簡易檢索 / 詳目顯示

研究生: 曾志中
Chih-Chung Tseng
論文名稱: 製備超順磁性水膠複合微粒及其在藥物傳輸系統上之應用
Preparation of Superparamagnetic Nanoparticle-Hydrogel Composites and their Application on Drug Delivery System
指導教授: 陳家俊
Chen, Chia-Chun
學位類別: 碩士
Master
系所名稱: 化學系
Department of Chemistry
論文出版年: 2007
畢業學年度: 95
語文別: 中文
論文頁數: 39
中文關鍵詞: 鐵鉑合金水膠複合物藥物傳輸系統
英文關鍵詞: FePt, Hydrogel, Composite, Drug Delivery System
論文種類: 學術論文
相關次數: 點閱:139下載:0
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 近幾年來,奈米粒子-高分子複合材料由於分析和合成技術的進步,受到廣泛的研究及討論。超順磁性的FePt奈米粒子經由Cysteamine表面修飾轉為水相後,藉由 TEM、XRD和SQUID儀器鑑定其結構及性質沒有改變,界面電位顯示水相FePt奈米粒子帶正電,利用此表面性質以化學方法和溫感型水膠結合形成奈米粒子-高分子複合微粒,經TEM、XRD證實此複合微粒具有水膠及FePt奈米粒子,亦觀察到此複合微粒擁有孔洞可用來攜帶藥物。以DLS在溫度變化下觀察到複合微粒反覆以收縮或膨潤應答,表示此複合微粒仍保有水膠之性質。在藥物傳輸系統上之應用,我們設計了完整的流程探求FePt奈米粒子-水膠複合微粒乘載和釋放藥物的能力,並且利用溫度的差異控制藥物釋放的程度和效率。因此我們認為這種奈米粒子-高分子複合微粒在磁熱治療上極具潛力。

    For the advances of analytic and synthetic technology recently, the nanoparticle-polymer composites are extensively researched and discussed. The properties and structures of the superparamagnetic FePt nanoparticles remain and are proven by TEM, XRD and SQUID after modified with Cysteamine and turning to be hydrophilic. Their zeta potential approves that they are positively charged. The FePt nanoparticles combining with temperature-sensitive hydrogels become nanoparticle-hydrogel composites and the composites indeed have FePt and hydrogel by TEM and XRD observations. The composites as well as the hydrogel swell or shrink by DLS detection when temperature changes and this effect reveals that the composites retain the properties of the hydrogel. We have good avenues to measure the ability of the composites to load and release drugs under the subject of drug delivery system. We also control the quantity and efficiency of drug releasing by tuning temperature. We think that the composites promise well on the field of magnetic hyperthermia.

    第一章 緒論..............................................1 1-1 引言................................................1 1-2 藥物傳輸系統.........................................2 1-3 水膠................................................3 1-4超順磁性奈米粒子與磁熱治療.............................10 第二章 實驗.............................................12 2-1研究動機與目的........................................12 2-2超順磁性FePt奈米粒子之合成.............................14 2-2-1實驗藥品...........................................14 2-2-2實驗步驟...........................................15 2-3 FePt-水膠複合微粒之合成..............................16 2-3-1 實驗藥品..........................................16 2-3-2 實驗步驟..........................................17 2-4 FePt-水膠複合微粒的藥物傳輸...........................18 2-4-1實驗藥品...........................................18 2-4-2 透析器具..........................................18 2-4-3藥物乘載實驗步驟....................................19 2-4-4 藥物釋放實驗步驟...................................20 第三章 結果與討論........................................21 3-1 FePt奈米粒子之製備與性質..............................21 3-2 FePt-水膠複合微粒之製備與性質.........................28 3-3 複合微粒的藥物乘載和釋放效率...........................34 第四章 結論與未來展望.....................................39

    1.Balazs, A. C.; Emrick, T.; Russell, T. P. Science 2006, 17, 1107-1110.
    2. Kingsley, J. D.; Dou, H.; Morehead, J.; Rabinow, B.; Gendelman, H. E.; Destanche, C. J. J. Neuroimmune. Pharmacol. 2006, 1, 340-350.
    3.Allen, T. M.; Cullis, P. R. Science 2004, 303, 1818-1822.
    4.Soppimath, K. S.; Aminabhavi T. M.; Dave A. M.; Kumbar S. G.; Rudzinski W. E. Drug Dev. Ind. Pharm. 2002, 28,957-974.
    5.Bromberg, L. E.; Ron E. S. Adv. Drug Deliv. Rev. 1998, 31, 197-221.
    6.Sershen, S.; West J. Adv. Drug Deliv. Rev. 2002, 54, 1225-1235.
    7.Zhang, X. Z.; Zhuo, R. X.; Cui, J. Z.; Zhang, J. T. Int. J. Pharm. 2002, 235, 43-50.
    8.Yoshida, R.; Sakai, K.; Okano, T.; Sakurai, Y. J. Biomater. Sci. Polym. Ed. 1994. 6, 585-598.
    9.Yoshida, R.; Sakai, K.; Okano, T.; Sakurai, Y. J. Biomater. Sci. Polym. Ed. 1992, 3, 243-252.
    10.Chen, G.; Hoffman, A. S. Macromol. Rapid Commun. 1995, 16, 175-182.
    11.Qiu, Y.; Park, K. Adv. Drug Deliv. Rev. 2001, 53, 321-339.
    12.Lee, S. J.; Park, K. J. Mol. Recognit. 1996, 9, 549-557.
    13.Ishihara, K.; Kobayashi, M.; Ishimura, N.; Shinohara, I. Polym. J. 1984, 16 625-631.
    14.Sershen, S. R.; Westcott, S. L.; Halas; N. J.; West, J. L. J. Biomed. Mater. Res. 2000, 51, 293-298.
    15.Mamada, A.; Tanaka, T.; Kungwachakun, D.; Irie, M. Macromolecules 1990, 23, 1517-1519.
    16.Hsieh, D. S. T.; Langer, R.; Folkman, J. Proc. Natl. Acad. Sci. USA 1981, 78, 1863-1867.
    17.Saslawski, O.; Weigarten, C.; Benoit, J. P.; Couvreur, P. Life Sci. 1988, 42, 1521-1528.
    18.Kost, J.; Noecker, R.; Kunica, E.; Langer, R. J. Biomed. Mater. Res. 1985, 19, 935-940.
    19.Liu, T. Y.; Hu, S. H.; Liu, K. H.; Liu, D. M.; Chen, S. Y. J. Magn. Magn. Mater. 2006, 304, 397-399.
    20.Tanaka, T.; Nishio, I.; Sun, S. T.; Ueno-Nishio, S. Science 1982, 218, 467-469.
    21.Kwok, C. S.; Mourad, P. D.; Crum, L.A.; Ranter, B. D. J. Biomed. Mater. Res. 2001, 57, 151-164.
    22.Lee, K. K.; Cussler, E. L.; Marchetti, M.; McHugh, M. A. Chem. Eng. Sci. 1990, 45, 766-767.
    23.Starodoubtsev, S. G.; Khokhlov, A. R.; Sokolov, E. L.; Chu, B. Macromolecules 1995, 28, 3930-3936.
    24.Miyata, T.; Asami, N.; Uragami, T. Nature 1999, 399, 766-769.
    25.Kurisawa, W.; Yui, N. J. Control. Release 1998, 54, 191-200.
    26.Schütt, W.; Grüttner, C.; Häfeli, U.; Zborowski, M.; Teller, J.; Putzar, H.; Schümichen, C. Hybridoma 1997, 16, 109-117.
    27.Babes, L.; Denizot, B.; Tanguy, G.; Le Jeune, J. J.; Jallet, P. J. Colloid Interface Sci. 1999, 212, 474-482.
    28.Chatterhee, J.; Haik, Y.; Chen, C. J. J. Magn. Magn. Mater. 2001, 225, 21-29.
    29.Ström, V.; Hultenby, K.; Grüttner, C.; Teller, J.; Xu, B.; Holgersson, J. Nanotechnology 2004, 15, 457-466.
    30.Neuberger, T.; Schöpf, B.; Hofmann, H.; Hofmann, M.;
    von Rechenberg, B. J. Magn. Magn. Mater. 2005, 293, 483-496.
    31.Moroz, P.; Jones, S. K.; Gray, B. N. Int. J. Hyperthermia 2002, 18, 267-284.
    32.Hergt, R.; Dutz, S.; Müller, R.; Zeisberger, M. J. Phys.: Condens. Matter. 2006, 18, S2919-S2934.
    33.Sun, S.; Murray, C. B.; Weller, D.; Folks, L.; Moser, A. Science 2000, 287, 1989-1992.
    34. Moser, A.; Takano, K.; Margulies, D. T.; Albrecht, M.; Snobe, Y.; Ikeda, Y.; Sun, S.; Fullerton, E. E. J. Phys. D: Appl. Phys. 2002, 35, R157-R167.
    35.Sun, S. Adv. Mater. 2006, 18, 393-403.
    36.Maenosono, S.; Saita, S. IEEE T. Magn. 2006, 42, 1638-1642.

    無法下載圖示 本全文未授權公開
    QR CODE