Mater., 194 , 65 (1999)
    [25]J. Bauer, J. Chromatography B: Biomedical Sciences and Applications, 722, 55 (1999).
    [26]P.J. Fisher, M.J. Springett, A.B. Dietz, P.A. Bulur, and S. Vuk-Pavlovic, J. Immunological Methods, 262, 95 (2002).
    [27]W.Q. Jiang, H.C. Yang, S.Y. Yang, H.E. Horng, J.C. Hung, Y.C. Chen, and Chin-Yih Hong, J. Magn. Magn. Mater., 283, 210 (2004).
    [28]H.E. Horng, S. Y. Yang, Y. W. Huang, W. Q. Jiang, C.-Y. ong, and H.C. Yang, IEEE Trans. Appl. Supercond., 15, 668 (2005).
    [29]H.E. Horng, Chin-Yih Hong, S.Y. Yang, H.C. Yang, S.H. Liao, C.M. Liu, and C.C. Wu, J. Korean Phys. Soc., 48, 999 (2006)
    [30]Paul M. Ridker,Julie E. Buring,Nancy R.Cook,Nader Rifai., Circulation 107:391-397 (2003)
    [31]Pradhan AD,Manson JE,Rifai N, JAMA 286:327-334 (2001)
    [32]Ridker PM,Hennekens CH,Buring JE, N Engl J Med. 342:836-843 (2000)
    [33]A. Thomas, A. George, R. Wayne Alexander, Jeffry L.Anderson , Circulation 107:499-511 (2003)
    [34]Shu-Hsien Liao, Kai-Wen Huang, Hong-Chang Yang*, Chang-Te Yen, M. J. Chen, Hsin-Hsien Chen, Herng-Er Horng*, and Shieh Yueh Yang, Appl. Phys. Lett. 97, 263701 (2010)
    [35]Chieh-Wen Liu,The Research of Magnetic Relaxation in Fe304-Anti CRP by Using Low-Field NMR System (2011)
    [36]I. Sasada and Y. Nakashim,”Planar coil system consisting of three coil pairs for producing a uniform magnetic field”, J. Appl. Phys. 99, 08D904 (2006)
    [37]http://www.cis.rit.edu/htbooks/mri/
    [38]S. Godefroy, M. Fleury, F. Deflandre, and J.-P. Korb,J. Phys. Chem. B,106 , 11183-11190 (2002)

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