本研究為利用常見的自由基誘發劑-過氧化苯甲醯基 (Benzoyl peroxide)，將酯類之烷氧殘基以具立體選擇性的方式引入，合成3-芳香基丙烯酯類衍生物。其反應機構首先係利用過氧化苯甲醯基於高溫下裂解形成自由基，再利用它拔取酯類烷氧殘基上的氫原子，所形成之自由基進一步加成至(E)--硝基苯乙烯((E)--Nitrostyrene)系列物，最後脫去二氧化氮自由基(NO2‧)可得一系列3-芳香基丙烯酯類化合物。
反應過程中，除了高立體選擇性外，也具有中至高產率的結果。同時可使用具有不同取代基之(E)--硝基苯乙烯系列物，與含不同立障的烷氧殘基之酯類，來置備各式各樣的(E)-苯乙烯酯類，此策略及結果可充分驗證本反應的應用價值。
最後，本研究利用乙酸丙酯(Propyl acetate)，在相似反應條件下，與受質(E)-2,6-雙甲氧基--硝基苯乙烯反應，將分離得到之’位向取代的產物，進一步利用氫氧化鋰水解後，形成之(E)-苯丁烯醇為天然物中具活性之特徵結構。因此，此步驟簡單，產率亦較文獻報導高出許多之自由基加成-脫去反應，應用在合成具有生物活性之相關衍生物，為本研究最終目標與極富價值性之發展；另外，本論文部分結果也已發表於Tetrahedron Letters 2004, 45, 3685. 顯示其價值性已受肯定。

Various geometrically pure (E)-alkenes have been synthesized by radical substitution of alcohol moieties generated via hydrogen abstraction within ethyl esters. These reactions occurred with high regio-selectivity and gave a new access to 1-methyl-3-aryl-allyl esters.

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