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研究生: 郭念芸
Kuo, Nien-Yun
論文名稱: 飛秒脈衝雷射技術在牙周病診斷及植入醫材表面改質之應用研究
Application of Femtosecond Pulsed Laser Technology in Periodontal Disease Diagnosis and Surface Modification of Medical Implants
指導教授: 張天立
Chang, Tien-Li
口試委員: 張天立
Chang, Tien-Li
李青澔
Li, Ching-Hao
王建評
Wang, Chien-Ping
劉正哲
Liu, Chen-Che
口試日期: 2024/07/17
學位類別: 碩士
Master
系所名稱: 機電工程學系
Department of Mechatronic Engineering
論文出版年: 2024
畢業學年度: 112
語文別: 中文
論文頁數: 90
中文關鍵詞: 飛秒雷射Ti6Al4V抗菌元件細菌檢測元件金奈米粒子
英文關鍵詞: Femtosecond laser, Ti6Al4V, Antibacterial component, Bacterial detection component, Gold nanoparticles
研究方法: 實驗設計法
DOI URL: http://doi.org/10.6345/NTNU202401736
論文種類: 學術論文
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  • 摘要 i Abstract ii 致謝 iv 目錄 vi 表目錄 ix 圖目錄 x 第一章 緒論 1 1.1 飛秒雷射簡介 1 1.2 研究動機與目的 1 1.3 鈦合金於生醫應用 2 1.4 水滴接觸角 4 1.4.1 Wenzel 模型 5 1.4.2 Cassie-Baxter 模型 5 1.5 核酸雜合反應(Hybridization) 6 1.6 雷射誘導石墨烯(Laser induced graphene) 7 1.7 三電極系統檢測原理(Thouree-electrode system) 9 第二章 文獻回顧 11 2.1 飛秒雷射製程介紹 11 2.1.1 飛秒雷射的製程 11 2.1.2 飛秒雷射製程之應用 20 2.2 Ti6Al4V材料特性 25 2.2.1 Ti6Al4V材料於植牙之應用 25 2.2.2 Ti6Al4V 製成微結構之親疏水變化 27 2.2.3 Ti6Al4V親疏水表面對抗菌度之影響 32 2.3 雷射誘導石墨烯介紹 36 2.3.1 雷射誘導石墨烯(Laser Induced Graphene, LIG)應用 36 2.3.2 生物感測器原理 38 2.3.3 聚醯亞胺(Polyimide, PI)雷射還原石墨烯(LIG)之生物感測器應用 39 第三章 研究方法與設計 44 3.1 實驗設計 44 3.2 飛秒脈衝雷射製程 46 3.2.1 雷射剝離閾值 48 3.3 Ti6Al4V雷射製程抗菌元件設計 49 3.3.1 微結構對親疏水影響 50 3.4 Pg菌檢測元件設計 52 3.5 抗菌元件之Pg菌製備 53 3.5.1 Ti6Al4V上的Pg菌培養 54 3.5.2 PI檢測元件的Pg菌檢測 55 3.5.3 元件電性檢測Pg 56 3.6 實驗與量測設備 57 第四章 結果與討論 58 4.1 飛秒雷射對Ti6Al4V雷射製成陣列微結構 58 4.1.1 雷射之剝離閾值 58 4.1.2 雷射製程後之熱影響 59 4.1.3 陣列微結構之表面形貌與材料分析 60 4.1.4 粗糙度與潤濕性變化 66 4.2 飛秒雷射對PI雷射誘導誘導石墨烯(LIG) 71 4.2.1 PI雷射之閾值 72 4.2.2 LIG之表面形貌與材料分析 73 4.2.4 LIG表面電極修飾金奈米粒子(AuNPs) 74 4.3 Pg菌診斷元件 75 4.3.1 潤濕性對抗菌程度之影響 76 4.3.2 Pg菌之檢測元件電性變化 80 第五章 結論與未來展望 83 5.1 結論 83 5.2 未來展望 84 參考文獻 86

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