研究生: |
劉書豪 Liu, Shu-Hao |
---|---|
論文名稱: |
以自組裝攜帶型人體呼氣感測裝置對人體各種狀態下的呼吸商進行探討 Explore the Respiratory Quotient in Various States of Human Body by Self-Assembled Portable Human Breath Sensing Device |
指導教授: |
林震煌
Lin, Cheng-Huang |
學位類別: |
碩士 Master |
系所名稱: |
化學系 Department of Chemistry |
論文出版年: | 2021 |
畢業學年度: | 109 |
語文別: | 中文 |
論文頁數: | 121 |
中文關鍵詞: | 氣體感測器 、人體呼氣 、呼吸商 、氧氣 、二氧化碳 |
DOI URL: | http://doi.org/10.6345/NTNU202100067 |
論文種類: | 學術論文 |
相關次數: | 點閱:128 下載:0 |
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本研究使用氣體感測器為基礎,結合LabVIEW(Laboratory Virtual Instrumentation Engineering Workbench)電腦語言程式及獨創的氣哨聲波技術,成功開發出一款新型的攜帶式人體呼氣感測裝置,此裝置不只能對環境的氧氣及二氧化碳進行即時監測,還能對人體呼氣進行分析,本研究突破了以往大多數氣體分析實驗中須使用龐大且昂貴的氣象層析質譜儀的限制,人體呼氣感測裝置不只具有體積小且價格合理的優點,同時具備測量精準、操作簡單、不受環境限制及非侵入式設計等優勢,讓人體呼氣感測裝置在未來有相當大的發展空間。
在人體呼氣實驗中對受試者各種狀態下的呼吸商(respiratory quotient,RQ)進行探討,其中包含正常狀態、睡眠狀態(正常睡眠、午睡、失眠與賴床)及運動狀態(有氧運動與無氧運動),發現人體在睡眠狀態時,呼吸商大幅降低且隨著睡眠深度改變呈現三階段變化,而人體在有氧運動狀態時呼吸商呈S形線性下降,在無氧運動狀態時則小幅度上升,這些趨勢證明呼吸商與身體狀態具備高度關連性,使用人體呼氣感測裝置檢測呼吸商能作為判斷身體狀況的依據。
In this study, we used a gas sensor as the basis, in conjunction with the LabVIEW(Laboratory Virtual Instrumentation Engineering Workbench)computer language program and the original whistle sound wave technology, successfully developed a portable human breath sensing device. This device is not only used in the concentration measurement of the environment, but also used to analyze human breath. We break through the limitation of using large and expensive gas chromatography mass spectrometry in most gas analysis experiments. The advantage of human breath sensing device is small size, reasonable price, accurate measurement, simple operation and without the limitation of environment.
In the human breath experiment, the respiratory quotient of the subject under various states was explored. It was found that when human is in sleep state, the respiratory quotient is greatly reduced and presents a three-stage change according to sleep depth. We also found that the respiratory quotient decreases as an S-shape during aerobic exercise and increases slightly during anaerobic exercise.
1. Schulz, S., et al., SNOMED reaching its adolescence: Ontologists’ and logicians’ health check. International journal of medical informatics, 2009. 78: p. S86-S94.
2. Artac, M., et al., Uptake of the NHS Health Check programme in an urban setting. Family practice, 2013. 30(4): p. 426-435.
3. Ferket, B.S., et al., Systematic review of guidelines on cardiovascular risk assessment: which recommendations should clinicians follow for a cardiovascular health check? Archives of internal medicine, 2010. 170(1): p. 27-40.
4. Laaksonen, M., et al., Register-based study among employees showed small nonparticipation bias in health surveys and check-ups. Journal of clinical epidemiology, 2008. 61(9): p. 900-906.
5. Thorogood, M., et al., Factors affecting response to an invitation to attend for a health check. Journal of Epidemiology & Community Health, 1993. 47(3): p. 224-228.
6. Robson, J., et al., The NHS Health Check in England: an evaluation of the first 4 years. BMJ open, 2016. 6(1).
7. Bugaev, A., et al. Through wall sensing of human breathing and heart beating by monochromatic radar. in Proceedings of the Tenth International Conference on Grounds Penetrating Radar, 2004. GPR 2004. 2004. IEEE.
8. Cooke, W.H., et al., Controlled breathing protocols probe human autonomic cardiovascular rhythms. American Journal of Physiology-Heart and Circulatory Physiology, 1998. 274(2): p. H709-H718.
9. MacLarnon, A.M. and G.P. Hewitt, The evolution of human speech: The role of enhanced breathing control. American Journal of Physical Anthropology: The Official Publication of the American Association of Physical Anthropologists, 1999. 109(3): p. 341-363.
10. De Troyer, A. and M.G. Sampson, Activation of the parasternal intercostals during breathing efforts in human subjects. Journal of Applied Physiology, 1982. 52(3): p. 524-529.
11. Russo, M.A., D.M. Santarelli, and D. O’Rourke, The physiological effects of slow breathing in the healthy human. Breathe, 2017. 13(4): p. 298-309.
12. Pal, G.K. and S. Velkumary, Effect of short-term practice of breathing exercises on autonomic functions in normal human volunteers. Indian Journal of Medical Research, 2004. 120(2): p. 115.
13. Hirsch, J. and B. Bishop, Human breathing patterns on mouthpiece or face mask during air, CO2, or low O2. Journal of Applied Physiology, 1982. 53(5): p. 1281-1290.
14. Kutty, M., Respiratory quotient and ammonia excretion in Tilapia mossambica. Marine biology, 1972. 16(2): p. 126-133.
15. Walsberg, G. and B. Wolf, Variation in the respiratory quotient of birds and implications for indirect calorimetry using measurements of carbon dioxide production. Journal of Experimental Biology, 1995. 198(1): p. 213-219.
16. Gorostiaga, E., C. Maurer, and J. Eclache, Decrease in respiratory quotient during exercise following L-carnitine supplementation. International journal of sports medicine, 1989. 10(03): p. 169-174.
17. Feurer, I. and J.L. Mullen, Bedside measurement of resting energy expenditure and respiratory quotient via indirect calorimetry. Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition (USA), 1986.
18. Buck, C.L. and B.M. Barnes, Effects of ambient temperature on metabolic rate, respiratory quotient, and torpor in an arctic hibernator. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2000. 279(1): p. R255-R262.
19. Krogh, A. and J. Lindhard, The relative value of fat and carbohydrate as sources of muscular energy: with appendices on the correlation between standard metabolism and the respiratory quotient during rest and work. Biochemical Journal, 1920. 14(3-4): p. 290-363.
20. Himwich, H. and L. Nahum, The respiratory quotient of the brain. American Journal of Physiology-Legacy Content, 1932. 101(3): p. 446-453.
21. Flatt, J., Body composition, respiratory quotient, and weight maintenance. The American journal of clinical nutrition, 1995. 62(5): p. 1107S-1117S.
22. Richardson, H.B., The respiratory quotient. Physiological Reviews, 1929. 9(1): p. 61-125.
23. Issekutz Jr, B. and K. Rodahl, Respiratory quotient during exercise. Journal of applied physiology, 1961. 16(4): p. 606-610.
24. Westerterp, K., Food quotient, respiratory quotient, and energy balance. The American journal of clinical nutrition, 1993. 57(5): p. 759S-765S.
25. McClave, S.A., et al., Clinical use of the respiratory quotient obtained from indirect calorimetry. Journal of Parenteral and enteral Nutrition, 2003. 27(1): p. 21-26.
26. Peronnet, F. and D. Massicotte, Table of nonprotein respiratory quotient: an update. Can J Sport Sci, 1991. 16(1): p. 23-29.
27. Marcil, M., et al., Exercise training induces respiratory substrate-specific decrease in Ca2+-induced permeability transition pore opening in heart mitochondria. American Journal of Physiology-Heart and Circulatory Physiology, 2006. 290(4): p. H1549-H1557.
28. Atlante, A., et al., Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. Journal of Biological Chemistry, 2000. 275(47): p. 37159-37166.
29. Liu, H.S., et al., Respiratory substrate availability plays a crucial role in the response of soil respiration to environmental factors. Applied Soil Ecology, 2006. 32(3): p. 284-292.
30. Araújo, W.L., et al., Protein degradation–an alternative respiratory substrate for stressed plants. Trends in plant science, 2011. 16(9): p. 489-498.
31. Siirila, E.R., et al., A quantitative methodology to assess the risks to human health from CO2 leakage into groundwater. Advances in Water Resources, 2012. 36: p. 146-164.
32. Affek, H.P. and J.M. Eiler, Abundance of mass 47 CO2 in urban air, car exhaust, and human breath. Geochimica et Cosmochimica Acta, 2006. 70(1): p. 1-12.
33. Nagelkerken, I. and S.D. Connell, Global alteration of ocean ecosystem functioning due to increasing human CO2 emissions. Proceedings of the National Academy of Sciences, 2015. 112(43): p. 13272-13277.
34. Li, Q., et al., Properties of char particles obtained under O2/N2 and O2/CO2 combustion environments. Chemical Engineering and Processing: Process Intensification, 2010. 49(5): p. 449-459.
35. Chen, J., et al., Control of PM1 by kaolin or limestone during O2/CO2 pulverized coal combustion. Proceedings of the Combustion Institute, 2011. 33(2): p. 2837-2843.
36. Beran, A.V., et al., Investigation of transcutaneous O2-CO2 sensors and their application on human adults and newborns. Original Article Series, 1979. 15: p. 421.
37. Valtuena, S., J. Salas-Salvado, and P. Lorda, The respiratory quotient as a prognostic factor in weight-loss rebound. International journal of obesity, 1997. 21(9): p. 811-817.
38. Beaudry, R.M., Effect of carbon dioxide partial pressure on blueberry fruit respiration and respiratory quotient. Postharvest Biology and Technology, 1993. 3(3): p. 249-258.
39. Gnaiger, E., Calculation of energetic and biochemical equivalents of respiratory oxygen consumption, in Polarographic oxygen sensors. 1983, Springer. p. 337-345.
40. Cathcart, E. and J. Markowitz, The influence of various sugars on the respiratory quotient: A contribution to the significance of the RQ. The Journal of physiology, 1927. 63(4): p. 309.
41. Nishikawa, H., et al., Serum Zinc Level and non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases. Journal of Clinical Medicine, 2020. 9(1): p. 255.
42. Saito, M., et al., Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. Journal of gastroenterology, 2012. 47(6): p. 704-714.
43. Higgins, J.A., et al., Resistant starch consumption promotes lipid oxidation. Nutrition & Metabolism, 2004. 1(1): p. 8.
44. Saito, S., et al., Effects of diacylglycerol on postprandial energy expenditure and respiratory quotient in healthy subjects. Nutrition, 2006. 22(1): p. 30-35.
45. Elia, M. and G. Livesey, Theory and validity of indirect calorimetry during net lipid synthesis. The American Journal of Clinical Nutrition, 1988. 47(4): p. 591-607.
46. Lahaije, A., et al., Physiologic limitations during daily life activities in COPD patients. Respiratory medicine, 2010. 104(8): p. 1152-1159.
47. Ramires, B.R., et al., Resting energy expenditure and carbohydrate oxidation are higher in elderly patients with COPD: a case control study. Nutrition journal, 2012. 11(1): p. 37.
48. Cai, B., et al., Effect of supplementing a high-fat, low-carbohydrate enteral formula in COPD patients. Nutrition, 2003. 19(3): p. 229-232.
49. Carlson, T.N., R.R. Gillies, and T.J. Schmugge, An interpretation of methodologies for indirect measurement of soil water content. Agricultural and forest meteorology, 1995. 77(3-4): p. 191-205.
50. Dauncey, M., P. Murgatroyd, and T. Cole, A human calorimeter for the direct and indirect measurement of 24 h energy expenditure. British Journal of Nutrition, 1978. 39(3): p. 557-566.
51. Dixit, M.K., et al., Identification of parameters for embodied energy measurement: A literature review. Energy and buildings, 2010. 42(8): p. 1238-1247.
52. Berggren, M., J.-F. Lapierre, and P.A. Del Giorgio, Magnitude and regulation of bacterioplankton respiratory quotient across freshwater environmental gradients. The ISME journal, 2012. 6(5): p. 984-993.
53. Nakamura, M., Y. Nagai, and T. Sekiguchi, Gas sensor and gas sensor system. 2002, Google Patents.
54. Yamazoe, N. and K. Shimanoe, New perspectives of gas sensor technology. Sensors and Actuators B: Chemical, 2009. 138(1): p. 100-107.
55. Crighton, D., The jet edge-tone feedback cycle; linear theory for the operating stages. Journal of Fluid Mechanics, 1992. 234: p. 361-391.
56. Hobson, J.A., R. Lydic, and H. Baghdoyan, Evolving concepts of sleep cycle generation: from brain centers to neuronal populations. Behavioral and Brain Sciences, 1986. 9(3): p. 371-400.
57. Babloyantz, A., J. Salazar, and C. Nicolis, Evidence of chaotic dynamics of brain activity during the sleep cycle. Physics letters A, 1985. 111(3): p. 152-156.
58. Feinberg, I., Changes in sleep cycle patterns with age. Journal of psychiatric research, 1974. 10(3-4): p. 283-306.
59. Sutherland, K., et al., Effect of weight loss on upper airway size and facial fat in men with obstructive sleep apnoea. Thorax, 2011. 66(9): p. 797-803.
60. Nilsson, B.M., et al., Physical capacity, respiratory quotient and energy expenditure during exercise in male patients with schizophrenia compared with healthy controls. European psychiatry, 2012. 27(3): p. 206-212.
61. Kadish, A.H., R.L. Litle, and J.C. Sternberg, A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clinical Chemistry, 1968. 14(2): p. 116-131.
62. Abeln, V., et al., Brainwave entrainment for better sleep and post-sleep state of young elite soccer players–A pilot study. European journal of sport science, 2014. 14(5): p. 393-402.
63. Stein, P.K. and Y. Pu, Heart rate variability, sleep and sleep disorders. Sleep medicine reviews, 2012. 16(1): p. 47-66.
64. Campos, H. and X. Siles, Siesta and the risk of coronary heart disease: results from a population-based, case-control study in Costa Rica. International journal of epidemiology, 2000. 29(3): p. 429-437.
65. Tanaka, H., K.D. Monahan, and D.R. Seals, Age-predicted maximal heart rate revisited. Journal of the american college of cardiology, 2001. 37(1): p. 153-156.
66. Issekutz Jr, B., N. Birkhead, and K. Rodahl, Use of respiratory quotients in assessment of aerobic work capacity. Journal of Applied Physiology, 1962. 17(1): p. 47-50.
67. Himwich, H.E. and M.I. Rose, The respiratory quotient of exercising muscle. Proceedings of the Society for Experimental Biology and Medicine, 1926. 24(2): p. 169-170.
68. Treuth, M.S., G.R. Hunter, and M. Williams, Effects of exercise intensity on 24-h energy expenditure and substrate oxidation. Medicine and science in sports and exercise, 1996. 28(9): p. 1138-1143.