研究生: |
林懏濝 |
---|---|
論文名稱: |
利用碘催化以及一鍋到底的方法合成具有生物活性的分子片段 |
指導教授: | 姚清發 |
學位類別: |
博士 Doctor |
系所名稱: |
化學系 Department of Chemistry |
論文出版年: | 2006 |
畢業學年度: | 94 |
語文別: | 英文 |
論文頁數: | 364 |
中文關鍵詞: | 催化 、一鍋合成 、碘 |
論文種類: | 學術論文 |
相關次數: | 點閱:172 下載:0 |
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第一部份 中文摘要
在室溫下,利用碘(iodine)催化indole和pyrrol對nitroolefins進行Michael加成進而得到indolyl nitroalkane 5 和 pyrrolyl nitroalkane 7。相較於已知的路易士酸或貴重金屬當催化劑來說,此方法具有反應時間短及高產率的優點。
第二部份 中文摘要
在無溶劑的條件之下,利用碘 (iodine) 及2,4,6-trichloro﹝1,3,5﹞triazine (TCT) 加速醛 (aldehyde) 或酮 (ketone)、苯胺(aniline) 和亞磷酸三乙酯 (triethylphosphite)合成-胺基磷酸鹽類(-amino phosphonate),此反應可在室溫或是60 oC條件下,以一鍋的方式進行反應得到高產率的產物。
第三部份 中文摘要
在室溫下,利用碘(iodine)催化醛、苯胺和acetylcyclohenxene以具有選擇性的特性,一鍋合成trans-endo-decahydroquinolin-4-one;此方法具有易操作、反應時間短、高產率、單一產物已及溫和的反應條件的優點。
第四部份 中文摘要
利用碘(iodine)催化醛和2-hydroxyacetophenone一鍋合成flavanone,此方法具有易操作、高產率、單一產物以及適用於各種官能基的優點。
第五部份 中文摘要
3-Amino chromans的衍生物在神經生物學及藥物學上,扮演極重要的腳色,因此發展有效率的合成方法為當務之急。我們利用salicylaldehyde 1 和nitromethane 經由 Knovenagel 反應路徑,接著走Michael 加成及aldol 的反應機構,在一鍋的條件下,合成出3-amino chromans的衍生物。
part 1 Reference
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