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研究生: 陳厚諭
Chen, Hou-Yu
論文名稱: 不同咖啡因增補劑量對運動誘發肌肉損傷後之肌力表現與肌肉酸痛的影響
Effects of Different Caffeine Dose on Muscle Strength and Muscle Pain Following Eccentric Exercise-Induced Muscle Damage
指導教授: 王鶴森
Wang, Ho-Seng
學位類別: 博士
Doctor
系所名稱: 體育學系
Department of Physical Education
論文出版年: 2015
畢業學年度: 103
語文別: 中文
論文頁數: 91
中文關鍵詞: 最大自主等長肌力肌肉疲勞肌電圖同化性荷爾蒙劑量反應
英文關鍵詞: maximal voluntary isometric contractions, muscle fatigue, electromyography, anabolic hormone, dose-response
論文種類: 學術論文
相關次數: 點閱:240下載:91
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  • 目的︰探討離心運動誘發肌肉損傷 (EIMD) 後,增補不同劑量之咖啡因對肌肉力量(MVIC)、疲勞 (Tlim) 及肌肉酸痛 (DOMS) 的效應。方法:招募45位男性大學持拍類運動員,採雙盲、安慰劑控制及獨立樣本之設計,依前測之肘屈肌MVIC將受試者隨機分派至安慰劑組 (15名;年齡:22.33 ± 2.09歲) 、低劑量組 (15名;4 mg/kg;年齡:22.46 ± 3.11歲) 及高劑量組 (15位;8mg/kg;年齡:22.60 ± 2.09歲) 。所有受試者先以60下最大等速 (90°s-1) 肘屈肌離心收縮誘發肌肉損傷,接著在EIMD後24與48小時連續2天進行增補,並在增補前及增補後各進行1次肌力測試 {包含肘屈肌MVIC、最大肌電圖訊號 (EMGmax) 及肘屈肌Tlim},以評估咖啡因對EIMD所引起之肌力流失的效應,同時在肌力測量後並立即進行DOMS指數的收集。另外,在每次肌力測量前、增補後及運動後採血分析血液生化指標 (鉀離子、鈣離子、肌酸激酶、睪固酮、皮質醇) 。統計方法以體重及增補前各依變項數值為共變數,採混合設計2因子共變數分析。結果:所有指標在組別因子及時間因子之交互作用皆未達顯著 (p >.05) 。在組別因子主要效果中,低劑量組之MVIC (0.66 ± 0.20 Nm/kg) 及EMGmax (1207.87 ± 450.98 μV) 皆顯著優於安慰劑組 (MVIC: 0.64 ± 0.15 Nm/kg;EMG: 1051.23 ± 483.48 μV) 與高劑量組 (MVIC: 0.64 ± 0.21 Nm/kg;EMG: 893.76 ± 399.38 μV) ;安慰劑組之DOMS (63.83 ± 18.69 mm) 分別顯著高於高劑量組 (58.33 ± 24.75 mm) 與低劑量組 (43.33 ± 21.10 mm) (p <.05) ;高劑量組之Tlim (95.03 ± 50.42 秒) 顯著高於安慰劑組 (Tlim: 76.43 ± 16.17 秒) (p <.05) ;高劑量組之鉀離子 (3.69 ± 0.60 mmol/L) 及鈣離子 (10.01 ± 0.27 mg/dL) 濃度顯著高於安慰劑組 (鉀離子:4.24 ± 0.65 mmol/L;鈣離子:9.72 ± 0.19 mg/dL) (p <.05);高劑量組增補後及運動後之T/C ratio (0.025 ± 0.010;0.024 ± 0.015) 顯著低於安慰劑組 (0.034 ± 0.003;0.036 ± 0.010) (p <.05)。結論:每公斤體重4與8毫克的咖啡因增補劑量在EIMD期間對肌力表現恢復及DOMS的減緩並無劑量反應的關係存在。同時低劑量咖啡因增補可有效減緩DOMS並提升運動單位的招募,對促進MVIC的效果較具優勢;高劑量咖啡因則對肌耐力表現Tlim的促進較具優勢,可能原因為增補後Ca++的釋放並減緩血液K+濃度而有利於減緩肌肉疲勞有關。

    Purpose: The current study aimed to evaluate the dose-response effects of different doses of caffeine supplementation on muscle strength (MVIC), muscle fatigue (Tlim), and DOMS after eccentric exercise-induced muscle damage. Methods: With a double-blinded, placebo-controlled independent sample design, the present study recruited 45 male college racket sport athletes. College athletes were randomly assigned into placebo, low-dose, and high-dose groups. Muscle damage was firstly induced by prior elbow flexor maximal isokinetic eccentric contraction in every subject. Next, consecutive caffeine supplementations were administered in by each subject 24 hr and 48 hr after EIMD. To investigate the effects of caffeine on EIMD-induced muscle power depletion, strength tests {i.e., elbow flexor MVIC, maximal electromyography (EMGmax) , and elbow flexor Tlim} were performed before and after each supplementation, followed by data collection on DOMS index. Results: No significant group by time interaction was observed across all indices (p >.05). Regarding the main effects of group factor, MVIC (0.66 ± 0.20 Nm/kg) and EMGmax (1207.87 ± 450.98 μV) in the low-dose group were superior as compared with the placebo (MVIC: 0.64 ± 0.15 Nm/kg;EMG: 1051.23 ± 483.48 μV) and high-dose groups (MVIC: 0.64 ± 0.21 Nm/kg;EMG: 893.76 ± 399.38 μV). DOMS was significantly higher in the placebo (63.83 ± 18.69 mm) group as compared with the high-dose (58.33 ± 24.75 mm) and low-dose groups (43.33 ± 21.10 mm) (p >.05). Tlim in the high-dose group (95.03 ± 50.42 sec) was significantly higher than that in the placebo group (Tlim: 76.43 ± 16.17 sec) (p <.05). Levels of K+ (3.69 ± 0.60 mmol/L) and Ca++ (10.01 ± 0.27 mg/dL) were significantly higher in the high-dose group as compared with placebo group (K+: 4.24 ± 0.65 mmol/L;Ca++: 9.72 ± 0.19 mg/dL) (p <.05). T/C ratios at the post-supplement and post-exercise time points (0.025 ± 0.010;0.024 ± 0.015) were lower in the high-dose group as compared with the placebo group (0.034 ± 0.003;0.036 ± 0.010) (p <.05). Conclusion: There was no dose-response relation between caffeine dosage (i.e., 4g/kg, 8g/kg), muscle strength recovery, and DOMS attenuation. Low dosage of caffeine supplement can attenuate DOMS and facilitate recruitment of motor units, which may thereby benefit MVIC performance. High dosage of caffeine supplement may promote Tlim performance, an indicator of muscular endurance, possibly via the attenuation of muscle fatigue induced by the release of Ca++ and decreased serum K+ levels.

    中文摘要………………………………………………………………………………………i 英文摘要………………………………………………………………………………………ii 目次…………………………………………………………………………………………iii 圖次……………………………………………………………………………………………vi 表次…………………………………………………………………………………………vii 第壹章 緒論……………………………………………………………………1 第一節 研究背景………………………………………………………………………1 第二節 研究目的………………………………………………………………………5 第三節 研究假設………………………………………………………………………5 第四節 名詞操作性定義………………………………………………………………5 第五節 研究範圍與限制………………………………………………………………6 第六節 研究之重要性…………………………………………………………………6 第貳章 文獻探討………………………………………………………………7 第一節 DOMS簡介……………………………………………………………………7 第二節 咖啡因與無氧肌肉適能……………………………………………………… 9 第三節 咖啡因增補減緩運動中肌肉酸痛機制………………………………………13 第四節 咖啡因增補對肌肉酸痛與運動表現的文獻評述……………………………16 第五節 離心運動對睪固酮及皮質醇之影響…………………………………………17 第六節 本章總結………………………………………………………………………18 第參章 研究方法與步驟…………………………………………………… 20 第一節 研究對象………………………………………………………………………20 第二節 實驗時間與地點………………………………………………………………21 第三節 實驗方法與步驟………………………………………………………………21 第四節 資料處理………………………………………………………………………29 第肆章 結果…………………………………………………………………30 第一節 受試者基本資料………………………………………………………………30 第二節EIMD前、後對肌力表現、DOMS指數、肌肉發炎損傷及肌肉代謝 的影響…………………………………………………………………………31 第三節 EIMD期間增補不同咖啡因劑量後對肌力表現及DOMS指數的影響……35 第四節 EIMD期間不同咖啡因增補劑量對運動後血液生化指標的影響…………41 第五節 EIMD期間增補不同咖啡因劑量後對肌肉發炎損傷的影響………………44 第六節 EIMD期間不同咖啡因增補劑量對肌肉代謝的影響………………………46 第七節 不同咖啡因增補劑量在EIMD前及EIMD期間之肌力表現、肌肉酸痛及肌 肉損傷的反應…………………………………………………………………47 第伍章 討論…………………………………………………………………51 第一節、EIMD前、後之肌力表現、DOMS指數、肌肉發炎損傷及肌肉代謝的變化 ………………………………………………………………………………51 第二節 EIMD期間增補不同咖啡因劑量後對肌力表現、DOMS指數及肌肉損傷的 影響……………………………………………………………………………52 第三節 EIMD期間不同咖啡因增補劑量對運動後血液生化指標的影響…………55 第四節 EIMD期間不同咖啡因增補劑量對肌肉代謝反應的影響…………………56 第五節 結論與建議……………………………………………………………………58 參考文獻………………………………………………………………………59 附錄1 受試者知情同意書…………………………………………………………………67 附錄2 健康情況調查表……………………………………………………………………71 附錄3 咖啡因副作用紀錄表………………………………………………………………72 附錄4 咖啡因食/飲品成分表………………………………………………………………73 附錄5 每日飲食紀錄表……………………………………………………………………76 附錄6 肌肉酸痛量尺……………………………………………………………………77 附錄 7 不同劑量組別在EIMD前、後對MVIC影響之變異數分析摘要表……………78 附錄 8 不同劑量組別在EIMD前、後對RFD影響之變異數分析摘要表 ………………78 附錄 9不同劑量組別在EIMD前、後對Tlim影響之變異數分析摘要表…………79 附錄10不同劑量組別在EIMD前、後對MVICpost影響之變異數分析摘要表…………79 附錄11不同劑量組別在EIMD前、後對FI%影響之變異數分析摘要表………………80 附錄12不同劑量組別在EIMD前、後對RPE影響之變異數分析摘要表………………80 附錄13不同劑量組別在EIMD前、後對DOMS指數影響之變異數分析摘要表………81 附錄14不同劑量組別在EIMD前、後對CK活性影響之變異數分析摘要表…………81 附錄15不同劑量組別在EIMD前、後對Mb活性影響之變異數分析摘要表…………82 附錄16不同劑量組別在EIMD前、後對T/C ratio影響之變異數分析摘要表…………82 附錄17 EIMD期間增補不同咖啡因劑量後對MVIC影響之變異數分析摘要表………83 附錄18 EIMD期間增補不同咖啡因劑量後對EMGmax影響之變異數分析摘要表……83 附錄19 EIMD期間增補不同咖啡因劑量後對DOMS指數影響之變異數分析摘要表…84 附錄20 EIMD期間增補不同咖啡因劑量後對RFD影響之變異數分析摘要表…………84 附錄21 EIMD期間增補不同咖啡因劑量後對Tlim影響之變異數分析摘要表…………85 附錄22 EIMD期間增補不同咖啡因劑量後對MVICpost影響之變異數分析摘要表……85 附錄23 EIMD期間增補不同咖啡因劑量後對FI% 影響之變異數分析摘要表………86 附錄24 EIMD期間增補不同咖啡因劑量後對RPE影響之變異數分析摘要表………86 附錄25 EIMD期間不同咖啡因增補劑量對運動後血糖濃度影響之變異數分析摘要表87 附錄26 EIMD期間不同咖啡因增補劑量對運動後血乳酸濃度影響之變異數分析摘要87 附錄27 EIMD期間不同咖啡因增補劑量對運動後Ca++ 濃度影響之變異數分析摘要表88 附錄28 EIMD期間不同咖啡因增補劑量對運動後K+ 濃度影響之變異數分析摘要表…88 附錄29 EIMD期間增補不同咖啡因劑量後對CK活性影響之變異數分析摘要表……89 附錄30 EIMD期間增補不同咖啡因劑量後對Mb 活性影響之變異數分析摘要表……89 附錄31 EIMD期間增補不同咖啡因劑量後對T/C ratio 濃度影響之變異數分析摘要表90 個人小傳………………………………………………………………………91 圖次 圖1 咖啡因減緩痛覺的機制示意圖………………………………………………………15 圖2 實驗流程圖……………………………………………………………………………22 圖3 Biodex system 4 Pro肌力測試儀………………………………………………………24 圖4 肌力指標測量程序……………………………………………………………………25 圖5 肱二頭肌電採集位置…………………………………………………………………26 圖6 電極片黏貼固定示意圖………………………………………………………………26 圖7 EIMD期間增補不同劑量咖啡因後對MVIC的影響…………………………………37 圖8 EIMD期間增補不同劑量咖啡因後對EMGmax的影響………………………………37 圖9 EIMD期間增補不同劑量咖啡因後對RFD的影響…………………………………38 圖10 EIMD期間增補不同劑量咖啡因後對DOMS指數的影響…………………………38 圖11 EIMD期間增補不同劑量咖啡因後對Tlim的影響……………………………………39 圖12EIMD期間增補不同劑量咖啡因後對RPE的影響…………………………………39 圖13 EIMD期間增補不同劑量咖啡因後對MVICpost的影響……………………………40 圖14 EIMD期間增補不同劑量咖啡因後對FI%的影響…………………………………40 圖15 EIMD期間不同咖啡因增補劑量對運動後Ca++的影響……………………………43 圖16 EIMD期間不同咖啡因增補劑量對運動後K+的影響………………………………43 圖17 EIMD期間增補不同咖啡因增補劑量對T/C ratio的影響…………………………46 圖18不同咖啡因增補劑量組別在EIMD前及EIMD期間之MVIC的反應………………47 圖19不同咖啡因增補劑量組別在EIMD前及EIMD期間之EMGmax的反應……………48 圖20不同咖啡因增補劑量組別在EIMD前及EIMD期間之RFD的反應………………48 圖21不同咖啡因增補劑量組別在EIMD前及EIMD期間之Tlim的反應…………………49 圖22不同咖啡因增補劑量組別在EIMD前及EIMD期間之DOMS的反應……………49 圖23不同咖啡因增補劑量組別在EIMD前及EIMD期間之CK的反應…………………50 圖24不同咖啡因增補劑量組別在EIMD前及EIMD期間之Mb的反應…………………50 表次 表1 咖啡因攝取對等長肌力及肌肉疲勞測試表現之相關文獻………………………… 11 表2 腺苷酸接受器的類型與功能………………………………………………………… 14 表3 咖啡因增補對有或無EIMD條件下之肌肉酸痛的相關研究………………………17 表4 受試者基本資料………………………………………………………………………30 表5 不同組別在EIMD前、後對肌力表現及DOMS指數的影響………………………32 表6 不同組別在EIMD前、後對肌肉損傷及肌肉代謝的影響………………………34 表7 EIMD期間增補不同咖啡因劑量後對肌力表現及DOMS指數的影響……………36 表8 EIMD期間不同咖啡因劑量對運動後血液生化指標的影響………………………42 表9 EIMD期間增補不同咖啡因劑量後對肌肉損傷指標的影響………………………45

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