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研究生: 徐嘉敏
Hsu, Chia-Min
論文名稱: 核磁共振系統應用於肝癌檢體之應用研究
Application Research of Nuclear Magnetic Resonance System in Liver Cancer Samples
指導教授: 廖書賢
Liao, Shu-Hsien
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2020
畢業學年度: 108
語文別: 中文
論文頁數: 38
中文關鍵詞: 中低場核磁共振系統肝癌組織檢測橫向鬆弛時間縱向鬆弛時間
DOI URL: http://doi.org/10.6345/NTNU202001272
論文種類: 學術論文
相關次數: 點閱:117下載:0
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  • 本研究使用電子核磁共振系統量測中低場核磁共振系統應用於肝臟(Liver)樣品之縱向鬆弛時間T_1(Longitudinal relaxation time)與橫向鬆弛時間T_2(Transverse relaxation time)之特性。
    利用電子核磁共振系統的Carr-Purcell-Meiboom-Gill(CPMG序列)、 Spin echo序列模式進行T_1 T_2之數據量測,並透過統計學的方法來討論T_1 T_2是否不因組織相同或相異而產生特定之結果。
    研究取用微量0.075g~0.130g的肝臟樣品,經實驗測量,縱向鬆弛時間T_1對比於正常組織在腫瘤組織上具有較高的數值,具有明顯的生物特性,與過去本實驗室進行各種腫瘤組織之T_1量測特性相同。
    研究中也以統計學中T-Test與ROC Curve兩種方式分析其數據,而橫向鬆弛時間T_2的研究部份,其不具可辨識之生物特性。

    In the research, we measured the Longitudinal relaxation time and Transverse relaxation time of the Liver sample with the electronic nuclear magnetic resonance system in the medium and low field nuclear magnetic resonance system.
    Use the instrument's Carr-Purcell-Meiboom-Gill and Spin echo sequence mode to measure Longitudinal relaxation time and Transverse relaxation time, and use statistical methods to discuss the data models of Longitudinal relaxation time and Transverse relaxation time.
    Using a small number of liver samples of 0.075g~0.130g, the Longitudinal relaxation time in this study has a significant difference between normal tissues and tumor tissues. It has the same characteristics as various tumor tissue measurements performed by our laboratory in the past, and is statistically T-Test and ROC Curve verify its data in two ways, and the Transverse relaxation time study proves that it has no identifiable biological characteristics.

    謝誌 i 摘要 ii 第一章 緒論 1 第二章 實驗原理 2 2.1.原子核特性 2 2.2.核磁共振原理 3 2.3.射頻脈衝 4 2.3.1.90°射頻脈衝 5 2.3.2.180°射頻脈衝 5 2.4.自由感應衰減(Free Induction Decay) 6 2.5.鬆弛時間常數(Relaxation) 7 2.5.1.縱向鬆弛時間T1 7 2.5.2 橫向鬆弛時間T2 8 第三章 實驗方法 9 3.1.實驗硬體系統架構 9 3.2.實驗軟體系統架設 11 3.3.檢體檢測方法 17 3.4.波序量測 18 3.5.數據分析 20 第四章 實驗結果 21 4.1.T1量測結果 21 4.2.T2量測結果 30 第五章 結論 36 參考文獻 37

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