腎上腺素接受器β2 (adrenergic receptor β2，ADRB2)是分佈廣泛的腎上腺素接受器，；運動刺激神經傳導物質（主要為兒茶酚胺）分泌與ADRB2結合後，引起心跳加速、支氣管擴張、肝醣及脂肪分解上升等生理反應；其對能量代謝及支氣管擴張的影響，讓ADRB2被視為影響耐力運動的可能基因。ADRB2基因位於5q31～32，常提及的基因多形性 (polymorphism)有三個：Arg16Gly（精胺酸變成甘胺酸，A/G）、Gln27Glu（麩胺變成麩胺酸，C/G）及Thr164Ile （酥胺酸變成異白胺酸，C/T）。目前ADRB2基因多形性與耐力運動表現研究較少，結果也不一致，需深入的探討。目的：探討台灣耐力運動表現是否與ADRB2基因有關，且提供台灣的ADRB2基因多形性頻率(frequency)資料。方法：本研究採國內優秀選手（自由車、划船、羽球、足球、網球、桌球及橄欖球選手）142位及一般民眾246位做為控制組之DNA檢體，進行ADRB2基因之判別(PCR -RFLP)；以SPSS 13.0執行χ2-test(α =.05)，考驗台灣優秀耐力運動選手與一般民眾在ADRB2基因是否有差異。結果：Thr164Ile在本次實驗皆為野生型，無變異產生；Arg16Gly與控制組無顯著差異；網球選手與控制組Gln27Glu基因型與allele number達到顯著差異(p=0.019/p=.034)； G allele frequency為23%，較控制組與其他運動高；Gln27Glu控制組的allele number達到性別上差異(p=0.057)。結論：網球選手與控制組Gln27Glu基因型與allele number達到顯著差異，可能與網球強調肌力及速度的特質，在運動能量來源上較趨向爆發力運動有關，Gln27Glu 的G allele的分佈頻率與性別有關，但是否會影響肌力、肌耐力及肌肉生長，及男性激素對於其作用，均有待再研究；G allele或許可以成為較佳的肌力及肌耐力的參考指標。

Adrenergic receptor β2(ADRB2) exists in cells such as heart, muscle, vessels, bronchus & lipocyte. ADRB2 combines exercise-induced catecholamines to elevate heartbeat, lipolysis, glycogenolysis & bronchodilation. ADRB2 locates in 5q31~32, three single-nucleotide polymorphisms (SNPs) of ADRB2 (Arg16Gly, Gln27Glu & Thr164Ile) are hypothesize to associate with endurance- performance due to ADRB2’s regulation of cardiopulmonary, lipid metabolism & skeletal muscle. Researches about ADRB2 & endurance-exercise are rare & the results are inconsistent. Exercise-induced mechanisms of ADRB2 remain unclear, and more study is necessary. Purpose: To investigate whether ADRB2 SNPs are associated with endurance-exercise performance, & provide frequency data of ADRB2 polymorphism in Taiwan. Methods: We examined 142 elite endurance athletes (road-cycling, rowing, badminton, soccer, tennis, table-tennis & rugby) and 246 healthy people (as controls) from Taiwan general population. ADRB2 genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) form blood-extracted DNA. Differences were evaluated using SPSS 13.0 χ2-test (α= .05). Results: Thr164Ile has no mutation & Arg16Gly genotype did not differ among athletes and controls. Tennis players’ Gln27Glu genotype distribution differ significantly as compare to controls ( p=.034). Gln27Glu allele number is higher in Tennis players (G allele frequency is 23%) than the controls (p=0.019). Gln27Glu allele number also significantly different by genders (p=0.057).Conclusion: The emphasize of muscle strength & speed in Tennis, leading it to anaerobic demand might cause the significant different between Tennis players and the controls. Gln27Glu allele number is associated with gender, whether it affects muscle strength, endurance & growth is unknown. The interaction of androgen also need further study. The G allele of Gln27Glu might be a candidate gene for athletes’ muscle strength & endurance.

于家城、林嘉志、施科念、高美媚、張林松、陳瑩玲 （譯） （2006） 。人體生理學。台北市：新文京開發出版社。(Fox, S. I., 2004)。

李雋、孔維佳 （2005） 。腎上腺素β受體和膽鹼能M受體對邊緣細胞鉀離子轉運的調控。國際耳鼻咽喉頭頸外科雜誌，29（6），323-325。

林正常（1998）。運動生理學。台北市：師大書苑。

林正常（1996）。運動生理學實驗指引。台北市：師大書苑。

陳淑華、李玲慧、黃曉薇、林介華、林仲彥（譯）（2006） 。人類分子遺傳學。台北縣：藝軒圖書。(Strachan, T. & Read, A. P., 2003)

韓鴻志、陳穎信、劉曉東、 朱士傑、藍國徵、劉敏英（2000）。乙二型腎上腺素接受體基因多型性變化在國人慢性阻塞性肺疾病的研究。中華民國急救加護醫學會雜誌， 11（2）， 69-78。

李麗珍、陳慕聰、黃宏裕、 陳宗與、蘇福新（2005）。運動調控基因表現：與健康相關性之研究。大專體育學刊，7（2）， 287-299。

林俊宏、洪彰岑（2005）。影響網球運動表現的因素與訓練之探討。中華體育季刊，19（3），74-82。

林正常、蔡崇濱、劉立宇、林政東、吳忠芳（2003）。運動訓練法。臺北市: 藝軒。

洪偉欽（2006）。不同族群體適能相關基因之多型性研究。未出版博士論文，國立台灣師範大學，臺北市。

國際人類基因組單體型圖計劃(International HapMap Porject)，2009年7月25日，取自國際人類基因組單體型圖計劃網站。
Akhmetov, II, Astranenkova, I. V., & Rogozkin, V. A. (2007). Association of PPARD gene polymorphism with human physical performance. Molekuliarnaia Biologiia, 41(5), 852-857.

Aynacioglu, A. S., Cascorbi, I., Gungor, K., Ozkur, M., Bekir, N., Roots, I., et al. (1999). Population frequency, mutation linkage and analytical methodology for the Arg16Gly, Gln27Glu and Thr164Ile polymorphisms in the beta2-adrenergic receptor among Turks. British Journal of Clinical Pharmacology, 48(5), 761-764.

Boord, J. B., Fazio, S., & Linton, M. F. (2002). Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis. Current Opinion in Lipidology, 13(2), 141-147.

Bray, M. S., Hagberg, J. M., Perusse, L., Rankinen, T., Roth, S. M., Wolfarth, B., et al. (2009). The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Medicine and Science in Sports and Exercise, 41(1), 35-73.

Buxton, B. F., Jones, C. R., Molenaar, P., & Summers, R. J. (1987). Characterization and autoradiographic localization of beta-adrenoceptor subtypes in human cardiac tissues. British Journal of Pharmacology, 92(2), 299-310.

Costill, D. L. (1967). The relationship between selected physiological variables and distance running performance. The Journal of Sports Medicine and Physical Fitness, 7(2), 61-66.

Davids, K., & Baker, J. (2007). Genes, environment and sport performance: why the nature-nurture dualism is no longer relevant. Sports Medicine, 37(11), 961-980.

Davis, E., Loiacono, R., & Summers, R. J. (2008). The rush to adrenaline: drugs in sport acting on the beta-adrenergic system. British Journal of Pharmacology, 154(3), 584-597.

Ellsworth, D. L., Coady, S. A., Chen, W., Srinivasan, S. R., Elkasabany, A., Gustat, J., et al. (2002). Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. International Journal of Obesity and Related Metabolic Disorder, 26(7), 928-937.

Farrell, P. A., Wilmore, J. H., Coyle, E. F., Billing, J. E., & Costill, D. L. (1979). Plasma lactate accumulation and distance running performance. Medicine and Science in Sports, 11(4), 338-344.

Green, S. A., Turki, J., Bejarano, P., Hall, I. P., & Liggett, S. B. (1995). Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology, 13(1), 25-33.

Guimaraes, S., & Moura, D. (2001). Vascular adrenoceptors: an update. Pharmacological Reviews, 53(2), 319-356.

Iwamoto, N., Ogawa, Y., Kajihara, S., Hisatomi, A., Yasutake, T., Yoshimura, T., et al. (2001). Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver. Clinica Chimica Acta; International Journal of Clinical Chemistry and Diagnostic Laboratory Medicine, 314(1-2), 85-91.

Jocken, J. W., Blaak, E. E., Schiffelers, S., Arner, P., van Baak, M. A., & Saris, W. H. (2007). Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation. International Journal of Obesity , 31(5), 813-819.

Jocken, J. W., Blaak, E. E., van der Kallen, C. J., van Baak, M. A., & Saris, W. H. (2008). Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene. Metabolism: Clinical and Experimental.57(3), 326-332.

Kawaguchi, H., Masuo, K., Katsuya, T., Sugimoto, K., Rakugi, H., Ogihara, T., et al. (2006). beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals. Hypertension Research, 29(12), 951-959.

Macho-Azcarate, T., Marti, A., Calabuig, J., & Martinez, J. A. (2003). Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism. The Journal of Nutritional Biochemistry, 14(5), 275-279.

Macho-Azcarate, T., Marti, A., Gonzalez, A., Martinez, J. A., & Ibanez, J. (2002). Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women. International Journal of Obesity and Related Metabolic Disorders, 26(11), 1434-1441.

McArdil, W. D., Katch, F. I., & Katch, V. L. (2001). Exercise physiology: Energy, nutrition, and human performance. Lippincott Williams and Wilkins .

Meirhaeghe, A., Helbecque, N., Cottel, D., & Amouyel, P. (1999). Beta2-adrenoceptor gene polymorphism, body weight, and physical activity. Lancet, 353(9156), 896.

Moore, G. E., Shuldiner, A. R., Zmuda, J. M., Ferrell, R. E., McCole, S. D., & Hagberg, J. M. (2001). Obesity gene variant and elite endurance performance. Metabolism: Clinical and Experimental, 50(12), 1391-1392.

Rang HP, Dale MM, Ritter JM, & Moore, P. (2003). Pharmacology, (5th ed.). Churchill Livingstone: Edinburgh.

Rankinen, T., Bray, M. S., Hagberg, J. M., Perusse, L., Roth, S. M., Wolfarth, B., et al. (2006). The human gene map for performance and health-related fitness phenotypes: the 2005 update. Medicine and Science in Sports and Exercise, 38(11), 1863-1888.

Snyder, E. M., Beck, K. C., Dietz, N. M., Eisenach, J. H., Joyner, M. J., Turner, S. T., et al. (2006). Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans. The Journal of Physiology, 571(Pt 1), 121-130.

Snyder, SE. M., Johnson, B. D., & Joyner, M. J. (2008). Genetics of beta2-adrenergic receptors and the cardiopulmonary response to exercise. Exercise and Sport Sciences Reviews, 36(2), 98-105.

Stob, N. R., Seals, D. R., Jorgen, J., van Baak, M. A., Steig, A. J., Lindstrom, R. C., et al. (2007). Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density. Experimental Physiology, 92(5), 823-830.

Trombetta, I. C., Batalha, L. T., Rondon, M. U., Laterza, M. C., Frazzatto, E., Alves, M. J., et al. (2005). Gly16 + Glu27 beta2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans. Journal of Applied Physiology, 98(3), 787-794.

Turki, J., Pak, J., Green, S. A., Martin, R. J., & Liggett, S. B. (1995). Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. The Journal of Clinical Investigation, 95(4), 1635-1641.

Vatner, D. E., Knight, D. R., Homcy, C. J., Vatner, S. F., & Young, M. A. (1986). Subtypes of beta-adrenergic receptors in bovine coronary arteries. Circulation Research, 59(4), 463-473.

Wagoner, L. E., Craft, L. L., Singh, B., Suresh, D. P., Zengel, P. W., McGuire, N., et al. (2000). Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. Circulation Research, 86(8), 834-840.

Wasserman, K., Van Kessel, A. L., & Burton, G. G. (1967). Interaction of physiological mechanisms during exercise. Journal of Applied Physiology, 22(1), 71-85.

Wolfarth, B., Rankinen, T., Muhlbauer, S., Scherr, J., Boulay, M. R., Perusse, L., et al. (2007). Association between a beta2-adrenergic receptor polymorphism and elite endurance performance. Metabolism: Clinical and Experimental,56(12), 1649-1651.

Yu, I. W., & Bukaveckas, B. L. (2008). Pharmacogenetic tests in asthma therapy. Clinics in Laboratory Medicine, 28(4), 645-665.