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研究生: 李希捷
Lee, Hsi-Chieh
論文名稱: 不同碳水化合物攝取頻率對耐力運動之腸道損傷及腸胃舒適度的影響
Effects of Different Frequency of Carbohydrate Intake on Intestinal Injury and Gastrointestinal Comfort during Endurance Exercise
指導教授: 王鶴森
Wang, Ho-Seng
口試委員: 吳慧君
Wu, Huey-June
陳勇志
Chen, Yung-Chih
王鶴森
Wang, Ho-Seng
口試日期: 2023/06/26
學位類別: 碩士
Master
系所名稱: 體育與運動科學系
Department of Physical Education and Sport Sciences
論文出版年: 2023
畢業學年度: 111
語文別: 中文
論文頁數: 73
中文關鍵詞: 長跑馬拉松運動營養
英文關鍵詞: long-distance running, marathon, exercise nutrition
研究方法: 實驗設計法
DOI URL: http://doi.org/10.6345/NTNU202300616
論文種類: 學術論文
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  • 背景:長距離耐力運動容易導致腸道損傷並破壞腸道的完整性,亦會引發腸胃不適感,而運動中適當地攝取碳水化合物不但能降低腸胃不適,也能減緩腸道損傷。目的:探討長距離跑步中以不同碳水化合物攝取頻率對腸道損傷及腸胃舒適度之影響。方法:採重複量數、平衡次序設計,招募10位有馬拉松經驗之男性,於跑步機上進行 32 公里 65% V̇O2max之固定速度跑步及接續之8公里計時測驗,並於運動中進行每 5 公里攝取 22 克的高頻率攝取 (HCF) 及每 7.5 公里攝取 33 克的低頻率攝取 (LCF) 之不同碳水化合物攝取頻率,但總量皆為 132 克的兩種實驗處理,並測量基準值、運動第30公里及運動後立即之腸道損傷指標(腸道脂肪酸結合蛋白,I-FABP;內毒素),且於運動前、運動中每10公里及運動後立即測量腸胃舒適度量表 (腹部不適量表,AD;腹部飽足感量表,GF),比較處理間腸道損傷與腸胃舒適度之差異。結果:(1) I-FABP、內毒素:皆無處理及距離間的交互作用;I-FABP 30~40公里曲線下面積與相對強度呈正相關 (r = 0.455,p < .05)。(2) AD、GF:皆無處理及距離間的交互作用;AD 處理主效果 LCF < HCF (p < .05);AD 曲線下面積: 30~40 公里,LCF < HCF (p < .05)。(3) I-FABP變化量與腹部不適感的相關為 r = - 0.151 (p > .05),未達顯著。結論:在 40 公里的跑步運動中,每 5 公里攝取 22 克或每 7.5 公里攝取 33 克碳水化合物並不會影響腸道損傷,但隨著距離增加,腹部不適感會上升,同時高頻率的攝取會有較高的腹部不適感,但不影響運動表現。

    Background: Endurance exercise is likely to cause intestinal injury and increase gastrointestinal discomfort. Intaking carbohydrates during exercise can relieve gastrointestinal discomfort and alleviate intestinal injuries. Purpose: To examine the effects of different frequencies of carbohydrate intake on intestinal injury and gastrointestinal comfort during 40 km running. Method: 10 men (PB: 3 hr 8 min ± 17 min, V̇O2max :57.3 ± 5.7 ml/kg/min) were required to perform two trials of the 32 km at 65% V̇O2max following an 8 km time trial. Subjects participated in the following two trials in a counterbalanced, crossover design. 1.HCF (high carbohydrate frequency): 22 grams per 5 km. 2.LCF (low carbohydrate frequency): 33 grams per 7.5 km in (LCF). Total energy gel consumed in both trials were 132g carbohydrate. Plasma intestinal fatty-acid binding protein (I-FABP), endotoxin, and the gastrointestinal comfort scales (abdominal discomfort, AD; gut fullness, GF) were measured. Results: (1) I-FABP, endotoxin: No interactions between treatment and distance; Area under curve of I-FABP in 30-40 km was positively correlated with relative intensity (r = 0.455,p < .05). (2) AD, GF: No interactions between treatment and distance; treatment main effect of AD was LCF < HCF (p < .05); Area under curve of AD was LCF < HCF at 30-40 km (p < .05). (3) No correlation between the change in I-FABP and AD (r = - 0.151, p > .05). Conclusion: In a 40-km run, consuming 22 grams of carbohydrates per 5 km or 33 grams per 7.5 km did not affect intestinal damage. Abdominal discomfort increased with distance and HCF causes higher abdominal discomfort but does not affect performance.

    第壹章 緒論 1 第一節 研究背景 1 第二節 研究目的 4 第三節 研究假設 4 第四節 名詞操作性定義 4 第五節 研究重要性 5 第貳章 文獻探討 7 第一節 運動與腸胃道的關係 7 第二節 耐力運動與腸胃道的關係 10 第三節 耐力運動中攝取碳水化合物對腸胃道的影響 13 第四節 本章總結 20 第參章 研究方法 21 第一節 研究參與者 21 第二節 實驗時間與地點 22 第三節 實驗方法與步驟 22 第四節 資料處理 29 第肆章 結果 31 第一節 研究參與者基本資料及實驗控制與環境相關變項 31 第二節 不同碳水化合物攝取頻率對耐力運動表現及生理指標的影響 32 第三節 不同碳水化合物攝取頻率對 I-FABP 的影響 41 第四節 不同碳水化合物攝取頻率對內毒素的影響 43 第五節 不同碳水化合物攝取頻率對腸胃舒適度的影響 44 第六節 I-FABP與腹部不適感之相關 47 第伍章 討論 48 第一節 不同碳水化合物攝取頻率對耐力運動表現的影響 48 第二節 不同碳水化合物攝取頻率對腸道損傷的影響 49 第三節 不同碳水化合物攝取頻率對腸胃舒適度的影響 52 第四節 I-FABP與腸胃舒適度之相關 53 第五節 結論與建議 54 參考文獻 55 附錄 67 附件一 研究參與者知情同意書 67 附件二 最大攝氧量氧量記錄表 69 附件三 運動強度自覺量表 70 附件四 腹部不適感視覺量表 71 附件五 腹部飽足感視覺量表 72 附件六 飲食紀錄表 73

    Barberio, M. D., Elmer, D. J., Laird, R. H., Lee, K. A., Gladden, B., & Pascoe, D. D. (2015). Systemic LPS and inflammatory response during consecutive days of exercise in heat. International journal of Sports Medicine, 36(3), 262-270. https://doi.org/10.1055/s-0034-1389904

    Borg, G. (1970). Perceived exertion as an indicator of somatic stress. Scandinavian Journal of Rehabilitation Medicine, 2(2), 92-98.

    Bruce, R. A., Blackmon, J. R., Jones, J. W., & Strait, G. (1963). Exercising testing in adult normal subjects and cardiac patients. Pediatrics, 32, Suppl 742-756.

    Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., Waget, A., Delmée, E., Cousin, B., Sulpice, T., Chamontin, B., Ferrières, J., Tanti, J. F., Gibson, G. R., Casteilla, L., Delzenne, N. M., Alessi, M. C., & Burcelin, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761-1772. https://doi.org/10.2337/db06-1491

    Cermak, N. M., & van Loon, L. J. (2013). The use of carbohydrates during exercise as an ergogenic aid. Sports Medicine, 43(11), 1139-1155. https://doi.org/10.1007/s40279-013-0079-0

    Chantler, S., Griffiths, A., Matu, J., Davison, G., Holliday, A., & Jones, B. (2022). A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability. PLoS One, 17(4). https://doi.org/10.1371/journal.pone.0266379

    Chantler, S., Griffiths, A., Matu, J., Davison, G., Jones, B., & Deighton, K. (2021). The effects of exercise on indirect markers of gut damage and permeability: A systematic review and meta-analysis. Sports Medicine, 51(1), 113-124. https://doi.org/10.1007/s40279-020-01348-y

    Chelakkot, C., Ghim, J., & Ryu, S. H. (2018). Mechanisms regulating intestinal barrier integrity and its pathological implications. Experimental and Molecular Medicine, 50(8), 1-9. https://doi.org/10.1038/s12276-018-0126-x

    Chowdhury, A. H., Murray, K., Hoad, C. L., Costigan, C., Marciani, L., Macdonald, I. A., Bowling, T. E., & Lobo, D. N. (2016). Effects of bolus and continuous nasogastric feeding on gastric emptying, small bowel water content, superior mesenteric artery blood flow, and plasma hormone concentrations in healthy adults: a randomized crossover study. Annals of Surgery, 263(3), 450-457. https://doi.org/-10.1097/sla.0000000000001110

    Costa, R. J., Snipe, R., Camões-Costa, V., Scheer, V., & Murray, A. (2016). The impact of gastrointestinal symptoms and dermatological injuries on nutritional intake and hydration status during ultramarathon events. Sports Medicine Open, 2, 16. https://doi.org/10.1186/s40798-015-0041-9

    Costa, R. J. S., Camões-Costa, V., Snipe, R. M. J., Dixon, D., Russo, I., & Huschtscha, Z. (2019). Impact of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, and systemic endotoxin and inflammatory profile. Journal of Applied Physiology, 126(5), 1281-1291. https://doi.org/10.1152/japplphysiol.01032.2018

    Costa, R. J. S., Miall, A., Khoo, A., Rauch, C., Snipe, R., Camões-Costa, V., & Gibson, P. (2017). Gut-training: the impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance. Applied Physiology, Nutrition, and Metabolism, 42(5), 547-557. https://doi.org/10.1139/apnm-2016-0453

    Costa, R. J. S., Oliver, S. J., Laing, S. J., Walters, R., Bilzon, J. L. J., & Walsh, N. P. (2009). Influence of Timing of Postexercise Carbohydrate-Protein Ingestion on Selected Immune Indices. International Journal of Sport Nutrition and Exercise Metabolism, 19(4), 366-384. https://doi.org/10.1123/ijsnem.19.4.366

    Costa, R. J. S., Snipe, R. M. J., Kitic, C. M., & Gibson, P. R. (2017). Systematic review: exercise-induced gastrointestinal syndrome-implications for health and intestinal disease. Alimentary Pharmacology and Therapeutics, 46(3), 246-265. https://doi.org/10.1111/apt.14157

    De Oliveira, E. P., & Burini, R. C. (2009). The impact of physical exercise on the gastrointestinal tract. Current Opinion in Clinical Nutrition and Metabolic Care, 12(5), 533-538. https://doi.org/10.1097/MCO.0b013e32832e6776

    De Oliveira, E. P., Burini, R. C., & Jeukendrup, A. (2014). Gastrointestinal complaints during exercise: prevalence, etiology, and nutritional recommendations. Sports Medicine, 44 Suppl 1(Suppl 1), S79-85. https://doi.org/10.1007/s40279-014-0153-2

    Derikx, J. P., Luyer, M. D., Heineman, E., & Buurman, W. A. (2010). Non-invasive markers of gut wall integrity in health and disease. World Journal of Gastroenterology, 16(42), 5272-5279. https://doi.org/10.3748/wjg.v16.i42.5272

    Dill, D. B., & Costill, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology, 37(2), 247-248. https://doi.org/10.1152/jappl.1974.37.2.247

    Duchman, S. M., Ryan, A. J., Schedl, H. P., Summers, R. W., Bleiler, T. L., & Gisolfi, C. V. (1997). Upper limit for intestinal absorption of a dilute glucose solution in men at rest. Medicine and Science in Sports and Exercise, 29(4), 482-488. https://doi.org/10.1097/00005768-199704000-00009

    Edinburgh, R. M., Hengist, A., Smith, H. A., Travers, R. L., Koumanov, F., Betts, J. A., Thompson, D., Walhin, J.-P., Wallis, G. A., & Hamilton, D. L. (2018). Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men. American Journal of Physiology-Endocrinology and Metabolism, 315(5), E1062-E1074.

    Edwards, K. H., Ahuja, K. D., Watson, G., Dowling, C., Musgrave, H., Reyes, J., Cherry, J., & Kitic, C. M. (2021). The influence of exercise intensity and exercise mode on gastrointestinal damage. Applied Physiology, Nutrition, and Metabolism, 46(9), 1105-1110. https://doi.org/10.1139/apnm-2020-0883

    Eriksen, M., & Waaler, B. A. (1994). Priority of blood flow to splanchnic organs in humans during pre- and post-meal exercise. Acta Physiologica Scandinavica, 150(4), 363-372. https://doi.org/10.1111/j.1748-1716.1994.tb09700.x

    Evennett, N. J., Petrov, M. S., Mittal, A., & Windsor, J. A. (2009). Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World Journal of Surgery, 33(7), 1374-1383. https://doi.org/10.1007/s00268-009-0074-7

    Flood, T. R., Montanari, S., Wicks, M., Blanchard, J., Sharp, H., Taylor, L., Kuennen, M. R., & Lee, B. J. (2020). Addition of pectin-alginate to a carbohydrate beverage does not maintain gastrointestinal barrier function during exercise in hot-humid conditions better than carbohydrate ingestion alone. Applied Physiology, Nutrition, and Metabolism, 45(10), 1145-1155. https://doi.org/10.1139/apnm-2020-0118

    Gaskell, S. K., Burgell, R., Wiklendt, L., Dinning, P. G., & Costa, R. J. S. (2023). Impact of exercise duration on gastrointestinal function and symptoms. Journal of Applied Physiology, 134(1), 160-171. https://doi.org/10.1152/japplphysiol.00393.2022

    Gill, S. K., Hankey, J., Wright, A., Marczak, S., Hemming, K., Allerton, D. M., Ansley-Robson, P., & Costa, R. J. (2015). The impact of a 24-h ultra-marathon on circulatory endotoxin and cytokine profile. International journal of Sports Medicine, 36(8), 688-695. https://doi.org/10.1055/s-0034-1398535

    Hawley, J. A., & Leckey, J. J. (2015). Carbohydrate dependence during prolonged, intense endurance exercise. Sports Medicine, 45, 5-12. https://doi.org/10.1007/s40279-015-0400-1

    Holmes, J. H. t., Lieberman, J. M., Probert, C. B., Marks, W. H., Hill, M. E., Paull, D. L., Guyton, S. W., Sacchettini, J., & Hall, R. A. (2001). Elevated intestinal fatty acid binding protein and gastrointestinal complications following cardiopulmonary bypass: a preliminary analysis. Journal of Surgical Research, 100(2), 192-196. https://doi.org/10.1006/jsre.2001.6237

    Hoogervorst, D., van der Burg, N., Versteegen, J. J., Lambrechtse, K. J., Redegeld, M. I., Cornelissen, L. A. J., & Wardenaar, F. C. (2019). Gastrointestinal Complaints and Correlations with Self-Reported Macronutrient Intake in Independent Groups of (Ultra)Marathon Runners Competing at Different Distances. Sports (Basel), 7(6). https://doi.org/10.3390/sports7060140

    Horowitz, J. F., Mora-Rodriguez, R., Byerley, L. O., & Coyle, E. F. (1996). Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Medicine and Science in Sports and Exercise, 28(5), 74.

    Jeukendrup, A., Vet-Joop, K., Sturk, A., Stegen, J., Senden, J., Saris, W., & Wagenmakers, A. (2000). Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clinical science, 98(1), 47-55.

    Jeukendrup, A. E. (2004). Carbohydrate intake during exercise and performance. Nutrition, 20(7-8), 669-677. https://doi.org/10.1016/j.nut.2004.04.017

    Jeukendrup, A. E. (2017). Training the Gut for Athletes. Sports Medicine, 47(1), 101-110. https://doi.org/10.1007/s40279-017-0690-6

    Jeukendrup, A. E., & Jentjens, R. (2000). Oxidation of carbohydrate feedings during prolonged exercise: current thoughts, guidelines and directions for future research. Sports Medicien, 29(6), 407-424. https://doi.org/10.2165/00007256-200029060-00004

    Jeukendrup, A. E., & Wallis, G. A. (2005). Measurement of substrate oxidation during exercise by means of gas exchange measurements. International journal of sports medicine, 26(S 1), S28-S37.

    Jones, A. M., & Doust, J. H. (1996). A 1% treadmill grade most accurately reflects the energetic cost of outdoor running. Journal of Sports Sciences, 14(4), 321-327. https://doi.org/10.1080/02640419608727717

    Jonvik, K. L., Lenaerts, K., Smeets, J. S. J., Kolkman, J. J., LJC, V. A. N. L., & Verdijk, L. B. (2019). Sucrose but not nitrate ingestion reduces strenuous cycling-induced intestinal injury. Medicine and Science in Sports and Exercise, 51(3), 436-444. https://doi.org/10.1249/mss.0000000000001800

    Karahanoğlu, A. (2022). Psychological effects of energy gels: An investigation into runners’ energy gel choice and consumption strategies in marathon running. International Journal of Food Design, 7(1), 59-78.

    Karhu, E., Forsgård, R. A., Alanko, L., Alfthan, H., Pussinen, P., Hämäläinen, E., & Korpela, R. (2017). Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners. European Journal of Applied Physiology, 117(12), 2519-2526. https://doi.org/10.1007/s00421-017-3739-1

    Keeffe, E. B., Lowe, D. K., Goss, J. R., & Wayne, R. (1984). Gastrointestinal symptoms of marathon runners. The Western Journal Medicine, 141(4), 481-484.

    Kozlowski, K. F., Ferrentino-DePriest, A., & Cerny, F. (2021). Effects of energy gel ingestion on blood glucose, lactate, and performance measures during prolonged cycling. The Journal of Strength and Conditioning Research, 35(11), 3111-3119. https://doi.org/10.1519/jsc.0000000000003297

    Kwiatek, M. A., Menne, D., Steingoetter, A., Goetze, O., Forras-Kaufman, Z., Kaufman, E., Fruehauf, H., Boesiger, P., Fried, M., & Schwizer, W. (2009). Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRI. American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(5), G894-G901.

    Lambert, G. P. (2008). Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: the 'canary in the coal mine' during exercise-heat stress? Medicine and Sport Science, 53, 61-73. https://doi.org/10.1159/000151550

    Lambert, G. P., Broussard, L. J., Mason, B. L., Mauermann, W. J., & Gisolfi, C. V. (2001). Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages. Journal of Applied Physiology, 90(6), 2075-2080. https://doi.org/10.1152/jappl.2001.90.6.2075

    Lambert, G. P., Lang, J., Bull, A., Pfeifer, P. C., Eckerson, J., Moore, G., Lanspa, S., & O'Brien, J. (2008). Fluid restriction during running increases GI permeability. International journal of Sports Medicine, 29(3), 194-198. https://doi.org/10.1055/s-2007-965163

    Loudon, C. P., Corroll, V., Butcher, J., Rawsthorne, P., & Bernstein, C. N. (1999). The effects of physical exercise on patients with Crohn’s disease. The American Journal of Gastroenterology, 94(3), 697-703. https://doi.org/https://doi.org/10.1016/S0002-9270(98)00820-X

    Ma, T. Y. (1997). Intestinal epithelial barrier dysfunction in Crohn's disease. Proceedings of the Society for Experimental Biology and Medicine, 214(4), 318-327. https://doi.org/10.3181/00379727-214-44099

    Marchiando, A. M., Graham, W. V., & Turner, J. R. (2010). Epithelial barriers in homeostasis and disease. Annual Review of Pathology, 5, 119-144. https://doi.org/10.1146/-annurev.pathol.4.110807.092135

    Mears, S. A., Boxer, B., Sheldon, D., Wardley, H., Tarnowski, C. A., James, L. J., & Hulston, C. J. (2020). Sports drink intake pattern affects exogenous carbohydrate oxidation during running. Medicine and Science in Sports and Exercise, 52(9), 1976-1982. https://doi.org/10.1249/mss.0000000000002334

    Menzies, C., Wood, M., Thomas, J., Hengist, A., Walhin, J. P., Jones, R., Tsintzas, K., Gonzalez, J. T., & Betts, J. A. (2020). Frequent carbohydrate ingestion reduces muscle glycogen depletion and postpones fatigue relative to a single bolus. International Journal of Sport Nutrition and Exercise Metabolism, 30(3), 203–209. https://doi.org/10.1123/ijsnem.2019-0291

    Mitchell, J. B., & Voss, K. W. (1991). The influence of volume on gastric emptying and fluid balance during prolonged exercise. Medicine and Science in Sports and Exercise, 23(3), 314-319.

    Moses, F. M. (2005). Exercise-associated Intestinal Ischemia. Current Sports Medicine Reports, 4(2), 91-95. doi: 10.1097/01.csmr.0000306079.74945.ea.

    Neal, W. N., Jones, C. D., Pekmezi, D., & Motl, R. W. (2022). Physical activity in adults with Crohn’s disease: A scoping review. Crohn's and Colitis 360, 4(2). https://doi.org/10.1093/crocol/otac022

    Ng, Q. Y., Lee, K. W., Byrne, C., Ho, T. F., & Lim, C. L. (2008). Plasma endotoxin and immune responses during a 21-km road race under a warm and humid environment. Annals-Acadamy of Medicine Singapore, 37(4), 307.

    Ogoh, S. (2008). Autonomic control of cerebral circulation: exercise. Medicine and Science Sports and Exercise, 40(12), 2046-2054. https://doi.org/10.1249/MSS.0b013-e318180bc6f

    Pals, K. L., Chang, R. T., Ryan, A. J., & Gisolfi, C. V. (1997). Effect of running intensity on intestinal permeability. Journal of Applied Physiology, 82(2), 571-576. https://doi.org/10.1152/jappl.1997.82.2.571

    Park, J. H., Lee, D. H., Kim, S. I., Kim, N. K., & Jeon, J. Y. (2020). Moderate to vigorous physical activity participation associated with better quality of life among breast and colorectal cancer survivors in Korea. BMC Cancer, 20(1), 365. https://doi.org/10.1186/s12885-020-06819-z

    Perko, M. J. (2001). Duplex ultrasound for assessment of superior mesenteric artery blood flow. European Journal of Vascular Endovascular Surgery, 21(2), 106-117. https://doi.org/10.1053/ejvs.2001.1313

    Peters, H. P., Bos, M., Seebregts, L., Akkermans, L. M., van Berge Henegouwen, G. P., Bol, E., Mosterd, W. L., & de Vries, W. R. (1999). Gastrointestinal symptoms in long-distance runners, cyclists, and triathletes: prevalence, medication, and etiology. American Journal of Gastroenterology, 94(6), 1570-1581. https://doi.org/10.1111-/j.1572-0241.1999.01147.x

    Peters, H. P., Wiersma, J. W., Koerselman, J., Akkermans, L. M., Bol, E., Mosterd, W. L., & de Vries, W. R. (2000). The effect of a sports drink on gastroesophageal reflux during a run-bike-run test. International journal of Sports Medicine, 21(1), 65-70. https://doi.org/10.1055/s-2000-8858

    Pfeiffer, B., Cotterill, A., Grathwohl, D., Stellingwerff, T., & Jeukendrup, A. E. (2009). The effect of carbohydrate gels on gastrointestinal tolerance during a 16-km run. International Journal of Sport Nutrition and Exercise Metabolism, 19(5), 485-503. https://doi.org/10.1123/ijsnem.19.5.485

    Pfeiffer, B., Stellingwerff, T., Hodgson, A. B., Randell, R., Pöttgen, K., Res, P., & Jeukendrup, A. E. (2012). Nutritional intake and gastrointestinal problems during competitive endurance events. Medicine & Science in Sports & Exercise, 44(2), 344-351. https://doi.org/10.1249/MSS.0b013e31822dc809

    Pugh, J. N., Kirk, B., Fearn, R., Morton, J. P., & Close, G. L. (2018). Prevalence, severity and potential nutritional causes of gastrointestinal symptoms during a marathon in recreational runners. Nutrients, 10(7), 811.

    Qamar, M. I., & Read, A. E. (1987). Effects of exercise on mesenteric blood flow in man. Gut, 28(5), 583-587. https://doi.org/10.1136/gut.28.5.583

    Ravich, W. J., Bayless, T. M., & Thomas, M. (1983). Fructose: incomplete intestinal absorption in humans. Gastroenterology, 84(1), 26-29.

    Rehrer, N., Wagenmakers, A., Beckers, E., Halliday, D., Leiper, J., Brouns, F., Maughan, R., Westerterp, K., & Saris, W. (1992). Gastric emptying, absorption, and carbohydrate oxidation during prolonged exercise. Journal of Applied Physiology, 72(2), 468-475.

    Rehrer, N. J., Goes, E., DuGardeyn, C., Reynaert, H., & DeMeirleir, K. (2005). Effect of carbohydrate on portal vein blood flow during exercise. International journal of Sports Medicine, 26(3), 171-176. https://doi.org/10.1055/s-2004-820957

    Rehrer, N. J., & Meijer, G. A. (1991). Biomechanical vibration of the abdominal region during running and bicycling. The Journal of Sports Medicine and Physical Fitness, 31(2), 231-234.

    Rehrer, N. J., Smets, A., Reynaert, H., Goes, E., & De Meirleir, K. (2001). Effect of exercise on portal vein blood flow in man. Medicine and Science in Sports and Exercise, 33(9), 1533-1537. https://doi.org/10.1097/00005768-200109000-00017

    Rescigno, M. (2011). The intestinal epithelial barrier in the control of homeostasis and immunity. Trends in Immunology, 32(6), 256-264. https://doi.org/10.1016/j.it-2011.04.003

    Ribeiro, F. M., Petriz, B., Marques, G., Kamilla, L. H., & Franco, O. L. (2021). Is there an exercise-Intensity threshold capable of avoiding the leaky gut? Frontiers in Nutrition, 8, 627289. https://doi.org/10.3389/fnut.2021.627289

    Riddoch, C., & Trinick, T. (1988). Gastrointestinal disturbances in marathon runners. British Journal of Sports Medicine, 22(2), 71-74. https://doi.org/10.1136/bjsm.22.2.71

    Rodriguez, N. R., Di Marco, N. M., & Langley, S. (2009). American College of Sports Medicine position stand. Nutrition and athletic performance. Medicine and Science in Sports and Exercise, 41(3), 709-731. https://doi.org/10.1249/MSS.0b013e31890eb86

    Scheer, V. (2019). Participation trends of ultra endurance events. Sports Medicine and Arthroscopy Review, 27(1), 3-7. https://doi.org/10.1097/jsa.0000000000000198

    Sessions, J., Bourbeau, K., Rosinski, M., Szczygiel, T., Nelson, R., Sharma, N., & Zuhl, M. (2016). Carbohydrate gel ingestion during running in the heat on markers of gastrointestinal distress. European Journal of Sport Science, 16(8), 1064-1072. https://doi.org/10.1080/17461391.2016.1140231

    Snipe, R. M. J., & Costa, R. J. S. (2018). Does the temperature of water ingested during exertional-heat stress influence gastrointestinal injury, symptoms, and systemic inflammatory profile? Journal of Science and Medicine in Sport, 21(8), 771-776. https://doi.org/10.1016/j.jsams.2017.12.014

    Snipe, R. M. J., Khoo, A., Kitic, C. M., Gibson, P. R., & Costa, R. J. S. (2017). Carbohydrate and protein intake during exertional heat stress ameliorates intestinal epithelial injury and small intestine permeability. Applied Physiology, Nutrition and Metabolism, 42(12), 1283-1292. https://doi.org/10.1139/apnm-2017-0361

    Snipe, R. M. J., Khoo, A., Kitic, C. M., Gibson, P. R., & Costa, R. J. S. (2018). The impact of exertional-heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile. European Journal of Applied Physiology, 118(2), 389-400. https://doi.org/10.1007/s00421-017-3781-z

    Stellingwerff, T., & Cox, G. R. (2014). Systematic review: Carbohydrate supplementation on exercise performance or capacity of varying durations. Applied Physiology, Nutrition, and Metabolism, 39(9), 998-1011. https://doi.org/10.1139/apnm-2014-0027

    Stocks, B., Betts, J. A., & McGawley, K. (2016). Effects of carbohydrate dose and frequency on metabolism, gastrointestinal discomfort, and cross-country skiing performance. Scandinavian Journal of Medicine Science in Sports, 26(9), 1100-1108. https://doi.org/10.1111/sms.12544

    Stuempfle, K. J., & Hoffman, M. D. (2015). Gastrointestinal distress is common during a 161-km ultramarathon. Journal of Sports Sciences, 33(17), 1814-1821. https://doi.org/10.1080/02640414.2015.1012104

    Stuempfle, K. J., Valentino, T., Hew-Butler, T., Hecht, F. M., & Hoffman, M. D. (2016). Nausea is associated with endotoxemia during a 161-km ultramarathon. Journal of Sports Sciences, 34(17), 1662-1668. https://doi.org/10.1080/02640414.2015.1130238

    Tanaka, H., Monahan, K. D., & Seals, D. R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College Cardiology, 37(1), 153-156. https://doi.org/10.1016/s0735-1097(00)01054-8

    Ter Steege, R., & Kolkman, J. (2012). The pathophysiology and management of gastrointestinal symptoms during physical exercise, and the role of splanchnic blood flow. Alimentary Pharmacology and Therapeutics, 35(5), 516-528.

    Ter Steege, R. W., Van der Palen, J., & Kolkman, J. J. (2008). Prevalence of gastrointestinal complaints in runners competing in a long-distance run: an internet-based observational study in 1281 subjects. Scandinavian Journal of Gastroenterology, 43(12), 1477-1482. https://doi.org/10.1080/00365520802321170

    Thuijls, G., van Wijck, K., Grootjans, J., Derikx, J. P., van Bijnen, A. A., Heineman, E., Dejong, C. H., Buurman, W. A., & Poeze, M. (2011). Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins. Annals of Surgery, 253(2), 303-308. https://doi.org/10.1097/SLA.0b013e318207a767

    Torres, J., Mehandru, S., Colombel, J.-F., & Peyrin-Biroulet, L. (2017). Crohn's disease. The Lancet, 389(10080), 1741-1755. https://doi.org/https://doi.org/10.1016/S0140-6736(16)31711-1

    Ungaro, R., Mehandru, S., Allen, P. B., Peyrin-Biroulet, L., & Colombel, J. F. (2017). Ulcerative colitis. Lancet, 389(10080), 1756-1770. https://doi.org/10.1016/s0140-6736(16)32126-2

    Van Nieuwenhoven, M. A., Brummer, R. M., & Brouns, F. (2000). Gastrointestinal function during exercise: comparison of water, sports drink, and sports drink with caffeine. Journal of Applied Physiology, 89(3), 1079-1085. https://doi.org/10.1152/jappl.-2000.89.3.1079

    Van Venrooij, N. F. J., Wardenaar, F. C., Hoogervorst, D., Senden, J. M. G., van Dijk, J. W., & Jonvik, K. L. (2022). The association between gastrointestinal injury, complaints, and food intake in 60-km ultramarathon runners. Applied Physiology, Nutrition, and Metabolism, 47(5), 547-554. https://doi.org/10.1139/apnm-2021-0711

    Van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A., Poeze, M., van Loon, L. J., Dejong, C. H., & Buurman, W. A. (2012). Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention. American Journal of Physiology-Gastrointestinal Liver Physiology, 303(2), G155-168. https://doi.org/10.1152/ajpgi.00066.2012

    Van Wijck, K., Lenaerts, K., van Loon, L. J., Peters, W. H., Buurman, W. A., & Dejong, C. H. (2011). Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS One, 6(7), e22366. https://doi.org/10.1371/journal.pone.0022366

    Van Wijck, K., Pennings, B., van Bijnen, A. A., Senden, J. M., Buurman, W. A., Dejong, C. H., van Loon, L. J., & Lenaerts, K. (2013). Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 304(5), R356-361. https://doi.org/10.1152/ajpregu.00294.2012

    Walter, E., Gibson, O. R., Stacey, M., Hill, N., Parsons, I. T., & Woods, D. (2021). Changes in gastrointestinal cell integrity after marathon running and exercise-associated collapse. European Journal of Applied Physiology, 121, 1179-1187.

    Wittkopf, N., Neurath, M. F., & Becker, C. (2014). Immune-epithelial crosstalk at the intestinal surface. Journal of Gastroenterology, 49(3), 375-387. https://doi.org/10.1007/s00535-013-0929-4

    Yeh, Y. J., Law, L. Y., & Lim, C. L. (2013). Gastrointestinal response and endotoxemia during intense exercise in hot and cool environments. European Journal of Applied Physiology, 113(6), 1575-1583. https://doi.org/10.1007/s00421-013-2587-x

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