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研究生: 顏澤卉
論文名稱: 利用微波輔助合成一系列具有特殊藥性色烯類化合物 ;利用簡單且高效率的方式藉由一鍋化合成3-羥基與3-胺基黃酮類衍生物
指導教授: 姚清發
學位類別: 碩士
Master
系所名稱: 化學系
Department of Chemistry
論文出版年: 2010
畢業學年度: 98
語文別: 中文
論文頁數: 280
中文關鍵詞: 微波
論文種類: 學術論文
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  • 本論文主要分為兩部分,第一部分是在探討藉由微波反應器輔助且在不添加催化劑條件下,將硫醇類化合物、丙二腈與2-羥基苯甲醛合成屬於著名先驅藥物之一的Chromenopyridine為骨架之化合物,其具有多種生物活性及藥理作用。
    第二部分利用微波反應器透過一鍋化合成具生物活性3-氫氧基及3-氨基-2-苯基-4H-色烯-4-酮類化合物,本實驗主要是由3-硝基-2H-色烯類衍生物經反應後獲得中間物diethyl-4-ethoxy-3-(hydroxyimino) -2-phenylchroman-4-ylphosphonatey在乙醇作為溶劑於迴流條件下獲得產物。中間物以及產物結構已由XRD被確認。

    The first part of this dissertation describes the microwave assisted , one pot catalyst-free synthesis of chromenopyridine derivatives which achieved from the reaction of thiols, malononitrile and salicyaldehyde derivatives . The chromenopyridine derivatives framework is one of the well know privileged medicinal scaffolds diverse biological and pharmacological.
      The second part describes microwave promoted a novel and highly convenient approach for one-pot synthesis of 3-hydroxy and 3-amino-2-phenyl-4H-chromen-4-one was achieved from 3-nitro -2H-chromene derivatives via diethyl-4-ethoxy-3-(hydroxyimino) -2-phenylchroman-4-ylphosphonate in refluxing ethanol was developed. The structures of the prepared compounds were characterized by XRD method. The generality of this reaction was demonstrated by synthesizing an array of 3-hydroxy and 3-amino-2-phenyl-4H-chromen-4-one derivatives.

    壹、利用微波輔助合成一系列具有特殊藥性色烯類化合物 1-1、前言 1 1-1-1、多組成反應(Multicomponent reaction)的發展與應用 1 1-1-2、苯並吡喃(benzopyran)衍生物的介紹 7 1-1-3、微波輔助有機合成(Microwave-Assisted Organic Synthesis, MAOS) 12 1-2、研究目標 18 1-3、實驗結果與討論 19 1-3-1、利用微波反應器有效的合成Benzopyranpyridine 衍生物 20 1-3-2、結論 28 1-4、實驗部分 29 1-4-1、一般實驗方法 29 1-4-2、利用微波反應器有效的合成Benzopyranpyridine 衍生物實 驗步驟 31 1-5、參考文獻 32 1-6、光譜資料: 34 貳、利用簡單且高效率的方式藉由一鍋化合成3-羥基與3-胺基黃酮類 衍生物 2-1 前言 112 2-1-1、有機磷化學 112 2-1-2、亞磷酸衍生物的介紹及在有機合成上的應用 114 2-1-3、2H-硝基色烯類化合物的應用 120 2-1-4、類黃酮衍生物(Flavonoids)的發展及應用 122 2-2、研究目標 128 2-3、實驗結果與討論 129 2-3-1、一鍋化反應合成異黃酮類衍生物 129 2-3-2、結論 144 2-4、實驗部分 145 2-4-1、一般實驗方法 145 2-4-2、利用微波反應器有效的合成Benzopyranpyridine 衍生物實 驗步驟: 147 2-5、參考資料 148 2-6、光譜資料 150

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