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研究生: 孫聞賢
Sun, Wen-Hsien
論文名稱: 十二週阻力訓練對高齡者體脂率與發炎狀態的影響
Effects of 12 weeks resistance training on body fat percentage and inflammation in healthy older adults
指導教授: 劉宏文
Liu, Hung-Wen
學位類別: 碩士
Master
系所名稱: 體育學系
Department of Physical Education
論文出版年: 2020
畢業學年度: 108
語文別: 中文
論文頁數: 55
中文關鍵詞: 阻力運動老化發炎脂肪TNF-αIL-6
英文關鍵詞: resistance training, elderly, chronic inflammation, body fat percentage, TNF-α, IL-6
DOI URL: http://doi.org/10.6345/NTNU202001263
論文種類: 學術論文
相關次數: 點閱:220下載:54
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  • 根據內政部統計,臺灣自1993年起進入高齡化社會,2018年10月我國65歲以上老年人口達到339萬8022人,為總人口之14.41%,正式成為高齡社會結構,如何維護高齡人口的健康與生活品質是一大課題。伴隨老化而隨之增加的脂肪及脂肪相關發炎細胞激素的濃度會增加高齡者罹患慢性疾病的風險,如: 心血管疾病和二型糖尿病等。長期阻力訓練相較於有氧運動訓練,對於體脂肪和發炎細胞激素的影響仍未有一致的結論。本研究主要探討十二週阻力訓練介入,對於高齡者體脂率與發炎細胞激素的影響。方法:以19名健康高齡者為研究對象 (年齡:67.9 ± 3.2歲) ,訓練組10名進行12週、每週3次、每項動作執行3組的全身性漸進式阻力訓練;控制組9名則維持正常生活型態。觀察訓練介入前後體脂肪、脂肪相關細胞激素,如: 腫瘤壞死因子α (Tumor Necrosis Factor-α,TNF-α)、介白素6 (Interleukin-6, IL-6) 及瘦素 (leptin) 之變化,所得數據以混合設計二因子變異數分析進行分析。結果:訓練組及控制組十二週阻力訓練前後體重及BMI無顯著變化。十二週阻力訓練介入後,訓練組體脂率及皮脂厚度總和皆顯著下降,且與控制組有顯著差異 (p < .05)。本研究觀察到血清TNF-濃度後測值顯著低於前測值。訓練組及控制組十二週阻力訓練前後血清IL-6及leptin濃度無顯著差異。進一步比較訓練前後血清IL-6及leptin濃度變化量,觀察到訓練組有下降趨勢,而控制組有上升趨勢。結論:實施十二週阻力訓練,在未顯著改變體重情況下有效降低高齡者體脂率,代表阻力訓練可延緩隨著老化而增加的脂肪率。再者,血清細胞激素濃度在阻力訓練後呈下降的趨勢,高齡者長期從事阻力運動可降低與細胞激素相關的慢性疾病的風險。

    According to statistics from the Ministry of the Interior, Taiwan has entered an aging society since 1993. In October 2018, the number of elderly people over 65 in Taiwan reached 3,398,022, which was 14.41% of the total population, signifying that Taiwan has officially become an aging society. How to maintain the health conditions and the quality of life of the elderly population is a big issue. Adipose tissue and adipose-related inflammatory cytokines are increased with aging, thereby increasing the risk of chronic diseases, such as cardiovascular disease and type 2 diabetes. The effects of long-term resistance training on body fat and adipose-related inflammatory cytokines, compared with those of aerobic exercise traing, remain controversial, especially in older adults. The present study was to investigate the effects of a 12-week resistance training on body fat percentage and inflammatory cytokines in healthy older adults. Methods: Nineteen healthy older adults (Age:67.9 ± 3.2 years) without previous experience in resistance training were recruited. Exercise group (EX, n=10) performed progressive resistance training (3 times/week) and control group (CON, n=9) maintained their normal life style. Body weight, body mass index (BMI), body fat percentage (BFP), and levels of adipose-related cytokines were observed and analyzed by two-way ANOVA. Results: There were no significant differences in the BW and BMI of EX and CON groups after the 12-week resistance training. Yet, body fat percentage and skinfold thickness were significantly decreased in EX group compared with pre-training data and CON group (p < .05). Serum level of TNF-α was significantly decreased compared with pre-training. There were no significant differences in serum levels of IL-6 and leptin in EX and CON groups after the resistance training. With further comparison of the pre-training and post-training serum levels of IL-6 and leptin, there was a tendency of decrease in EX group, and a tendency of increase in CON group. Conclusion: Resistance training effectively lowered BFP without changing BW, suggesting that age-related increase in body fat percentage has been attenuated by resistance training. Levels of serum cytokines tend to decrease with resistance training. Therefore, older adults may lower their risk of cytokine-related chronic diseases.

    第壹章 緒論 1 第一節 研究背景 1 第二節 研究目的 2 第三節 研究假設 2 第四節 名詞操作性定義 2 第五節 研究限制 3 第六節 研究重要性 3 第貳章 文獻回顧 4 第一節 肥胖與疾病相關研究 4 第二節 發炎狀態相關研究 6 第三節 阻力訓練與發炎細胞激素的文獻探討 9 第四節 阻力訓練介入高齡者身體組成 13 第五節 高齡者阻力訓練處方 13 第六節 小結 14 第參章 研究方法 15 第一節 招募受試者 15 第二節 實驗時間與地點 15 第三節 實驗流程 15 第四節 實驗方法與步驟 17 第五節 資料處理及統計分析 23 第肆章 研究結果 24 第一節 受試者基本資料 24 第二節 身體組成參數之比較 26 第三節 發炎細胞激素之比較 29 第四節 身體組成參數與發炎細胞激素之相關性 33 第伍章 討論 35 第一節 阻力訓練對高齡者身體組成的影響 36 第二節 阻力訓練對於脂肪相關發炎細胞激素的影響 36 第三節 身體組成參數與發炎細胞激素之相關 38 第陸章 結論 40 引用文獻 41 附件 47 附件(一) 受試者同意書 47 附件(二) 健康狀況與運動習慣調查表 48 附件(三) 身體活動問卷調查表 52 附件(四) 迷你型營養狀況調查表 55

    李水碧, & 李志雄. (2004). 阻力運動與骨質疏鬆症. 中華體育季刊, 18(4), 48-57.

    Afoke, A., Eeg‐Olofsson, O., Hed, J., Kjellman, N. I., Lindblom, B., & Ludvigsson, J. (1993). Seasonal variation and sex differences of circulating macrophages, immunoglobulins and lymphocytes in healthy school children. Scandinavian Journal of Immunology, 37(2), 209-215.

    Anderson, T., & Kearney, J. T. (1982). Effects of three resistance training programs on muscular strength and absolute and relative endurance. Research Quarterly for Exercise and Sport, 53(1), 1-7.

    Argiles, J. M., Busquets, S., Stemmler, B., & Lopez-Soriano, F. J. (2015). Cachexia and sarcopenia: mechanisms and potential targets for intervention. Current Opinion in Pharmacology, 22, 100-106.

    Arnold, P., Njemini, R., Vantieghem, S., Gorus, E., Pool-Goudzwaard, A., Buyl, R., & Bautmans, I. (2018). Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product. Experimental Gerontology, 108, 118-124.

    Arnott, C. H., Scott, K. A., Moore, R. J., Hewer, A., Phillips, D. H., Parker, P., . . . Owens, D. M. J. O. (2002). Tumour necrosis factor-α mediates tumour promotion via a PKCα-and AP-1-dependent pathway. Oncogene, 21(31), 4728-4738.

    Bautmans, I., Njemini, R., Vasseur, S., Chabert, H., Moens, L., Demanet, C., & Mets, T. (2005). Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology, 51(4), 253-265.

    Bodine, S. C., & Baehr, L. M. (2014). Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1. American Journal of Physiology-Endocrinology and Metabolism, 307(6), E469-E484.

    Bonaccio, M., Di Castelnuovo, A., Pounis, G., De Curtis, A., Costanzo, S., Persichillo, M., . . . Iacoviello, L. (2016). A score of low-grade inflammation and risk of mortality: prospective findings from the Moli-sani study. Haematologica, 101(11), 1434-1441.

    Bruunsgaard, H., Bjerregaard, E., Schroll, M., & Pedersen, B. K. (2004). Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. Journal of the American Geriatrics Society, 52(2), 237-241.

    Bruunsgaard, H., Skinhøj, P., Pedersen, A. N., Schroll, M., & Pedersen, B. K. (2000). Ageing, tumour necrosis factor‐alpha (TNF‐α) and atherosclerosis. Clinical & Experimental Immunology, 121(2), 255-260.

    Córdova, C., Lopes-e-Silva Jr, F., Pires, A. S., Souza, V. C., Brito, C. J., Moraes, C. F., . . . Nóbrega, O. T. (2011). Long-term resistance training is associated with reduced circulating levels of IL-6, IFN-gamma and TNF-alpha in elderly women. Neuroimmunomodulation, 18(3), 165-170.

    C.E. Ruhl, T. B. H., J. Ding, B.H. Goodpaster, A.M. Kanaya, S.B. Kritchevsky, et al. . (2007). Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. The American Journal of Clinical Nutrition, 85(4), 1121-1126.

    Campbell, W. W., Crim, M. C., Young, V. R., & Evans, W. J. (1994). Increased energy requirements and changes in body composition with resistance training in older adults. The American Journal of Clinical Nutrition, 60(2), 167-175.

    Candow, D. G., Forbes, S. C., Little, J. P., Cornish, S. M., Pinkoski, C., & Chilibeck, P. D. (2012). Effect of nutritional interventions and resistance exercise on aging muscle mass and strength. Biogerontology, 13(4), 345-358.

    Chupel, M. U., Direito, F., Furtado, G. E., Minuzzi, L. G., Pedrosa, F. M., Colado, J. C., . . . Teixeira, A. M. (2017). Strength training decreases inflammation and increases cognition and physical fitness in older women with cognitive impairment. Frontiers in Physiology, 8, 377.

    Cornish, S. M., Myrie, S. B., Bugera, E. M., Chase, J. E., Turczyn, D., & Pinder, M. (2018). Omega-3 supplementation with resistance training does not improve body composition or lower biomarkers of inflammation more so than resistance training alone in older men. Nutrition Research, 60, 87-95.

    Delshad, M., Ghanbarian, A., Mehrabi, Y., Sarvghadi, F., & Ebrahim, K. (2013). Effect of strength training and short-term detraining on muscle mass in women aged over 50 years old. International Journal of Preventive Medicine, 4(12), 1386.

    El-Kader, S. M. A., & Al-Shreef, F. M. (2018). Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. African Health Sciences, 18(1), 120-131.

    Fatouros, I., Tournis, S., Leontsini, D., Jamurtas, A., Sxina, M., Thomakos, P., . . . Mitrakou, A. (2005). Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. The Journal of Clinical Endocrinology & Metabolism, 90(11), 5970-5977.

    Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 69(Suppl_1), S4-S9.

    Frontera, W. R., Meredith, C. N., O'Reilly, K. P., Knuttgen, H. G., & Evans, W. J. (1988). Strength conditioning in older men: skeletal muscle hypertrophy and improved function. Journal of Applied Physiology, 64(3), 1038-1044.

    Ghaben, A. L., & Scherer, P. E. (2019). Adipogenesis and metabolic health. Nature Reviews Molecular Cell Biology, 20(4), 242-258.

    Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011). The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews Immunology, 11(9), 607-615.

    Guerra, R., Amaral, T. F., Marques, E., Mota, J., & Restivo, M. (2010). Accuracy of Siri and Brozek equations in the percent body fat estimation in older adults. The Journal of Nutrition, Health & Aging, 14(9), 744-748.

    Hagstrom, A. D., Marshall, P. W., Lonsdale, C., Papalia, S., Cheema, B. S., Toben, C., . . . Green, S. (2016). The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial. Breast Cancer Research and Treatment, 155(3), 471-482.

    Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation, 95(5), 2409-2415.

    Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996). IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science, 271(5249), 665-670.

    Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993). Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259(5091), 87-91.

    Hunter, G. R., Wetzstein, C. J., Fields, D. A., Brown, A., & Bamman, M. M. (2000). Resistance training increases total energy expenditure and free-living physical activity in older adults. Journal of Applied Physiology, 89(3), 977-984.

    Hurley, B. F., & Roth, S. M. (2000). Strength training in the elderly. Sports Medicine, 30(4), 249-268.
    Koh, K. K., Park, S. M., & Quon, M. J. (2008). Leptin and cardiovascular disease: response to therapeutic interventions. Circulation, 117(25), 3238-3249.

    Kohrt, W. M., Landt, M., & Birge Jr, S. (1996). Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. The Journal of Clinical Endocrinology & Metabolism, 81(11), 3980-3985.

    Kohut, M., McCann, D., Russell, D., Konopka, D., Cunnick, J., Franke, W., . . . Vanderah, E. (2006). Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults. Brain, Behavior, and Immunity, 20(3), 201-209.

    Kraemer, W. J., Ratamess, N. A., & Komi, P. (2003). Endocrine responses and adaptations to strength and power training. Strength and Power in Sport, 2, 361-386.

    Lechleitner, M. (2008). Obesity and the metabolic syndrome in the elderly–a mini-review. Gerontology, 54(5), 253-259.

    Lu, K., Yu, F., Shi, T., Shen, S., Li, L., Li, Y., . . . Wang, W. (2018). Seasonal variance of serum biomarker levels in osteoarthritis patients: a cross-sectional study of 104 patients. Int J Clin Exp Med, 11(10), 10774-10780.

    Manolopoulos, K., Karpe, F., & Frayn, K. (2010). Gluteofemoral body fat as a determinant of metabolic health. International Journal of Obesity, 34(6), 949-959.

    Martins, M. S., Farinha, J. B., Benetti, C. B., Courtes, A. A., Duarte, T., Da Silva, J. C. N., . . . dos Santos, D. L. (2015). Positive effects of resistance training on inflammatory parameters in men with metabolic syndrome risk factors. Nutrición Hospitalaria, 32(2), 792-798.

    Matsuzawa, Y., Shimomura, I., Nakamura, T., Keno, Y., Kotani, K., & Tokunaga, K. (1995). Pathophysiology and pathogenesis of visceral fat obesity. Obesity Research, 3(S2), 187s-194s.

    Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D., Miles, J., Yudkin, J., . . . Coppack, S. (1997). Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. The Journal of Clinical Endocrinology & Metabolism, 82(12), 4196-4200.

    Ogawa, K., Sanada, K., Machida, S., Okutsu, M., & Suzuki, K. (2010). Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators of Inflammation, 2010.

    Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007). The epidemiology of obesity. Gastroenterology, 132(6), 2087-2102.

    Okosun, I. S., Liao, Y., Rotimi, C. N., Prewitt, T. E., & Cooper, R. S. (2000). Abdominal adiposity and clustering of multiple metabolic syndrome in White, Black and Hispanic Americans. Annals of Epidemiology, 10(5), 263-270.

    Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011). Adipokines in inflammation and metabolic disease. Nature Reviews Immunology, 11(2), 85.

    Paz-Filho, G., Mastronardi, C., Franco, C. B., Wang, K. B., Wong, M.-L., & Licinio, J. (2012). Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications. Arquivos Brasileiros de Endocrinologia & Metabologia, 56(9), 597-607.

    Phillips, M. D., Flynn, M. G., McFarlin, B. K., Stewart, L. K., & Timmerman, K. L. (2010). Resistance training at eight-repetition maximum reduces the inflammatory milieu in elderly women. Medicine & Science in Sports & Exercise, 42(2), 314-325.

    Phillips, M. D., Patrizi, R. M., Cheek, D. J., Wooten, J. S., Barbee, J. J., & Mitchell, J. B. (2012). Resistance training reduces subclinical inflammation in obese, postmenopausal women. Medicine & Science in Sports & Exercise, 44(11), 2099-2110.

    Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., . . . Ben-Neriah, Y. (2004). NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature, 431(7007), 461-466.

    Ryan, A., Pratley, R., Elahi, D., & Goldberg, A. (2000). Changes in plasma leptin and insulin action with resistive training in postmenopausal women. International Journal of Obesity, 24(1), 27-32.

    Santos-Alvarez, J., Goberna, R., & Sánchez-Margalet, V. (1999). Human leptin stimulates proliferation and activation of human circulating monocytes. Cellular Immunology, 194(1), 6-11.

    Seidell, J. C., & Visscher, T. L. (2000). Body weight and weight change and their health implications for the elderly. European Journal of Clinical Nutrition, 54(3), S33-S39.

    Serra, M. C., Ryan, A. S., Ortmeyer, H. K., Addison, O., & Goldberg, A. P. (2018). Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors. Menopause (New York, NY), 25(2), 211.

    Sethi, G., Sung, B., & Aggarwal, B. B. (2008). TNF: a master switch for inflammation to cancer. Front Biosci, 13(2), 5094-5107.

    Silva, B. S., Lira, F. S., Rossi, F. E., Ramos, D., Uzeloto, J. S., Freire, A. P., . . . Ramos, E. (2018). Inflammatory and metabolic responses to different resistance training on chronic obstructive pulmonary disease: a randomized control trial. Frontiers in Physiology, 9, 262.

    Singh, T., & Newman, A. B. (2011). Inflammatory markers in population studies of aging. Ageing Research Reviews, 10(3), 319-329.

    Sloan, R. P., Shapiro, P. A., DeMeersman, R. E., McKinley, P. S., Tracey, K. J., Slavov, I., . . . Flood, P. D. (2007). Aerobic exercise attenuates inducible TNF production in humans. Journal of Applied Physiology, 103(3), 1007-1011.

    Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., . . . Pfeiffer, A. F. (2003). Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes, 52(3), 812-817.

    Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003). Exercise and IL-6 infusion inhibit endotoxin-induced TNF-α production in humans. The FASEB Journal, 17(8), 884-886.

    Stowe, R. P., Peek, M. K., Cutchin, M. P., & Goodwin, J. S. (2010). Plasma cytokine levels in a population-based study: relation to age and ethnicity. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 65(4), 429-433.

    Suganuma, M., Okabe, S., Marino, M. W., Sakai, A., Sueoka,
    E., & Fujiki, H. (1999). Essential role of tumor necrosis factor α (TNF-α) in tumor promotion as revealed by TNF-α-deficient mice. Cancer Research, 59(18), 4516-4518.

    Tomeleri, C. M., Ribeiro, A. S., Souza, M. F., Schiavoni, D., Schoenfeld, B. J., Venturini, D., . . . Cyrino, E. S. (2016). Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial. Experimental Gerontology, 84, 80-87.

    Tomeleri, C. M., Souza, M. F., Burini, R. C., Cavaglieri, C. R., Ribeiro, A. S., Antunes, M., . . . Sardinha, L. B. (2018). Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial: 老年女性抗阻训练可减少代谢综合征以及炎症标志物: 一项随机对照试验. Journal of Diabetes, 10(4), 328-337.

    Toth, M. J., Matthews, D. E., Tracy, R. P., & Previs, M. J. (2005). Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. American Journal of Physiology-Endocrinology and Metabolism, 288(5), E883-E891.

    Van Dielen, F., Van't Veer, C., Schols, A., Soeters, P., Buurman, W., & Greve, J. (2001). Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. International Journal of Obesity, 25(12), 1759-1766.

    Van Gaal, L. F., Mertens, I. L., & Christophe, E. (2006). Mechanisms linking obesity with cardiovascular disease. Nature, 444(7121), 875-880.

    Wanderley, F. A., Moreira, A., Sokhatska, O., Palmares, C., Moreira, P., Sandercock, G., . . . Carvalho, J. (2013). Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults. Experimental Gerontology, 48(3), 326-333.

    Wannamethee, S. G., Tchernova, J., Whincup, P., Lowe, G. D., Kelly, A., Rumley, A., . . . Sattar, N. (2007). Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. Atherosclerosis, 191(2), 418-426.

    Wieser, M., & Haber, P. (2007). The effects of systematic resistance training in the elderly. International Journal of Sports Medicine, 28(01), 59-65.

    Willoughby, D. S., & Rosene, J. (2001). Effects of oral creatine and resistance training on myosin heavy chain expression. Medicine & Science in Sports & Exercise, 33(10), 1674-1681.

    Wu, Y.-d., & Zhou, B. (2010). TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion. British Journal of Cancer, 102(4), 639-644.

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