研究生: |
蔡易珊 Tsai, Yi-Shan |
---|---|
論文名稱: |
碳水化合物增補對耐力運動時肌肉激素-irisin及能量代謝指標之效應 Effects of Carbohydrate Supplementation on the Myokine Irisin and Indicators of Energy Metabolism during Endurance Exercise |
指導教授: |
王鶴森
Wang, Ho-Seng |
學位類別: |
碩士 Master |
系所名稱: |
體育學系 Department of Physical Education |
論文出版年: | 2016 |
畢業學年度: | 104 |
語文別: | 中文 |
論文頁數: | 59 |
中文關鍵詞: | 代謝症候群 、非顫抖性產熱 、運動營養 、能量受質 |
英文關鍵詞: | Metabolic Syndrome, non-shivering thermogenesis, sports nutrition, energy substrates |
DOI URL: | https://doi.org/10.6345/NTNU202204845 |
論文種類: | 學術論文 |
相關次數: | 點閱:173 下載:69 |
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背景:Irisin為骨骼肌所分泌之激素,運動能刺激irisin分泌,促使脂肪產生棕化 (browning) 現象,除了運動本身所造成的能量負平衡外,還可能透過irisin之作用得到整體能量代謝上的益處。目的:本研究旨在探討單次長時間耐力運動與碳水化合物增補對irisin的效應,及其與能量代謝指標間之關係。方法:招募12名有運動習慣的男性,以重複量數、平衡次序之設計,進行跑步運動(70% VO2 max 90分鐘+90% VO2 max漸增至衰竭)搭配增補碳水化合物或安慰劑兩種實驗處理,且於運動前分別增補高、低碳水化合物比例之飲食。每次實驗於基準值及隔日(24小時)安靜值時分別進行口服葡萄糖耐受度測驗 (OGTT);運動第20、40、60、80分鐘各增補一次,每次增補每公斤體重2.5毫升、濃度10 % 之碳水化合物溶液,或相同甜度之等量安慰劑溶液。每次實驗共採血六次,分別為基準值、運動前、運動中(第80分鐘)、運動後立即、運動後1小時,及隔日(24小時)安靜值,檢驗血液irisin、葡萄糖、乳酸、胰島素之濃度。另外,實驗過程亦收集呼吸、心跳、自覺量表等數據。結果:碳水化合物增補與安慰劑處理間及各時間點間之irisin濃度無顯著差異 (p > .05);碳水化合物增補與安慰劑處理間及各時間點間之OGTT數值無顯著差異 (p > .05);碳水化合物增補處理之高強度運動至衰竭的時間顯著大於安慰劑處理 (318.58 ± 92.67秒vs. 256.42 ± 116.32秒) (p < .05);碳水化合物增補處理在運動過程中的血糖濃度顯著高於安慰劑處理 (104.17 ± 9.20 mg/dL vs. 83.92 ± 9.54 mg/dL) (p < .05)。結論:單次長時間耐力運動前增補不同碳水化合物比例飲食及運動過程中搭配碳水化合物增補,皆不會改變血液irisin濃度。
Background:Irisin is a novel exercise-induced hormone secreted by skeletal muscle and possibly mediating the positive effects of exercise on metabolism via inducing “browning” of adipose tissue or facilitating glucose metabolism in muscle. Purpose: It aimed to investigate the effects of acute endurance exercise and CHO supplementation on irisin levels. Method: 12 young physically active men were recruited and completed two trials in a randomized, double-blinded and crossover design. Each trial consists of a treadmill run at 70% VO2 max for 90 mins and then increasing speed from 90% VO2 max until exhaustion. Every 20 mins during the run, participants consumed CHO solutions (10%, 2.5ml/kg) or PLA solutions of same amount and sweetness. OGTT tests were conducted with over-night fasting at baseline (and 24 hr later) and followed by a standard meal with high/low CHO%, and then the run 1 hr after meals. Irisin, blood glucose, lactate and insulin levels were measured at baseline, pre-exercise, during exercise (the 80th min of run), immediately after exercise and 24 hrs after baseline. Results:There were no significant differences in irisin levels or OGTT between trials and time points (p > .05);time to exhaustion is higher in CHO trial (318.58 ± 92.67 secs vs. 256.42 ± 116.32 secs) (p < .05);glucose during exercise is higher in CHO trial (104.17 ± 9.20 mg/dL vs. 83.92 ± 9.54 mg/dL) (p < .05)。Conclusion: Meals with high/low CHO% before and CHO ingestion during acute endurance exercise might not affect irisin levels.
Al-Daghri, N. M., Alkharfy, K. M., Rahman, S., Amer, O. E., Vinodson, B., Sabico, S., . . . Chrousos, G. P. (2014). Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects. European Journal of Clinical Investigation, 44(2), 119-124. doi: 10.1111/eci.12196
American Diabetes Association (2012). Diagnosis and classification of diabetes mellitus. Diabetis Care, 36, S67-S74.
Anastasilakis, A. D., Polyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., . . . Mantzoros, C. S. (2014). Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition. Journal of Clinical Endocrinology and Metabolism, 99(9), 3247-3255. doi: 10.1210/jc.2014-1367
Arias-Loste, M. T., Ranchal, I., Romero-Gomez, M., & Crespo, J. (2014). Irisin, a link among fatty liver disease, physical inactivity and insulin resistance. International Journal of Molecular Sciences, 15(12), 23163-23178. doi: 10.3390/ijms151223163
Aydin, S〔Suleyman〕, Aydin, S〔Suna〕, Kuloglu, T., Yilmaz, M., Kalayci, M., Sahin, I., & Cicek, D. (2013). Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running. Peptides, 50C, 13-18. doi: 10.1016/j.peptides.2013.09.011
Bartelt, A., & Heeren, J. (2013). Adipose tissue browning and metabolic health. Nature Reviews Endocrinology ,10(1), 24-36. doi: 10.1038/nrendo.2013.204
Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., . . . Viguerie, N. (2013). Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International Journal of Obesity, 38(5), 707-713. doi: 10.1038/ijo.2013.158
Blüher, S., Panagiotou, G., Petroff, D., Markert, J., Wagner, A., Klemm, T., . . . Mantzoros, C. S. (2014). Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity, 22(7), 1701-1708. doi: 10.1002/oby.20739
Borg, G. (1970). Perceived exertion as an indicator of somatic stress. Scandinavian Journal of Rehabilitation Medicine, 2(2), 92-98.
Boström, P., Wu, J., Jedrychowski, M., Korde, A., Ye, L., Lo, J., . . . Long, J. (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481, 463-468.
Brestoff, J. R., Clippinger, B., Spinella, T., von Duvillard, S. P., Nindl, B. C., & Arciero, P. J. (2009). An acute bout of endurance exercise but not sprint interval exercise enhances insulin sensitivity. Applied Physiology, Nutrition, and Metabolism, 34(1), 25-32. doi: 10.1139/h08-126
Burgess, M. L., Robertson, R. J., Davis, J. M., & Norris, J. M. (1991). RPE, blood glucose, and carbohydrate oxidation during exercise: effects of glucose feedings. Medicine and Science in Sports and Exercise, 23(3), 353-359.
Cannon, B., & Nedergaard, J. (2004). Brown adipose tissue: function and physiological significance. Physiological Reviews, 84(1), 277-359. doi: 10.1152/physrev.00015.2003
Carroll, S., & Dudfield, M. (2004). What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sports Medicine, 34(6), 371-418.
Cermak, N. M., & van Loon, L. J. (2013). The use of carbohydrates during exercise as an ergogenic aid. Sports Medicine, 43(11), 1139-1155. doi: 10.1007/s40279-013-0079-0
Chen, Y. T., Fredericson, M., Matheson, G., & Phillips, E. (2013). Exercise is medicine. Current Physical Medicine and Rehabilitation Reports, 1(1), 48-56. doi: 10.1007/s40141-013-0006-1
Choi, Y. K., Kim, M. K., Bae, K. H., Seo, H. A., Jeong, J. Y., Lee, W. K., . . . Park, K. G. (2013). Serum irisin levels in new-onset type 2 diabetes. Diabetes Research and Clinical Practice, 100(1), 96-101. doi: 10.1016/j.diabres.2013.01.007
Chryssanthopoulos, C., & Williams, C. (1997). Pre-exercise carbohydrate meal and endurance running capacity when carbohydrates are ingested during exercise. International Journal of Sports Medicine, 18(7), 543-548. doi: 10.1055/s-2007-972679
Cluberton, L. J., McGee, S. L., Murphy, R. M., & Hargreaves, M. (2005). Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression. Journal of Applied Physiology, 99(4), 1359-1363. doi: 10.1152/japplphysiol.00197.2005
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., . . . Braun, B. (2010). Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care, 33(12), e147-e167. doi: 10.2337/dc10-9990
Daskalopoulou, S. S., Cooke, A. B., Gomez, Y. H., Mutter, A. F., Filippaios, A., Mesfum, E. T., & Mantzoros, C. S. (2014). Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. European Journal of Endocrinology, 171(3), 343-352. doi: 10.1530/eje-14-0204
Diboll, D. C., Boone, W. T., & Lindsey, L. R. (1999). Cardiovascular and metabolic responses during 30 minutes of treadmill exercise shortly after consuming a small, high-carbohydrate meal. International Journal of Sports Medicine, 20(6), 384-389. doi: 10.1055/s-2007-971149
Dill, D. B., & Costill, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology, 37(2), 247-248.
Duran, I. D., Gulcelik, N. E., Unal, M., Topcuoglu, C., Sezer, S., Tuna, M. M., . . . Guler, S. (2015). Irisin levels in the progression of diabetes in sedentary women. Clinical Biochemistry, 48(18), 1268-1272. doi: 10.1016/j.clinbiochem.2015.07.098
Ebert, T., Focke, D., Petroff, D., Wurst, U., Richter, J., Bachmann, A., . . . Fasshauer, M. (2014). Serum levels of the myokine irisin in relation to metabolic and renal function. European Journal of Endocrinology, 170(4), 501-506. doi: 10.1530/eje-13-1053
Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metabolism, 17(2), 162-184. doi: http://dx.doi.org/10.1016/j.cmet.2012.12.012
Enerbäck, S. (2010). Human brown adipose tissue. Cell Metabolism, 11(4), 248-252. doi: 10.1016/j.cmet.2010.03.008
Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., . . . Giugliano, D. (2002). Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation, 106(16), 2067-2072.
Febbraio, M. A., Chiu, A., Angus, D. J., Arkinstall, M. J., & Hawley, J. A. (2000). Effects of carbohydrate ingestion before and during exercise on glucose kinetics and performance. Journal of Applied Physiology, 89(6), 2220-2226.
Friedrichsen, M., Mortensen, B., Pehmøller, C., Birk, J. B., & Wojtaszewski, J. F. P. (2013). Exercise-induced AMPK activity in skseletal muscle: Role in glucose uptake and insulin sensitivity. Molecular and Cellular Endocrinology, 366(2), 204-214. doi: http://dx.doi.org/10.1016/j.mce.2012.06.013
Gamas, L., Matafome, P., & Seiça, R. (2015). Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk. Journal of Diabetes Research, 2015, 359159. doi: 10.1155/2015/359159
Giralt, M., & Villarroya, F. (2013). White, brown, beige/brite: different adipose cells for different functions? Endocrinology, 154(9), 2992-3000. doi: 10.1210/en.2013-1403
Handschin, C., & Spiegelman, B. M. (2008). The role of exercise and PGC1α in inflammation and chronic disease. Nature, 454(7203), 463-469. doi: 10.1038/nature07206
Harms, M., & Seale, P. (2013). Brown and beige fat: development, function and therapeutic potential. Nature Medicine, 19(10), 1252-1263. doi: 10.1038/nm.3361
Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., . . . Meyer, T. (2013). Irisin and exercise training in humans - results from a randomized controlled training trial. BMC Medicine, 11, 235. doi: 10.1186/1741-7015-11-235
Hofmann, T., Elbelt, U., & Stengel, A. (2014). Irisin as a muscle-derived hormone stimulating thermogenesis - a critical update. Peptides, 54C, 89-100. doi: 10.1016/j.peptides.2014.01.016
Hood, D. A., Irrcher, I., Ljubicic, V., & Joseph, A. M. (2006). Coordination of metabolic plasticity in skeletal muscle. Journal of Experimental Biology, 209(Pt 12), 2265-2275. doi: 10.1242/jeb.02182
Huerta, A. E., Prieto-Hontoria, P. L., Fernandez-Galilea, M., Sainz, N., Cuervo, M., Martinez, J. A., & Moreno-Aliaga, M. J. (2015). Circulating irisin and glucose metabolism in overweight/obese women: effects of alpha-lipoic acid and eicosapentaenoic acid. Journal Physiology Biochemistry, 71(3), 547-558. doi: 10.1007/s13105-015-0400-5
Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014a). Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. International Journal of Obesity, 38(12), 1538-1544. doi: 10.1038/ijo.2014.42
Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., . . . Mantzoros, C. S. (2014b). Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. Journal of Clinical Endocrinology and Metabolism, 99(11), E2154-E2161. doi: 10.1210/jc.2014-1437
Huh, J. Y., Mougios, V., Skraparlis, A., Kabasakalis, A., & Mantzoros, C. S. (2014c). Irisin in response to acute and chronic whole-body vibration exercise in humans. Metabolism, 63(7), 918-921. doi: 10.1016/j.metabol.2014.04.001
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725-1738. doi: 10.1016/j.metabol.2012.09.002
Huh, J. Y., Siopi, A., Mougios, V., Park, K. H., & Mantzoros, C. S. (2014d). Irisin in response to exercise in humans with and without metabolic syndrome. Journal of Clinical Endocrinology and Metabolism, 100(3), E453-E457. doi: 10.1210/jc.2014-2416
Jeukendrup, A. (2014). A step towards personalized sports nutrition: carbohydrate intake during exercise. Sports Medicine, 44(Suppl 1), S25-S33. doi: 10.1007/s40279-014-0148-z
Jeukendrup, A. E., Wagenmakers, A. J., Stegen, J. H., Gijsen, A. P., Brouns, F., & Saris, W. H. (1999). Carbohydrate ingestion can completely suppress endogenous glucose production during exercise. American Journal of Physiology, 276(4 Pt 1), E672-E683.
King, D. S., Baldus, P. J., Sharp, R. L., Kesl, L. D., Feltmeyer, T. L., & Riddle, M. S. (1995). Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. Journal of Applied Physiology, 78(1), 17-22.
Kohara, A., Morishima, T., Uchida, H., Ito, T., & Goto, K. (2014). Carbohydrate gel ingestion immediately before prolonged exercise causes sustained higher glucose concentrations and lower fatigue. International Journal of Sport and Health Science, 12, 24-30. doi: 10.5432/ijshs.201323
Kraemer, R. R., Shockett, P., Webb, N. D., Shah, U., & Castracane, V. D. (2014). A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Hormone and Metabolic Research, 46(2), 150-154. doi: 10.1055/s-0033-1355381
Kuloglu, T., Aydin, S., Eren, M. N., Yilmaz, M., Sahin, İ., Kalayci, M., . . . Aydin, S. (2014). Irisin: A potentially candidate marker for myocardial infarction. Peptides, 55, 85-91. doi: 10.1016/j.peptides.2014.02.008
Kurdiova, T., Balaz, M., Vician, M., Maderova, D., Vlcek, M., Valkovic, L., . . . Ukropcova, B. (2014). Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. Journal of Physiology, 592(Pt 5), 1091-1107. doi: 10.1113/jphysiol.2013.264655
Kuzmicki, M., Telejko, B., Lipinska, D., Pliszka, J., Szamatowicz, M., Wilk, J., . . . Szamatowicz, J. (2014). Serum irisin concentration in women with gestational diabetes. Gynecological Endocrinology, 30(9), 636-639. doi: 10.3109/09513590.2014.920006
Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., . . . Celi, F. S. (2014). Irisin and FGF21 are cold-Induced endocrine activators of brown fat function in humans. Cell Metabolism, 19(2), 302-309. doi: http://dx.doi.org/10.1016/j.cmet.2013.12.017
Li, M., Yang, M., Zhou, X., Fang, X., Hu, W., Zhu, W., . . . Li, L. (2015). Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism, 100(4), 1485-1493. doi: 10.1210/jc.2014-2544
Lin, J., Handschin, C., & Spiegelman, B. M. (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, 1(6), 361-370. doi: 10.1016/j.cmet.2005.05.004
Liu, J. J., Liu, S., Wong, M. D., Tan, C. S., Tavintharan, S., Sum, C. F., & Lim, S. C. (2013). Relationship between circulating irisin, renal function and body composition in type 2 diabetes. Journal of Diabetes and its Complications, 28(2), 208-13. doi: 10.1016/j.jdiacomp.2013.09.011
Liu, T. Y., Shi, C. X., Gao, R., Sun, H. J., Xiong, X. Q., Ding, L., . . . Zhu, G. Q. (2015). Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. Clinical Science, 129(10), 839-850.
Löffler, D., Müller, U., Scheuermann, K., Friebe, D., Gesing, J., Bielitz, J., . . . Körner, A. (2015). Serum irisin levels are regulated by acute strenuous exercise. Journal of Clinical Endocrinology and Metabolism, jc.2014-2932. doi: 10.1210/jc.2014-2932
Lopez-Legarrea, P., de la Iglesia, R., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. A., & Martinez, J. A. (2014). Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects. Nutrition and Diabetes, 4, e110. doi: 10.1038/nutd.2014.7
Manning, P. J., Sutherland, W. H., McGrath, M. M., de Jong, S. A., Walker, R. J., & Williams, M. J. (2008). Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity, 16(9), 2046-2052. doi: 10.1038/oby.2008.334
McConell, G. K., Canny, B. J., Daddo, M. C., Nance, M. J., & Snow, R. J. (2000). Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise. Journal of Applied Physiology, 89(5), 1690-1698.
McConell, G., Snow, R. J., Proietto, J., & Hargreaves, M. (1999). Muscle metabolism during prolonged exercise in humans: influence of carbohydrate availability. Journal of Applied Physiology, 87(3), 1083-1086.
Moreno, M., Moreno-Navarrete, J. M., Serrano, M., Ortega, F., Delgado, E., Sanchez-Ragnarsson, C., . . . Fernández-Real, J. M. (2015). Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. PLoS One, 10(4), e0124100. doi: 10.1371/journal.pone.0124100
Nassif, C., Gomes, A. R., Peixoto, G. H., Chagas, M. H., Soares, D. D., Silami-Garcia, E., . . . Marino, F. E. (2014). The effect of double--blind carbohydrate ingestion during 60 km of self-paced exercise in warm ambient conditions. PLoS One, 9(8), e104710. doi: 10.1371/journal.pone.0104710
Nieman, D. C., Davis, J. M., Henson, D. A., Walberg-Rankin, J., Shute, M., Dumke, C. L., . . . McAnulty, L. S. (2003). Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. Journal of Applied Physiology, 94(5), 1917-1925.
Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., . . . Drevon, C. A. (2013). The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in human. FEBS Journal, 281(3), 739-749. doi: 10.1111/febs.12619
Okano, G., Sato, Y., Takumi, Y., & Sugawara, M. (1996). Effect of 4h preexercise high carbohydrate and high fat meal ingestion on endurance performance and metabolism. International Journal of Sports Medicine, 17(7), 530-534. doi: 10.1055/s-2007-972890
O’Neill, H. M. (2013). AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes and Metabolism Journal, 37(1), 1-21. doi: 10.4093/dmj.2013.37.1.1
Pardo, M., Crujeiras, A. B., Amil, M., Aguera, Z., Jimenez-Murcia, S., Banos, R., . . . Casanueva, F. F. (2014). Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. International Journal of Endocrinology, 2014, 857270. doi: 10.1155/2014/857270
Park, K. H., Zaichenko, L., Peter, P., Davis, C. R., Crowell, J. A., & Mantzoros, C. S. (2013). Diet quality is associated with circulating C-reactive protein but not irisin levels in humans. Metabolism, 63(2), 233-241. doi: 10.1016/j.metabol.2013.10.011
Pedersen, B. K. (2012). A Muscular twist on the fate of fat. New England Journal of Medicine, 366(16), 1544-1545. doi: 10.1056/NEJMcibr1201024
Pedersen, B. K., & Febbraio, M. A. (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457-465.
Pedersen, L., & Hojman, P. (2012). Muscle-to-organ cross talk mediated by myokines. Adipocyte, 1(3), 164-167. doi: 10.4161/adip.20344
Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pollanen, E., . . . Cheng, S. (2013). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? Journal of Physiology, 591(Pt 21), 5393-5400. doi: 10.1113/jphysiol.2013.263707
Qiu, S., Cai, X., Yin, H., Zügel, M., Sun, Z., Steinacker, J. M., & Schumann, U. (2016). Association between circulating irisin and insulin resistance in non-diabetic adults: a meta-analysis. Metabolism, in Press. doi: 10.1016/j.metabol.2016.02.006
Raschke, S., Elsen, M., Gassenhuber, H., Sommerfeld, M., Schwahn, U., Brockmann, B., . . . Eckel, J. (2013). Evidence against a beneficial effect of irisin in humans. PLoS One, 8(9), e73680. doi: 10.1371/journal.pone.0073680
Reinehr, T., Elfers, C., Lass, N., & Roth, C. L. (2015). Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis. Journal of Clinical Endocrinology and Metabolism, 100(5), 2123-2130. doi: 10.1210/jc.2015-1208
Richter, E. A., & Hargreaves, M. (2013). Exercise, GLUT4, and skeletal muscle glucose uptake. Physiological Reviews, 93(3), 993-1017.
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Belen Crujeiras, A., . . . Pardo, M. (2013). FNDC5/irisin is not only a myokine but also an adipokine. PLoS One, 8(4), e60563. doi: 10.1371/journal.pone.0060563
Rollo, I., & Williams, C. (2009). Influence of ingesting a carbohydrate-electrolyte solution before and during a 1-hr running performance test. International Journal of Sport Nutrition and Exercise Metabolism, 19(6), 645-658.
Scaplehorn, N. (2012). Muscle. Cell, 148(4), 629-631. doi: 10.1016/j.cell.2012.02.003
Schlögl, M. C., Piaggi, P., Votruba, S. B., Walter, M., Krakoff, J., & Thearle, M. S. (2015). Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans. Appetite, 90, 154-159. doi: http://dx.doi.org/10.1016/j.appet.2015.03.003
Sharma, N., Castorena, C., & Cartee, G. (2012). Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines. Nutrition and Metabolism, 9(1), 90.
Stellingwerff, T., & Cox, G. R. (2014). Systematic review: Carbohydrate supplementation on exercise performance or capacity of varying durations. Applied Physiology, Nutrition, and Metabolism, 39(9), 998-1011. doi: 10.1139/apnm-2014-0027
Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. F. (2013). Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-correlation with body mass index. Peptides, 39, 125-130. doi: 10.1016/j.peptides.2012.11.014
Swick, A. G., Orena, S., & O'Connor, A. (2013). Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism, 62(8), 1070-1073. doi: 10.1016/j.metabol.2013.02.012
Tanaka, H., Monahan, K. D., & Seals, D. R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37(1), 153-156. doi: http://dx.doi.org/10.1016/S0735-1097(00)01054-8
Temesi, J., Johnson, N. A., Raymond, J., Burdon, C. A., & O’Connor, H. T. (2011). Carbohydrate ingestion during endurance exercise improves performance in adults. The Journal of Nutrition, 141(5), 890-897. doi: 10.3945/jn.110.137075
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012). Is irisin a human exercise gene? Nature, 488(7413), E9-E10.
Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014). High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku Journal of Experimental Medicine, 233(2), 135-140.
Utter, A. C., Kang, J., Robertson, R. J., Nieman, D. C., Chaloupka, E. C., Suminski, R. R., & Piccinni, C. R. (2002). Effect of carbohydrate ingestion on ratings of perceived exertion during a marathon. Medicine and Science in Sports and Exercise, 34(11), 1779-1784. doi: 10.1249/01.mss.0000035055.01069.5c
Vaughan, R. A., Gannon, N. P., Barberena, M. A., Garcia-Smith, R., Bisoffi, M., Mermier, C. M., . . . Trujillo, K. A. (2014). Characterization of the metabolic effects of irisin on skeletal muscle in vitro. Diabetes, Obesity and Metabolism, 16(8), 711-718. doi: 10.1111/dom.12268
Williams, C., Nute, M. G., Broadbank, L., & Vinall, S. (1990). Influence of fluid intake on endurance running performance. A comparison between water, glucose and fructose solutions. European Journal of Applied Physiology and Occupational Physiology, 60(2), 112-119.
Wojtaszewski, J. F., Nielsen, J. N., & Richter, E. A. (2002). Invited review: effect of acute exercise on insulin signaling and action in humans. Journal of Applied Physiology, 93(1), 384-392. doi: 10.1152/japplphysiol.00043.2002
Wolever, T. M. (2000). Dietary carbohydrates and insulin action in humans. British Journal of Nutrition, 83(Suppl 1), S97-S102.
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., . . . Spiegelman, B. M. (2013). Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metabolism, 18(5), 649-659. doi: 10.1016/j.cmet.2013.09.008
Wu, J., Cohen, P., & Spiegelman, B. M. (2013). Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes and Development, 27(3), 234-250. doi: 10.1101/gad.211649.112
Yang, Z., Chen, X., Chen, Y., & Zhao, Q. (2015). Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. International Journal of Clinical and Experimental Pathology, 8(6), 6490-6497.
Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., . . . Segal, E. (2015). Personalized nutrition by prediction of glycemic responses. Cell, 163(5), 1079-1094. doi: 10.1016/j.cell.2015.11.001
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., . . . Tang, D. (2013). Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes, 63(2), 514-525. doi: 10.2337/db13-1106