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研究生: 蘇琬婷
Su, Wan-Ting
論文名稱: 樹豆及其活性成分對於大鼠子宮收縮之影響
The effects of Cajanus cajan (L) Millsp. and its bioactive constituents on rat uterine contractions
指導教授: 吳啟豪
Wu, Chi-Hao
學位類別: 碩士
Master
系所名稱: 人類發展與家庭學系
Department of Human Development and Family Studies
論文出版年: 2018
畢業學年度: 106
語文別: 中文
論文頁數: 132
中文關鍵詞: 原發性經痛樹豆前列腺素F2α
英文關鍵詞: Dysmenorrhea, Cajanus cajan (L) Millsp., Prostaglandin F2α
DOI URL: http://doi.org/10.6345/THE.NTNU.DHDFS.035.2018.A06
論文種類: 學術論文
相關次數: 點閱:183下載:1
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  • 原發性經痛 (primary dysmenorrhea)為子宮內膜分泌過多前列腺素F2α (prostaglandin F2α,PGF2α),刺激子宮平滑肌過度收縮而造成組織缺血所致。本研究選取臺灣原住民農作物樹豆 (Cajanus cajan (L) Millsp.)為試驗樣品,首先以不同比例之水及乙醇之溶劑進行萃取,探討上述各萃取物對於PGF2α誘導Sprague Dawley大鼠子宮平滑肌之收縮是否具緩解效果。鼠體子宮平滑肌收縮以八頻道偵測器搭配離體組織灌流裝置進行測定,同時以H&E Stain進行組織染色與病理判讀;進一步利用催產素誘導ICR小鼠扭體試驗探究樣品的陣痛效果。實驗結果顯示,樹豆及樹豆根之樣品以樹豆根50%乙醇萃取物 (CRE)表現36.8%之最佳抑制效果。進一步探討其次區分物活性。結果顯示,CRE之次區分物 : 95%乙醇萃取樹豆根 (CRE-E95)可顯著降低PGF2α、oxytocin、carbachol及acetylcholine所誘導之子宮收縮,亦能顯著抑制KCl所誘導之子宮強直性收縮,與Bay K8644 (L型鈣離子通道活化劑)所誘導的子宮收縮。組織病理學檢查顯示,與催產素組相比,利用CRE預處理可顯著降低子宮平滑肌收縮。綜上所述,樹豆根可能具有緩解女性經痛之潛力。

    Primary dysmenorrhea is a symptom causes by excessive levels of prostaglandin F2α (PGF2α) secreted by endometrium, which leads smooth muscle of uterine over contraction and insufficient blood flow to cause ischemia and pain. This study aimed to investigate the modulatory effects of Taiwan aboriginal crop: Cajanus cajan (L) Millsp. on uterine contraction and its possible underlying mechanisms. First, we extracted Cajanus cajan (L) Millsp. with different proportions of water and ethanol to investigate which proportion has the better effect of relieving uterine smooth muscle contraction induced by PGF2α in Sprague Dawley rats. Rat uterine smooth muscle contraction was detected with 8-Channel multi-valve perfusion system. At the same time, H&E stain was used for tissue staining and pathological interpretation. Furthermore, in order to investigate the effect of extracts on pain relieving, we used oxytocin to induced ICR mice uterine contraction as the model. The results showed that 50% ethanol extraction of Cajanus cajan (L) Millsp. root (CRE) had the best inhibition (36.8%) of uterine smooth muscle contraction effect. Further, we found out that the activity of the secondary partition, 95% ethanol extraction of Cajanus cajan (L) Millsp. root (CRE-E95) significantly reduced uterine contraction induced by PGF2α, oxytocin, carbachol and acetylcholine, and also significantly inhibited KCl and BayK8644 (L-type calcium channel activator) induced uterine tonic contraction and uterine excessive contraction. Histopathological examination showed pretreatment with CRE can significantly decrease uterine smooth muscle contractions when compared with the oxytocin group. In conclusion, Cajanus cajan (L) Millsp. root may have the impact on improved primary dysmenorrhea.

    摘要 i Abstract ii 目錄 iv 圖目錄 viii 表目錄 x 第一章 緒論 1 第一節 月經 1 一、 性軸線 1 二、 月經週期 2 第二節 經痛 (dysmenorrhea) 6 一、 經痛介紹 6 二、 經痛的分類 6 三、 經痛的症狀 9 四、 經痛的盛行率 11 五、 經痛的病因學 12 六、 經痛的病理生理學 14 七、 前列腺素 (prostaglandins) 16 八、 經痛與PGF2α的關係 21 第三節 子宮平滑肌收縮機轉 24 一、 鈣離子調節路徑 24 二、 非鈣離子調節路徑 26 第四節 臨床處理 30 一、 藥物治療: 可分成西藥治療及中藥治療 30 二、 非藥物治療 39 三、 外科手術 40 第五節 食物緩解經痛的相關研究 41 第六節 樹豆 (Cajanus cajan (L) Millsp.) 45 一、 樹豆介紹 45 二、 樹豆的機能性成分與生理活性 53 第二章 研究目的 58 第三章 實驗架構 60 第四章 材料與方法 61 第一節 實驗動物與飼料 61 第二節 實驗藥品與試劑 62 第三節 儀器與實驗耗材 65 第四節 實驗方法 69 一、 子宮平滑肌組織收縮測定 69 二、 病理組織切片觀察 (H&E stain) 75 三、 催產素誘導ICR小鼠經痛模式 80 四、 統計分析 81 第五章 結果 82 第一節 樹豆及樹豆根的不同萃取物對於緩解經痛之效果 82 一、 DMSO不會影響PGF2α所誘導的SD大鼠子宮收縮 82 二、 CW、CE對於PGF2α所誘導的SD大鼠子宮收縮之影響 84 三、 CRW、CRE對於PGF2α所誘導的SD大鼠子宮收縮之影響 86 四、 CRE-W、CRE-E50及CRE-E95對於PGF2α所誘導的SD大鼠子宮收縮之影響 88 第二節 探討最具抑制效果的區分物對不同刺激子宮收縮物之影響 90 一、 CRE-E95可抑制SD大鼠的子宮自發性收縮 90 二、 CRE-E95可抑制oxytocin、acetylcholine及carbachol所誘導的SD大鼠子宮收縮 92 三、 CRE-E95對於鈣離子依賴性收縮反應之抑制效果 94 四、 CRE-E95可抑制KCl及BayK8644誘導的SD大鼠子宮收縮 96 第三節 樹豆根之活性成分對於緩解經痛之效果 98 一、 樹豆根之活性成分cajanol, genistein及daidzein對於PGF2α所誘導的SD大鼠子宮收縮之影響 98 第四節 CRE-E95對於子宮平滑肌病理組織的影響 100 一、 CRE-E95可減少病理組織切片中子宮平滑肌收縮的情形 100 第五節 CRE對於催產素誘導ICR小鼠經痛模式的影響 102 一、 CRE可減少催產素誘導ICR小鼠經痛模式的疼痛次數 102 第六章 討論 105 第七章 結論 110 第八章 參考文獻 111

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